TW306921B - - Google Patents

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Publication number
TW306921B
TW306921B TW081109648A TW81109648A TW306921B TW 306921 B TW306921 B TW 306921B TW 081109648 A TW081109648 A TW 081109648A TW 81109648 A TW81109648 A TW 81109648A TW 306921 B TW306921 B TW 306921B
Authority
TW
Taiwan
Prior art keywords
compound
item
patent application
formula
alkyl
Prior art date
Application number
TW081109648A
Other languages
English (en)
Chinese (zh)
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Application granted granted Critical
Publication of TW306921B publication Critical patent/TW306921B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW081109648A 1991-12-05 1992-12-02 TW306921B (https=)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919125900A GB9125900D0 (en) 1991-12-05 1991-12-05 Piperazine derivatives

Publications (1)

Publication Number Publication Date
TW306921B true TW306921B (https=) 1997-06-01

Family

ID=10705770

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081109648A TW306921B (https=) 1991-12-05 1992-12-02

Country Status (22)

Country Link
US (1) US5710149A (https=)
EP (1) EP0625977B1 (https=)
JP (1) JP3262333B2 (https=)
KR (1) KR100244626B1 (https=)
AT (1) ATE162527T1 (https=)
AU (1) AU658242B2 (https=)
BR (1) BR9206861A (https=)
CA (1) CA2124680C (https=)
DE (1) DE69224212T2 (https=)
DK (1) DK0625977T3 (https=)
ES (1) ES2111654T3 (https=)
FI (1) FI942635A7 (https=)
GB (2) GB9125900D0 (https=)
GR (1) GR3025988T3 (https=)
HU (2) HUT70755A (https=)
IL (1) IL103944A (https=)
MX (1) MX9206939A (https=)
NZ (1) NZ246007A (https=)
RU (1) RU2125566C1 (https=)
TW (1) TW306921B (https=)
WO (1) WO1993011122A1 (https=)
ZA (1) ZA929317B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8322764B2 (en) 2010-06-11 2012-12-04 Mag-Lok Tools, Inc. Modular long handled tool component system

