TWI256310B - Stabilized aqueous suspensions for parenteral use - Google Patents
Stabilized aqueous suspensions for parenteral useInfo
- Publication number
- TWI256310B TWI256310B TW090111029A TW90111029A TWI256310B TW I256310 B TWI256310 B TW I256310B TW 090111029 A TW090111029 A TW 090111029A TW 90111029 A TW90111029 A TW 90111029A TW I256310 B TWI256310 B TW I256310B
- Authority
- TW
- Taiwan
- Prior art keywords
- aqueous suspensions
- parenteral use
- stabilized aqueous
- biologically active
- active compound
- Prior art date
Links
- 239000007900 aqueous suspension Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- UOACKFBJUYNSLK-XRKIENNPSA-N Estradiol Cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]21C)C(=O)CCC1CCCC1 UOACKFBJUYNSLK-XRKIENNPSA-N 0.000 abstract 2
- 229960005416 estradiol cypionate Drugs 0.000 abstract 2
- 229960002985 medroxyprogesterone acetate Drugs 0.000 abstract 2
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 abstract 2
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 229930195722 L-methionine Natural products 0.000 abstract 1
- 229960000255 exemestane Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229960004452 methionine Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/571,395 US6495534B2 (en) | 2000-05-15 | 2000-05-15 | Stabilized aqueous suspensions for parenteral use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI256310B true TWI256310B (en) | 2006-06-11 |
Family
ID=24283530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW090111029A TWI256310B (en) | 2000-05-15 | 2001-05-09 | Stabilized aqueous suspensions for parenteral use |
Country Status (30)
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495534B2 (en) * | 2000-05-15 | 2002-12-17 | Pharmacia & Upjohn Spa | Stabilized aqueous suspensions for parenteral use |
| US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
| ATE345277T1 (de) | 2002-08-21 | 2006-12-15 | Pharmacia Corp | Injizierbare pharmazeutische suspension in einer phiole mit zwei kammern |
| AU2003290647A1 (en) * | 2002-11-08 | 2004-06-03 | Bristol-Myers Squibb Company | Pharmaceutical compositions and methods of using taxane derivatives |
| CL2004000698A1 (es) * | 2003-03-31 | 2005-05-20 | Alza Corp | Comosicion farmaceutica no acuosa que comprende al menos un ingrediente activo y un vehiculo de fase unica que contiene al menos un polimero y al menos un solvente, siendo el vehiculo miscible en agua; procedimiento para su preparacion; dispositivo d |
| EP1660009B1 (en) * | 2003-09-03 | 2015-01-28 | Miscon Trading S.A. | Methods for the treatment of endometriosis |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| US20050106214A1 (en) * | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
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| US20070154546A1 (en) * | 2005-12-30 | 2007-07-05 | Zhang Jack Y | Sustained release pharmaceutical compositions |
| EP1988878A2 (en) * | 2006-02-15 | 2008-11-12 | Tika Läkemedel AB | Sterilization of corticosteroids with reduced mass loss |
| TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| JP5371180B2 (ja) * | 2006-06-15 | 2013-12-18 | 日立コンシューマエレクトロニクス株式会社 | 投写型映像表示装置 |
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| GB0813628D0 (en) * | 2008-07-25 | 2008-09-03 | Arrow Int Ltd | Stable coated anti-cancer agent |
| UY33103A (es) * | 2009-12-15 | 2011-07-29 | Techsphere S A De C V | Formulacion farmaceutica parenteral en suspension, de liberacion sostenida, en dosis baja y ultra baja, en terapia hormonal en el sindrome climaterico |
| CN106442039B (zh) | 2011-06-19 | 2020-08-07 | 阿博根公司 | 用于样品采集的装置、溶液和方法 |
| PL2782584T3 (pl) | 2011-11-23 | 2021-12-13 | Therapeuticsmd, Inc. | Naturalne skojarzone hormonalne formulacje i terapie zastępcze |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| UA74095U (ru) * | 2012-07-20 | 2012-10-10 | Николай Иванович Гуменюк | Препарат для лечения туберкулеза |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| WO2015042163A1 (en) * | 2013-09-17 | 2015-03-26 | Terapio Corporation | Methods of preventing or treating mucositis using rlip76 |
