BR0311804A - 1-phenylalkyl piperazine - Google Patents
1-phenylalkyl piperazineInfo
- Publication number
- BR0311804A BR0311804A BR0311804-5A BR0311804A BR0311804A BR 0311804 A BR0311804 A BR 0311804A BR 0311804 A BR0311804 A BR 0311804A BR 0311804 A BR0311804 A BR 0311804A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- alkyl
- thiocarbonyl
- group
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"1-FENIL-ALQUIL-PIPERAZINAS". Descreve-se compostos da fórmula (I) (R e R~ 1~ são uma ampla série de substituintes, Q é CO, CHOH ou CHOR~ 2~, R~ 2~ é um grupo alquila, alquenila ou ciclo-alquila, cada um sendo opcionalmente substituído ou é alcanoíla, alcanoilóxi, amino-carbonila, alquil-amino-carbonila, dialquil-amihocarbonila, amino-tiocarbonila, alquil-amino-tiocarbonila ou dialquil-amino-tiocarbonila, R~ 3~ é H, um grupo alquila, alquenila, alquinila, ciclo-alquila, arila ou heterociclo, cada um dos quais sendo opcionalmente substituído, n é 1 ou 2, A é uma ligação ou um grupo metileno ou etileno, e R~ 4~ é um grupo arila ou heteroarila, qualquer um dos dois sendo opcionalmente substituído), que têm afinidade por receptores serotoninérgicos. Estes compostos e seus enanciómeros, diastereoisómeros, N-óxidos de piperazina, polimorfos, solvatos e sais farmaceuticamente aceitáveis, são úteis no tratamento de pacientes com disfunção neuromuscular do trato urinário inferior e doenças relacionadas à atividade de receptores de 5-HT~ 1A~."1-FENIL-ALKYL-PIPERAZINES". Compounds of formula (I) are described. (R and R 1 - are a wide range of substituents, Q is CO, CHOH or CHOR 2 -, R 2 - is an alkyl, alkenyl or cycloalkyl group each optionally substituted being either alkanoyl, alkanoyloxy, aminocarbonyl, alkylamino carbonyl, dialkyl amiocarbonyl, amino thiocarbonyl, alkylamino thiocarbonyl or dialkylamino thiocarbonyl, R 3 is H, an alkyl group alkenyl, alkynyl, cycloalkyl, aryl or heterocycle, each of which being optionally substituted, n is 1 or 2, A is a bond or a methylene or ethylene group, and R 4 is an aryl or heteroaryl group, either being optionally substituted), which have affinity for serotonergic receptors. These compounds and their pharmaceutically acceptable enantiomers, diastereoisomers, piperazine N-oxides, polymorphs, solvates and salts are useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT 1A receptor activity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI001327A ITMI20021327A1 (en) | 2002-06-14 | 2002-06-14 | NEW OSSIALCHILPIPERAZINE |
PCT/EP2003/006289 WO2003106443A1 (en) | 2002-06-14 | 2003-06-16 | 1-phenylalkyl-piperazines |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311804A true BR0311804A (en) | 2005-03-29 |
Family
ID=29727276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311804-5A BR0311804A (en) | 2002-06-14 | 2003-06-16 | 1-phenylalkyl piperazine |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1549627A1 (en) |
JP (1) | JP2006502102A (en) |
KR (1) | KR20050055628A (en) |
CN (1) | CN1659155A (en) |
AU (1) | AU2003246434A1 (en) |
BR (1) | BR0311804A (en) |
CA (1) | CA2489449A1 (en) |
EA (1) | EA200500024A1 (en) |
HR (1) | HRP20050033A2 (en) |
IL (1) | IL165569A0 (en) |
IT (1) | ITMI20021327A1 (en) |
MX (1) | MXPA04012489A (en) |
NO (1) | NO20050147L (en) |
NZ (1) | NZ537470A (en) |
PL (1) | PL372702A1 (en) |
RS (1) | RS109004A (en) |
TW (1) | TW200406394A (en) |
WO (1) | WO2003106443A1 (en) |
ZA (1) | ZA200500317B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7071197B2 (en) * | 2002-06-14 | 2006-07-04 | Recordati S.A. | N,N-disubstituted diazocycloalkanes |