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives
US5609849A (en) * 1994-03-11 1997-03-11 The Trustees Of The University Of Pennsylvania Serotonin (5-HT1A) receptor ligands and imaging agents
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
GB9419024D0 (en) * 1994-09-21 1994-11-09 Wyeth John & Brother Ltd Bicyclic carboxamides
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
US5466688A (en) * 1994-10-20 1995-11-14 American Home Products Corporation Pyrido[3,4-B]indole derivatives as serotonergic agents
US5439915A (en) * 1994-10-20 1995-08-08 American Home Products Corporation Pyrido[3,4-B]indole carboxamide derivatives as serotonergic agents
US5451584A (en) * 1994-11-10 1995-09-19 American Home Products Corporation N-alkynyl carboxamides as sertonergic agents
US5541179A (en) * 1995-05-02 1996-07-30 American Home Products Corporation Tropon-2-one piperazine carboxamides as serotonergic agents
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
US5610164A (en) * 1996-07-24 1997-03-11 American Home Products Corporation (Thiophen-2-yl)-piperidin or tetrahydropyridin azabicyclocarboxamides
US6482827B1 (en) * 1997-07-10 2002-11-19 Pharmacia & Upjohn S.P.A. Matrix metalloproteinase inhibitors
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
WO1999065887A1 (en) * 1998-06-15 1999-12-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
EP1483256A2 (en) * 2002-03-12 2004-12-08 Wyeth Process for making chiral 1,4-disubstituted piperazines
CA2477892C (en) * 2002-03-12 2010-11-23 Gregg Brian Feigelson Process for synthesizing chiral n-aryl piperazines
ITMI20021327A1 (it) * 2002-06-14 2003-12-15 Recordati Chem Pharm Nuove ossialchilpiperazine
KR100755580B1 (ko) * 2002-12-03 2007-09-06 에프. 호프만-라 로슈 아게 Ｃｎｓ-장애의 치료를 위한 5-ｈｔ6-수용체 리간드로서의아미노알콕시인돌
US20050215561A1 (en) * 2004-03-19 2005-09-29 Krishnendu Ghosh Pharmaceutical dosage forms and compositions
US20070099931A1 (en) * 2004-03-19 2007-05-03 Wyeth Pharmaceutical dosage forms and compositions
US20050209245A1 (en) * 2004-03-19 2005-09-22 Wyeth Process for preparing N-aryl-piperazine derivatives
CN101137648A (zh) * 2005-03-01 2008-03-05 惠氏公司 结晶和非晶4－氰基－n－{(2r)－2－[4－(2,3－二氢－苯并[1,4]二氧杂环己烯－5－基)－哌嗪－1－基]－丙基}－n－吡啶－2－基－苯甲酰胺盐酸盐
US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
ES2379848T3 (es) * 2007-05-14 2012-05-04 Sk Biopharmaceuticals Co., Ltd. Compuesto arilpiperazina arilalcanoil carbomoiloxi novedoso, composiciones farmacéuticas que comprenden el compuesto y método para tratar el dolor, ansiedad y depresión al administrar el compuesto
US8367676B2 (en) * 2009-06-30 2013-02-05 Astrazeneca Ab 2-carboxamide-7-piperazinyl-benzofuran derivatives 774
US12553903B2 (en) 2023-06-01 2026-02-17 Cg Pharmaceuticals, Inc Ivaltinostat combination therapy for treating pancreatic cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU534071A1 (ru) * 1974-03-26 1980-04-30 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср -Замещенные пиперазины,обладающие психотропной активностью
AU577802B2 (en) * 1983-10-17 1988-10-06 Duphar International Research B.V. Blood-pressure lowering piperazine derivatives
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
FI102175B1 (fi) * 1989-04-22 1998-10-30 Wyeth John & Brother Ltd Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten valmistamiseksi
FI93832C (fi) * 1989-04-22 1995-06-12 Wyeth John & Brother Ltd Menetelmä terapeuttisesti aktiivisten piperatsiniijohdannaisten valmistamiseksi
US5340812A (en) * 1989-04-22 1994-08-23 John Wyeth & Brother, Limited Piperazine derivatives
US5382583A (en) * 1989-04-22 1995-01-17 John Wyeth & Brother, Limited Piperazine derivatives
US4935511A (en) * 1989-09-26 1990-06-19 Rorer Pharmaceutical Corporation Benzoxazine and benzoxazepine carboxamide 5-HT3 antagonists
GB9022790D0 (en) * 1990-10-19 1990-12-05 Wyeth John & Brother Ltd Piperazine derivatives
GB9022820D0 (en) * 1990-10-19 1990-12-05 Wyeth John & Brother Ltd Piperazine derivatives
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
GB9112697D0 (en) * 1991-06-13 1991-07-31 Shell Int Research Biocidal compounds
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
GB9308725D0 (en) * 1993-04-27 1993-06-09 Wyeth John & Brother Ltd Piperazine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8322764B2 (en) 2010-06-11 2012-12-04 Mag-Lok Tools, Inc. Modular long handled tool component system

Also Published As

Publication number Publication date
BR9206861A (pt) 1995-11-21
GB2262093B (en) 1995-06-07
NZ246007A (en) 1995-04-27
CA2124680A1 (en) 1993-06-10
IL103944A (en) 1997-06-10
RU94030476A (ru) 1996-04-20
DE69224212D1 (de) 1998-02-26
GR3025988T3 (en) 1998-04-30
GB2262093A (en) 1993-06-09
FI942635L (fi) 1994-06-03
WO1993011122A1 (en) 1993-06-10
RU2125566C1 (ru) 1999-01-27
DE69224212T2 (de) 1998-04-30
ATE162527T1 (de) 1998-02-15
KR100244626B1 (ko) 2000-05-01
GB9125900D0 (en) 1992-02-05
HU211518A9 (en) 1995-11-28
ZA929317B (en) 1994-06-01
JPH07501803A (ja) 1995-02-23
ES2111654T3 (es) 1998-03-16
CA2124680C (en) 2004-02-17
JP3262333B2 (ja) 2002-03-04
DK0625977T3 (da) 1998-05-04
AU658242B2 (en) 1995-04-06
HU9401686D0 (en) 1994-09-28
IL103944A0 (en) 1993-05-13
GB9225121D0 (en) 1993-01-20
AU2953792A (en) 1993-06-28
HUT70755A (en) 1995-10-30
US5710149A (en) 1998-01-20
MX9206939A (es) 1993-06-01
FI942635A0 (fi) 1994-06-03
EP0625977A1 (en) 1994-11-30
FI942635A7 (fi) 1994-06-03
EP0625977B1 (en) 1998-01-21

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