TW201240679A - Pharmaceutical formulations - Google Patents
Pharmaceutical formulations Download PDFInfo
- Publication number
- TW201240679A TW201240679A TW101112145A TW101112145A TW201240679A TW 201240679 A TW201240679 A TW 201240679A TW 101112145 A TW101112145 A TW 101112145A TW 101112145 A TW101112145 A TW 101112145A TW 201240679 A TW201240679 A TW 201240679A
- Authority
- TW
- Taiwan
- Prior art keywords
- weight
- dosage form
- release
- capsule
- drug
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title description 4
- 239000002775 capsule Substances 0.000 claims abstract description 70
- 229920000642 polymer Polymers 0.000 claims abstract description 37
- 239000002552 dosage form Substances 0.000 claims abstract description 31
- 239000007787 solid Substances 0.000 claims abstract description 23
- 239000011159 matrix material Substances 0.000 claims abstract description 8
- 108010001267 Protein Subunits Proteins 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 38
- 229940079593 drug Drugs 0.000 claims description 37
- 239000000314 lubricant Substances 0.000 claims description 17
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 10
- 229920003151 Eudragit® RL polymer Polymers 0.000 claims description 8
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 6
- DNKKLDKIFMDAPT-UHFFFAOYSA-N n,n-dimethylmethanamine;2-methylprop-2-enoic acid Chemical compound CN(C)C.CC(=C)C(O)=O.CC(=C)C(O)=O DNKKLDKIFMDAPT-UHFFFAOYSA-N 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 5
- 230000002496 gastric effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 abstract description 62
- 238000001746 injection moulding Methods 0.000 abstract description 26
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 229940088679 drug related substance Drugs 0.000 abstract 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 39
- 239000000463 material Substances 0.000 description 31
- 238000009472 formulation Methods 0.000 description 29
- 238000012360 testing method Methods 0.000 description 29
- 239000003795 chemical substances by application Substances 0.000 description 20
- -1 hydroxypropyl decyl Chemical group 0.000 description 19
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 19
- 229920003155 Eudragit® RL 100 Polymers 0.000 description 16
- 239000000546 pharmaceutical excipient Substances 0.000 description 15
- 239000002702 enteric coating Substances 0.000 description 14
- 238000009505 enteric coating Methods 0.000 description 14
- 238000012545 processing Methods 0.000 description 14
- 238000002347 injection Methods 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 239000004094 surface-active agent Substances 0.000 description 12
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 11
- 229920002678 cellulose Polymers 0.000 description 11
- 235000010980 cellulose Nutrition 0.000 description 11
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 239000000523 sample Substances 0.000 description 11
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 10
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 10
- 239000001913 cellulose Substances 0.000 description 10
- 239000008101 lactose Substances 0.000 description 10
- 101000939517 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 2 Proteins 0.000 description 9
- 101000777220 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 3 Proteins 0.000 description 9
- 102100029643 Ubiquitin carboxyl-terminal hydrolase 2 Human genes 0.000 description 9
- 102100031287 Ubiquitin carboxyl-terminal hydrolase 3 Human genes 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 9
- 229920003134 Eudragit® polymer Polymers 0.000 description 8
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 8
- 230000006835 compression Effects 0.000 description 8
- 239000004014 plasticizer Substances 0.000 description 8
- 229920001983 poloxamer Polymers 0.000 description 8
- 238000003825 pressing Methods 0.000 description 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 7
- 229920001577 copolymer Polymers 0.000 description 7
- 238000004090 dissolution Methods 0.000 description 7
- 238000001125 extrusion Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000000465 moulding Methods 0.000 description 7
- 229920003159 Eudragit® RS 100 Polymers 0.000 description 6
- 239000013543 active substance Substances 0.000 description 6
- 239000000443 aerosol Substances 0.000 description 6
- 238000000748 compression moulding Methods 0.000 description 6
- 239000007888 film coating Substances 0.000 description 6
- 238000009501 film coating Methods 0.000 description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 208000021017 Weight Gain Diseases 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 238000013268 sustained release Methods 0.000 description 5
- 239000012730 sustained-release form Substances 0.000 description 5
- 230000004584 weight gain Effects 0.000 description 5
- 235000019786 weight gain Nutrition 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 229920002959 polymer blend Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 239000006057 Non-nutritive feed additive Substances 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 3
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 229920001400 block copolymer Polymers 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 229920001531 copovidone Polymers 0.000 description 3
- 238000013265 extended release Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229940075507 glyceryl monostearate Drugs 0.000 description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 208000024794 sputum Diseases 0.000 description 3
- 210000003802 sputum Anatomy 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 229940032147 starch Drugs 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- 239000001069 triethyl citrate Substances 0.000 description 3
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 3
- 235000013769 triethyl citrate Nutrition 0.000 description 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 229920003138 Eudragit® L 30 D-55 Polymers 0.000 description 2
- 229920003152 Eudragit® RS polymer Polymers 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 229920003083 Kollidon® VA64 Polymers 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 description 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000007887 hard shell capsule Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000009474 hot melt extrusion Methods 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000000281 joint capsule Anatomy 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 239000003605 opacifier Substances 0.000 description 2
- 239000006186 oral dosage form Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229940069328 povidone Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- KGYXYKHTHJPEBX-UHFFFAOYSA-N 5-ethoxy-3-ethoxycarbonyl-3-hydroxy-5-oxopentanoic acid Chemical compound CCOC(=O)CC(O)(CC(O)=O)C(=O)OCC KGYXYKHTHJPEBX-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- JNJAYWLAYAXPTI-UHFFFAOYSA-N C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(=C)N1C(CCC1)=O Chemical compound C(C)(=O)O.C(C)(=O)O.C(C)(=O)O.C(=C)N1C(CCC1)=O JNJAYWLAYAXPTI-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000270722 Crocodylidae Species 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920003149 Eudragit® E 100 Polymers 0.000 description 1
- 229920003148 Eudragit® E polymer Polymers 0.000 description 1
- 229920003136 Eudragit® L polymer Polymers 0.000 description 1
- 229920003137 Eudragit® S polymer Polymers 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920003085 Kollidon® CL Polymers 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 241000238367 Mya arenaria Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 229920003072 Plasdone™ povidone Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 1
- GCSPRLPXTPMSTL-IBDNADADSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCSPRLPXTPMSTL-IBDNADADSA-N 0.000 description 1
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- UGZICOVULPINFH-UHFFFAOYSA-N acetic acid;butanoic acid Chemical compound CC(O)=O.CCCC(O)=O UGZICOVULPINFH-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000049 anti-anxiety effect Effects 0.000 description 1
- 230000002365 anti-tubercular Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003200 antithyroid agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 239000003633 blood substitute Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 229920003020 cross-linked polyethylene Polymers 0.000 description 1
- 239000004703 cross-linked polyethylene Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- FWLDHHJLVGRRHD-UHFFFAOYSA-N decyl prop-2-enoate Chemical compound CCCCCCCCCCOC(=O)C=C FWLDHHJLVGRRHD-UHFFFAOYSA-N 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- LNNWVNGFPYWNQE-GMIGKAJZSA-N desomorphine Chemical compound C1C2=CC=C(O)C3=C2[C@]24CCN(C)[C@H]1[C@@H]2CCC[C@@H]4O3 LNNWVNGFPYWNQE-GMIGKAJZSA-N 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 238000004512 die casting Methods 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- JZCUVERBGWDXHL-UHFFFAOYSA-L disodium 2-hydroxyacetic acid sulfate Chemical compound S(=O)(=O)([O-])[O-].[Na+].C(CO)(=O)O.[Na+] JZCUVERBGWDXHL-UHFFFAOYSA-L 0.000 description 1
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 239000013583 drug formulation Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 238000004401 flow injection analysis Methods 0.000 description 1
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000012778 molding material Substances 0.000 description 1
- 239000003149 muscarinic antagonist Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 210000004417 patella Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008016 pharmaceutical coating Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 229920003168 pharmaceutical polymer Polymers 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000012744 reinforcing agent Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910001925 ruthenium oxide Inorganic materials 0.000 description 1
- WOCIAKWEIIZHES-UHFFFAOYSA-N ruthenium(iv) oxide Chemical compound O=[Ru]=O WOCIAKWEIIZHES-UHFFFAOYSA-N 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- FCZYGJBVLGLYQU-UHFFFAOYSA-M sodium;2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethoxy]ethanesulfonate Chemical compound [Na+].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCS([O-])(=O)=O)C=C1 FCZYGJBVLGLYQU-UHFFFAOYSA-M 0.000 description 1
- SBAUKWBTLWFQQR-UHFFFAOYSA-M sodium;dodecoxy-oxido-oxo-sulfanylidene-$l^{6}-sulfane Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=S SBAUKWBTLWFQQR-UHFFFAOYSA-M 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
- 239000004291 sulphur dioxide Substances 0.000 description 1
- 235000010269 sulphur dioxide Nutrition 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 229940127230 sympathomimetic drug Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Injection Moulding Of Plastics Or The Like (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55249904P | 2004-03-12 | 2004-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201240679A true TW201240679A (en) | 2012-10-16 |
Family
ID=34993424
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101112145A TW201240679A (en) | 2004-03-12 | 2005-03-10 | Pharmaceutical formulations |
| TW094107228A TW200539903A (en) | 2004-03-12 | 2005-03-10 | Pharmaceutical formulations |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094107228A TW200539903A (en) | 2004-03-12 | 2005-03-10 | Pharmaceutical formulations |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8147871B2 (enExample) |
| EP (1) | EP1729744A4 (enExample) |
| JP (2) | JP2007528901A (enExample) |
| KR (3) | KR20120044365A (enExample) |
| CN (1) | CN1953739B (enExample) |
| AR (1) | AR048033A1 (enExample) |
| AU (1) | AU2005222612C1 (enExample) |
| BR (1) | BRPI0508342A (enExample) |
| CA (1) | CA2559227A1 (enExample) |
| IL (1) | IL177566A (enExample) |
| MA (1) | MA28489B1 (enExample) |
| NO (1) | NO20064570L (enExample) |
| NZ (1) | NZ549264A (enExample) |
| PE (1) | PE20060003A1 (enExample) |
| RU (2) | RU2447885C2 (enExample) |
| TW (2) | TW201240679A (enExample) |
| WO (1) | WO2005089726A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2391707C (en) * | 1999-07-30 | 2010-05-11 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
| US7842308B2 (en) * | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US7883721B2 (en) | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
| MY142179A (en) * | 2002-07-25 | 2010-10-15 | Glaxo Group Ltd | Multicomponent pharmaceutical dosage form |
| EP2359817B1 (en) * | 2003-03-28 | 2018-01-10 | Sigmoid Pharma Limited | Solid oral dosage form containing seamless microcapsules |
| TW200526274A (en) * | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| DE602005010899D1 (de) * | 2004-09-27 | 2008-12-18 | Sigmoid Pharma Ltd | Mikrokapseln mit einem methylxanthin und einem kortikosteroid |
| EP1836665B1 (en) * | 2004-11-19 | 2013-01-16 | GlaxoSmithKline LLC | Method for customized dispensing of variable dose drug combination products for individualizing of therapies |
| BRPI0520830A2 (pt) * | 2005-12-30 | 2009-05-19 | Accu Break Technologies Inc | forma de dosagem farmacêutica sólida, método de subdividir uma forma de dosagem farmacêutica sólida, método de administração de uma parte de uma subunidade ativa de uma forma de dosagem farmacêutica sólida, método de administração de um ingrediente farmacêutico ativo que está presente dentro de uma subunidade ativa de uma forma de dosagem farmacêutica sólida e método de produção de uma forma de dosagem farmacêutica sólida |
| BRPI0707616A2 (pt) | 2006-02-09 | 2011-05-10 | Alba Therapuetics Corp | formulaÇÕes para um efetor de junÇço oclusiva |
| CA2652620A1 (en) * | 2006-06-02 | 2007-12-13 | Teva Pharmaceutical Industries Ltd. | Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof |
| US8034776B2 (en) | 2006-10-26 | 2011-10-11 | Alba Therapeutics Corporation | Materials and methods for the treatment of celiac disease |
| EP2380564B1 (en) * | 2007-04-04 | 2014-10-22 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
| JP2010527285A (ja) * | 2007-04-26 | 2010-08-12 | シグモイド・ファーマ・リミテッド | 複数のミニカプセルの製造 |
| NZ580803A (en) * | 2007-04-27 | 2012-03-30 | Endo Pharmaceuticals Solutions | Implant device release agents and methods of using same |
| CA2685591A1 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
| EP2209455A1 (en) * | 2007-10-15 | 2010-07-28 | Glaxo Group Limited | Paneled capsule shells for release of pharmaceutical compositions |
| CN101827571A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放一种或多种药物成分的多部分剂型的连接件及所得剂型 |
| EP2219583B1 (en) | 2007-10-15 | 2012-11-21 | Capsugel Belgium NV | Method and apparatus for manufacturing filled linkers |
| EP2219624A2 (en) | 2007-11-08 | 2010-08-25 | Glaxo Group Limited | Pharmaceutical formulations |
| EP2227226B1 (en) * | 2007-12-21 | 2016-10-26 | Johnson & Johnson Consumer Inc. | Manufacture of a tablet |
| EP2320876A2 (en) * | 2008-06-13 | 2011-05-18 | Pfizer Inc. | Hydroxypropyl cellulose capsule shell |
| IT1393245B1 (it) * | 2008-07-24 | 2012-04-12 | Universita' Degli Studi Di Milano | Forme farmaceutiche per il rilascio tempo-specifico di farmaci |
| US8900634B2 (en) * | 2008-11-03 | 2014-12-02 | Nal Pharmaceuticals, Ltd. | Diethylstilbestrol dosage form and methods of treatment using thereof |
| CN109044985A (zh) | 2009-01-09 | 2018-12-21 | 前进制药知识产权有限公司 | 包含溶蚀骨架中的一种或多种富马酸酯的药物制剂 |
| CN105213318A (zh) | 2009-05-18 | 2016-01-06 | 希格默伊德药业有限公司 | 包含油滴的组合物 |
| CN102573802A (zh) | 2009-08-12 | 2012-07-11 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| AU2011224350B2 (en) * | 2010-03-09 | 2015-07-02 | Alkermes Pharma Ireland Limited | Alcohol resistant enteric pharmaceutical compositions |
| KR101900966B1 (ko) * | 2010-10-26 | 2018-09-20 | 캡슈겔 벨지엄 엔브이 | 벌크한 장용성 캡슐 쉘 |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| WO2013055668A1 (en) | 2011-10-12 | 2013-04-18 | Dow Global Technologies Llc | Injection-molded dosage form |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| EP3065720A1 (en) | 2013-11-04 | 2016-09-14 | Capsugel Belgium NV | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| TWI535784B (zh) | 2014-08-26 | 2016-06-01 | 財團法人工業技術研究院 | 剪切增稠配方、及包含其之複合材料 |
| DK3215127T3 (da) | 2014-11-07 | 2021-02-01 | Sublimity Therapeutics Ltd | Sammensætninger omfattende cyclosporin |
| US20160331689A1 (en) | 2015-05-12 | 2016-11-17 | SE Tylose USA, Inc. | Aqueous enteric coating composition |
| CN118975972A (zh) * | 2015-10-23 | 2024-11-19 | 林德拉治疗公司 | 用于治疗剂缓释的胃驻留系统及其使用方法 |
| BR112018011636B1 (pt) | 2015-12-08 | 2024-03-12 | Lyndra Therapeutics, Inc | Sistema de residência gástrico para liberação sustentada de um agente terapêutico |
| CN119925721A (zh) | 2016-05-27 | 2025-05-06 | 林德拉治疗公司 | 用于胃驻留系统的材料结构 |
| CN110022861B (zh) | 2016-09-30 | 2024-06-28 | 林德拉治疗公司 | 用于金刚烷类药物缓释的胃驻留系统 |
| AU2018279853B2 (en) | 2017-06-09 | 2024-07-04 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| WO2019082171A1 (en) * | 2017-10-27 | 2019-05-02 | Alvit Pharma | ORAL CANNABINOID COMPOSITIONS HAVING ENHANCED BIOAVAILABILITY |
| CN112499717B (zh) * | 2020-12-10 | 2021-10-22 | 江南大学 | 一种聚合物包含膜在染料吸附中的应用 |
Family Cites Families (166)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3186910A (en) * | 1962-03-08 | 1965-06-01 | Jacob A Glassman | Method for producing peroral capsules |
| US3228789A (en) | 1962-10-22 | 1966-01-11 | Jacob A Glassman | Peroral capsules and tablets and the method for making same |
| US3278521A (en) | 1963-02-08 | 1966-10-11 | Hercules Inc | Hydroxypropyl cellulose and process |
| US3394983A (en) * | 1963-06-14 | 1968-07-30 | American Cyanamid Co | Dip-dyeing capsules |
| FR1454013A (fr) | 1965-08-18 | 1966-07-22 | Pluripharm | Mode de présentation de deux médicaments associés |
| US3399803A (en) | 1966-10-11 | 1968-09-03 | Parke Davis & Co | Self-locking medicament capsule |
| US3779942A (en) | 1970-12-04 | 1973-12-18 | Minnesota Mining & Mfg | Capsules and process for forming capsules |
| US3723312A (en) | 1970-12-18 | 1973-03-27 | Ppg Industries Inc | Combined stain retardant and separator interleaving material for glass sheets |
| DE2428397C3 (de) | 1974-06-12 | 1978-05-18 | Scherer Hartkapsel Gmbh, 6930 Eberbach | Zweiteilige Kapsel aus Hartgelatine |
| NL7610038A (en) | 1976-09-09 | 1978-03-13 | Tapanahony N V | Multichambered capsule for therapeutically active substances - has chambers of different solubility with contents differing quantitatively and qualitatively |
| DE2722822C2 (de) | 1977-05-20 | 1984-11-08 | Capsugel AG, Basel | Verfahren zum Herstellen einer zum Aufnehmen eines viskosen Stoffes, insbesondere eines flüssigen Arzneimittels, geeigneten Steckkapsel |
| US4250097A (en) * | 1978-03-08 | 1981-02-10 | Syntex (U.S.A.) Inc. | Compositions for and a method of preventing diabetic complications |
| FI63335B (fi) | 1979-02-02 | 1983-02-28 | Orion Yhtymae Oy | Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne |
| US4281763A (en) | 1979-10-31 | 1981-08-04 | Pace Joseph A | Two-piece hardshell, soluble and digestible liquid containing gelatin capsule |
| US4766728A (en) * | 1983-03-28 | 1988-08-30 | Rexa Corporation | Flow matching valve and hydraulic system employing same |
| US4417591A (en) | 1980-12-31 | 1983-11-29 | Braintech, Inc. | Apparatus and method for topographic display of multichannel EEG data |
| US4498080A (en) | 1980-12-31 | 1985-02-05 | Braintech, Inc. | Apparatus and method for topographic display of multichannel data |
| USRE34390E (en) | 1980-12-31 | 1993-09-28 | Nicolet Instrument Corporation | Apparatus and method for topographic display of multichannel EEG data |
| US4378817A (en) * | 1981-07-06 | 1983-04-05 | Superior Valve Corporation | Slide valve assembly |
| WO1983001454A1 (en) | 1981-10-21 | 1983-04-28 | Smith, Charles, E. | A method and composition for substrate coating |
| US4790881A (en) | 1982-03-26 | 1988-12-13 | Warner-Lambert Company | Molded hydrophilic polymer |
| EG16028A (en) | 1982-03-26 | 1986-12-30 | Warner Lambert Co | Apparatus and method for molding capsules |
| US4655840A (en) | 1982-03-26 | 1987-04-07 | Warner-Lambert Company | Hydrophilic polymer compositions for injection molding |
| FR2524311A1 (fr) | 1982-04-05 | 1983-10-07 | Azalbert Gilles | Gelule compartimentee aux fins d'ingestions simultanees a effets differes |
| US4550238A (en) | 1982-11-05 | 1985-10-29 | Warner-Lambert Company | Apparatus and method for sealing capsules |
| USD285837S (en) | 1982-12-20 | 1986-09-23 | Warner-Lambert Company | Pharmaceutical capsule |
| US4487327A (en) | 1982-12-21 | 1984-12-11 | Grayson Robert E | Locking capsule |
| US4625513A (en) | 1983-03-28 | 1986-12-02 | Rexa Corporation | Controlled flow hydraulic system |
| US4557180A (en) | 1983-03-28 | 1985-12-10 | Rexa Corporation | Control valve and hydraulic system employing same |
| US4696163A (en) | 1983-03-28 | 1987-09-29 | Rexa Corporation | Control valve and hydraulic system employing same |
| US4543138A (en) | 1983-07-07 | 1985-09-24 | Eli Lilly & Company | Capsule-sealing method and apparatus |
| US4564363A (en) | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
| US4576284A (en) * | 1983-12-02 | 1986-03-18 | Warner-Lambert Company | Closing of filled capsules |
| US4738724A (en) | 1983-11-04 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from starch compositions |
| CH661878A5 (de) | 1983-11-04 | 1987-08-31 | Warner Lambert Co | Kapsel-dosierungsformen. |
| US4738817A (en) * | 1983-11-17 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from hydrophilic polymers |
| US4673438A (en) * | 1984-02-13 | 1987-06-16 | Warner-Lambert Company | Polymer composition for injection molding |
| EP0164669B1 (de) | 1984-06-13 | 1991-01-23 | Röhm Gmbh | Verfahren zum Überziehen von Arzneiformen |
| US5082655A (en) * | 1984-07-23 | 1992-01-21 | Zetachron, Inc. | Pharmaceutical composition for drugs subject to supercooling |
| US4629621A (en) | 1984-07-23 | 1986-12-16 | Zetachron, Inc. | Erodible matrix for sustained release bioactive composition |
| US4678516A (en) * | 1984-10-09 | 1987-07-07 | The Dow Chemical Company | Sustained release dosage form based on highly plasticized cellulose ether gels |
| DE3438291A1 (de) | 1984-10-19 | 1986-04-24 | Röhm GmbH, 6100 Darmstadt | Verfahren zur herstellung einer waessrigen ueberzugsmitteldispersion und ihre verwendung zum ueberziehen von arzneimitteln |
| GB2172569A (en) | 1985-03-21 | 1986-09-24 | Warner Lambert Co | Improved capsule construction |
| WO1986004501A1 (fr) | 1985-01-31 | 1986-08-14 | Fujisawa Pharmaceutical Co., Ltd. | Capsule souple a cavites multiples; son procede et appareil de fabrication |
| DE3524963A1 (de) | 1985-07-12 | 1987-01-22 | Scherer R P Hartkapsel Gmbh | Zweiteilige steckkapsel |
| IL77186A0 (en) * | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
| DE3543912A1 (de) | 1985-12-12 | 1987-06-19 | Linde Ag | Steuergeraet |
| EP0228067B1 (en) | 1985-12-26 | 1991-09-18 | Taisho Pharmaceutical Co. Ltd | Seamless soft capsule |
| US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| US4928840A (en) | 1986-02-25 | 1990-05-29 | American Home Products Corporation | Tamper proof encapsulated medicaments |
| CH674800A5 (enExample) | 1986-03-12 | 1990-07-31 | Warner Lambert Co | |
| DE3612212A1 (de) * | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
| US4793493A (en) | 1986-09-18 | 1988-12-27 | Makiej Jr Walter J | Multidose capsules |
| US4936461A (en) * | 1986-09-18 | 1990-06-26 | Makiej Jr Walter J | Multidose capsules |
| DE3631826A1 (de) * | 1986-09-19 | 1988-03-31 | Roehm Gmbh | Herstellung eines methylmethacrylat-copolymerisats |
| US5074426A (en) | 1986-11-13 | 1991-12-24 | Warner-Lambert Company | Dividable capsule |
| KR890003520Y1 (ko) | 1986-12-20 | 1989-05-27 | 주식회사 서흥캅셀 | 의약용 캅셀 |
| US4724019A (en) * | 1987-03-20 | 1988-02-09 | Warner-Lambert Company | Method and apparatus for sealing capsules |
| US5236689A (en) * | 1987-06-25 | 1993-08-17 | Alza Corporation | Multi-unit delivery system |
| US4795644A (en) | 1987-08-03 | 1989-01-03 | Merck & Co., Inc. | Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins |
| DE3727894A1 (de) | 1987-08-21 | 1989-03-02 | Stephan Dieter | Kapsel fuer pharmazeutisch wirksame inhaltsstoffe einer droge |
| DE3735260A1 (de) | 1987-10-17 | 1989-04-27 | Bosch Gmbh Robert | Verschliessvorrichtung fuer zweiteilige kapseln |
| DE3830013C2 (de) | 1988-09-03 | 1996-10-17 | Bosch Gmbh Robert | Füll- und Schließmaschine für zweiteilige Kapseln |
| US4944906A (en) | 1988-10-11 | 1990-07-31 | Spirex Corporation | Methods of injection molding and extruding wet hygroscopic ionomers |
| US5004601A (en) * | 1988-10-14 | 1991-04-02 | Zetachron, Inc. | Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith |
| US5244668A (en) | 1988-10-14 | 1993-09-14 | Zetachron, Inc. | Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith |
| US5135752A (en) * | 1988-10-14 | 1992-08-04 | Zetachron, Inc. | Buccal dosage form |
| US5139790A (en) * | 1988-10-14 | 1992-08-18 | Zetachron, Inc. | Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith |
| US4936074A (en) | 1988-11-17 | 1990-06-26 | D. M. Graham Laboratories, Inc. | Process for preparing solid encapsulated medicament |
| DE3902653A1 (de) | 1989-01-30 | 1990-08-02 | Roehm Gmbh | Elastomere acrylharze |
| US6200600B1 (en) | 1989-02-16 | 2001-03-13 | Btg International Limited | Controlled delay release device |
| DE3907019A1 (de) * | 1989-03-04 | 1990-09-06 | Roehm Gmbh | Thermoplastisch verarbeitbare loesungsmittelbestaendige kunststoffmischungen |
| JPH0729926B2 (ja) | 1989-07-25 | 1995-04-05 | 大塚製薬株式会社 | 易吸収性製剤用組成物 |
| US5456919A (en) | 1989-12-29 | 1995-10-10 | Bristol-Myers Squibb Company | Capsule and caplet combination |
| DE4002904A1 (de) * | 1990-02-01 | 1991-08-08 | Roehm Gmbh | Verfahren zum imidieren eines methacrylester-polymerisats |
| PT100054A (pt) | 1991-01-30 | 1994-04-29 | Alza Corp | Dispositivo distribuidor que embebe um fluido, com duas pecas que se separam de maneira deslizante e processo para a descarga inicial retardada de um agente activo para um ambiente fluido |
| US5976571A (en) | 1991-01-31 | 1999-11-02 | Port Systems, L.L.C. | Method for making a multi-stage drug delivery system |
| US5674530A (en) | 1991-01-31 | 1997-10-07 | Port Systems, L.L.C. | Method for making a multi-stage drug delivery system |
| US5387421A (en) | 1991-01-31 | 1995-02-07 | Tsrl, Inc. | Multi stage drug delivery system |
| CA2068402C (en) | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
| DE4121652A1 (de) | 1991-06-29 | 1993-01-07 | Roehm Gmbh | Schlagzaeh-modifizierungsmittel |
| US5225202A (en) | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
| DE4138513A1 (de) | 1991-11-23 | 1993-05-27 | Basf Ag | Feste pharmazeutische retardform |
| GB9223144D0 (en) | 1992-11-05 | 1992-12-16 | Scherer Corp R P | Controlled release device |
| GB9223172D0 (en) | 1992-11-05 | 1992-12-16 | Scherer Corp R P | Capsule construction |
| US5312008A (en) | 1993-05-26 | 1994-05-17 | Davis Bradford L | Personal time capsule |
| WO1996010996A1 (en) * | 1993-07-21 | 1996-04-18 | The University Of Kentucky Research Foundation | A multicompartment hard capsule with control release properties |
| US5443461A (en) | 1993-08-31 | 1995-08-22 | Alza Corporation | Segmented device for simultaneous delivery of multiple beneficial agents |
| GB9325445D0 (en) | 1993-12-13 | 1994-02-16 | Cortecs Ltd | Pharmaceutical formulations |
| DE4402666A1 (de) | 1994-01-29 | 1995-08-03 | Roehm Gmbh | Verfahren zum kurzzeitigen Behandeln einer Kunststoffschmelze mit einem flüssigen Behandlungsmittel und dabei hergestellter thermoplastischer Kunststoff |
| DE4413350A1 (de) | 1994-04-18 | 1995-10-19 | Basf Ag | Retard-Matrixpellets und Verfahren zu ihrer Herstellung |
| JP3867171B2 (ja) * | 1994-04-22 | 2007-01-10 | アステラス製薬株式会社 | 結腸特異的薬物放出システム |
| DE19509807A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen |
| DE9414065U1 (de) * | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen |
| DE9414066U1 (de) | 1994-08-31 | 1994-11-03 | Röhm GmbH & Co. KG, 64293 Darmstadt | Überzugs- und Bindemittel für Arzneiformen sowie damit hergestellte Arzneiform |
| DE4445498A1 (de) * | 1994-12-20 | 1996-06-27 | Roehm Gmbh | Universell verträgliche Pigmentdispergatoren |
| DE19504832A1 (de) | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
| DE19504831A1 (de) | 1995-02-14 | 1996-09-05 | Basf Ag | Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose |
| DE29502547U1 (de) | 1995-02-16 | 1995-03-30 | Röhm GmbH, 64293 Darmstadt | Thermoplastisches Überzugs- und Bindemittel für Arzneiformen |
| DE19509805A1 (de) | 1995-03-21 | 1996-09-26 | Basf Ag | Transparente, schnell freisetzende Zubereitungen von nichtsteroidalen Analgetica |
| SG80553A1 (en) | 1995-07-20 | 2001-05-22 | Tanabe Seiyaku Co | Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract |
| DE19531277A1 (de) | 1995-08-25 | 1997-02-27 | Basf Ag | Verwendung von Lipiden als Hilfsmittel bei der Herstellung von festen Arzneiformen nach dem Schmelzextrusionsverfahren |
| US5769267A (en) * | 1995-11-09 | 1998-06-23 | Warner-Lambert Company | Container |
| DE19544562B4 (de) | 1995-11-30 | 2004-05-27 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von Poly(meth)acrylimiden mit bei thermischer Belastung verbesserter Farbstabilität und daraus erhältliche Formkörper |
| DE19701441C2 (de) | 1997-01-17 | 1998-11-05 | Roehm Gmbh | Verfahren zur Herstellung farbneutraler Polymethylmethacrylat-Formmassen |
| DE19718597C1 (de) | 1997-05-02 | 1999-01-07 | Roehm Gmbh | Zweistufiges Verfahren zur Entwässerung von Kunststoffdispersionen |
| DE19721467A1 (de) * | 1997-05-22 | 1998-11-26 | Basf Ag | Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe |
| SK180499A3 (en) * | 1997-07-01 | 2001-08-06 | Pfizer | Sertraline salts and sustained-release dosage forms of sertraline |
| DE19733505A1 (de) | 1997-08-01 | 1999-02-04 | Knoll Ag | Schnell wirksames Analgeticum |
| DE19753298A1 (de) * | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19753300A1 (de) | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19753299A1 (de) | 1997-12-01 | 1999-06-02 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19800927A1 (de) | 1998-01-13 | 1999-07-15 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
| DE19835346A1 (de) * | 1998-08-05 | 2000-02-10 | Boehringer Ingelheim Pharma | Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
| DE19843904A1 (de) * | 1998-09-24 | 2000-03-30 | Basf Ag | Feste Dosierungsform mit polymerem Bindemittel |
| US6139875A (en) | 1998-09-29 | 2000-10-31 | Eastman Chemical Company | Aqueous enteric coating composition and low gastric permeability enteric coating |
| CA2352389C (en) * | 1998-11-27 | 2009-01-20 | Kanji Takada | An oral formulation for gastrointestinal drug delivery |
| US6797283B1 (en) * | 1998-12-23 | 2004-09-28 | Alza Corporation | Gastric retention dosage form having multiple layers |
| IT1316684B1 (it) | 1999-03-13 | 2003-04-24 | Bosch Gmbh Robert | Supporto delle parti di capsule in una macchina di caricamento e dichiusura per capsule in due parti |
| US6248807B1 (en) | 1999-03-15 | 2001-06-19 | Fina Technology, Inc. | Method for the preparation of core-shell morphologies from polybutadiene-polystyrene graft copolymers |
| DE19914605A1 (de) | 1999-03-30 | 2000-10-05 | Roehm Gmbh | Polyalkylmethacrylat-Plastisole mit verbesserten Fließeigenschaften |
| CA2391707C (en) * | 1999-07-30 | 2010-05-11 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
| DE19958007A1 (de) * | 1999-12-02 | 2001-06-07 | Roehm Gmbh | Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen |
| DE19960494A1 (de) * | 1999-12-15 | 2001-06-21 | Knoll Ag | Vorrichtung und Verfahren zum Herstellen von festen wirkstoffhaltigen Formen |
| DE19961334A1 (de) | 1999-12-17 | 2001-06-21 | Roehm Gmbh | Spritzgußverfahren für neutrale und säuregruppenhaltige (Meth)acrylat-Copolymere |
| GB0001621D0 (en) | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
| MXPA02008023A (es) * | 2000-02-18 | 2005-06-30 | Yeda Res & Dev | Formulaciones de copolimero 1 para dosificacion oral, nasal y pulmonar. |
| US6551617B1 (en) | 2000-04-20 | 2003-04-22 | Bristol-Myers Squibb Company | Taste masking coating composition |
| US6270797B1 (en) * | 2000-05-18 | 2001-08-07 | Usv Limited | Sustained release pharmaceutical composition containing glipizide and method for producing same |
| DE10026698A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| DE10043868A1 (de) | 2000-09-04 | 2002-04-04 | Roehm Gmbh | PMMA Formmassen mit verbesserter Schlagzähigkeit |
| DE10054051A1 (de) * | 2000-10-31 | 2002-05-29 | Roehm Gmbh | PMMA-Formmasse mit verbesserter Kälteschlagzähigkeit |
| GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US7883721B2 (en) | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US7842308B2 (en) | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US20050175687A1 (en) | 2001-01-30 | 2005-08-11 | Mcallister Stephen M. | Pharmaceutical formulations |
| DE10127134A1 (de) * | 2001-06-05 | 2002-12-12 | Roehm Gmbh | verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß |
| EA005537B1 (ru) * | 2001-07-10 | 2005-04-28 | Тева Фармасьютикал Индастриес Лтд. | Система доставки лекарственного вещества по нулевому порядку, нулевому порядку - двухстадийной, возрастающей или убывающей доставки препарата |
| US6949154B2 (en) * | 2001-07-28 | 2005-09-27 | Boehringer Ingelheim Pharma Kg | Method and apparatus for sealing medicinal capsules |
| US7217381B2 (en) | 2001-09-28 | 2007-05-15 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| USD481456S1 (en) | 2002-01-30 | 2003-10-28 | Smithkline Beecham P.L.C. | Capsule |
| DE10204890A1 (de) | 2002-02-06 | 2003-08-14 | Roehm Gmbh | Schlagzähe Formmasse und Formkörper |
| US20030194429A1 (en) | 2002-04-10 | 2003-10-16 | Miller Frederick H. | Multi-phase, multi-compartment capsular delivery apparatus for therapeutic compositions and methods for using same |
| US7670612B2 (en) * | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
| MY142179A (en) * | 2002-07-25 | 2010-10-15 | Glaxo Group Ltd | Multicomponent pharmaceutical dosage form |
| USD506545S1 (en) * | 2002-07-29 | 2005-06-21 | Smithkline Beecham P.L.C. | Capsule linker |
| DE10243062A1 (de) | 2002-09-16 | 2004-03-25 | Röhm GmbH & Co. KG | Heißwasserwechseltestbeständiges Sanitärmaterial aus PMMA-Formmasse oder schlagzäher PMMA-Formmasse |
| DE10260089A1 (de) | 2002-12-19 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von wässrigen Dispersionen |
| DE10260065A1 (de) | 2002-12-19 | 2004-07-01 | Röhm GmbH & Co. KG | Kern-Schale-Teilchen zur Schlagzähmodifizierung von Poly(meth)acrylat-Formmassen |
| DE10329938A1 (de) * | 2003-07-02 | 2005-03-17 | Röhm GmbH & Co. KG | Kunststoffkörper mit mikrostrukturierter Oberfläche |
| TW200526274A (en) | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| DE10349142A1 (de) | 2003-10-17 | 2005-05-12 | Roehm Gmbh | Polymermischung sowie deren Verwendung für Spritzgußteile |
| DE10349144A1 (de) * | 2003-10-17 | 2005-05-12 | Roehm Gmbh | Polymermischung für mattierte Spritzgußteile |
| DE10351535A1 (de) * | 2003-11-03 | 2005-06-09 | Röhm GmbH & Co. KG | Mehrschichtfolie aus (Meth)acrylatcopolymer und Polycarbonat |
| DE10354379A1 (de) * | 2003-11-20 | 2005-06-23 | Röhm GmbH & Co. KG | Formmasse, enthaltend ein Mattierungsmittel |
| US20070160677A1 (en) | 2004-01-16 | 2007-07-12 | Pillai Raviraj S | Encapsulation of lipid-based formulations in enteric polymers |
| DE102004022540A1 (de) | 2004-05-05 | 2005-12-08 | Röhm GmbH & Co. KG | Formmasse für Formkörper mit hoher Witterungsbeständigkeit |
| JP4354360B2 (ja) * | 2004-07-26 | 2009-10-28 | Ｏｋｉセミコンダクタ株式会社 | 降圧電源装置 |
| DE102004045296A1 (de) | 2004-09-16 | 2006-03-23 | Röhm GmbH & Co. KG | Verwendung von Polyalkyl (meth) acrylat-Perlpolymerisaten und Formmasse zur Herstellung von extrudierten Formteilen mit mattierter Oberfläche |
| MX2007012220A (es) | 2005-04-06 | 2007-12-06 | Mallinckrodt Inc | Formulacion farmaceutica de liberacion por pulsos a base de matriz. |
| EP2219583B1 (en) * | 2007-10-15 | 2012-11-21 | Capsugel Belgium NV | Method and apparatus for manufacturing filled linkers |
| CN101827571A (zh) * | 2007-10-15 | 2010-09-08 | 葛兰素集团有限公司 | 用于释放一种或多种药物成分的多部分剂型的连接件及所得剂型 |
| EP2209455A1 (en) * | 2007-10-15 | 2010-07-28 | Glaxo Group Limited | Paneled capsule shells for release of pharmaceutical compositions |
| JP2011500626A (ja) * | 2007-10-15 | 2011-01-06 | グラクソ グループ リミテッド | １種または複数の物質を段階的に放出させるためのマルチパートカプセル |
| EP2219624A2 (en) * | 2007-11-08 | 2010-08-25 | Glaxo Group Limited | Pharmaceutical formulations |
| EP2320876A2 (en) * | 2008-06-13 | 2011-05-18 | Pfizer Inc. | Hydroxypropyl cellulose capsule shell |
-
2005
- 2005-03-10 AR ARP050100929A patent/AR048033A1/es unknown
- 2005-03-10 PE PE2005000274A patent/PE20060003A1/es not_active Application Discontinuation
- 2005-03-10 TW TW101112145A patent/TW201240679A/zh unknown
- 2005-03-10 TW TW094107228A patent/TW200539903A/zh unknown
- 2005-03-11 BR BRPI0508342-7A patent/BRPI0508342A/pt not_active IP Right Cessation
- 2005-03-11 KR KR1020127004334A patent/KR20120044365A/ko not_active Ceased
- 2005-03-11 KR KR1020127031532A patent/KR20130010511A/ko not_active Ceased
- 2005-03-11 US US11/078,077 patent/US8147871B2/en not_active Expired - Fee Related
- 2005-03-11 US US10/598,810 patent/US20070178156A1/en not_active Abandoned
- 2005-03-11 JP JP2007503046A patent/JP2007528901A/ja not_active Ceased
- 2005-03-11 KR KR1020067018523A patent/KR101242988B1/ko not_active Expired - Fee Related
- 2005-03-11 WO PCT/US2005/008147 patent/WO2005089726A1/en not_active Ceased
- 2005-03-11 NZ NZ549264A patent/NZ549264A/en unknown
- 2005-03-11 AU AU2005222612A patent/AU2005222612C1/en not_active Ceased
- 2005-03-11 RU RU2006136020/15A patent/RU2447885C2/ru not_active IP Right Cessation
- 2005-03-11 EP EP05727507A patent/EP1729744A4/en not_active Withdrawn
- 2005-03-11 CA CA002559227A patent/CA2559227A1/en not_active Abandoned
- 2005-03-11 CN CN200580015367XA patent/CN1953739B/zh not_active Expired - Fee Related
-
2006
- 2006-08-17 IL IL177566A patent/IL177566A/en not_active IP Right Cessation
- 2006-09-27 MA MA29346A patent/MA28489B1/fr unknown
- 2006-10-10 NO NO20064570A patent/NO20064570L/no not_active Application Discontinuation
-
2011
- 2011-07-06 RU RU2011127852/15A patent/RU2011127852A/ru not_active Application Discontinuation
- 2011-11-30 JP JP2011262441A patent/JP2012097088A/ja not_active Withdrawn
-
2012
- 2012-01-31 US US13/362,429 patent/US20120196940A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005222612C1 (en) | 2011-12-08 |
| EP1729744A1 (en) | 2006-12-13 |
| EP1729744A4 (en) | 2012-10-31 |
| RU2011127852A (ru) | 2013-01-20 |
| AR048033A1 (es) | 2006-03-22 |
| RU2006136020A (ru) | 2008-04-20 |
| US20050249807A1 (en) | 2005-11-10 |
| WO2005089726A1 (en) | 2005-09-29 |
| TW200539903A (en) | 2005-12-16 |
| KR20120044365A (ko) | 2012-05-07 |
| AU2005222612A1 (en) | 2005-09-29 |
| KR20070002004A (ko) | 2007-01-04 |
| BRPI0508342A (pt) | 2007-07-24 |
| IL177566A (en) | 2011-03-31 |
| KR101242988B1 (ko) | 2013-03-13 |
| JP2012097088A (ja) | 2012-05-24 |
| US20070178156A1 (en) | 2007-08-02 |
| US20120196940A1 (en) | 2012-08-02 |
| NZ549264A (en) | 2010-07-30 |
| IL177566A0 (en) | 2006-12-10 |
| KR20130010511A (ko) | 2013-01-28 |
| PE20060003A1 (es) | 2006-03-01 |
| RU2447885C2 (ru) | 2012-04-20 |
| CN1953739A (zh) | 2007-04-25 |
| JP2007528901A (ja) | 2007-10-18 |
| CA2559227A1 (en) | 2005-09-29 |
| US8147871B2 (en) | 2012-04-03 |
| CN1953739B (zh) | 2011-12-14 |
| AU2005222612B2 (en) | 2011-04-21 |
| MA28489B1 (fr) | 2007-03-01 |
| NO20064570L (no) | 2006-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW201240679A (en) | Pharmaceutical formulations | |
| TWI257871B (en) | Pharmaceutical formulation | |
| TW201010745A (en) | Pharmaceutical formulations | |
| TW200936186A (en) | Pharmaceutical formulations | |
| JP7034343B2 (ja) | 自己調節性の浸透性胃保持性薬物送達システム | |
| JP2012140433A (ja) | 製薬用処方 | |
| US20050175687A1 (en) | Pharmaceutical formulations | |
| JP2023533420A (ja) | 膨潤性経口医薬組成物 | |
| MXPA06010335A (en) | Pharmaceutical formulations | |
| JP2011528677A (ja) | 時間別薬物送達のための医薬剤形 |