| CN104706578B (zh) * | 2013-12-14 | 2019-04-23 | 天津金耀集团有限公司 | 一种醋酸甲泼尼龙混悬注射液组合物的制备方法 |
| AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US9265396B1 (en) | 2015-03-16 | 2016-02-23 | Irobot Corporation | Autonomous floor cleaning with removable pad |
| US9907449B2 (en) | 2015-03-16 | 2018-03-06 | Irobot Corporation | Autonomous floor cleaning with a removable pad |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US11135154B2 (en) | 2016-03-02 | 2021-10-05 | Teva Pharmaceutical Industries Ltd. | Medroxyprogesterone acetate injectable compositions and methods of use |
| EP3435977A4 (en) | 2016-04-01 | 2019-10-16 | Therapeuticsmd, Inc. | PHARMACEUTICAL COMPOSITION OF STEROID HORMONE |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| US11590077B2 (en) * | 2016-05-06 | 2023-02-28 | Eagle Pharmaceuticals, Inc. | Fulvestrant formulations and methods of their use |
| IL285928B2 (en) | 2016-05-06 | 2025-06-01 | Eagle Pharmaceuticals Inc | Fulvestrant formulations and methods of their use |
| RS62362B1 (sr) | 2017-07-14 | 2021-10-29 | Janssen Pharmaceutica Nv | Formulacije sa dugotrajnim dejstvom |
| WO2019049081A1 (en) * | 2017-09-07 | 2019-03-14 | Teva Pharmaceutical Industries Ltd. | INJECTABLE COMPOSITIONS OF MEDROXYPROGESTERONE ACETATE AND METHODS OF USE |
| WO2019048906A1 (en) * | 2017-09-07 | 2019-03-14 | Teva Pharmaceutical Industries Ltd. | INJECTABLE COMPOSITIONS OF MEDROXYPROGESTERONE ACETATE AND METHODS OF USE |
| MA50570A (fr) * | 2017-11-08 | 2020-09-16 | Eagle Pharmaceuticals Inc | Formulations de fulvestrant et méthodes d'utilisation de ces dernières |
| MX2020007368A (es) | 2018-01-11 | 2020-10-12 | Viropharma Biologics Llc | Composiciones estables de corticosteroides. |
| US11752095B2 (en) | 2018-09-07 | 2023-09-12 | Family Health International | Medroxyprogesterone acetate injectable compositions and methods of use |
| US10544923B1 (en) | 2018-11-06 | 2020-01-28 | Verifone, Inc. | Devices and methods for optical-based tamper detection using variable light characteristics |
| AU2019384801A1 (en) | 2018-11-20 | 2021-06-10 | Spectrum Solutions, Llc | Sample collection system including sealing cap and valve |
| IT201900002857A1 (it) | 2019-02-27 | 2020-08-27 | Ntc S R L | Procedimento di riempimento di contenitori con una polvere |
| US11701094B2 (en) | 2019-06-20 | 2023-07-18 | Spectrum Solutions L.L.C. | Sample collection system including valve and plug assemblies |
| WO2021146215A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| TW202239408A (zh) * | 2021-01-29 | 2022-10-16 | 瑞士商艾克泰聯製藥有限公司 | 包含二苯基吡𠯤衍生物的醫藥組成物 |
| US20240237929A1 (en) * | 2021-05-19 | 2024-07-18 | Acies Medical Llc | Point-of-use calibration system for iron ion detection system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2861920A (en) * | 1954-05-04 | 1958-11-25 | Upjohn Co | Therapeutic suspensions of steroids containing pvp and/or pva |
| JPS5831210B2 (ja) * | 1973-04-09 | 1983-07-05 | 武田薬品工業株式会社 | アンテイナスイセイケンダクエキノセイゾウホウ |
| US4038389A (en) * | 1975-05-07 | 1977-07-26 | The Upjohn Company | Medroxyprogesterone acetate compositions |
| US4154820A (en) * | 1976-02-23 | 1979-05-15 | Akzona Incorporated | Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers |
| JP2577744B2 (ja) | 1986-07-18 | 1997-02-05 | 中外製薬株式会社 | 安定な顆粒球コロニ−刺激因子含有製剤 |
| US5208261A (en) * | 1989-12-06 | 1993-05-04 | Akzo N.V. | Stabilized solutions of psychotropic agents |
| ATE99943T1 (de) * | 1989-12-06 | 1994-01-15 | Akzo Nv | Psychotropische wirkstoffe enthaltende stabilisierte loesungen. |
| JPH0597671A (ja) | 1991-10-04 | 1993-04-20 | Sumitomo Pharmaceut Co Ltd | 注射用凍結乾燥製剤 |
| CA2120197A1 (en) | 1993-04-02 | 1994-10-03 | Kenji Endo | Stable aqueous dispersions containing liposomes |
| JP3862295B2 (ja) * | 1993-09-30 | 2006-12-27 | 独立行政法人理化学研究所 | 抗肥満剤 |
| US5540930A (en) * | 1993-10-25 | 1996-07-30 | Pharmos Corporation | Suspension of loteprednol etabonate for ear, eye, or nose treatment |
| JP3543144B2 (ja) | 1995-03-11 | 2004-07-14 | 国際試薬株式会社 | 臨床検査用製剤 |
