DE69321609T2 - Piperazinderivate - Google Patents
PiperazinderivateInfo
- Publication number
- DE69321609T2 DE69321609T2 DE69321609T DE69321609T DE69321609T2 DE 69321609 T2 DE69321609 T2 DE 69321609T2 DE 69321609 T DE69321609 T DE 69321609T DE 69321609 T DE69321609 T DE 69321609T DE 69321609 T2 DE69321609 T2 DE 69321609T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- date
- sec
- aryl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939300195A GB9300195D0 (en) | 1993-01-06 | 1993-01-06 | Piperazine derivatives |
PCT/GB1993/002660 WO1994015919A1 (en) | 1993-01-06 | 1993-12-24 | Piperazine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69321609D1 DE69321609D1 (de) | 1998-11-19 |
DE69321609T2 true DE69321609T2 (de) | 1999-03-25 |
Family
ID=10728387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69321609T Expired - Fee Related DE69321609T2 (de) | 1993-01-06 | 1993-12-24 | Piperazinderivate |
Country Status (14)
Country | Link |
---|---|
US (1) | US5627177A (de) |
EP (1) | EP0678090B1 (de) |
JP (1) | JPH08505156A (de) |
AT (1) | ATE172193T1 (de) |
AU (1) | AU5819794A (de) |
DE (1) | DE69321609T2 (de) |
DK (1) | DK0678090T3 (de) |
ES (1) | ES2123756T3 (de) |
GB (1) | GB9300195D0 (de) |
IL (1) | IL108258A (de) |
MX (1) | MX9400253A (de) |
MY (1) | MY131381A (de) |
PH (1) | PH31303A (de) |
WO (1) | WO1994015919A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5434158A (en) * | 1994-04-26 | 1995-07-18 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin-3 antagonists |
GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
JP3155008B2 (ja) * | 1994-07-26 | 2001-04-09 | ファイザー・インコーポレーテッド | セロトニンアゴニストおよびアンタゴニストとしての4−インドール誘導体 |
GB9419024D0 (en) * | 1994-09-21 | 1994-11-09 | Wyeth John & Brother Ltd | Bicyclic carboxamides |
US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
FR2735127B1 (fr) * | 1995-06-09 | 1997-08-22 | Pf Medicament | Nouvelles piperazines heteroaromatiques utiles comme medicaments. |
US5990114A (en) * | 1996-02-28 | 1999-11-23 | Recordati, S.A., Chemical And Pharmaceutical Company | Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence |
ATE253058T1 (de) * | 1997-09-02 | 2003-11-15 | Duphar Int Res | Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten |
EP0900792B1 (de) * | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten |
CA2336117A1 (en) | 1998-06-30 | 2000-01-06 | Sidney Xi Liang | Piperidine derivatives having effects on serotonin related systems |
US6743796B2 (en) | 2001-05-07 | 2004-06-01 | Wyeth | Piperazinyl-isatins |
US7071197B2 (en) * | 2002-06-14 | 2006-07-04 | Recordati S.A. | N,N-disubstituted diazocycloalkanes |
US20040072839A1 (en) * | 2002-06-14 | 2004-04-15 | Amedeo Leonardi | 1-Phenylalkylpiperazines |
ITMI20021327A1 (it) * | 2002-06-14 | 2003-12-15 | Recordati Chem Pharm | Nuove ossialchilpiperazine |
GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5382583A (en) * | 1989-04-22 | 1995-01-17 | John Wyeth & Brother, Limited | Piperazine derivatives |
EP0395313B1 (de) * | 1989-04-22 | 1999-12-15 | American Home Products Corporation | Tertiäre alkyl funktionalisierte Piperazin-Derivate |
KR0173310B1 (ko) * | 1989-04-22 | 1999-02-01 | 폴 에이 리쳐 | 피페라진 유도체 |
DK203990D0 (da) * | 1990-08-24 | 1990-08-24 | Novo Nordisk As | Piperazinylderivater |
GB9022821D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
MX9201991A (es) * | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
GB9125900D0 (en) * | 1991-12-05 | 1992-02-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1993
- 1993-01-06 GB GB939300195A patent/GB9300195D0/en active Pending
- 1993-12-21 MY MYPI93002785A patent/MY131381A/en unknown
- 1993-12-24 US US08/446,601 patent/US5627177A/en not_active Expired - Lifetime
- 1993-12-24 DE DE69321609T patent/DE69321609T2/de not_active Expired - Fee Related
- 1993-12-24 DK DK94903945T patent/DK0678090T3/da active
- 1993-12-24 AU AU58197/94A patent/AU5819794A/en not_active Abandoned
- 1993-12-24 JP JP6515781A patent/JPH08505156A/ja active Pending
- 1993-12-24 AT AT94903945T patent/ATE172193T1/de active
- 1993-12-24 EP EP94903945A patent/EP0678090B1/de not_active Expired - Lifetime
- 1993-12-24 WO PCT/GB1993/002660 patent/WO1994015919A1/en active IP Right Grant
- 1993-12-24 ES ES94903945T patent/ES2123756T3/es not_active Expired - Lifetime
-
1994
- 1994-01-03 IL IL10825894A patent/IL108258A/en not_active IP Right Cessation
- 1994-01-04 MX MX9400253A patent/MX9400253A/es not_active IP Right Cessation
- 1994-01-05 PH PH47581D patent/PH31303A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0678090B1 (de) | 1998-10-14 |
IL108258A (en) | 1998-12-06 |
GB9300195D0 (en) | 1993-03-03 |
DK0678090T3 (da) | 1999-06-23 |
EP0678090A1 (de) | 1995-10-25 |
MX9400253A (es) | 1994-08-31 |
IL108258A0 (en) | 1994-04-12 |
AU5819794A (en) | 1994-08-15 |
ATE172193T1 (de) | 1998-10-15 |
ES2123756T3 (es) | 1999-01-16 |
PH31303A (en) | 1998-07-06 |
MY131381A (en) | 2007-08-30 |
JPH08505156A (ja) | 1996-06-04 |
US5627177A (en) | 1997-05-06 |
DE69321609D1 (de) | 1998-11-19 |
WO1994015919A1 (en) | 1994-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69321609T2 (de) | Piperazinderivate | |
MY107756A (en) | Piperazine derivatives. | |
DK0677046T3 (da) | Piperazinderivater som 5-HT-antagonister. | |
FI942635A0 (fi) | Piperatsiinijohdannaiset 5HT1A-antagonisteina | |
NO972938L (no) | Farmasöytiske piperazinforbindelser | |
GB9306103D0 (en) | Piperazine derivatives | |
DK0689534T3 (da) | Amidderivater som 5-HT1A-ligander | |
TW257758B (en) | Piperazine derivatives (1) | |
KR970706280A (ko) | 5-HT1A 길항제로서의 비사이클릭 카복스아미드(Bicyclic carboxamides as 5-HT1 antagonists) | |
DE69403896D1 (de) | 4-amino-2-(hetero)aryl-butanamide verwenbar als 5-ht1a-antagonisten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |