BR0311804A - 1-fenil-alquil-piperazinas - Google Patents
1-fenil-alquil-piperazinasInfo
- Publication number
- BR0311804A BR0311804A BR0311804-5A BR0311804A BR0311804A BR 0311804 A BR0311804 A BR 0311804A BR 0311804 A BR0311804 A BR 0311804A BR 0311804 A BR0311804 A BR 0311804A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- alkyl
- thiocarbonyl
- group
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Abstract
"1-FENIL-ALQUIL-PIPERAZINAS". Descreve-se compostos da fórmula (I) (R e R~ 1~ são uma ampla série de substituintes, Q é CO, CHOH ou CHOR~ 2~, R~ 2~ é um grupo alquila, alquenila ou ciclo-alquila, cada um sendo opcionalmente substituído ou é alcanoíla, alcanoilóxi, amino-carbonila, alquil-amino-carbonila, dialquil-amihocarbonila, amino-tiocarbonila, alquil-amino-tiocarbonila ou dialquil-amino-tiocarbonila, R~ 3~ é H, um grupo alquila, alquenila, alquinila, ciclo-alquila, arila ou heterociclo, cada um dos quais sendo opcionalmente substituído, n é 1 ou 2, A é uma ligação ou um grupo metileno ou etileno, e R~ 4~ é um grupo arila ou heteroarila, qualquer um dos dois sendo opcionalmente substituído), que têm afinidade por receptores serotoninérgicos. Estes compostos e seus enanciómeros, diastereoisómeros, N-óxidos de piperazina, polimorfos, solvatos e sais farmaceuticamente aceitáveis, são úteis no tratamento de pacientes com disfunção neuromuscular do trato urinário inferior e doenças relacionadas à atividade de receptores de 5-HT~ 1A~.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI001327A ITMI20021327A1 (it) | 2002-06-14 | 2002-06-14 | Nuove ossialchilpiperazine |
PCT/EP2003/006289 WO2003106443A1 (en) | 2002-06-14 | 2003-06-16 | 1-phenylalkyl-piperazines |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311804A true BR0311804A (pt) | 2005-03-29 |
Family
ID=29727276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311804-5A BR0311804A (pt) | 2002-06-14 | 2003-06-16 | 1-fenil-alquil-piperazinas |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1549627A1 (pt) |
JP (1) | JP2006502102A (pt) |
KR (1) | KR20050055628A (pt) |
CN (1) | CN1659155A (pt) |
AU (1) | AU2003246434A1 (pt) |
BR (1) | BR0311804A (pt) |
CA (1) | CA2489449A1 (pt) |
EA (1) | EA200500024A1 (pt) |
HR (1) | HRP20050033A2 (pt) |
IL (1) | IL165569A0 (pt) |
IT (1) | ITMI20021327A1 (pt) |
MX (1) | MXPA04012489A (pt) |
NO (1) | NO20050147L (pt) |
NZ (1) | NZ537470A (pt) |
PL (1) | PL372702A1 (pt) |
RS (1) | RS109004A (pt) |
TW (1) | TW200406394A (pt) |
WO (1) | WO2003106443A1 (pt) |
ZA (1) | ZA200500317B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7071197B2 (en) * | 2002-06-14 | 2006-07-04 | Recordati S.A. | N,N-disubstituted diazocycloalkanes |
US7365076B2 (en) * | 2003-10-14 | 2008-04-29 | Wyeth | Substituted aryl cycloalkanol derivatives and methods of their use |
KR101468553B1 (ko) | 2007-05-14 | 2014-12-09 | 에스케이바이오팜 주식회사 | 신규 카바모일옥시 아릴알칸노일 아릴피페라진계 화합물,이를 함유하는 약제학적 조성물 및 상기 화합물 투여에의한 통증, 불안증 및 우울증 치료 방법 |
