TNSN98204A1 - Nouveaux pyrrole-amides et leur procede de production - Google Patents
Nouveaux pyrrole-amides et leur procede de productionInfo
- Publication number
- TNSN98204A1 TNSN98204A1 TNTNSN98204A TNSN98204A TNSN98204A1 TN SN98204 A1 TNSN98204 A1 TN SN98204A1 TN TNSN98204 A TNTNSN98204 A TN TNSN98204A TN SN98204 A TNSN98204 A TN SN98204A TN SN98204 A1 TNSN98204 A1 TN SN98204A1
- Authority
- TN
- Tunisia
- Prior art keywords
- amides
- production process
- novel pyrrole
- reaction
- pyrrole
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 1
- 108091008681 GABAA receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- HWCKGOZZJDHMNC-UHFFFAOYSA-M tetraethylammonium bromide Chemical compound [Br-].CC[N+](CC)(CC)CC HWCKGOZZJDHMNC-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Tea And Coffee (AREA)
- Fats And Perfumes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
L'INVENTION CONCERNE UN PROCEDE DE PRODUCTION DE PYRROLE-CARBOXAMIDES DE FORMULE III QUI COMPREND LA REACTION DE 1,3- CYCLOALCANEDIONES AVEC L'ACETATE DE BROMETHYLE SUIVIE DE LA REACTION DU PRODUIT RESULTANT AVEC UN HALOGENURE D'ACIDE PUIS DE LA REACTION AVEC UNE AMINE AROMATIQUE ET FINALEMENT AVEC UNE SOURCE D'AMMONIUM A UNE TEMPERATURE ELEVEE. LES COMPOSES DE L'INVENTION SE FIXENT SELECTIVEMENT AUX RECEPTEURS DE GABAa
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6542297P | 1997-11-13 | 1997-11-13 | |
| US7426698P | 1998-02-10 | 1998-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN98204A1 true TNSN98204A1 (fr) | 2005-03-15 |
Family
ID=26745584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNTNSN98204A TNSN98204A1 (fr) | 1997-11-13 | 1998-11-11 | Nouveaux pyrrole-amides et leur procede de production |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6262272B1 (fr) |
| EP (1) | EP1030838B1 (fr) |
| JP (1) | JP3497469B2 (fr) |
| KR (1) | KR100386722B1 (fr) |
| CN (2) | CN1280566A (fr) |
| AT (1) | ATE231492T1 (fr) |
| AU (1) | AU745788B2 (fr) |
| BG (1) | BG64530B1 (fr) |
| BR (1) | BR9814161A (fr) |
| CA (1) | CA2310095A1 (fr) |
| CZ (1) | CZ20001769A3 (fr) |
| DE (1) | DE69810959T2 (fr) |
| DK (1) | DK1030838T3 (fr) |
| DZ (1) | DZ2651A1 (fr) |
| EA (1) | EA002243B1 (fr) |
| ES (1) | ES2186232T3 (fr) |
| HR (1) | HRP20000298A2 (fr) |
| HU (1) | HUP0100235A3 (fr) |
| ID (1) | ID24135A (fr) |
| IL (1) | IL135710A0 (fr) |
| IS (1) | IS5469A (fr) |
| MA (1) | MA24697A1 (fr) |
| NO (1) | NO20002214L (fr) |
| NZ (1) | NZ503916A (fr) |
| OA (1) | OA11378A (fr) |
| PA (1) | PA8462901A1 (fr) |
| PL (1) | PL340554A1 (fr) |
| PT (1) | PT1030838E (fr) |
| SK (1) | SK6872000A3 (fr) |
| TN (1) | TNSN98204A1 (fr) |
| TR (1) | TR200001343T2 (fr) |
| TW (1) | TW509675B (fr) |
| UY (1) | UY25249A1 (fr) |
| WO (1) | WO1999025684A1 (fr) |
| YU (1) | YU27300A (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA12015A (en) | 1999-08-31 | 2006-04-19 | Neurogen Corp | Fused pyrrolecarboxamides: gaba brain receptor ligands. |
| EP1315703A1 (fr) * | 2000-09-06 | 2003-06-04 | Neurogen Corporation | Tetrahydroindazoles substitues par aryle et leur utilisation comme ligands pour le recepteur de gaba-a |
| CA2430841A1 (fr) * | 2000-12-04 | 2002-06-13 | Pfizer Products Inc. | Synthese de pyrrolescarboxamides fusionnes |
| WO2003066634A1 (fr) | 2002-02-07 | 2003-08-14 | Neurogen Corporation | Arylamides d'acide pyrazolecarboxylique substitues, fusionnes, et composes associes |
