CN101243096B - 抗病毒化合物 - Google Patents

抗病毒化合物 Download PDF

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Publication number
CN101243096B
CN101243096B CN2006800298851A CN200680029885A CN101243096B CN 101243096 B CN101243096 B CN 101243096B CN 2006800298851 A CN2006800298851 A CN 2006800298851A CN 200680029885 A CN200680029885 A CN 200680029885A CN 101243096 B CN101243096 B CN 101243096B
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CN
China
Prior art keywords
alkyl
acid
compounds
compound
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800298851A
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English (en)
Chinese (zh)
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CN101243096A (zh
Inventor
A·昭
金正恩
X·C·圣
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Gilead Sciences Inc
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Gilead Sciences Inc
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Filing date
Publication date
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Publication of CN101243096A publication Critical patent/CN101243096A/zh
Application granted granted Critical
Publication of CN101243096B publication Critical patent/CN101243096B/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2006800298851A 2005-07-14 2006-07-14 抗病毒化合物 Expired - Fee Related CN101243096B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69909605P 2005-07-14 2005-07-14
US60/699,096 2005-07-14
US70055905P 2005-07-18 2005-07-18
US60/700,559 2005-07-18
PCT/US2006/027605 WO2007009109A2 (en) 2005-07-14 2006-07-14 Antiviral compounds

Publications (2)

Publication Number Publication Date
CN101243096A CN101243096A (zh) 2008-08-13
CN101243096B true CN101243096B (zh) 2013-02-06

Family

ID=37387254

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800298851A Expired - Fee Related CN101243096B (zh) 2005-07-14 2006-07-14 抗病毒化合物

Country Status (13)

Country Link
US (1) US20070072809A1 (enExample)
EP (1) EP1907403B1 (enExample)
JP (1) JP2009501724A (enExample)
KR (1) KR101345008B1 (enExample)
CN (1) CN101243096B (enExample)
AR (1) AR054838A1 (enExample)
AU (1) AU2006267066A1 (enExample)
BR (1) BRPI0613056A2 (enExample)
CA (1) CA2614276A1 (enExample)
MX (1) MX2008000609A (enExample)
NZ (1) NZ564830A (enExample)
TW (1) TWI389908B (enExample)
WO (1) WO2007009109A2 (enExample)

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Also Published As

Publication number Publication date
AR054838A1 (es) 2007-07-18
CA2614276A1 (en) 2007-01-18
MX2008000609A (es) 2008-03-19
KR101345008B1 (ko) 2013-12-31
US20070072809A1 (en) 2007-03-29
AU2006267066A1 (en) 2007-01-18
NZ564830A (en) 2010-12-24
EP1907403A2 (en) 2008-04-09
TW200738741A (en) 2007-10-16
KR20080027947A (ko) 2008-03-28
BRPI0613056A2 (pt) 2010-12-14
EP1907403B1 (en) 2013-12-25
WO2007009109A2 (en) 2007-01-18
TWI389908B (zh) 2013-03-21
CN101243096A (zh) 2008-08-13
JP2009501724A (ja) 2009-01-22
WO2007009109A3 (en) 2007-06-07

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