EA200500024A1 - 1-фенилалкил-пиперазины - Google Patents
1-фенилалкил-пиперазиныInfo
- Publication number
- EA200500024A1 EA200500024A1 EA200500024A EA200500024A EA200500024A1 EA 200500024 A1 EA200500024 A1 EA 200500024A1 EA 200500024 A EA200500024 A EA 200500024A EA 200500024 A EA200500024 A EA 200500024A EA 200500024 A1 EA200500024 A1 EA 200500024A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dialkylaminocarbonyl
- alkylaminocarbonyl
- aminocarbonyl
- denotes
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Соединения формулы I(R и Rпредставляют широкий диапазон заместителей, Q обозначает CO, CHOH или CHOR, Rобозначает группы алкила, алкенила, алкинила или циклоалкила, каждый из которых произвольно замещен, или обозначает алканоил, алканоилокси, аминокарбонил, алкиламинокарбонил, диалкиламинокарбонил, аминотиокарбонил, алкиламинотиокарбонил или диалкиламинотиокарбонил, Rобозначает группы H, алкила, алкенила, алкинила, циклоалкила, арила или гетероциклическую группу, каждая из которых произвольно замещена, n обозначает 1 или 2, A обозначает связь или группу метилена или этилена и Rобозначает группу арила или гетероарила, любой из которых произвольно замещен) имеют сродство к серотонинергическим рецепторам. Эти соединения и их энантиомеры, диастереомеры, N-пиперазин оксиды, полиморфы, гидраты и фармацевтически приемлемые соли используют при лечении больных с нервно-мышечной дисфункцией при пониженной функции мочевых путей и заболеваниях, связанных с активностью 5-HTрецептора.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI001327A ITMI20021327A1 (it) | 2002-06-14 | 2002-06-14 | Nuove ossialchilpiperazine |
PCT/EP2003/006289 WO2003106443A1 (en) | 2002-06-14 | 2003-06-16 | 1-phenylalkyl-piperazines |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200500024A1 true EA200500024A1 (ru) | 2005-06-30 |
Family
ID=29727276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500024A EA200500024A1 (ru) | 2002-06-14 | 2003-06-16 | 1-фенилалкил-пиперазины |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1549627A1 (ru) |
JP (1) | JP2006502102A (ru) |
KR (1) | KR20050055628A (ru) |
CN (1) | CN1659155A (ru) |
AU (1) | AU2003246434A1 (ru) |
BR (1) | BR0311804A (ru) |
CA (1) | CA2489449A1 (ru) |
EA (1) | EA200500024A1 (ru) |
HR (1) | HRP20050033A2 (ru) |
IL (1) | IL165569A0 (ru) |
IT (1) | ITMI20021327A1 (ru) |
MX (1) | MXPA04012489A (ru) |
NO (1) | NO20050147L (ru) |
NZ (1) | NZ537470A (ru) |
PL (1) | PL372702A1 (ru) |
RS (1) | RS109004A (ru) |
TW (1) | TW200406394A (ru) |
WO (1) | WO2003106443A1 (ru) |
ZA (1) | ZA200500317B (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7071197B2 (en) * | 2002-06-14 | 2006-07-04 | Recordati S.A. | N,N-disubstituted diazocycloalkanes |
US7365076B2 (en) | 2003-10-14 | 2008-04-29 | Wyeth | Substituted aryl cycloalkanol derivatives and methods of their use |
WO2008140198A1 (en) | 2007-05-14 | 2008-11-20 | Sk Holdings Co., Ltd. | Novel carbamoyloxy arylalkanoyl arylpiperazine compound, pharmaceutical compositions comprising the compound and method for treating pain, anxiety and depression by administering the compound |