| US20080153629A1 (en) * | 2004-05-07 | 2008-06-26 | Sullivan Michael J | Thick Outer Cover Layer Golf Ball |
| CN102786458B (zh) * | 2012-06-04 | 2014-02-12 | 天津渤海职业技术学院 | 吡咯甲酰胺衍生物、其制备方法和用途 |
| MX2016009621A (es) * | 2014-01-24 | 2016-11-17 | Abbvie Inc | Derivados de fur0-3-carboxamida y metodos de uso. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750702A (en) | 1993-10-27 | 1998-05-12 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands |
| US5484944A (en) | 1993-10-27 | 1996-01-16 | Neurogen Corporation | Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands |
| US5804686A (en) | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| EP0888300A1 (fr) | 1996-03-22 | 1999-01-07 | Neurogen Corporation | Certains pyrrolecarboxamides fusionnes utilises comme ligands de recepteurs cerebraux gaba |
-
1998
- 1998-10-21 ID IDW20000893A patent/ID24135A/id unknown
- 1998-10-21 IL IL13571098A patent/IL135710A0/xx unknown
- 1998-10-21 AU AU93639/98A patent/AU745788B2/en not_active Ceased
- 1998-10-21 JP JP2000521068A patent/JP3497469B2/ja not_active Expired - Fee Related
- 1998-10-21 BR BR9814161-9A patent/BR9814161A/pt not_active Application Discontinuation
- 1998-10-21 NZ NZ503916A patent/NZ503916A/xx unknown
- 1998-10-21 TR TR2000/01343T patent/TR200001343T2/xx unknown
- 1998-10-21 CN CN98811119A patent/CN1280566A/zh active Pending
- 1998-10-21 EA EA200000413A patent/EA002243B1/ru not_active IP Right Cessation
- 1998-10-21 CA CA002310095A patent/CA2310095A1/fr not_active Abandoned
- 1998-10-21 EP EP98946678A patent/EP1030838B1/fr not_active Expired - Lifetime
- 1998-10-21 HU HU0100235A patent/HUP0100235A3/hu unknown
- 1998-10-21 PL PL98340554A patent/PL340554A1/xx not_active Application Discontinuation
- 1998-10-21 CZ CZ20001769A patent/CZ20001769A3/cs unknown
- 1998-10-21 CN CNA031594727A patent/CN1508129A/zh active Pending
- 1998-10-21 PT PT98946678T patent/PT1030838E/pt unknown
- 1998-10-21 ES ES98946678T patent/ES2186232T3/es not_active Expired - Lifetime
- 1998-10-21 DE DE69810959T patent/DE69810959T2/de not_active Expired - Fee Related
- 1998-10-21 SK SK687-2000A patent/SK6872000A3/sk unknown
- 1998-10-21 US US09/403,985 patent/US6262272B1/en not_active Expired - Fee Related
- 1998-10-21 WO PCT/IB1998/001672 patent/WO1999025684A1/fr not_active Application Discontinuation
- 1998-10-21 YU YU27300A patent/YU27300A/sh unknown
- 1998-10-21 AT AT98946678T patent/ATE231492T1/de not_active IP Right Cessation
- 1998-10-21 DK DK98946678T patent/DK1030838T3/da active
- 1998-10-21 KR KR10-2000-7005185A patent/KR100386722B1/ko not_active IP Right Cessation
- 1998-11-10 TW TW087118708A patent/TW509675B/zh not_active IP Right Cessation
- 1998-11-10 PA PA19988462901A patent/PA8462901A1/es unknown
- 1998-11-11 DZ DZ980261A patent/DZ2651A1/fr active
- 1998-11-11 MA MA25342A patent/MA24697A1/fr unknown
- 1998-11-11 TN TNTNSN98204A patent/TNSN98204A1/fr unknown
- 1998-11-13 UY UY25249A patent/UY25249A1/es not_active IP Right Cessation
-
2000
- 2000-04-26 IS IS5469A patent/IS5469A/is unknown
- 2000-04-28 NO NO20002214A patent/NO20002214L/no unknown
- 2000-05-09 BG BG104413A patent/BG64530B1/bg unknown
- 2000-05-12 HR HR20000298A patent/HRP20000298A2/hr not_active Application Discontinuation
- 2000-05-12 OA OA1200000136A patent/OA11378A/en unknown
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