TW201632516A - 細胞壞死抑制劑與相關方法 - Google Patents
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
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| EP2968276A4 (en) | 2013-03-15 | 2017-02-15 | President and Fellows of Harvard College | Hybrid necroptosis inhibitors |
| US9944628B2 (en) | 2014-12-11 | 2018-04-17 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
| CN106619619A (zh) * | 2017-01-06 | 2017-05-10 | 浙江大学 | 化合物hubin‑1在制备肝脏炎症性疾病预防和/或治疗药物中的用途 |
| CN110573504A (zh) | 2017-02-27 | 2019-12-13 | 葛兰素史克知识产权开发有限公司 | 作为激酶抑制剂的杂环酰胺 |
| KR102637541B1 (ko) | 2017-05-17 | 2024-02-15 | 데날리 테라퓨틱스 인크. | 화합물, 조성물 및 방법 |
| CN108191835A (zh) * | 2018-01-09 | 2018-06-22 | 中国药科大学 | 一类新型的含吡咯环和吲哚啉结构rip1激酶抑制剂及其用途 |
| CN110759895B (zh) * | 2018-07-25 | 2020-10-27 | 浙江大学 | 新型rip1/rip3双靶点抑制剂及其在一药多靶疾病治疗中的用途 |
| WO2020044206A1 (en) | 2018-08-29 | 2020-03-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors for use in the treatment cancer |
| CN111978311B (zh) * | 2019-05-21 | 2024-05-31 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| US20210147842A1 (en) * | 2019-11-13 | 2021-05-20 | President And Fellows Of Harvard College | Methods and compositions for inhibiting necroptosis in neurovascular and/or neurodegenerative diseases or disorders |
| CN112263576A (zh) * | 2020-09-30 | 2021-01-26 | 浙江大学 | 化合物zju-37在制备肝脏疾病预防和/或治疗药物中的应用 |
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2015
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- 2015-12-11 JP JP2017531307A patent/JP2017538712A/ja active Pending
- 2015-12-11 CN CN201580075297.0A patent/CN107530350A/zh active Pending
- 2015-12-11 CA CA2970525A patent/CA2970525A1/en not_active Abandoned
- 2015-12-11 SG SG11201704764PA patent/SG11201704764PA/en unknown
- 2015-12-11 TW TW104141658A patent/TW201632516A/zh unknown
- 2015-12-11 EA EA201791289A patent/EA201791289A1/ru unknown
- 2015-12-11 EP EP15866758.4A patent/EP3229807A4/en not_active Withdrawn
- 2015-12-11 AU AU2015360291A patent/AU2015360291A1/en not_active Abandoned
- 2015-12-11 WO PCT/US2015/065349 patent/WO2016094846A1/en not_active Ceased
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- 2015-12-11 MX MX2017007607A patent/MX2017007607A/es unknown
- 2015-12-11 KR KR1020177019221A patent/KR20170123607A/ko not_active Withdrawn
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2016
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2017
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2018
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| EP3229807A4 (en) | 2018-10-17 |
| WO2016094846A1 (en) | 2016-06-16 |
| US10508102B2 (en) | 2019-12-17 |
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| EA201791289A1 (ru) | 2017-12-29 |
| CA2970525A1 (en) | 2016-06-16 |
| MX2017007607A (es) | 2018-05-28 |
| US9944628B2 (en) | 2018-04-17 |
| SG11201704764PA (en) | 2017-07-28 |
| AU2015360291A1 (en) | 2017-07-13 |
| IL252827A0 (en) | 2017-08-31 |
| US9499521B2 (en) | 2016-11-22 |
| EP3229807A1 (en) | 2017-10-18 |
| KR20170123607A (ko) | 2017-11-08 |
| JP2017538712A (ja) | 2017-12-28 |
| US20190023690A1 (en) | 2019-01-24 |
| US20160304498A1 (en) | 2016-10-20 |
| AR102981A1 (es) | 2017-04-05 |
| US20160168128A1 (en) | 2016-06-16 |
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