WO2015132733A1 (en) * | 2014-03-05 | 2015-09-11 | Universita' Degli Studi Di Pavia | Use of arylalkanolamines as sigma-1 receptor antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5826348B2 (ja) * | 1974-07-01 | 1983-06-02 | 住友化学工業株式会社 | 新規ベンゾイソキサゾ−ル誘導体の製造法 |
FR2527605A1 (fr) * | 1982-05-25 | 1983-12-02 | Fordonal Sa | Derives de piperazine, procede de fabrication et medicaments en resultant |
GB9021535D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9022820D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9125900D0 (en) * | 1991-12-05 | 1992-02-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
JP3523887B2 (ja) * | 1992-03-09 | 2004-04-26 | 武田薬品工業株式会社 | 縮合複素環ケトン誘導体、その製造法、中間体および剤 |
NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9419024D0 (en) * | 1994-09-21 | 1994-11-09 | Wyeth John & Brother Ltd | Bicyclic carboxamides |
GB9514384D0 (en) * | 1995-07-13 | 1995-09-13 | American Home Prod | Medical treatment |
UA66370C2 (en) * | 1997-12-16 | 2004-05-17 | Lilly Co Eli | Arylpiperazines having activity to setotonin 1 receptors |
-
2002
- 2002-06-14 IT IT2002MI001327A patent/ITMI20021327A1/it unknown
-
2003
- 2003-06-16 TW TW092116294A patent/TW200406394A/zh unknown
- 2003-06-16 PL PL03372702A patent/PL372702A1/xx unknown
- 2003-06-16 RS YUP-1090/04A patent/RS109004A/sr unknown
- 2003-06-16 MX MXPA04012489A patent/MXPA04012489A/es unknown
- 2003-06-16 KR KR1020047020369A patent/KR20050055628A/ko not_active Application Discontinuation
- 2003-06-16 NZ NZ537470A patent/NZ537470A/en unknown
- 2003-06-16 CA CA002489449A patent/CA2489449A1/en not_active Abandoned
- 2003-06-16 CN CN038136759A patent/CN1659155A/zh active Pending
- 2003-06-16 EP EP03759960A patent/EP1549627A1/en not_active Withdrawn
- 2003-06-16 BR BR0311804-5A patent/BR0311804A/pt not_active IP Right Cessation
- 2003-06-16 WO PCT/EP2003/006289 patent/WO2003106443A1/en not_active Application Discontinuation
- 2003-06-16 EA EA200500024A patent/EA200500024A1/ru unknown
- 2003-06-16 JP JP2004513275A patent/JP2006502102A/ja active Pending
- 2003-06-16 AU AU2003246434A patent/AU2003246434A1/en not_active Abandoned
-
2004
- 2004-12-06 IL IL16556904A patent/IL165569A0/xx unknown
-
2005
- 2005-01-11 NO NO20050147A patent/NO20050147L/no not_active Application Discontinuation
- 2005-01-12 HR HR20050033A patent/HRP20050033A2/xx not_active Application Discontinuation
- 2005-01-13 ZA ZA200500317A patent/ZA200500317B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NO20050147L (no) | 2005-03-14 |
ZA200500317B (en) | 2006-11-29 |
WO2003106443A1 (en) | 2003-12-24 |
HRP20050033A2 (en) | 2006-11-30 |
ITMI20021327A1 (it) | 2003-12-15 |
MXPA04012489A (es) | 2005-06-08 |
CN1659155A (zh) | 2005-08-24 |
KR20050055628A (ko) | 2005-06-13 |
AU2003246434A1 (en) | 2003-12-31 |
EA200500024A1 (ru) | 2005-06-30 |
PL372702A1 (en) | 2005-07-25 |
NZ537470A (en) | 2006-06-30 |
JP2006502102A (ja) | 2006-01-19 |
NO20050147D0 (no) | 2005-01-11 |
EP1549627A1 (en) | 2005-07-06 |
RS109004A (en) | 2007-02-05 |
IL165569A0 (en) | 2006-01-15 |
TW200406394A (en) | 2004-05-01 |
CA2489449A1 (en) | 2003-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010. |