US7365076B2 (en) * | 2003-10-14 | 2008-04-29 | Wyeth | Substituted aryl cycloalkanol derivatives and methods of their use |
WO2008140197A1 (en) * | 2007-05-14 | 2008-11-20 | Sk Holdings Co., Ltd. | Novel carbamoyloxy aryl alkan arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound |
EP3113768B1 (en) * | 2014-03-05 | 2018-09-26 | Universita' Degli Studi Di Pavia | Use of arylalkanolamines as sigma-1 receptor antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5826348B2 (en) * | 1974-07-01 | 1983-06-02 | 住友化学工業株式会社 | Method for producing new benzisoxazole derivatives |
DE3318577A1 (en) * | 1982-05-25 | 1983-12-01 | Fordonal S.A., Madrid | Piperazine derivatives |
GB9021535D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9022820D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9125900D0 (en) * | 1991-12-05 | 1992-02-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
JP3523887B2 (en) * | 1992-03-09 | 2004-04-26 | 武田薬品工業株式会社 | Condensed heterocyclic ketone derivative, production method thereof, intermediate and agent |
NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9419024D0 (en) * | 1994-09-21 | 1994-11-09 | Wyeth John & Brother Ltd | Bicyclic carboxamides |
GB9514384D0 (en) * | 1995-07-13 | 1995-09-13 | American Home Prod | Medical treatment |
UA66370C2 (en) * | 1997-12-16 | 2004-05-17 | Lilly Co Eli | Arylpiperazines having activity to setotonin 1 receptors |
-
2002
- 2002-06-14 IT IT2002MI001327A patent/ITMI20021327A1/en unknown
-
2003
- 2003-06-16 AU AU2003246434A patent/AU2003246434A1/en not_active Abandoned
- 2003-06-16 RS YUP-1090/04A patent/RS109004A/en unknown
- 2003-06-16 JP JP2004513275A patent/JP2006502102A/en active Pending
- 2003-06-16 WO PCT/EP2003/006289 patent/WO2003106443A1/en not_active Application Discontinuation
- 2003-06-16 EP EP03759960A patent/EP1549627A1/en not_active Withdrawn
- 2003-06-16 CN CN038136759A patent/CN1659155A/en active Pending
- 2003-06-16 PL PL03372702A patent/PL372702A1/en unknown
- 2003-06-16 CA CA002489449A patent/CA2489449A1/en not_active Abandoned
- 2003-06-16 KR KR1020047020369A patent/KR20050055628A/en not_active Application Discontinuation
- 2003-06-16 EA EA200500024A patent/EA200500024A1/en unknown
- 2003-06-16 NZ NZ537470A patent/NZ537470A/en unknown
- 2003-06-16 MX MXPA04012489A patent/MXPA04012489A/en unknown
- 2003-06-16 TW TW092116294A patent/TW200406394A/en unknown
- 2003-06-16 BR BR0311804-5A patent/BR0311804A/en not_active IP Right Cessation
-
2004
- 2004-12-06 IL IL16556904A patent/IL165569A0/en unknown
-
2005
- 2005-01-11 NO NO20050147A patent/NO20050147L/en not_active Application Discontinuation
- 2005-01-12 HR HR20050033A patent/HRP20050033A2/en not_active Application Discontinuation
- 2005-01-13 ZA ZA200500317A patent/ZA200500317B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2003106443A1 (en) | 2003-12-24 |
AU2003246434A1 (en) | 2003-12-31 |
NO20050147L (en) | 2005-03-14 |
EP1549627A1 (en) | 2005-07-06 |
ITMI20021327A1 (en) | 2003-12-15 |
NO20050147D0 (en) | 2005-01-11 |
PL372702A1 (en) | 2005-07-25 |
RS109004A (en) | 2007-02-05 |
EA200500024A1 (en) | 2005-06-30 |
JP2006502102A (en) | 2006-01-19 |
MXPA04012489A (en) | 2005-06-08 |
KR20050055628A (en) | 2005-06-13 |
ZA200500317B (en) | 2006-11-29 |
NZ537470A (en) | 2006-06-30 |
HRP20050033A2 (en) | 2006-11-30 |
CA2489449A1 (en) | 2003-12-24 |
TW200406394A (en) | 2004-05-01 |
IL165569A0 (en) | 2006-01-15 |
CN1659155A (en) | 2005-08-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010. |