JP2009173687A - リン酸結合性ポリマー製剤 - Google Patents

リン酸結合性ポリマー製剤 Download PDF

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Publication number
JP2009173687A
JP2009173687A JP2009118371A JP2009118371A JP2009173687A JP 2009173687 A JP2009173687 A JP 2009173687A JP 2009118371 A JP2009118371 A JP 2009118371A JP 2009118371 A JP2009118371 A JP 2009118371A JP 2009173687 A JP2009173687 A JP 2009173687A
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JP
Japan
Prior art keywords
tablet
phosphate
binding polymer
weight
hardness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009118371A
Other languages
English (en)
Japanese (ja)
Inventor
Katsuya Matsuda
勝也 松田
Ryuji Kubota
隆二 窪田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP2009118371A priority Critical patent/JP2009173687A/ja
Publication of JP2009173687A publication Critical patent/JP2009173687A/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
JP2009118371A 1997-04-04 2009-05-15 リン酸結合性ポリマー製剤 Withdrawn JP2009173687A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009118371A JP2009173687A (ja) 1997-04-04 2009-05-15 リン酸結合性ポリマー製剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8658197 1997-04-04
JP2009118371A JP2009173687A (ja) 1997-04-04 2009-05-15 リン酸結合性ポリマー製剤

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2002066314A Division JP2002265371A (ja) 1997-04-04 2002-03-12 リン酸結合性ポリマー製剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012230662A Division JP5681156B2 (ja) 1997-04-04 2012-10-18 リン酸結合性ポリマー製剤

Publications (1)

Publication Number Publication Date
JP2009173687A true JP2009173687A (ja) 2009-08-06

Family

ID=13890981

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009118371A Withdrawn JP2009173687A (ja) 1997-04-04 2009-05-15 リン酸結合性ポリマー製剤
JP2012230662A Expired - Fee Related JP5681156B2 (ja) 1997-04-04 2012-10-18 リン酸結合性ポリマー製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012230662A Expired - Fee Related JP5681156B2 (ja) 1997-04-04 2012-10-18 リン酸結合性ポリマー製剤

Country Status (15)

Country Link
US (2) US6383518B1 (cg-RX-API-DMAC7.html)
EP (2) EP1304104B1 (cg-RX-API-DMAC7.html)
JP (2) JP2009173687A (cg-RX-API-DMAC7.html)
KR (1) KR100456202B1 (cg-RX-API-DMAC7.html)
CN (1) CN1180782C (cg-RX-API-DMAC7.html)
AT (2) ATE244013T1 (cg-RX-API-DMAC7.html)
AU (1) AU726142B2 (cg-RX-API-DMAC7.html)
CA (1) CA2286003C (cg-RX-API-DMAC7.html)
CY (1) CY1106823T1 (cg-RX-API-DMAC7.html)
DE (2) DE69837945T2 (cg-RX-API-DMAC7.html)
DK (1) DK1304104T3 (cg-RX-API-DMAC7.html)
ES (2) ES2201463T3 (cg-RX-API-DMAC7.html)
PT (1) PT1304104E (cg-RX-API-DMAC7.html)
TW (1) TW592727B (cg-RX-API-DMAC7.html)
WO (1) WO1998044933A1 (cg-RX-API-DMAC7.html)

