EA200801144A1 - Полициклическое карбамоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вич - Google Patents
Полициклическое карбамоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вичInfo
- Publication number
- EA200801144A1 EA200801144A1 EA200801144A EA200801144A EA200801144A1 EA 200801144 A1 EA200801144 A1 EA 200801144A1 EA 200801144 A EA200801144 A EA 200801144A EA 200801144 A EA200801144 A EA 200801144A EA 200801144 A1 EA200801144 A1 EA 200801144A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbamoylpyridon
- polycyclic
- derivative
- respect
- inhibitor activity
- Prior art date
Links
- PQCVYHSKABCYON-UHFFFAOYSA-N 2-oxo-1h-pyridine-3-carboxamide Chemical class NC(=O)C1=CC=CN=C1O PQCVYHSKABCYON-UHFFFAOYSA-N 0.000 title 1
- 102000012330 Integrases Human genes 0.000 title 1
- 108010061833 Integrases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 abstract 1
- 229940124411 anti-hiv antiviral agent Drugs 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005312076 | 2005-10-27 | ||
| JP2006223875 | 2006-08-21 | ||
| PCT/JP2006/321335 WO2007049675A1 (ja) | 2005-10-27 | 2006-10-26 | Ｈｉｖインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200801144A1 true EA200801144A1 (ru) | 2008-10-30 |
Family
ID=37967785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200801144A EA200801144A1 (ru) | 2005-10-27 | 2006-10-26 | Полициклическое карбамоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вич |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8188271B2 (xx) |
| EP (1) | EP1950212B1 (xx) |
| JP (1) | JP5131689B2 (xx) |
| KR (1) | KR20080064182A (xx) |
| AU (1) | AU2006307101A1 (xx) |
| BR (1) | BRPI0617842A2 (xx) |
| CA (1) | CA2626956A1 (xx) |
| EA (1) | EA200801144A1 (xx) |
| ES (1) | ES2569357T3 (xx) |
| IL (1) | IL190879A0 (xx) |
| MA (1) | MA29879B1 (xx) |
| MX (1) | MX2008005137A (xx) |
| NO (1) | NO20081892L (xx) |
| TW (1) | TW200800988A (xx) |
| WO (1) | WO2007049675A1 (xx) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2749043C2 (ru) * | 2016-12-02 | 2021-06-03 | Мерк Шарп И Доум Корп. | Трициклические гетероциклические соединения, полезные в качестве ингибиторов интегразы вич |
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| DK3187225T3 (da) | 2005-04-28 | 2022-02-28 | Viiv Healthcare Co | Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet |
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| US7482345B2 (en) * | 2005-12-05 | 2009-01-27 | Meng-Hsin Chen | P38 kinase inhibiting agents |
| EP2574610A1 (en) | 2007-11-15 | 2013-04-03 | Gilead Sciences, Inc. | Inhibitors of human immonodeficiency virus replication |
| US8377960B2 (en) | 2007-11-15 | 2013-02-19 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| CN101918365B (zh) | 2007-11-16 | 2013-10-09 | 吉联亚科学股份有限公司 | 人类免疫缺陷病毒复制的抑制剂 |
| EP2320909B8 (en) | 2008-07-25 | 2016-03-30 | VIIV Healthcare Company | Chemical compounds |
| RU2527451C2 (ru) | 2008-12-11 | 2014-08-27 | Вайв Хелткер Компани | Синтез карбамоилпиридоновых ингибиторов интегразы вич и промежуточных соединений |
| EP2376453B1 (en) | 2008-12-11 | 2019-11-20 | VIIV Healthcare Company | Intermediates for carbamoylpyridone hiv integrase inhibitors |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| HUE038837T2 (hu) | 2009-06-15 | 2018-11-28 | Shionogi & Co | Helyettesített policiklusos karbamoilpiridon-származék |
| CN102574854B (zh) * | 2009-10-13 | 2014-04-16 | 伊兰科动物健康爱尔兰有限公司 | 大环整合酶抑制剂 |
| KR20120130185A (ko) * | 2010-02-26 | 2012-11-29 | 니뽄 다바코 산교 가부시키가이샤 | １,３,４,８―테트라히드로―２Ｈ―피리도［１,２―ａ］피라진 유도체 및 그의 ＨＩＶ 인테그라제 저해제로서의 이용 |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Ｖｉｉｖ醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| WO2011129095A1 (ja) * | 2010-04-12 | 2011-10-20 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
| PL2620436T3 (pl) | 2010-09-24 | 2018-10-31 | Shionogi & Co., Ltd. | Prolek podstawionej policyklicznej pochodnej karbamoilopirydonowej |
| KR20140090197A (ko) * | 2011-10-12 | 2014-07-16 | 시오노기세야쿠 가부시키가이샤 | 인터그라아제 억제 활성을 갖는 폴리사이클릭 피리돈 유도체 |
