TW200800988A - Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity - Google Patents
Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activityInfo
- Publication number
- TW200800988A TW200800988A TW095139466A TW95139466A TW200800988A TW 200800988 A TW200800988 A TW 200800988A TW 095139466 A TW095139466 A TW 095139466A TW 95139466 A TW95139466 A TW 95139466A TW 200800988 A TW200800988 A TW 200800988A
- Authority
- TW
- Taiwan
- Prior art keywords
- optionally substituted
- lower alkyl
- alkyl group
- group
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005312076 | 2005-10-27 | ||
JP2006223875 | 2006-08-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200800988A true TW200800988A (en) | 2008-01-01 |
Family
ID=37967785
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095139466A TW200800988A (en) | 2005-10-27 | 2006-10-26 | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
Country Status (15)
Country | Link |
---|---|
US (2) | US8188271B2 (zh) |
EP (1) | EP1950212B1 (zh) |
JP (1) | JP5131689B2 (zh) |
KR (1) | KR20080064182A (zh) |
AU (1) | AU2006307101A1 (zh) |
BR (1) | BRPI0617842A2 (zh) |
CA (1) | CA2626956A1 (zh) |
EA (1) | EA200801144A1 (zh) |
ES (1) | ES2569357T3 (zh) |
IL (1) | IL190879A0 (zh) |
MA (1) | MA29879B1 (zh) |
MX (1) | MX2008005137A (zh) |
NO (1) | NO20081892L (zh) |
TW (1) | TW200800988A (zh) |
WO (1) | WO2007049675A1 (zh) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ562339A (en) | 2005-04-28 | 2011-01-28 | Smithkline Beecham Corp | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
TW200800988A (en) | 2005-10-27 | 2008-01-01 | Shionogi & Amp Co Ltd | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
US7482345B2 (en) * | 2005-12-05 | 2009-01-27 | Meng-Hsin Chen | P38 kinase inhibiting agents |
EP2220095B1 (en) | 2007-11-15 | 2013-01-02 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
JP5269086B2 (ja) | 2007-11-15 | 2013-08-21 | ギリアード サイエンシス インコーポレーテッド | ヒト免疫不全ウイルスの複製阻害薬 |
UA100250C2 (uk) | 2007-11-16 | 2012-12-10 | Гілеад Сайнсіз, Інк. | Інгібітори реплікації вірусу імунодефіциту людини |
JP5586602B2 (ja) | 2008-07-25 | 2014-09-10 | ビーブ・ヘルスケア・カンパニー | 化合物 |
KR101682058B1 (ko) | 2008-12-11 | 2016-12-02 | 비이브 헬쓰케어 컴퍼니 | 카르바모일피리돈 hiv 인테그라제 억제제를 위한 제조방법 및 중간체 |
AU2009325128B2 (en) | 2008-12-11 | 2015-01-29 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
LT2444400T (lt) * | 2009-06-15 | 2018-06-11 | Shionogi & Co., Ltd. | Pakeistasis policiklinis karbamoilpiridono darinys |
ES2446720T3 (es) * | 2009-10-13 | 2014-03-10 | Elanco Animal Health Ireland Limited | Inhibidores de la integrasa macrocíclica |
KR20120130185A (ko) | 2010-02-26 | 2012-11-29 | 니뽄 다바코 산교 가부시키가이샤 | 1,3,4,8―테트라히드로―2H―피리도[1,2―a]피라진 유도체 및 그의 HIV 인테그라제 저해제로서의 이용 |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
WO2011129095A1 (ja) * | 2010-04-12 | 2011-10-20 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
HUE039859T2 (hu) * | 2010-09-24 | 2019-02-28 | Shionogi & Co | Helyettesített policiklusos karbamoil-piridon-származék prodrug |
AU2012321762A1 (en) * | 2011-10-12 | 2014-04-17 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
PT2797416T (pt) | 2011-12-28 | 2017-10-23 | Global Blood Therapeutics Inc | Compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos |
ES2790358T3 (es) | 2011-12-28 | 2020-10-27 | Global Blood Therapeutics Inc | Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular |
US9714243B2 (en) | 2012-12-17 | 2017-07-25 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as HIV integrase inhibitors |
