TR199701122T1 - Siklik peptit antifungal ajanlar. - Google Patents

Siklik peptit antifungal ajanlar.

Info

Publication number
TR199701122T1
TR199701122T1 TR97/01122T TR9701122T TR199701122T1 TR 199701122 T1 TR199701122 T1 TR 199701122T1 TR 97/01122 T TR97/01122 T TR 97/01122T TR 9701122 T TR9701122 T TR 9701122T TR 199701122 T1 TR199701122 T1 TR 199701122T1
Authority
TR
Turkey
Prior art keywords
benzyl
antifungal agents
hydrogen
cyclic peptide
formula
Prior art date
Application number
TR97/01122T
Other languages
English (en)
Inventor
S. Borromeo Peter
A. Jamison James
J. Rodriguez Michael
W. Turner William
Vasudevan Venkatraghavan
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR199701122T1 publication Critical patent/TR199701122T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Fungal ve parazitik aktiviteyi inhibe etmek için bir formül (I) bilesiginin kullanildigi farmasötik bilesimleri ve yöntemler. Bu formülde R' hidrojen, metil veya NH2C(O)CH2-; R" ve R" bagimsiz olarak metil veya hidrojen; Rx1, Rx2, Ry1, Ry2, Ry3 ve Ry4 bagimsiz olarak hidroksi veya hidrojen; R0 bir formül (1) grubu; R1, C1-C6 alkil, C1-C6 alkoksi, fenil, p-halo-fenil, p-nitrofenil-fenoksi,benzil, p-halo-benzil veya nitro-benzil; R2 ise burada tanimlandigi gibi bir açil yan zinciridir.
TR97/01122T 1995-04-07 1996-04-03 Siklik peptit antifungal ajanlar. TR199701122T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41834195A 1995-04-07 1995-04-07

Publications (1)

Publication Number Publication Date
TR199701122T1 true TR199701122T1 (tr) 1998-02-21

Family

ID=23657711

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/01122T TR199701122T1 (tr) 1995-04-07 1996-04-03 Siklik peptit antifungal ajanlar.

Country Status (29)

Country Link
US (1) US5646111A (tr)
EP (1) EP0736541B1 (tr)
JP (1) JPH11504005A (tr)
KR (1) KR19980703646A (tr)
CN (1) CN1185739A (tr)
AR (2) AR004170A1 (tr)
AT (1) ATE228535T1 (tr)
AU (1) AU702841B2 (tr)
BR (1) BR9604906A (tr)
CA (1) CA2217048A1 (tr)
CO (1) CO4700480A1 (tr)
CZ (1) CZ291702B6 (tr)
DE (1) DE69624966T2 (tr)
EA (1) EA000464B1 (tr)
ES (1) ES2187617T3 (tr)
HU (1) HUP9800809A3 (tr)
IL (1) IL117749A (tr)
IN (1) IN181897B (tr)
MX (1) MX9707611A (tr)
MY (1) MY132116A (tr)
NO (1) NO974562L (tr)
NZ (1) NZ305735A (tr)
PE (1) PE39097A1 (tr)
PL (1) PL322821A1 (tr)
TR (1) TR199701122T1 (tr)
UA (1) UA46759C2 (tr)
WO (1) WO1996031228A1 (tr)
YU (1) YU22496A (tr)
ZA (1) ZA962598B (tr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6743777B1 (en) 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
AU1851797A (en) * 1996-02-01 1997-08-22 Eli Lilly And Company Cyclic peptide antifungal agents
WO1999006062A1 (en) * 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
FR2784993B1 (fr) * 1998-10-26 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides
UA72200C2 (uk) 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
AU2003200556B2 (en) * 1997-12-10 2005-12-01 Novexel Echinocandin derivative and their preparation method
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
MA26663A1 (fr) 1998-07-23 2004-12-20 Hoffmann La Roche Nouvelles aerothricines et leurs applications antifongiques
CA2340676A1 (en) 1998-08-20 2000-03-02 Eli Lilly And Company Ring modified cyclic peptide analogs
JP2003511345A (ja) 1998-12-09 2003-03-25 イーライ リリー アンド カンパニー Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製
RU2250763C2 (ru) * 1999-03-03 2005-04-27 Эли Лилли Энд Компани Фармацевтические препараты эхинокандина, содержащие мицелообразующие поверхностно-активные вещества
IL145187A0 (en) 1999-03-03 2002-06-30 Lilly Co Eli Echinocandin/carbohydrate complexes
DK1155034T3 (da) 1999-03-03 2007-01-08 Lilly Co Eli Dannelse og anionbytning af indre krystallinske echinocandin B-ammoniumsalte
CA2362482A1 (en) 1999-03-03 2000-09-08 Eli Lilly And Company Processes for making pharmaceutical oral ecb formulations and compositions
FR2794747B1 (fr) * 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
ATE293637T1 (de) 2000-01-17 2005-05-15 Basilea Pharmaceutica Ag Aerothricin analoge, deren herstellung und verwendung
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
CN103570530B (zh) * 2012-07-26 2016-08-10 鲁南新时代生物技术有限公司 一种阿尼芬净侧链中间体的制备方法
CN104003895B (zh) * 2014-05-29 2016-02-24 黑龙江大学 一种钯催化的串联反应合成三联苯类化合物的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
IE990233A1 (en) * 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
TW264477B (tr) * 1992-03-19 1995-12-01 Lilly Co Eli

Also Published As

Publication number Publication date
MX9707611A (es) 1997-12-31
EP0736541B1 (en) 2002-11-27
CA2217048A1 (en) 1996-10-10
IN181897B (tr) 1998-10-24
AR004170A1 (es) 1998-11-04
HUP9800809A3 (en) 1998-12-28
EA199700307A1 (ru) 1998-04-30
IL117749A0 (en) 1996-08-04
CO4700480A1 (es) 1998-12-29
PL322821A1 (en) 1998-02-16
BR9604906A (pt) 1998-07-21
NO974562D0 (no) 1997-10-02
NZ305735A (en) 1999-01-28
NO974562L (no) 1997-11-28
ATE228535T1 (de) 2002-12-15
MY132116A (en) 2007-09-28
WO1996031228A1 (en) 1996-10-10
JPH11504005A (ja) 1999-04-06
EP0736541A1 (en) 1996-10-09
AU702841B2 (en) 1999-03-04
ZA962598B (en) 1997-10-01
CZ310297A3 (cs) 1998-06-17
ES2187617T3 (es) 2003-06-16
US5646111A (en) 1997-07-08
CZ291702B6 (cs) 2003-05-14
AR002731A1 (es) 1998-04-29
YU22496A (sh) 1999-06-15
PE39097A1 (es) 1997-10-13
DE69624966T2 (de) 2003-03-27
AU5383496A (en) 1996-10-23
CN1185739A (zh) 1998-06-24
KR19980703646A (ko) 1998-12-05
UA46759C2 (uk) 2002-06-17
EA000464B1 (ru) 1999-08-26
HUP9800809A2 (hu) 1998-08-28
IL117749A (en) 2000-06-01
DE69624966D1 (de) 2003-01-09

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