TW542831B - Novel pyrimidine derivatives and processes for the preparation thereof - Google Patents

Novel pyrimidine derivatives and processes for the preparation thereof Download PDF

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Publication number
TW542831B
TW542831B TW087104605A TW87104605A TW542831B TW 542831 B TW542831 B TW 542831B TW 087104605 A TW087104605 A TW 087104605A TW 87104605 A TW87104605 A TW 87104605A TW 542831 B TW542831 B TW 542831B
Authority
TW
Taiwan
Prior art keywords
methyl
pyrimidine
dimethyl
fluoroaniline
mmol
Prior art date
Application number
TW087104605A
Other languages
English (en)
Chinese (zh)
Inventor
Jong-Wook Lee
Bong-Yong Lee
Chang-Seop Kim
Seung-Kyu Lee
Keun-Seog Song
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Application granted granted Critical
Publication of TW542831B publication Critical patent/TW542831B/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW087104605A 1997-03-27 1998-03-27 Novel pyrimidine derivatives and processes for the preparation thereof TW542831B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970010862 1997-03-27
KR19970010863 1997-03-27

Publications (1)

Publication Number Publication Date
TW542831B true TW542831B (en) 2003-07-21

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
TW087104605A TW542831B (en) 1997-03-27 1998-03-27 Novel pyrimidine derivatives and processes for the preparation thereof

Country Status (21)

Country Link
US (1) US6352993B1 (enEXAMPLES)
EP (1) EP1015444B1 (enEXAMPLES)
JP (1) JP3176379B2 (enEXAMPLES)
KR (1) KR100278857B1 (enEXAMPLES)
CN (1) CN1118464C (enEXAMPLES)
AR (1) AR012181A1 (enEXAMPLES)
AT (1) ATE241613T1 (enEXAMPLES)
AU (1) AU720385B2 (enEXAMPLES)
BR (1) BR9808070A (enEXAMPLES)
CA (1) CA2284795C (enEXAMPLES)
DE (1) DE69815126T2 (enEXAMPLES)
DK (1) DK1015444T3 (enEXAMPLES)
ES (1) ES2200324T3 (enEXAMPLES)
HU (1) HUP0000851A3 (enEXAMPLES)
IN (1) IN188411B (enEXAMPLES)
PT (1) PT1015444E (enEXAMPLES)
RU (1) RU2203894C2 (enEXAMPLES)
TR (1) TR199902383T2 (enEXAMPLES)
TW (1) TW542831B (enEXAMPLES)
UY (1) UY24938A1 (enEXAMPLES)
WO (1) WO1998043968A1 (enEXAMPLES)

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JP4634144B2 (ja) 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
EP1648877A1 (en) * 2003-07-22 2006-04-26 Neurogen Corporation Substituted pyridin-2-ylamine analogues
WO2005039506A2 (en) * 2003-10-24 2005-05-06 Exelixis, Inc. P70s6 kinase modulators and method of use
EP1974730A1 (en) 2003-11-03 2008-10-01 AstraZeneca AB Imidazo[1,2-a]pyridine derivatives for use in the treatment of sleep disturbance due to silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
JP2009511548A (ja) * 2005-10-14 2009-03-19 ノイロサーチ アクティーゼルスカブ 新規ピリミジン−2,4−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びtv受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
WO2010016490A1 (ja) 2008-08-05 2010-02-11 第一三共株式会社 イミダゾピリジン-2-オン誘導体
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
CA2817165A1 (en) 2010-11-15 2012-05-24 Patrick Chaltin Novel antiviral compounds
MX337477B (es) 2011-02-25 2016-03-07 Yuhan Corp Derivados de diaminopiridina y procesos para su preparacion.
CA2864825C (en) * 2012-02-17 2021-01-26 Abbvie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
IN2014MN02314A (enEXAMPLES) 2012-05-29 2015-08-07 Momentive Performance Mat Inc
HK1215032A1 (zh) 2012-11-21 2016-08-12 Ptc Therapeutics, Inc. 取代的反向嘧啶bmi-1抑制劑
MX2015011898A (es) 2013-03-13 2016-05-05 Genentech Inc Compuestos de pirazolo y usos de los mismos.
CA2922657C (en) * 2013-08-30 2022-04-12 Ptc Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
JP6507157B2 (ja) * 2013-10-07 2019-04-24 カドモン コーポレイション,リミティド ライアビリティ カンパニー Rhoキナーゼ阻害剤
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
CN107206004A (zh) * 2014-10-22 2017-09-26 德克萨斯大学系统董事会 靶向盘状结构域受体1的小分子抑制剂及其用途
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
UA125377C2 (uk) * 2016-01-04 2022-03-02 Мерк Сероно С.А. L-валінат карбоксамідного похідного гідроксипропілтіазолідину та його сольова форма, кристалічна поліморфна форма
US11477982B2 (en) * 2017-04-05 2022-10-25 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidine derivatives and their use for controlling undesired plant growth
JP2021535198A (ja) 2018-08-17 2021-12-16 ピーティーシー セラピューティクス, インコーポレイテッド 膵臓癌を治療する方法
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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WO1995005363A1 (en) * 1993-08-12 1995-02-23 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
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RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
CA2197298C (en) * 1994-08-13 1999-10-19 Jong Wook Lee Novel pyrimidine derivatives and processes for the preparation thereof
DK0900214T3 (da) 1996-05-04 2002-01-28 Yuhan Corp Fremgangsmåde til fremstilling af pyrmidin-derivater

Also Published As

Publication number Publication date
ES2200324T3 (es) 2004-03-01
KR100278857B1 (ko) 2001-01-15
PT1015444E (pt) 2003-10-31
RU2203894C2 (ru) 2003-05-10
BR9808070A (pt) 2000-03-08
HUP0000851A3 (en) 2002-04-29
JP2000513014A (ja) 2000-10-03
EP1015444B1 (en) 2003-05-28
DK1015444T3 (da) 2003-08-18
IN188411B (enEXAMPLES) 2002-09-21
CA2284795C (en) 2004-01-20
HK1026418A1 (en) 2000-12-15
KR19980080789A (ko) 1998-11-25
US6352993B1 (en) 2002-03-05
JP3176379B2 (ja) 2001-06-18
DE69815126T2 (de) 2004-04-08
CN1118464C (zh) 2003-08-20
HUP0000851A1 (hu) 2001-04-28
EP1015444A1 (en) 2000-07-05
AR012181A1 (es) 2000-09-27
TR199902383T2 (xx) 2000-06-21
AU720385B2 (en) 2000-06-01
CN1251586A (zh) 2000-04-26
WO1998043968A1 (en) 1998-10-08
CA2284795A1 (en) 1998-10-08
DE69815126D1 (de) 2003-07-03
ATE241613T1 (de) 2003-06-15
UY24938A1 (es) 2001-01-31
AU6523998A (en) 1998-10-22

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