ITMI20021327A1 - Nuove ossialchilpiperazine - Google Patents

Nuove ossialchilpiperazine

Info

Publication number
ITMI20021327A1
ITMI20021327A1 IT2002MI001327A ITMI20021327A ITMI20021327A1 IT MI20021327 A1 ITMI20021327 A1 IT MI20021327A1 IT 2002MI001327 A IT2002MI001327 A IT 2002MI001327A IT MI20021327 A ITMI20021327 A IT MI20021327A IT MI20021327 A1 ITMI20021327 A1 IT MI20021327A1
Authority
IT
Italy
Prior art keywords
ossialchilpiperazine
new
new ossialchilpiperazine
Prior art date
Application number
IT2002MI001327A
Other languages
English (en)
Inventor
Amedeo Leonardi
Elena Poggesi
Gianni Motta
Carlo Riva
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Priority to IT2002MI001327A priority Critical patent/ITMI20021327A1/it
Priority to KR1020047020369A priority patent/KR20050055628A/ko
Priority to JP2004513275A priority patent/JP2006502102A/ja
Priority to BR0311804-5A priority patent/BR0311804A/pt
Priority to TW092116294A priority patent/TW200406394A/zh
Priority to US10/463,196 priority patent/US20040072839A1/en
Priority to CA002489449A priority patent/CA2489449A1/en
Priority to YUP-1090/04A priority patent/RS109004A/sr
Priority to PCT/EP2003/006289 priority patent/WO2003106443A1/en
Priority to EP03759960A priority patent/EP1549627A1/en
Priority to AU2003246434A priority patent/AU2003246434A1/en
Priority to NZ537470A priority patent/NZ537470A/en
Priority to PL03372702A priority patent/PL372702A1/xx
Priority to MXPA04012489A priority patent/MXPA04012489A/es
Priority to CN038136759A priority patent/CN1659155A/zh
Priority to EA200500024A priority patent/EA200500024A1/ru
Publication of ITMI20021327A1 publication Critical patent/ITMI20021327A1/it
Priority to IL16556904A priority patent/IL165569A0/xx
Priority to NO20050147A priority patent/NO20050147L/no
Priority to HR20050033A priority patent/HRP20050033A2/xx
Priority to ZA200500317A priority patent/ZA200500317B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT2002MI001327A 2002-06-14 2002-06-14 Nuove ossialchilpiperazine ITMI20021327A1 (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT2002MI001327A ITMI20021327A1 (it) 2002-06-14 2002-06-14 Nuove ossialchilpiperazine
EP03759960A EP1549627A1 (en) 2002-06-14 2003-06-16 1-phenylalkyl-piperazines
AU2003246434A AU2003246434A1 (en) 2002-06-14 2003-06-16 1-phenylalkyl-piperazines
BR0311804-5A BR0311804A (pt) 2002-06-14 2003-06-16 1-fenil-alquil-piperazinas
TW092116294A TW200406394A (en) 2002-06-14 2003-06-16 1-Phenylalkyl-piperazines
US10/463,196 US20040072839A1 (en) 2002-06-14 2003-06-16 1-Phenylalkylpiperazines
CA002489449A CA2489449A1 (en) 2002-06-14 2003-06-16 1-phenylalkyl-piperazines
YUP-1090/04A RS109004A (en) 2002-06-14 2003-06-16 1-phenylalkyl-piperazines
PCT/EP2003/006289 WO2003106443A1 (en) 2002-06-14 2003-06-16 1-phenylalkyl-piperazines
KR1020047020369A KR20050055628A (ko) 2002-06-14 2003-06-16 1-페닐알킬-피페라진
JP2004513275A JP2006502102A (ja) 2002-06-14 2003-06-16 １−フェニルアルキル−ピペラジン
NZ537470A NZ537470A (en) 2002-06-14 2003-06-16 1-phenylalkyl-piperazines having affinity for serotoninergic receptors, pharmaceutical compositions containing them and uses thereof for reducing the frequency of bladder contractions
PL03372702A PL372702A1 (en) 2002-06-14 2003-06-16 1-phenylalkyl-piperazines
MXPA04012489A MXPA04012489A (es) 2002-06-14 2003-06-16 1-fenilalquilpiperazinas.
CN038136759A CN1659155A (zh) 2002-06-14 2003-06-16 1－苯基烷基－哌嗪
EA200500024A EA200500024A1 (ru) 2002-06-14 2003-06-16 1-фенилалкил-пиперазины
IL16556904A IL165569A0 (en) 2002-06-14 2004-12-06 1-phenylalkyl-piperazines
NO20050147A NO20050147L (no) 2002-06-14 2005-01-11 1-fenylalkyl-piperaziner
HR20050033A HRP20050033A2 (en) 2002-06-14 2005-01-12 1-phenylalkyl-piperazines
ZA200500317A ZA200500317B (en) 2002-06-14 2005-01-13 1-phenylalkyl-piperazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI001327A ITMI20021327A1 (it) 2002-06-14 2002-06-14 Nuove ossialchilpiperazine

