TWI389908B - 抗病毒化合物類 - Google Patents

抗病毒化合物類 Download PDF

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Publication number
TWI389908B
TWI389908B TW095125697A TW95125697A TWI389908B TW I389908 B TWI389908 B TW I389908B TW 095125697 A TW095125697 A TW 095125697A TW 95125697 A TW95125697 A TW 95125697A TW I389908 B TWI389908 B TW I389908B
Authority
TW
Taiwan
Prior art keywords
group
alkyl
compound
acid
reaction
Prior art date
Application number
TW095125697A
Other languages
English (en)
Chinese (zh)
Other versions
TW200738741A (en
Inventor
Aesop Cho
Choung U Kim
Xiaoning C Sheng
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of TW200738741A publication Critical patent/TW200738741A/zh
Application granted granted Critical
Publication of TWI389908B publication Critical patent/TWI389908B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
TW095125697A 2005-07-14 2006-07-13 抗病毒化合物類 TWI389908B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69909605P 2005-07-14 2005-07-14
US70055905P 2005-07-18 2005-07-18

Publications (2)

Publication Number Publication Date
TW200738741A TW200738741A (en) 2007-10-16
TWI389908B true TWI389908B (zh) 2013-03-21

Family

ID=37387254

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095125697A TWI389908B (zh) 2005-07-14 2006-07-13 抗病毒化合物類

Country Status (13)

Country Link
US (1) US20070072809A1 (enExample)
EP (1) EP1907403B1 (enExample)
JP (1) JP2009501724A (enExample)
KR (1) KR101345008B1 (enExample)
CN (1) CN101243096B (enExample)
AR (1) AR054838A1 (enExample)
AU (1) AU2006267066A1 (enExample)
BR (1) BRPI0613056A2 (enExample)
CA (1) CA2614276A1 (enExample)
MX (1) MX2008000609A (enExample)
NZ (1) NZ564830A (enExample)
TW (1) TWI389908B (enExample)
WO (1) WO2007009109A2 (enExample)

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Also Published As

Publication number Publication date
AU2006267066A1 (en) 2007-01-18
WO2007009109A2 (en) 2007-01-18
CN101243096A (zh) 2008-08-13
NZ564830A (en) 2010-12-24
EP1907403B1 (en) 2013-12-25
KR20080027947A (ko) 2008-03-28
WO2007009109A3 (en) 2007-06-07
MX2008000609A (es) 2008-03-19
CN101243096B (zh) 2013-02-06
BRPI0613056A2 (pt) 2010-12-14
JP2009501724A (ja) 2009-01-22
AR054838A1 (es) 2007-07-18
KR101345008B1 (ko) 2013-12-31
US20070072809A1 (en) 2007-03-29
TW200738741A (en) 2007-10-16
CA2614276A1 (en) 2007-01-18
EP1907403A2 (en) 2008-04-09

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