TWI405761B - 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚 - Google Patents

適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚 Download PDF

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TWI405761B
TWI405761B TW96101771A TW96101771A TWI405761B TW I405761 B TWI405761 B TW I405761B TW 96101771 A TW96101771 A TW 96101771A TW 96101771 A TW96101771 A TW 96101771A TW I405761 B TWI405761 B TW I405761B
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compound
agent
ring
group
disease
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TW96101771A
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TW200806664A (en
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Luc Farmer
Gabriel Martinez-Botella
Albert Pierce
Francesco Salituro
Jian Wang
Marion Wannamaker
Tiansheng Wang
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Vertex Pharma
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Diabetes (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Rheumatology (AREA)
TW96101771A 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚 TWI405761B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75936706P 2006-01-17 2006-01-17
US84247106P 2006-09-06 2006-09-06

Publications (2)

Publication Number Publication Date
TW200806664A TW200806664A (en) 2008-02-01
TWI405761B true TWI405761B (zh) 2013-08-21

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ID=38197739

Family Applications (4)

Application Number Title Priority Date Filing Date
TW96101771A TWI405761B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW101137542A TWI423976B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW101137037A TWI424999B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW102147300A TW201412738A (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚

Family Applications After (3)

Application Number Title Priority Date Filing Date
TW101137542A TWI423976B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW101137037A TWI424999B (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
TW102147300A TW201412738A (zh) 2006-01-17 2007-01-17 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚

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US (6) US7767816B2 (enExample)
EP (3) EP1973911B1 (enExample)
JP (4) JP5591471B2 (enExample)
KR (3) KR20130041313A (enExample)
CN (3) CN102532133A (enExample)
AR (1) AR060316A1 (enExample)
AU (1) AU2007207533B8 (enExample)
BR (2) BRPI0722364A2 (enExample)
CA (1) CA2636189A1 (enExample)
CL (1) CL2008002140A1 (enExample)
HK (1) HK1210780A1 (enExample)
IL (1) IL191902A0 (enExample)
NO (1) NO20083501L (enExample)
NZ (3) NZ601687A (enExample)
RU (2) RU2453548C2 (enExample)
TW (4) TWI405761B (enExample)
UA (1) UA95940C2 (enExample)
WO (1) WO2007084557A2 (enExample)
ZA (2) ZA200805053B (enExample)

Families Citing this family (101)

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WO2005095400A1 (en) 2004-03-30 2005-10-13 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of jak and other protein kinases
RU2435769C2 (ru) * 2005-05-20 2011-12-10 Вертекс Фармасьютикалз Инкорпорейтед Пирролопиридины, полезные в качестве ингибиторов протеинкиназы
US20070149506A1 (en) 2005-09-22 2007-06-28 Arvanitis Argyrios G Azepine inhibitors of Janus kinases
KR101391900B1 (ko) 2005-12-13 2014-05-02 인사이트 코포레이션 야누스 키나아제 억제제로서의 헤테로아릴 치환된 피롤로［2,3-ｂ］피리딘 및 피롤로［2,3-ｂ］피리미딘
NZ601687A (en) 2006-01-17 2014-03-28 Vertex Pharma Azaindoles useful as inhibitors of janus kinases
US8741912B2 (en) * 2006-04-05 2014-06-03 Vertex Pharmaceuticals Incorporated Deazapurines useful as inhibitors of Janus kinases
US7754838B2 (en) * 2006-08-08 2010-07-13 E.I. Du Pont De Nemours And Company Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide
CN101678022A (zh) 2006-12-21 2010-03-24 弗特克斯药品有限公司 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物
EP2121692B1 (en) 2006-12-22 2013-04-10 Incyte Corporation Substituted heterocycles as janus kinase inhibitors
MX2009010127A (es) * 2007-03-22 2009-11-05 Vertex Pharma Compuestos utiles como inhibidores de janus cinasas.
WO2008157208A2 (en) 2007-06-13 2008-12-24 Incyte Corporation Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
EP2262498A2 (en) * 2008-03-10 2010-12-22 Vertex Pharmceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
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WO2007084557A2 (en) 2007-07-26
BRPI0706537A2 (pt) 2011-03-29
US9120790B2 (en) 2015-09-01
RU2011151085A (ru) 2013-06-20
TWI423976B (zh) 2014-01-21
EP2537849A3 (en) 2013-04-03
NZ592968A (en) 2012-08-31
AU2007207533A1 (en) 2007-07-26
BRPI0722364A2 (pt) 2011-08-16
KR20130041313A (ko) 2013-04-24
KR101409727B1 (ko) 2014-06-20
EP1973911A2 (en) 2008-10-01
CN104650077A (zh) 2015-05-27
TW201412738A (zh) 2014-04-01
EP2559694A2 (en) 2013-02-20
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RU2453548C2 (ru) 2012-06-20
IL191902A0 (en) 2008-12-29
NO20083501L (no) 2008-10-14
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AU2007207533B8 (en) 2012-06-28
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US20160008359A1 (en) 2016-01-14
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US8450489B2 (en) 2013-05-28
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CL2008002140A1 (es) 2009-03-06
ZA200805053B (en) 2010-11-24
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US20140336171A1 (en) 2014-11-13
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