TW592727B - Phosphate-binding polymer preparations - Google Patents
Phosphate-binding polymer preparations Download PDFInfo
- Publication number
- TW592727B TW592727B TW087104092A TW87104092A TW592727B TW 592727 B TW592727 B TW 592727B TW 087104092 A TW087104092 A TW 087104092A TW 87104092 A TW87104092 A TW 87104092A TW 592727 B TW592727 B TW 592727B
- Authority
- TW
- Taiwan
- Prior art keywords
- phosphate
- binding polymer
- less
- particle size
- tablet
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract description 10
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 title abstract description 4
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 title abstract description 4
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract description 11
- 229920002678 cellulose Polymers 0.000 abstract description 3
- 239000001913 cellulose Substances 0.000 abstract description 3
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 abstract description 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000033001 locomotion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 11
- 239000007937 lozenge Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
- 238000005299 abrasion Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 230000002079 cooperative effect Effects 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 229920000083 poly(allylamine) Polymers 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000013585 weight reducing agent Substances 0.000 description 2
- PCTMTFRHKVHKIS-BMFZQQSSSA-N (1s,3r,4e,6e,8e,10e,12e,14e,16e,18s,19r,20r,21s,25r,27r,30r,31r,33s,35r,37s,38r)-3-[(2r,3s,4s,5s,6r)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10 Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2.O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 PCTMTFRHKVHKIS-BMFZQQSSSA-N 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical group ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical class CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 1
- 229940081735 acetylcellulose Drugs 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- -1 propylpropoxy Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8658197 | 1997-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW592727B true TW592727B (en) | 2004-06-21 |
Family
ID=13890981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW087104092A TW592727B (en) | 1997-04-04 | 1998-03-19 | Phosphate-binding polymer preparations |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6383518B1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP0997148B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2009173687A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100456202B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1180782C (cg-RX-API-DMAC7.html) |
| AT (2) | ATE244013T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU726142B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2286003C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1106823T1 (cg-RX-API-DMAC7.html) |
| DE (2) | DE69816082T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1304104T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2287215T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1304104E (cg-RX-API-DMAC7.html) |
| TW (1) | TW592727B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1998044933A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720061D0 (en) | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
| JP3718341B2 (ja) | 1998-05-12 | 2005-11-24 | 信越化学工業株式会社 | 低置換度ヒドロキシプロピルセルロースとその製造方法 |
| TW568788B (en) * | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
| US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
| US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
| HUP0203334A2 (hu) * | 1999-10-19 | 2003-02-28 | Geltex Pharmaceuticals, Inc. | Közvetlen kompresszióval előállított polimer tabletta magok |
| US6680069B1 (en) | 1999-11-09 | 2004-01-20 | Shin-Etsu Chemical Co., Ltd. | Low-substituted hydroxypropyl cellulose and process for manufacturing the same |
| JP3552160B2 (ja) | 2000-01-14 | 2004-08-11 | 信越化学工業株式会社 | 低置換度ヒドロキシプロピルセルロース粒子の形成方法 |
| US6710162B2 (en) | 2001-02-16 | 2004-03-23 | Genzyme Corporation | Method of drying a material having a cohesive phase |