| PT3738434T (pt) | 2011-12-28 | 2023-11-13 | Global Blood Therapeutics Inc | Intermediários para obter compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos |
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| EP2931730B1 (en) * | 2012-12-17 | 2019-08-07 | Merck Sharp & Dohme Corp. | 4-pyridinonetriazine derivatives as hiv integrase inhibitors |
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| EP2940019B1 (en) * | 2012-12-27 | 2018-03-28 | Japan Tobacco Inc. | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR |
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| AU2003248872A1 (en) | 2002-07-09 | 2004-01-23 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
| US7358249B2 (en) | 2002-08-13 | 2008-04-15 | Shionogi & Co., Ltd. | Heterocyclic compounds having inhibitory activity against HIV integrase |
| EP1549315A4 (en) | 2002-09-11 | 2007-05-23 | Merck & Co Inc | DIHYDROXYPYRIDOPYRAZINE-1,6-DION COMPOUNDS AS HIV INTEGRASE INHIBITORS |
| BR0317749A (pt) | 2002-12-27 | 2005-11-22 | Angeletti P Ist Richerche Bio | Composto, composição farmacêutica, e, uso de um composto |
| JP2004244320A (ja) | 2003-02-10 | 2004-09-02 | Shionogi & Co Ltd | 含窒素複素環抗ウイルス剤 |
| TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| EP1725554A1 (en) | 2004-03-09 | 2006-11-29 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Hiv integrase inhibitors |
| EP1973906A1 (en) | 2004-12-23 | 2008-10-01 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
| JP5317257B2 (ja) * | 2005-02-21 | 2013-10-16 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体 |
| DK3187225T3 (da) * | 2005-04-28 | 2022-02-28 | Viiv Healthcare Co | Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet |
| JP2005312076A (ja) | 2005-05-26 | 2005-11-04 | Olympus Corp | 電子撮像装置 |
| MX2008005137A (es) | 2005-10-27 | 2008-09-29 | Shionogi & Co | Derivado de carbamoilpiridona policiclica que tiene actividad inhibidora en vih integrasa. |
-
2006
- 2006-10-26 MX MX2008005137A patent/MX2008005137A/es not_active Application Discontinuation
- 2006-10-26 BR BRPI0617842-1A patent/BRPI0617842A2/pt not_active IP Right Cessation
- 2006-10-26 AU AU2006307101A patent/AU2006307101A1/en not_active Abandoned
- 2006-10-26 EA EA200801144A patent/EA200801144A1/xx unknown
- 2006-10-26 KR KR1020087012320A patent/KR20080064182A/ko not_active Application Discontinuation
- 2006-10-26 US US12/084,128 patent/US8188271B2/en active Active
- 2006-10-26 EP EP06822311.4A patent/EP1950212B1/en active Active
- 2006-10-26 JP JP2007542639A patent/JP5131689B2/ja active Active
- 2006-10-26 ES ES06822311.4T patent/ES2569357T3/es active Active
- 2006-10-26 CA CA002626956A patent/CA2626956A1/en not_active Abandoned
- 2006-10-26 TW TW095139466A patent/TW200800988A/zh unknown
- 2006-10-26 WO PCT/JP2006/321335 patent/WO2007049675A1/ja active Application Filing
-
2008
- 2008-04-15 IL IL190879A patent/IL190879A0/en unknown
- 2008-04-22 NO NO20081892A patent/NO20081892L/no not_active Application Discontinuation
- 2008-04-23 MA MA30862A patent/MA29879B1/fr unknown
-
2012
- 2012-03-23 US US13/428,242 patent/US20120208998A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2749043C2 (ru) * | 2016-12-02 | 2021-06-03 | Мерк Шарп И Доум Корп. | Трициклические гетероциклические соединения, полезные в качестве ингибиторов интегразы вич |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2626956A1 (en) | 2007-05-03 |
| MX2008005137A (es) | 2008-09-29 |
| IL190879A0 (en) | 2008-11-03 |
| US8188271B2 (en) | 2012-05-29 |
| EP1950212B1 (en) | 2016-02-24 |
| EP1950212A4 (en) | 2010-08-04 |
| AU2006307101A1 (en) | 2007-05-03 |
| KR20080064182A (ko) | 2008-07-08 |
| NO20081892L (no) | 2008-06-23 |
| ES2569357T3 (es) | 2016-05-10 |
| MA29879B1 (fr) | 2008-10-03 |
| JPWO2007049675A1 (ja) | 2009-04-30 |
| BRPI0617842A2 (pt) | 2011-08-09 |
| EP1950212A1 (en) | 2008-07-30 |
| US20090143356A1 (en) | 2009-06-04 |
| JP5131689B2 (ja) | 2013-01-30 |
| TW200800988A (en) | 2008-01-01 |
| US20120208998A1 (en) | 2012-08-16 |
| WO2007049675A1 (ja) | 2007-05-03 |
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