CA3012242C (en) | 2012-12-21 | 2021-11-02 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
SG11201504982PA (en) * | 2012-12-27 | 2015-07-30 | Japan Tobacco Inc | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
AP2015008718A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
MY180206A (en) | 2013-03-15 | 2020-11-25 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CN105073728A (zh) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
EP3008044B1 (en) | 2013-06-13 | 2018-11-21 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
NO2865735T3 (zh) | 2013-07-12 | 2018-07-21 | ||
JP6411491B2 (ja) | 2013-07-12 | 2018-10-24 | ギリアード サイエンシス インコーポレーテッド | 多環式カルバモイルピリドン化合物およびhiv感染症を処置するためのその使用 |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
WO2015089847A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors |
DK3102208T3 (da) | 2014-02-07 | 2021-03-08 | Global Blood Therapeutics Inc | Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd |
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
NO2717902T3 (zh) | 2014-06-20 | 2018-06-23 | ||
JPWO2016027879A1 (ja) * | 2014-08-22 | 2017-06-01 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
TWI738321B (zh) * | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
AU2016244035B2 (en) | 2015-04-02 | 2018-11-01 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
FI3290424T3 (fi) | 2015-04-28 | 2024-02-26 | Shionogi & Co | Substituoituneita polysyklisiä pyridonijohdannaisia ja niiden aihiolääkkeitä |
KR102409779B1 (ko) | 2015-04-28 | 2022-06-16 | 시오노기세야쿠 가부시키가이샤 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그 |
WO2016187788A1 (en) * | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds useful for treating hiv infection |
MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
RU2745071C2 (ru) | 2015-12-15 | 2021-03-18 | Сионоги Энд Ко., Лтд. | Лекарственный препарат для лечения гриппа, характеризующийся тем, что в нем объединены ингибитор кэп-зависимой эндонуклеазы и лекарственное средство против гриппа |
AR108435A1 (es) | 2016-05-12 | 2018-08-22 | Global Blood Therapeutics Inc | Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído |
CN110494141A (zh) | 2016-08-10 | 2019-11-22 | 盐野义制药株式会社 | 含有被取代的多环性吡啶酮衍生物及其前药的药物组合物 |
TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
MX2019006449A (es) | 2016-12-02 | 2019-09-10 | Merck Sharp & Dohme | Compuestos heterociclicos triciclicos utiles como inhibidores de la integrasa del virus de inmunodeficiencia humana (vih). |
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WO2019160783A1 (en) * | 2018-02-15 | 2019-08-22 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
TW202323254A (zh) * | 2018-05-31 | 2023-06-16 | 日商鹽野義製藥股份有限公司 | 多環性吡啶并三𠯤衍生物 |
KR20210018324A (ko) * | 2018-05-31 | 2021-02-17 | 시오노기 앤드 컴파니, 리미티드 | 다환성 피리돈 유도체 |
BR112020024077A2 (pt) | 2018-05-31 | 2021-02-09 | Shionogi & Co., Ltd. | derivado de carbamoilpiridona policíclica |
JP7307412B2 (ja) * | 2018-06-27 | 2023-07-12 | 国立大学法人北海道大学 | 多環性カルバモイルピリドン誘導体を含有するアレナウイルス増殖阻害剤 |
EP3849979A1 (en) * | 2018-09-12 | 2021-07-21 | Novartis AG | Antiviral pyridopyrazinedione compounds |
WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
WO2020197991A1 (en) | 2019-03-22 | 2020-10-01 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
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JP7361013B2 (ja) | 2019-11-28 | 2023-10-13 | 塩野義製薬株式会社 | 多環性カルバモイルピリドン誘導体を含有する医薬組成物 |
JPWO2021107065A1 (zh) * | 2019-11-28 | 2021-06-03 | ||
