CA2284795C - Novel pyrimidine derivatives and processes for the preparation thereof - Google Patents

Novel pyrimidine derivatives and processes for the preparation thereof Download PDF

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Publication number
CA2284795C
CA2284795C CA002284795A CA2284795A CA2284795C CA 2284795 C CA2284795 C CA 2284795C CA 002284795 A CA002284795 A CA 002284795A CA 2284795 A CA2284795 A CA 2284795A CA 2284795 C CA2284795 C CA 2284795C
Authority
CA
Canada
Prior art keywords
methyl
pyrimidine
fluorophenylamino
dimethyl
tetrahydroisoquinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002284795A
Other languages
English (en)
French (fr)
Other versions
CA2284795A1 (en
Inventor
Jong Wook Lee
Bong Yong Lee
Chang Seop Kim
Seung Kyu Lee
Keun Seog Song
Song Jin Lee
Woo Jeon Shim
Man Soon Hwang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of CA2284795A1 publication Critical patent/CA2284795A1/en
Application granted granted Critical
Publication of CA2284795C publication Critical patent/CA2284795C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002284795A 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof Expired - Fee Related CA2284795C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR1997/10862 1997-03-27
KR19970010862 1997-03-27
KR1997/10863 1997-03-27
KR19970010863 1997-03-27
PCT/KR1998/000058 WO1998043968A1 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Publications (2)

Publication Number Publication Date
CA2284795A1 CA2284795A1 (en) 1998-10-08
CA2284795C true CA2284795C (en) 2004-01-20

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002284795A Expired - Fee Related CA2284795C (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Country Status (21)

Country Link
US (1) US6352993B1 (enEXAMPLES)
EP (1) EP1015444B1 (enEXAMPLES)
JP (1) JP3176379B2 (enEXAMPLES)
KR (1) KR100278857B1 (enEXAMPLES)
CN (1) CN1118464C (enEXAMPLES)
AR (1) AR012181A1 (enEXAMPLES)
AT (1) ATE241613T1 (enEXAMPLES)
AU (1) AU720385B2 (enEXAMPLES)
BR (1) BR9808070A (enEXAMPLES)
CA (1) CA2284795C (enEXAMPLES)
DE (1) DE69815126T2 (enEXAMPLES)
DK (1) DK1015444T3 (enEXAMPLES)
ES (1) ES2200324T3 (enEXAMPLES)
HU (1) HUP0000851A3 (enEXAMPLES)
IN (1) IN188411B (enEXAMPLES)
PT (1) PT1015444E (enEXAMPLES)
RU (1) RU2203894C2 (enEXAMPLES)
TR (1) TR199902383T2 (enEXAMPLES)
TW (1) TW542831B (enEXAMPLES)
UY (1) UY24938A1 (enEXAMPLES)
WO (1) WO1998043968A1 (enEXAMPLES)