| US5780431A (en) | 1996-09-20 | 1998-07-14 | Neurobiological Technologies, Inc. | Pharmaceutical formulations of corticotropin releasing factor having improved stability in liquid form |
| JP2001501619A (ja) | 1996-10-04 | 2001-02-06 | アムジェン インコーポレーテッド | ｍｐｌリガンドを含有する医薬組成物 |
| US5773432A (en) * | 1996-10-30 | 1998-06-30 | Schering Aktiengesellschaft | Method for lowering plasma levels of lipoprotein(a) |
| US5880116A (en) * | 1996-12-13 | 1999-03-09 | Neurocal International | Use of celastrol to treat alzheimer's disease |
| JP3748970B2 (ja) | 1997-01-31 | 2006-02-22 | 電気化学工業株式会社 | ヒアルロン酸ナトリウム含有水溶液 |
| KR100508227B1 (ko) | 1997-03-14 | 2006-03-23 | 센주 세이야꾸 가부시키가이샤 | 로테프레드놀에타보네이트수성현탁액 |
| KR100711990B1 (ko) | 1997-09-23 | 2007-05-02 | 렌트슐러 비오테히놀로기 게엠베하 | 액상 인터페론-베타 제제 |
| US5968918A (en) * | 1997-10-17 | 1999-10-19 | Kanda; Iwao | Method for the prevention of coronary artery spasm |
| US5972921A (en) * | 1997-12-12 | 1999-10-26 | Hormos Medical Oy Ltd. | Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men |
| ATE254918T1 (de) | 1998-04-02 | 2003-12-15 | Akzo Nobel Nv | Orale flüssige lösung enthaltend das antidepressivum mirtazapine |
| US6525102B1 (en) | 1999-10-04 | 2003-02-25 | Chiron Corporation | Stabilized liquid polypeptide-containing pharmaceutical compositions |
| US6495534B2 (en) * | 2000-05-15 | 2002-12-17 | Pharmacia & Upjohn Spa | Stabilized aqueous suspensions for parenteral use |
-
2000
- 2000-05-15 US US09/571,395 patent/US6495534B2/en not_active Expired - Lifetime
-
2001
- 2001-04-25 AU AU6737101A patent/AU6737101A/xx active Pending
- 2001-04-25 NZ NZ522324A patent/NZ522324A/en not_active IP Right Cessation
- 2001-04-25 CZ CZ20023750A patent/CZ303872B6/cs not_active IP Right Cessation
- 2001-04-25 CN CNB018095895A patent/CN100473376C/zh not_active Expired - Lifetime
- 2001-04-25 CA CA002409059A patent/CA2409059C/en not_active Expired - Lifetime
- 2001-04-25 IL IL152537A patent/IL152537A/en active IP Right Grant
- 2001-04-25 DK DK01945040T patent/DK1282402T3/da active
- 2001-04-25 SI SI200130485T patent/SI1282402T1/sl unknown
- 2001-04-25 HU HU0302021A patent/HU229800B1/hu unknown
- 2001-04-25 ES ES01945040T patent/ES2254443T3/es not_active Expired - Lifetime
- 2001-04-25 EE EEP200200631A patent/EE05376B1/xx unknown
- 2001-04-25 AU AU2001267371A patent/AU2001267371B2/en not_active Expired
- 2001-04-25 MX MXPA02011195A patent/MXPA02011195A/es active IP Right Grant
- 2001-04-25 SK SK1598-2002A patent/SK287641B6/sk not_active IP Right Cessation
- 2001-04-25 KR KR1020027015431A patent/KR100828957B1/ko not_active Expired - Lifetime
- 2001-04-25 JP JP2001583735A patent/JP4205341B2/ja not_active Expired - Lifetime
- 2001-04-25 WO PCT/EP2001/004643 patent/WO2001087266A1/en active IP Right Grant
- 2001-04-25 DE DE60116084T patent/DE60116084T2/de not_active Expired - Lifetime
- 2001-04-25 PL PL365793A patent/PL203075B1/pl unknown
- 2001-04-25 HK HK03106493.6A patent/HK1054194B/zh not_active IP Right Cessation
- 2001-04-25 EA EA200201208A patent/EA007682B1/ru not_active IP Right Cessation
- 2001-04-25 AT AT01945040T patent/ATE313316T1/de active
- 2001-04-25 EP EP01945040A patent/EP1282402B1/en not_active Expired - Lifetime
- 2001-04-25 IN IN1996CH2002 patent/IN224279B/en unknown
- 2001-04-25 BR BR0110841-7A patent/BR0110841A/pt not_active Application Discontinuation
- 2001-05-09 TW TW090111029A patent/TWI256310B/zh not_active IP Right Cessation
- 2001-05-14 AR ARP010102268A patent/AR029924A1/es not_active Application Discontinuation
- 2001-05-14 PE PE2001000431A patent/PE20011322A1/es active IP Right Grant
-
2002
- 2002-08-21 US US10/225,320 patent/US20030114430A1/en not_active Abandoned
- 2002-10-10 US US10/267,690 patent/US20030130245A1/en not_active Abandoned
- 2002-10-29 ZA ZA200208738A patent/ZA200208738B/xx unknown
- 2002-11-13 NO NO20025431A patent/NO332215B1/no not_active IP Right Cessation
-
2004
- 2004-12-21 IL IL16588804A patent/IL165888A0/xx unknown
-
2014
- 2014-12-18 AR ARP140104760A patent/AR098830A2/es unknown
-
2018
- 2018-05-14 AR ARP180101264A patent/AR111695A2/es unknown
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