JPWO2021107066A1 (zh) | 2019-11-28 | 2021-06-03 | ||
CA3166480A1 (en) | 2020-02-24 | 2021-09-02 | Lan Jiang | Tetracyclic compounds for treating hiv infection |
PE20231297A1 (es) | 2021-01-19 | 2023-08-22 | Gilead Sciences Inc | Compuestos de piridotriazina sustituidos y usos de estos |
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JPH0296506A (ja) | 1988-09-30 | 1990-04-09 | Daicel Chem Ind Ltd | 除草剤組成物 |
JP2533796B2 (ja) | 1988-10-18 | 1996-09-11 | ダイセル化学工業株式会社 | 5−アルコキシピリジン−3−カルボキサミド誘導体とその製造方法及び植物成長抑制剤 |
JP2551472B2 (ja) | 1988-10-18 | 1996-11-06 | ダイセル化学工業株式会社 | 5−アルコキシ−γ−ピロン−3−カルボキサミド誘導体とその製造方法及び植物成長抑制剤 |
IL155089A0 (en) | 2000-10-12 | 2003-10-31 | Merck & Co Inc | Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
JP4338192B2 (ja) | 2001-08-10 | 2009-10-07 | 塩野義製薬株式会社 | 抗ウイルス剤 |
SI1441734T1 (sl) | 2001-10-26 | 2007-08-31 | Angeletti P Ist Richerche Bio | Dihidropirimidin karboksamidni inhibitorji HIV-integraze |
US7300364B2 (en) | 2004-02-06 | 2007-11-27 | Acushnet Company | Multi-layer golf ball having velocity gradient from faster center to slower cover |
US7109186B2 (en) | 2002-07-09 | 2006-09-19 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
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NZ562339A (en) * | 2005-04-28 | 2011-01-28 | Smithkline Beecham Corp | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
JP2005312076A (ja) | 2005-05-26 | 2005-11-04 | Olympus Corp | 電子撮像装置 |
TW200800988A (en) | 2005-10-27 | 2008-01-01 | Shionogi & Amp Co Ltd | Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity |
-
2006
- 2006-10-26 TW TW095139466A patent/TW200800988A/zh unknown
- 2006-10-26 WO PCT/JP2006/321335 patent/WO2007049675A1/ja active Application Filing
- 2006-10-26 ES ES06822311.4T patent/ES2569357T3/es active Active
- 2006-10-26 KR KR1020087012320A patent/KR20080064182A/ko not_active Application Discontinuation
- 2006-10-26 CA CA002626956A patent/CA2626956A1/en not_active Abandoned
- 2006-10-26 AU AU2006307101A patent/AU2006307101A1/en not_active Abandoned
- 2006-10-26 BR BRPI0617842-1A patent/BRPI0617842A2/pt not_active IP Right Cessation
- 2006-10-26 EP EP06822311.4A patent/EP1950212B1/en active Active
- 2006-10-26 EA EA200801144A patent/EA200801144A1/xx unknown
- 2006-10-26 JP JP2007542639A patent/JP5131689B2/ja active Active
- 2006-10-26 MX MX2008005137A patent/MX2008005137A/es not_active Application Discontinuation
- 2006-10-26 US US12/084,128 patent/US8188271B2/en active Active
-
2008
- 2008-04-15 IL IL190879A patent/IL190879A0/en unknown
- 2008-04-22 NO NO20081892A patent/NO20081892L/no not_active Application Discontinuation
- 2008-04-23 MA MA30862A patent/MA29879B1/fr unknown
-
2012
- 2012-03-23 US US13/428,242 patent/US20120208998A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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AU2006307101A1 (en) | 2007-05-03 |
EP1950212B1 (en) | 2016-02-24 |
US8188271B2 (en) | 2012-05-29 |
US20120208998A1 (en) | 2012-08-16 |
NO20081892L (no) | 2008-06-23 |
BRPI0617842A2 (pt) | 2011-08-09 |
WO2007049675A1 (ja) | 2007-05-03 |
EA200801144A1 (ru) | 2008-10-30 |
ES2569357T3 (es) | 2016-05-10 |
US20090143356A1 (en) | 2009-06-04 |
IL190879A0 (en) | 2008-11-03 |
CA2626956A1 (en) | 2007-05-03 |
EP1950212A4 (en) | 2010-08-04 |
JPWO2007049675A1 (ja) | 2009-04-30 |
EP1950212A1 (en) | 2008-07-30 |
MX2008005137A (es) | 2008-09-29 |
KR20080064182A (ko) | 2008-07-08 |
JP5131689B2 (ja) | 2013-01-30 |
MA29879B1 (fr) | 2008-10-03 |
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