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KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
TW200302728A (en) 2002-02-01 2003-08-16 Novartis Ag Substituted amines as IgE inhibitors
JP4634144B2 (ja) 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
EP1648877A1 (en) * 2003-07-22 2006-04-26 Neurogen Corporation Substituted pyridin-2-ylamine analogues
WO2005039506A2 (en) * 2003-10-24 2005-05-06 Exelixis, Inc. P70s6 kinase modulators and method of use
EP1974730A1 (en) 2003-11-03 2008-10-01 AstraZeneca AB Imidazo[1,2-a]pyridine derivatives for use in the treatment of sleep disturbance due to silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
JP2009511548A (ja) * 2005-10-14 2009-03-19 ノイロサーチ アクティーゼルスカブ 新規ピリミジン−2,4−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びtv受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
WO2010016490A1 (ja) 2008-08-05 2010-02-11 第一三共株式会社 イミダゾピリジン-2-オン誘導体
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
CA2817165A1 (en) 2010-11-15 2012-05-24 Patrick Chaltin Novel antiviral compounds
MX337477B (es) 2011-02-25 2016-03-07 Yuhan Corp Derivados de diaminopiridina y procesos para su preparacion.
CA2864825C (en) * 2012-02-17 2021-01-26 Abbvie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
IN2014MN02314A (enEXAMPLES) 2012-05-29 2015-08-07 Momentive Performance Mat Inc
HK1215032A1 (zh) 2012-11-21 2016-08-12 Ptc Therapeutics, Inc. 取代的反向嘧啶bmi-1抑制劑
MX2015011898A (es) 2013-03-13 2016-05-05 Genentech Inc Compuestos de pirazolo y usos de los mismos.
CA2922657C (en) * 2013-08-30 2022-04-12 Ptc Therapeutics, Inc. Substituted pyrimidine bmi-1 inhibitors
JP6507157B2 (ja) * 2013-10-07 2019-04-24 カドモン コーポレイション,リミティド ライアビリティ カンパニー Rhoキナーゼ阻害剤
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
CN107206004A (zh) * 2014-10-22 2017-09-26 德克萨斯大学系统董事会 靶向盘状结构域受体1的小分子抑制剂及其用途
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
UA125377C2 (uk) * 2016-01-04 2022-03-02 Мерк Сероно С.А. L-валінат карбоксамідного похідного гідроксипропілтіазолідину та його сольова форма, кристалічна поліморфна форма
US11477982B2 (en) * 2017-04-05 2022-10-25 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidine derivatives and their use for controlling undesired plant growth
JP2021535198A (ja) 2018-08-17 2021-12-16 ピーティーシー セラピューティクス, インコーポレイテッド 膵臓癌を治療する方法
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
TR25912A (tr) 1989-03-22 1993-11-01 Ciba Geigy Ag 2-ANILIN-PRIMIDIN TüREVLERI BU MADDELERINELDE EDIL MELERI VE ZARARLILARA KARSI MüCADELEDE KULLANILMA- LARI
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
FI932032L (fi) 1990-11-06 1993-05-05 Pfizer Kinazolinderivat foer oekande av antitumoeraktivitet
DK0580753T3 (da) * 1991-04-17 1995-07-03 Pfizer Pyrimidinderivater til forøgelse af antitumoraktivitet
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
WO1995005363A1 (en) * 1993-08-12 1995-02-23 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
DK0640599T3 (da) 1993-08-26 1998-09-28 Ono Pharmaceutical Co 4-Aminopyrimidin-derivater
RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
CA2197298C (en) * 1994-08-13 1999-10-19 Jong Wook Lee Novel pyrimidine derivatives and processes for the preparation thereof
DK0900214T3 (da) 1996-05-04 2002-01-28 Yuhan Corp Fremgangsmåde til fremstilling af pyrmidin-derivater

Also Published As

Publication number Publication date
ES2200324T3 (es) 2004-03-01
KR100278857B1 (ko) 2001-01-15
PT1015444E (pt) 2003-10-31
RU2203894C2 (ru) 2003-05-10
BR9808070A (pt) 2000-03-08
HUP0000851A3 (en) 2002-04-29
JP2000513014A (ja) 2000-10-03
EP1015444B1 (en) 2003-05-28
DK1015444T3 (da) 2003-08-18
IN188411B (enEXAMPLES) 2002-09-21
HK1026418A1 (en) 2000-12-15
KR19980080789A (ko) 1998-11-25
US6352993B1 (en) 2002-03-05
JP3176379B2 (ja) 2001-06-18
DE69815126T2 (de) 2004-04-08
CN1118464C (zh) 2003-08-20
TW542831B (en) 2003-07-21
HUP0000851A1 (hu) 2001-04-28
EP1015444A1 (en) 2000-07-05
AR012181A1 (es) 2000-09-27
TR199902383T2 (xx) 2000-06-21
AU720385B2 (en) 2000-06-01
CN1251586A (zh) 2000-04-26
WO1998043968A1 (en) 1998-10-08
CA2284795A1 (en) 1998-10-08
DE69815126D1 (de) 2003-07-03
ATE241613T1 (de) 2003-06-15
UY24938A1 (es) 2001-01-31
AU6523998A (en) 1998-10-22

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