| WO2002085379A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for improving vascular access in patients with vascular shunts |
| AU2002257145B2 (en) | 2001-04-18 | 2005-06-02 | Genzyme Corporation | Method for lowering serum glucose |
| MXPA03009572A (es) | 2001-04-18 | 2004-02-12 | Genzyme Corp | Formas de polialilamina con bajo contenido en sal. |
| FR2827771B1 (fr) * | 2001-07-25 | 2003-10-24 | Apis Spheromont | Formulation et procede de preparation de spheroides pouvant etre fortement titres et a dispersion rapide |
| US6600011B2 (en) | 2001-10-09 | 2003-07-29 | Genzyme Corporation | Process for purification and drying of polymer hydrogels |
| TWI231760B (en) * | 2001-12-20 | 2005-05-01 | Chugai Pharmaceutical Co Ltd | Coated lozenge and manufacturing method thereof |
| US7767768B2 (en) | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7608674B2 (en) | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| US7459502B2 (en) | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
| US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7335795B2 (en) | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
| US7385012B2 (en) | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
| US20060177415A1 (en) * | 2004-11-01 | 2006-08-10 | Burke Steven K | Once a day formulation for phosphate binders |
| US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| EP1869090A1 (en) * | 2005-03-16 | 2007-12-26 | Council Of Scientific And Industrial Research | An improved process for the preparation of crosslinked polyallylamine polymer. |
| JP2009507019A (ja) | 2005-09-02 | 2009-02-19 | ジェンザイム・コーポレーション | リン酸塩を除去する方法およびそれに使用される重合体 |
| DK1924246T3 (en) | 2005-09-15 | 2016-01-18 | Genzyme Corp | PORTION LETTER DEFINITION OF amine polymers |
| GB0601899D0 (en) * | 2006-01-31 | 2006-03-08 | Ineos Silicas Ltd | Compositions |
| MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
| DK1818048T3 (da) * | 2006-02-14 | 2009-04-20 | Teva Pharma | Farmaceutiske formuleringer af alifatiske aminpolymerer og metoder til deres fremstilling |
| CN101404982A (zh) | 2006-02-14 | 2009-04-08 | 特瓦制药工业有限公司 | 脂族胺聚合物的药物制剂和它们的制造方法 |
| EP2016114A2 (en) * | 2006-05-05 | 2009-01-21 | Genzyme Corporation | Amine condensation polymers as phosphate sequestrants |
| US20100124542A1 (en) * | 2006-07-18 | 2010-05-20 | Genzyme Corporation | Amine dendrimers |
| RU2009111853A (ru) | 2006-09-01 | 2010-10-10 | Юсв Лимитед (In) | Способ получения гидрохлорида севеламера и его лекарственной формы |
| US7964182B2 (en) | 2006-09-01 | 2011-06-21 | USV, Ltd | Pharmaceutical compositions comprising phosphate-binding polymer |
| BRPI0717545A2 (pt) | 2006-09-29 | 2013-10-22 | Gezyme Corp | Composição farmacêutica, método para tratar uma doença, polímero de amida, rede de polímero, e, método para preparar um polímero de amida |
| BRPI0720234A2 (pt) * | 2006-12-14 | 2013-12-24 | Genzyme Corp | Composição farmacêutica |
| JP2010519298A (ja) * | 2007-02-23 | 2010-06-03 | ゲンズイメ コーポレーション | アミンポリマー組成物 |
| US20100196305A1 (en) * | 2007-03-08 | 2010-08-05 | Dhal Pradeep K | Sulfone polymer compositions |
| EP2152277A1 (en) * | 2007-04-27 | 2010-02-17 | Genzyme Corporation | Amido-amine dendrimer compositions |
| GB0714670D0 (en) | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
| WO2009034540A1 (en) * | 2007-09-11 | 2009-03-19 | Ranbaxy Laboratories Limited | Pharmaceutical composition of sevelamer |
| GB0720220D0 (en) | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
| EP2217215A1 (en) * | 2007-12-14 | 2010-08-18 | Genzyme Corporation | Coated pharmaceutical compositions |
| WO2009154747A1 (en) * | 2008-06-20 | 2009-12-23 | Genzyme Corporation | Pharmaceutical compositions |
| DE102008030046A1 (de) | 2008-06-25 | 2009-12-31 | Ratiopharm Gmbh | Kompaktiertes Polyallylamin-Polymer |
| RU2011134847A (ru) * | 2009-01-22 | 2013-02-27 | Юсв Лимитед | Фармацевтические композиции, содержащие фосфатсвязывающий полимер |
| US20100330175A1 (en) * | 2009-06-24 | 2010-12-30 | Jobdevairakkam Christopher N | Cross-linked polyallylamine tablet core |
| WO2010149794A2 (en) | 2009-06-26 | 2010-12-29 | Combino Pharm, S.L. | Novel pharmaceutical composition comprising poly (allylamin-co-n,n'-diallyl- 1,3-diamino-2-hydroxypropane) |
| GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
| EP2490675B1 (en) * | 2009-10-22 | 2019-01-23 | Synthon B.V. | Pharmaceutical compositions of sevelamer |
| GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
| EP2545907A1 (en) | 2011-07-15 | 2013-01-16 | Combino Pharm, S.L. | Aqueous wet granulation process for cross-linked polyallylamine polymers |
| MA41202A (fr) | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
| US20180015119A1 (en) * | 2015-02-23 | 2018-01-18 | Amneal Pharmaceuticals Company Gmbh | Process for granulating sevelamer carbonate |
| BR112019013364A2 (pt) | 2016-12-28 | 2020-04-14 | Fujifilm Corp | emulsão de polímero contendo átomo de nitrogênio ou sal do mesmo, método de produção para o mesmo e método de produção para partículas |
| EP3698799B1 (en) | 2017-10-16 | 2022-01-26 | FUJIFILM Corporation | Hyperphosphatemia treatment agent |
| CN111246857A (zh) * | 2017-10-16 | 2020-06-05 | 富士胶片株式会社 | 高磷血症治疗剂及粒子 |
| JP2019182818A (ja) * | 2018-04-17 | 2019-10-24 | ライオン株式会社 | 舌苔除去用の口腔内崩壊錠及び舌苔除去方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6090243A (ja) | 1983-10-25 | 1985-05-21 | Nitto Boseki Co Ltd | 小球状モノアリルアミン橋かけ重合体の製造方法 |
| US4631305A (en) * | 1985-03-22 | 1986-12-23 | The Upjohn Company | Polymeric material as a disintegrant in a compressed tablet |
| ES2039226T3 (es) | 1986-12-30 | 1993-09-16 | American Cyanamid Company | Procedimiento para preparar composiciones que contienen policarbofil. |
| US4956182A (en) * | 1989-03-16 | 1990-09-11 | Bristol-Myers Company | Direct compression cholestyramine tablet and solvent-free coating therefor |
| JPH02286621A (ja) | 1989-04-26 | 1990-11-26 | Mitsubishi Kasei Corp | 経口コレステロール低下剤 |
| JPH0413627A (ja) | 1990-04-27 | 1992-01-17 | Mitsubishi Kasei Corp | 経口コレステロール低下剤 |
| JP2609022B2 (ja) | 1990-11-29 | 1997-05-14 | 北陸製薬株式会社 | ポリカルボフィルカルシウム含有製剤 |
| JPH06157325A (ja) | 1992-11-30 | 1994-06-03 | Mitsubishi Kasei Corp | 経口コレステロール低下剤 |
| TW272942B (cg-RX-API-DMAC7.html) | 1993-02-10 | 1996-03-21 | Takeda Pharm Industry Co Ltd | |
| US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| WO1996021454A1 (en) * | 1995-01-12 | 1996-07-18 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| JP3836893B2 (ja) | 1995-01-24 | 2006-10-25 | アボットジャパン株式会社 | ポリカルボフィルカルシウム含有製剤 |
| TW438608B (en) | 1995-08-02 | 2001-06-07 | Hisamitsu Pharmaceutical Co | A tablet containing anion exchange resin |
| JP3389493B2 (ja) * | 1997-04-04 | 2003-03-24 | 中外製薬株式会社 | リン酸結合性ポリマー製剤 |
-
1998
- 1998-03-19 TW TW087104092A patent/TW592727B/zh not_active IP Right Cessation
- 1998-04-03 WO PCT/JP1998/001536 patent/WO1998044933A1/ja not_active Ceased
- 1998-04-03 AU AU65223/98A patent/AU726142B2/en not_active Expired
- 1998-04-03 DE DE69816082T patent/DE69816082T2/de not_active Expired - Lifetime
- 1998-04-03 EP EP98911187A patent/EP0997148B1/en not_active Expired - Lifetime
- 1998-04-03 DE DE69837945T patent/DE69837945T2/de not_active Expired - Lifetime
- 1998-04-03 PT PT02025683T patent/PT1304104E/pt unknown
- 1998-04-03 CN CNB988046245A patent/CN1180782C/zh not_active Expired - Lifetime
- 1998-04-03 ES ES02025683T patent/ES2287215T3/es not_active Expired - Lifetime
- 1998-04-03 CA CA002286003A patent/CA2286003C/en not_active Expired - Lifetime
- 1998-04-03 AT AT98911187T patent/ATE244013T1/de active
- 1998-04-03 US US09/381,506 patent/US6383518B1/en not_active Expired - Lifetime
- 1998-04-03 EP EP02025683A patent/EP1304104B1/en not_active Expired - Lifetime
- 1998-04-03 KR KR10-1999-7009058A patent/KR100456202B1/ko not_active Expired - Lifetime
- 1998-04-03 ES ES98911187T patent/ES2201463T3/es not_active Expired - Lifetime
- 1998-04-03 AT AT02025683T patent/ATE364377T1/de active
- 1998-04-03 DK DK02025683T patent/DK1304104T3/da active
-
2002
- 2002-03-06 US US10/090,622 patent/US6696087B2/en not_active Expired - Lifetime
-
2007
- 2007-08-23 CY CY20071101107T patent/CY1106823T1/el unknown
-
2009
- 2009-05-15 JP JP2009118371A patent/JP2009173687A/ja not_active Withdrawn
-
2012
- 2012-10-18 JP JP2012230662A patent/JP5681156B2/ja not_active Expired - Fee Related
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