TW201002682A - Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine - Google Patents
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine Download PDFInfo
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- TW201002682A TW201002682A TW098118594A TW98118594A TW201002682A TW 201002682 A TW201002682 A TW 201002682A TW 098118594 A TW098118594 A TW 098118594A TW 98118594 A TW98118594 A TW 98118594A TW 201002682 A TW201002682 A TW 201002682A
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- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
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- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5871708P | 2008-06-04 | 2008-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201002682A true TW201002682A (en) | 2010-01-16 |
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ID=41277466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098118594A TW201002682A (en) | 2008-06-04 | 2009-06-04 | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8420811B2 (https=) |
| EP (2) | EP2280956A2 (https=) |
| JP (3) | JP5567557B2 (https=) |
| KR (1) | KR20110011653A (https=) |
| CN (2) | CN102112464A (https=) |
| AR (1) | AR071997A1 (https=) |
| ES (1) | ES2652462T3 (https=) |
| TW (1) | TW201002682A (https=) |
| WO (2) | WO2009149259A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10149842B2 (en) | 2013-11-15 | 2018-12-11 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ552397A (en) | 2004-07-15 | 2011-04-29 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| ATE473978T1 (de) * | 2005-12-06 | 2010-07-15 | Neurosearch As | Neue diazabicyclische arylderivate und medizinische verwendung dafür |
| AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| AU2010247735B2 (en) | 2009-05-12 | 2015-07-16 | Albany Molecular Research, Inc. | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof |
| AU2010247763B2 (en) * | 2009-05-12 | 2015-12-24 | Albany Molecular Research, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
| WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| WO2012024397A2 (en) | 2010-08-17 | 2012-02-23 | Albany Molecular Research, Inc. | 2,5-methano-and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| NO2686520T3 (https=) | 2011-06-06 | 2018-03-17 | ||
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| WO2014159501A2 (en) * | 2013-03-14 | 2014-10-02 | Bristol-Myers Squibb Company | Processes for preparing tetrahydroisoquinolines |
| CN103601699A (zh) * | 2013-11-04 | 2014-02-26 | 南京大学 | 一类1,3,4-噻二唑-2-酰胺衍生物及其制备方法 |
| US11713298B2 (en) | 2018-05-09 | 2023-08-01 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
| WO2021117767A1 (ja) | 2019-12-10 | 2021-06-17 | 田辺三菱製薬株式会社 | 含窒素ヘテロアリールカルボキサミド酢酸誘導体の製造方法 |
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| US3947456A (en) * | 1970-01-06 | 1976-03-30 | Hoffman-La Roche Inc. | Substituted 4-phenyl isoquinolines |
| CH527194A (de) | 1970-01-06 | 1972-08-31 | Hoffmann La Roche | Verfahren zur Herstellung von Isochinolin-Derivaten |
| US3666763A (en) * | 1970-01-06 | 1972-05-30 | Hoffmann La Roche | 4-phenyl isoquinolines and process for preparing same |
| GB1504424A (en) * | 1975-08-09 | 1978-03-22 | Beecham Group Ltd | Isoquinoline-derived aminoethers |
| US4340600A (en) * | 1980-05-22 | 1982-07-20 | Smithkline Corporation | Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines |
| DE3333994A1 (de) * | 1983-09-21 | 1985-04-04 | Troponwerke GmbH & Co KG, 5000 Köln | Neue pyridoindolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| US4843071A (en) * | 1986-12-05 | 1989-06-27 | Serotonin Industries Of Charleston | Method and composition for treating obesity, drug abuse, and narcolepsy |
| CA1327795C (en) * | 1987-08-14 | 1994-03-15 | Jules Freedman | Antidepressants which are aryloxy inadanamines |
| EP0360390A1 (en) | 1988-07-25 | 1990-03-28 | Glaxo Group Limited | Spirolactam derivatives |
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| US4902710A (en) * | 1988-12-14 | 1990-02-20 | Eli Lilly And Company | Serotonin and norepinephrine uptake inhibitors |
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| BG49761A1 (en) | 1989-04-24 | 1992-02-14 | Vissh Khim T I | 4- (4'- chalophenyl)- 2- methyl- 1, 2, 3, 4- tetrahydroisohinolines and method for its preparation |