Publications (1)

Publication Number Publication Date
ITMI20021327A1 true ITMI20021327A1 (it) 2003-12-15

Family

ID=29727276

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002MI001327A ITMI20021327A1 (it) 2002-06-14 2002-06-14 Nuove ossialchilpiperazine

Country Status (19)

Country Link
EP (1) EP1549627A1 (it)
JP (1) JP2006502102A (it)
KR (1) KR20050055628A (it)
CN (1) CN1659155A (it)
AU (1) AU2003246434A1 (it)
BR (1) BR0311804A (it)
CA (1) CA2489449A1 (it)
EA (1) EA200500024A1 (it)
HR (1) HRP20050033A2 (it)
IL (1) IL165569A0 (it)
IT (1) ITMI20021327A1 (it)
MX (1) MXPA04012489A (it)
NO (1) NO20050147L (it)
NZ (1) NZ537470A (it)
PL (1) PL372702A1 (it)
RS (1) RS109004A (it)
TW (1) TW200406394A (it)
WO (1) WO2003106443A1 (it)
ZA (1) ZA200500317B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7071197B2 (en) * 2002-06-14 2006-07-04 Recordati S.A. N,N-disubstituted diazocycloalkanes
US7365076B2 (en) 2003-10-14 2008-04-29 Wyeth Substituted aryl cycloalkanol derivatives and methods of their use
ES2402173T3 (es) 2007-05-14 2013-04-29 Sk Biopharmaceuticals Co., Ltd. Compuesto arilpiperazina alcanarilo carbamoiloxi novedoso, composiciones farmacéuticas que comprenden el compuesto y método para tratar dolor, ansiedad y depresión al administrar el compuesto
WO2015132733A1 (en) * 2014-03-05 2015-09-11 Universita' Degli Studi Di Pavia Use of arylalkanolamines as sigma-1 receptor antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5826348B2 (ja) * 1974-07-01 1983-06-02 住友化学工業株式会社 新規ベンゾイソキサゾ−ル誘導体の製造法
DE3318577A1 (de) * 1982-05-25 1983-12-01 Fordonal S.A., Madrid Piperazinderivate
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
GB9022820D0 (en) * 1990-10-19 1990-12-05 Wyeth John & Brother Ltd Piperazine derivatives
GB9125900D0 (en) * 1991-12-05 1992-02-05 Wyeth John & Brother Ltd Piperazine derivatives
JP3523887B2 (ja) * 1992-03-09 2004-04-26 武田薬品工業株式会社 縮合複素環ケトン誘導体、その製造法、中間体および剤
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
GB9300195D0 (en) * 1993-01-06 1993-03-03 Wyeth John & Brother Ltd Piperazine derivatives
GB9419024D0 (en) * 1994-09-21 1994-11-09 Wyeth John & Brother Ltd Bicyclic carboxamides
GB9514384D0 (en) * 1995-07-13 1995-09-13 American Home Prod Medical treatment
UA66370C2 (en) * 1997-12-16 2004-05-17 Lilly Co Eli Arylpiperazines having activity to setotonin 1 receptors

Also Published As

Publication number Publication date
NZ537470A (en) 2006-06-30
NO20050147D0 (no) 2005-01-11
EP1549627A1 (en) 2005-07-06
CN1659155A (zh) 2005-08-24
NO20050147L (no) 2005-03-14
PL372702A1 (en) 2005-07-25
KR20050055628A (ko) 2005-06-13
BR0311804A (pt) 2005-03-29
AU2003246434A1 (en) 2003-12-31
CA2489449A1 (en) 2003-12-24
IL165569A0 (en) 2006-01-15
WO2003106443A1 (en) 2003-12-24
EA200500024A1 (ru) 2005-06-30
RS109004A (en) 2007-02-05
HRP20050033A2 (en) 2006-11-30
MXPA04012489A (es) 2005-06-08
TW200406394A (en) 2004-05-01
ZA200500317B (en) 2006-11-29
JP2006502102A (ja) 2006-01-19

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