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TW568788B (en) 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
DE60017285T2 (de) * 1999-10-19 2005-12-08 Genzyme Corp., Cambridge Direktkomprimierter tablettenkern auf polymerbasis
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US6680069B1 (en) 1999-11-09 2004-01-20 Shin-Etsu Chemical Co., Ltd. Low-substituted hydroxypropyl cellulose and process for manufacturing the same
JP3552160B2 (ja) 2000-01-14 2004-08-11 信越化学工業株式会社 低置換度ヒドロキシプロピルセルロース粒子の形成方法
WO2002066543A1 (en) 2001-02-16 2002-08-29 Genzyme Corporation Method of drying a material having a cohesive phase
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
DK1392331T3 (da) 2001-04-18 2008-06-23 Genzyme Corp Anvendelse af colesevelam eller sevelamer, hydrogenchlorid til sænkning af serumglucoseniveauet
CN1290515C (zh) 2001-04-18 2006-12-20 基酶有限公司 低盐含量的聚烯丙胺
FR2827771B1 (fr) * 2001-07-25 2003-10-24 Apis Spheromont Formulation et procede de preparation de spheroides pouvant etre fortement titres et a dispersion rapide
US6600011B2 (en) 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
TWI231760B (en) * 2001-12-20 2005-05-01 Chugai Pharmaceutical Co Ltd Coated lozenge and manufacturing method thereof
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7449605B2 (en) 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
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EP1951266A2 (en) * 2005-09-02 2008-08-06 Genzyme Corporation Method for removing phosphate and polymer used therefore
DK1924246T3 (en) 2005-09-15 2016-01-18 Genzyme Corp PORTION LETTER DEFINITION OF amine polymers
GB0601899D0 (en) * 2006-01-31 2006-03-08 Ineos Silicas Ltd Compositions
MY157620A (en) * 2006-01-31 2016-06-30 Cytochroma Dev Inc A granular material of a solid water-soluble mixed metal compound capable of binding phosphate
ES2320265T3 (es) * 2006-02-14 2009-05-20 Teva Pharmaceutical Industries, Ltd. Formulaciones farmaceuticas de polimeros amino alifaticos y procedimientos para su preparacion.
CN101404982A (zh) 2006-02-14 2009-04-08 特瓦制药工业有限公司 脂族胺聚合物的药物制剂和它们的制造方法
EP2016114A2 (en) * 2006-05-05 2009-01-21 Genzyme Corporation Amine condensation polymers as phosphate sequestrants
WO2008011047A2 (en) * 2006-07-18 2008-01-24 Genzyme Corporation Amine dendrimers
US7964182B2 (en) 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
CA2749074A1 (en) * 2006-09-01 2008-05-29 Usv Limited Process for the preparation of sevelamer hydrochloride and formulation thereof
EP2066293A2 (en) 2006-09-29 2009-06-10 Genzyme Corporation Amide dendrimer compositions
JP2010513271A (ja) 2006-12-14 2010-04-30 ゲンズイメ コーポレーション アミド−アミンポリマー組成物
WO2008103368A1 (en) * 2007-02-23 2008-08-28 Genzyme Corporation Amine polymer compositions
JP2010520285A (ja) * 2007-03-08 2010-06-10 ゲンズイメ コーポレーション スルホンポリマー組成物
WO2008133954A1 (en) * 2007-04-27 2008-11-06 Genzyme Corporation Amido-amine dendrimer compositions
GB0714670D0 (en) 2007-07-27 2007-09-05 Ineos Healthcare Ltd Use
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
GB0720220D0 (en) 2007-10-16 2007-11-28 Ineos Healthcare Ltd Compound
WO2009078958A1 (en) * 2007-12-14 2009-06-25 Genzyme Corporation Coated pharmaceutical compositions
WO2009154747A1 (en) * 2008-06-20 2009-12-23 Genzyme Corporation Pharmaceutical compositions
DE102008030046A1 (de) 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
BRPI1006969A2 (pt) 2009-01-22 2016-04-12 Usv Ltd composições farmacêuticas compreendendo polímero de ligação a fosfato
US20100330175A1 (en) * 2009-06-24 2010-12-30 Jobdevairakkam Christopher N Cross-linked polyallylamine tablet core
WO2010149794A2 (en) 2009-06-26 2010-12-29 Combino Pharm, S.L. Novel pharmaceutical composition comprising poly (allylamin-co-n,n'-diallyl- 1,3-diamino-2-hydroxypropane)
GB0913525D0 (en) 2009-08-03 2009-09-16 Ineos Healthcare Ltd Method
DK2490675T3 (en) * 2009-10-22 2019-04-29 Synthon Bv Pharmaceutical compositions with sevelamer
GB201001779D0 (en) 2010-02-04 2010-03-24 Ineos Healthcare Ltd Composition
EP2545907A1 (en) 2011-07-15 2013-01-16 Combino Pharm, S.L. Aqueous wet granulation process for cross-linked polyallylamine polymers
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
WO2016135065A1 (en) * 2015-02-23 2016-09-01 Amneal Pharmaceuticals Company Gmbh Process for granulating sevelamer carbonate
TWI757398B (zh) 2016-12-28 2022-03-11 日商富士軟片股份有限公司 含氮原子的聚合物或其鹽的乳化液、其製造方法、及粒子的製造方法
CN111225674A (zh) 2017-10-16 2020-06-02 富士胶片株式会社 高磷血症治疗剂
TW201922268A (zh) * 2017-10-16 2019-06-16 日商富士軟片股份有限公司 高磷血症治療劑及粒子
JP2019182818A (ja) * 2018-04-17 2019-10-24 ライオン株式会社 舌苔除去用の口腔内崩壊錠及び舌苔除去方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03236326A (ja) * 1989-03-16 1991-10-22 Bristol Myers Squibb Co 直接圧縮コレスチラミン錠剤及びその無溶剤被覆物
JPH05246861A (ja) * 1990-11-29 1993-09-24 Hokuriku Seiyaku Co Ltd ポリカルボフィルカルシウム含有製剤
JPH06157325A (ja) * 1992-11-30 1994-06-03 Mitsubishi Kasei Corp 経口コレステロール低下剤
WO1997004789A1 (en) * 1995-08-02 1997-02-13 Hisamitsu Pharmaceutical Co., Inc. Tablets containing anion exchange resin

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JPS6090243A (ja) 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
US4631305A (en) 1985-03-22 1986-12-23 The Upjohn Company Polymeric material as a disintegrant in a compressed tablet
DE3776116D1 (de) * 1986-12-30 1992-02-27 American Cyanamid Co Zusammensetzung die ein polycarbophil enthaelt.
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JP3389493B2 (ja) * 1997-04-04 2003-03-24 中外製薬株式会社 リン酸結合性ポリマー製剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03236326A (ja) * 1989-03-16 1991-10-22 Bristol Myers Squibb Co 直接圧縮コレスチラミン錠剤及びその無溶剤被覆物
JPH05246861A (ja) * 1990-11-29 1993-09-24 Hokuriku Seiyaku Co Ltd ポリカルボフィルカルシウム含有製剤
JPH06157325A (ja) * 1992-11-30 1994-06-03 Mitsubishi Kasei Corp 経口コレステロール低下剤
WO1997004789A1 (en) * 1995-08-02 1997-02-13 Hisamitsu Pharmaceutical Co., Inc. Tablets containing anion exchange resin

Also Published As

Publication number Publication date
CA2286003A1 (en) 1998-10-15
EP1304104A3 (en) 2003-11-12
EP0997148A4 (en) 2000-05-03
AU726142B2 (en) 2000-11-02
US6383518B1 (en) 2002-05-07
DE69837945T2 (de) 2008-02-21
CN1254287A (zh) 2000-05-24
EP1304104A2 (en) 2003-04-23
JP2013010803A (ja) 2013-01-17
ES2287215T3 (es) 2007-12-16
EP0997148A1 (en) 2000-05-03
HK1055387A1 (en) 2004-01-09
KR20010005980A (ko) 2001-01-15
DE69816082D1 (de) 2003-08-07
ATE364377T1 (de) 2007-07-15
CY1106823T1 (el) 2012-05-23
WO1998044933A1 (en) 1998-10-15
CN1180782C (zh) 2004-12-22
EP1304104B1 (en) 2007-06-13
HK1027506A1 (en) 2001-01-19
AU6522398A (en) 1998-10-30
CA2286003C (en) 2007-06-05
DE69816082T2 (de) 2004-04-15
DK1304104T3 (da) 2007-07-16
PT1304104E (pt) 2007-07-27
EP0997148B1 (en) 2003-07-02
ATE244013T1 (de) 2003-07-15
ES2201463T3 (es) 2004-03-16
DE69837945D1 (de) 2007-07-26
US6696087B2 (en) 2004-02-24
US20020122786A1 (en) 2002-09-05
TW592727B (en) 2004-06-21
KR100456202B1 (ko) 2004-11-09
JP5681156B2 (ja) 2015-03-04

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