| US5164372A (en) | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
| FI97540C (fi) | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
| FR2654725B1 (fr) | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2654726B1 (fr) | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
| GB8929070D0 (en) | 1989-12-22 | 1990-02-28 | Fujisawa Pharmaceutical Co | Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same |
| UA41251C2 (uk) | 1990-01-04 | 2001-09-17 | Пфайзер, Інк. | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі |
| US5321032A (en) | 1990-02-15 | 1994-06-14 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds and pharmaceutical compositions thereof |
| JPH072740B2 (ja) | 1990-06-01 | 1995-01-18 | フアイザー・インコーポレイテツド | 3―アミノ―2―アリールキヌクリジン |
| ATE116317T1 (de) | 1990-07-23 | 1995-01-15 | Pfizer | Chinuclidinderivate. |
| HUT68667A (en) | 1990-09-28 | 1995-07-28 | Pfizer | Fused ring analogs of nitrogen containing nonaromatic heterocycles |
| GB9023116D0 (en) | 1990-10-24 | 1990-12-05 | Fujisawa Pharmaceutical Co | Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same |
| JPH04193867A (ja) | 1990-11-23 | 1992-07-13 | Nippon Shinyaku Co Ltd | イソキノリノール誘導体及び医薬 |
| DK0498069T3 (da) | 1990-12-21 | 1995-12-04 | Fujisawa Pharmaceutical Co | Ny anvendelse af peptidderivat |
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-
2009
- 2009-06-03 AR ARP090101990A patent/AR071997A1/es not_active Application Discontinuation
- 2009-06-04 US US12/995,776 patent/US8420811B2/en active Active
- 2009-06-04 KR KR1020107027200A patent/KR20110011653A/ko not_active Ceased
- 2009-06-04 CN CN2009801307194A patent/CN102112464A/zh active Pending
- 2009-06-04 US US12/995,771 patent/US8445494B2/en active Active
- 2009-06-04 EP EP09759418A patent/EP2280956A2/en not_active Withdrawn
- 2009-06-04 JP JP2011512646A patent/JP5567557B2/ja not_active Expired - Fee Related
- 2009-06-04 ES ES09759417.0T patent/ES2652462T3/es active Active
- 2009-06-04 WO PCT/US2009/046259 patent/WO2009149259A2/en not_active Ceased
- 2009-06-04 JP JP2011512645A patent/JP2011522827A/ja active Pending
- 2009-06-04 EP EP09759417.0A patent/EP2280955B8/en active Active
- 2009-06-04 TW TW098118594A patent/TW201002682A/zh unknown
- 2009-06-04 CN CN200980130762.0A patent/CN102112465B/zh active Active
- 2009-06-04 WO PCT/US2009/046256 patent/WO2009149258A2/en not_active Ceased
-
2012
- 2012-10-31 US US13/664,546 patent/US20130060027A1/en not_active Abandoned
-
2014
- 2014-05-14 JP JP2014100580A patent/JP2014169312A/ja active Pending
-
2015
- 2015-03-18 US US14/661,063 patent/US20150191494A1/en not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10149842B2 (en) | 2013-11-15 | 2018-12-11 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| TWI665190B (zh) * | 2013-11-15 | 2019-07-11 | 阿克比治療有限公司 | {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式,其組合物及用途 |
| US10596158B2 (en) | 2013-11-15 | 2020-03-24 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| US11065237B2 (en) | 2013-11-15 | 2021-07-20 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| US11690836B2 (en) | 2013-11-15 | 2023-07-04 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| US12419877B2 (en) | 2013-11-15 | 2025-09-23 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2280955B8 (en) | 2017-12-27 |
| US8420811B2 (en) | 2013-04-16 |
| CN102112465A (zh) | 2011-06-29 |
| EP2280955B1 (en) | 2017-10-18 |
| US20150191494A1 (en) | 2015-07-09 |
| EP2280956A2 (en) | 2011-02-09 |
| JP2011524346A (ja) | 2011-09-01 |
| WO2009149259A2 (en) | 2009-12-10 |
| WO2009149258A3 (en) | 2010-02-04 |
| US20130060027A1 (en) | 2013-03-07 |
| KR20110011653A (ko) | 2011-02-08 |
| CN102112464A (zh) | 2011-06-29 |
| US8445494B2 (en) | 2013-05-21 |
| US20110160220A1 (en) | 2011-06-30 |
| JP5567557B2 (ja) | 2014-08-06 |
| JP2011522827A (ja) | 2011-08-04 |
| US20110077400A1 (en) | 2011-03-31 |
| WO2009149258A2 (en) | 2009-12-10 |
| JP2014169312A (ja) | 2014-09-18 |
| EP2280955A2 (en) | 2011-02-09 |
| AR071997A1 (es) | 2010-07-28 |
| WO2009149259A3 (en) | 2010-04-15 |
| ES2652462T3 (es) | 2018-02-02 |
| CN102112465B (zh) | 2014-09-24 |
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