WO2003106421A3 - Phenylalkylamines and pyridylalkylamines with serotoninergic receptor affinity - Google Patents

Phenylalkylamines and pyridylalkylamines with serotoninergic receptor affinity Download PDF

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Publication number
WO2003106421A3
WO2003106421A3 PCT/EP2003/006290 EP0306290W WO03106421A3 WO 2003106421 A3 WO2003106421 A3 WO 2003106421A3 EP 0306290 W EP0306290 W EP 0306290W WO 03106421 A3 WO03106421 A3 WO 03106421A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
optionally substituted
alkynyl
alkenyl
aryl
Prior art date
Application number
PCT/EP2003/006290
Other languages
French (fr)
Other versions
WO2003106421A2 (en
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Luciano Guarneri
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Priority to AU2003276982A priority Critical patent/AU2003276982A1/en
Publication of WO2003106421A2 publication Critical patent/WO2003106421A2/en
Publication of WO2003106421A3 publication Critical patent/WO2003106421A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of formula (I), (A is CH or N, R and R1 are a wide range of substituents, Q is CO, CHOH or CHOR2, R2 is alkyl, alkenyl, alkynyl or cycloalkyl group, each of which is optionally substituted, or is alkanoyl, alkanoyoxy, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminothiocarbonyl, alkylaminothiocarbonyl or dialkylaminothiocarbonyl, R3 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, each of which is optionally substituted, m is 1 or 2, R4 is an aryl or heteroaryl group, either of which is optionally substituted, R5 is either (II) or (III), wherein m is 1 or 2, R6 is H or alkyl, R7 is O, S, NR6 or CH2, B is a bond, O, S, NR6 or CH2 and ------- represents a single or double bond) have affinity for serotoninergic receptors. These compounds and their enantiomers, diastereoisomers, N-piperazine oxides, polymorphs, solvates and pharmaceutically acceptable salts are useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT1A receptor activity.
PCT/EP2003/006290 2002-06-14 2003-06-16 Phenylalkylamines and pyridylalkylamines WO2003106421A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003276982A AU2003276982A1 (en) 2002-06-14 2003-06-16 Phenylalkylamines and pyridylalkylamines with serotoninergic receptor affinity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI001329A ITMI20021329A1 (en) 2002-06-14 2002-06-14 NEW OXIALYKYLAMES REPLACED
ITMI2002A001329 2002-06-14

Publications (2)

Publication Number Publication Date
WO2003106421A2 WO2003106421A2 (en) 2003-12-24
WO2003106421A3 true WO2003106421A3 (en) 2004-06-17

Family

ID=29727278

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/006290 WO2003106421A2 (en) 2002-06-14 2003-06-16 Phenylalkylamines and pyridylalkylamines

Country Status (4)

Country Link
AU (1) AU2003276982A1 (en)
IT (1) ITMI20021329A1 (en)
TW (1) TW200409632A (en)
WO (1) WO2003106421A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957073A1 (en) 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
DE10315917A1 (en) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Highly pure bases of 3,3-diphenylpropylamine monoesters
EP2663553B1 (en) 2010-09-01 2015-08-26 Ambit Biosciences Corporation Quinoline and isoquinoline derivatives for use as jak modulators
EP2611812A1 (en) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Thienopyridine and thienopyrimidine compounds and methods of use thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE671440A (en) *
EP0680962A2 (en) * 1994-05-03 1995-11-08 Zeneca Limited Heterocyclic compounds
WO1996016961A1 (en) * 1994-11-28 1996-06-06 American Home Products Corporation (thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides
US5585374A (en) * 1992-08-05 1996-12-17 John Wyeth Brother, Limited Amide derivatives
US5610295A (en) * 1993-03-06 1997-03-11 John Wyeth & Brother, Ltd. 4-amino-2-(hetero)aryl-butanamides useful as 5-HT1A -antagonists
US5610164A (en) * 1996-07-24 1997-03-11 American Home Products Corporation (Thiophen-2-yl)-piperidin or tetrahydropyridin azabicyclocarboxamides
EP0924205A1 (en) * 1997-12-16 1999-06-23 Eli Lilly And Company Arylpiperazines having activity at the serotonin 1a receptor
EP0982304A1 (en) * 1998-06-30 2000-03-01 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE671440A (en) *
US5585374A (en) * 1992-08-05 1996-12-17 John Wyeth Brother, Limited Amide derivatives
US5610295A (en) * 1993-03-06 1997-03-11 John Wyeth & Brother, Ltd. 4-amino-2-(hetero)aryl-butanamides useful as 5-HT1A -antagonists
EP0680962A2 (en) * 1994-05-03 1995-11-08 Zeneca Limited Heterocyclic compounds
WO1996016961A1 (en) * 1994-11-28 1996-06-06 American Home Products Corporation (thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides
US5610164A (en) * 1996-07-24 1997-03-11 American Home Products Corporation (Thiophen-2-yl)-piperidin or tetrahydropyridin azabicyclocarboxamides
EP0924205A1 (en) * 1997-12-16 1999-06-23 Eli Lilly And Company Arylpiperazines having activity at the serotonin 1a receptor
EP0982304A1 (en) * 1998-06-30 2000-03-01 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems

Also Published As

Publication number Publication date
AU2003276982A8 (en) 2003-12-31
AU2003276982A1 (en) 2003-12-31
ITMI20021329A1 (en) 2003-12-15
WO2003106421A2 (en) 2003-12-24
TW200409632A (en) 2004-06-16

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