US20170015640A1 (en) * | 2014-03-05 | 2017-01-19 | Università Degli Studi Di Pavia | Use of arylalkanolamines as sigma-1 receptor antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5826348B2 (ja) * | 1974-07-01 | 1983-06-02 | 住友化学工業株式会社 | 新規ベンゾイソキサゾ−ル誘導体の製造法 |
DE3318577A1 (de) * | 1982-05-25 | 1983-12-01 | Fordonal S.A., Madrid | Piperazinderivate |
GB9021535D0 (en) * | 1990-10-03 | 1990-11-14 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9022820D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9125900D0 (en) * | 1991-12-05 | 1992-02-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
JP3523887B2 (ja) * | 1992-03-09 | 2004-04-26 | 武田薬品工業株式会社 | 縮合複素環ケトン誘導体、その製造法、中間体および剤 |
NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9419024D0 (en) * | 1994-09-21 | 1994-11-09 | Wyeth John & Brother Ltd | Bicyclic carboxamides |
GB9514384D0 (en) * | 1995-07-13 | 1995-09-13 | American Home Prod | Medical treatment |
UA66370C2 (en) * | 1997-12-16 | 2004-05-17 | Lilly Co Eli | Arylpiperazines having activity to setotonin 1 receptors |
-
2002
- 2002-06-14 IT IT2002MI001327A patent/ITMI20021327A1/it unknown
-
2003
- 2003-06-16 NZ NZ537470A patent/NZ537470A/en unknown
- 2003-06-16 AU AU2003246434A patent/AU2003246434A1/en not_active Abandoned
- 2003-06-16 RS YUP-1090/04A patent/RS109004A/sr unknown
- 2003-06-16 PL PL03372702A patent/PL372702A1/xx unknown
- 2003-06-16 BR BR0311804-5A patent/BR0311804A/pt not_active IP Right Cessation
- 2003-06-16 CN CN038136759A patent/CN1659155A/zh active Pending
- 2003-06-16 EA EA200500024A patent/EA200500024A1/ru unknown
- 2003-06-16 EP EP03759960A patent/EP1549627A1/en not_active Withdrawn
- 2003-06-16 JP JP2004513275A patent/JP2006502102A/ja active Pending
- 2003-06-16 TW TW092116294A patent/TW200406394A/zh unknown
- 2003-06-16 MX MXPA04012489A patent/MXPA04012489A/es unknown
- 2003-06-16 WO PCT/EP2003/006289 patent/WO2003106443A1/en not_active Application Discontinuation
- 2003-06-16 KR KR1020047020369A patent/KR20050055628A/ko not_active Application Discontinuation
- 2003-06-16 CA CA002489449A patent/CA2489449A1/en not_active Abandoned
-
2004
- 2004-12-06 IL IL16556904A patent/IL165569A0/xx unknown
-
2005
- 2005-01-11 NO NO20050147A patent/NO20050147L/no not_active Application Discontinuation
- 2005-01-12 HR HR20050033A patent/HRP20050033A2/xx not_active Application Discontinuation
- 2005-01-13 ZA ZA200500317A patent/ZA200500317B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL165569A0 (en) | 2006-01-15 |
AU2003246434A1 (en) | 2003-12-31 |
MXPA04012489A (es) | 2005-06-08 |
RS109004A (en) | 2007-02-05 |
PL372702A1 (en) | 2005-07-25 |
NZ537470A (en) | 2006-06-30 |
EP1549627A1 (en) | 2005-07-06 |
JP2006502102A (ja) | 2006-01-19 |
CA2489449A1 (en) | 2003-12-24 |
TW200406394A (en) | 2004-05-01 |
NO20050147D0 (no) | 2005-01-11 |
ZA200500317B (en) | 2006-11-29 |
CN1659155A (zh) | 2005-08-24 |
ITMI20021327A1 (it) | 2003-12-15 |
BR0311804A (pt) | 2005-03-29 |
NO20050147L (no) | 2005-03-14 |
HRP20050033A2 (en) | 2006-11-30 |
WO2003106443A1 (en) | 2003-12-24 |
KR20050055628A (ko) | 2005-06-13 |
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