TJ244R3 - (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment - Google Patents

(-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment

Info

Publication number
TJ244R3
TJ244R3 TJ94000128A TJ94000128A TJ244R3 TJ 244 R3 TJ244 R3 TJ 244R3 TJ 94000128 A TJ94000128 A TJ 94000128A TJ 94000128 A TJ94000128 A TJ 94000128A TJ 244 R3 TJ244 R3 TJ 244R3
Authority
TJ
Tajikistan
Prior art keywords
oxathiolan
pyrimidin
hydroxymethyl
fluoro
amino
Prior art date
Application number
TJ94000128A
Other languages
English (en)
Inventor
Gervais Dionne
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10699340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TJ244(R3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Priority to TJ94000128A priority Critical patent/TJ244R3/xx
Publication of TJ244R3 publication Critical patent/TJ244R3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D411/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/38Nucleosides
    • C12P19/40Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
TJ94000128A 1991-08-01 1994-12-15 (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment TJ244R3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TJ94000128A TJ244R3 (en) 1991-08-01 1994-12-15 (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919116601A GB9116601D0 (en) 1991-08-01 1991-08-01 1,3-oxathiolane nucleoside analogues
PCT/CA1992/000321 WO1993003027A1 (en) 1991-08-01 1992-07-24 1,3-oxathiolane nucleoside analogues
TJ94000128A TJ244R3 (en) 1991-08-01 1994-12-15 (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment

Publications (1)

Publication Number Publication Date
TJ244R3 true TJ244R3 (en) 1999-11-24

Family

ID=10699340

Family Applications (1)

Application Number Title Priority Date Filing Date
TJ94000128A TJ244R3 (en) 1991-08-01 1994-12-15 (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment

Country Status (41)

Country Link
US (2) US5538975A (sk)
EP (2) EP0526253B1 (sk)
JP (1) JP2960778B2 (sk)
KR (1) KR100242454B1 (sk)
CN (5) CN101066970A (sk)
AP (1) AP321A (sk)
AT (2) ATE227720T1 (sk)
AU (1) AU659668B2 (sk)
BG (1) BG61693B1 (sk)
CA (2) CA2114221C (sk)
CZ (1) CZ283765B6 (sk)
DE (2) DE69232845T2 (sk)
DK (2) DK0526253T3 (sk)
EE (1) EE03002B1 (sk)
EG (1) EG20193A (sk)
ES (2) ES2186667T3 (sk)
FI (1) FI940435A (sk)
GB (1) GB9116601D0 (sk)
GE (1) GEP20002094B (sk)
HK (2) HK1008672A1 (sk)
HN (1) HN1997000118A (sk)
HU (2) HUT70030A (sk)
IL (1) IL102616A (sk)
MA (1) MA22919A1 (sk)
MD (1) MD1434C2 (sk)
MX (1) MX9204474A (sk)
NO (3) NO300842B1 (sk)
NZ (1) NZ243637A (sk)
OA (1) OA09883A (sk)
PH (1) PH30983A (sk)
PT (2) PT526253E (sk)
RS (1) RS49993B (sk)
RU (1) RU2126405C1 (sk)
SG (1) SG68541A1 (sk)
SK (1) SK280131B6 (sk)
TJ (1) TJ244R3 (sk)
TN (1) TNSN92070A1 (sk)
TW (2) TWI232217B (sk)
WO (1) WO1993003027A1 (sk)
YU (1) YU49259B (sk)
ZA (1) ZA925668B (sk)

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Also Published As

Publication number Publication date
BG61693B1 (bg) 1998-03-31
MD1434C2 (ro) 2000-12-31
AU659668B2 (en) 1995-05-25
CN101074228A (zh) 2007-11-21
HUT70030A (en) 1995-09-28
YU72303A (sh) 2006-05-25
PH30983A (en) 1997-12-23
HU211333A9 (en) 1995-11-28
NO2008009I1 (no) 2008-06-30
CN1132073A (zh) 1996-10-02
CZ283765B6 (cs) 1998-06-17
DE69232845T2 (de) 2003-04-24
AP9200414A0 (en) 1992-07-31
CN1070191A (zh) 1993-03-24
IL102616A (en) 1996-10-31
OA09883A (en) 1994-09-15
MA22919A1 (fr) 1993-04-01
RS49993B (sr) 2008-09-29
CA2682254A1 (en) 1993-02-18
TWI232217B (en) 2005-05-11
US5538975A (en) 1996-07-23
YU74992A (sh) 1995-12-04
IL102616A0 (en) 1993-01-14
NO2005017I1 (no) 2005-09-05
FI940435A0 (fi) 1994-01-28
SK280131B6 (sk) 1999-08-06
HK1038189A1 (en) 2002-03-08
HN1997000118A (es) 1999-11-12
GEP20002094B (en) 2000-05-10
MD950114A (en) 1996-06-28
NO300842B1 (no) 1997-08-04
CZ20394A3 (en) 1994-07-13
EP1155695A1 (en) 2001-11-21
SG68541A1 (en) 1999-11-16
CA2114221C (en) 2009-12-22
FI940435A (fi) 1994-01-28
SK10494A3 (en) 1994-12-07
EP1155695B1 (en) 2009-11-18
CN1302612A (zh) 2001-07-11
ES2335968T3 (es) 2010-04-07
BG98616A (bg) 1995-03-31
ATE227720T1 (de) 2002-11-15
NO2005017I2 (no) 2007-10-01
EG20193A (en) 1997-10-30
NO940322L (no) 1994-03-21
TW366347B (en) 1999-08-11
WO1993003027A1 (en) 1993-02-18
DE69233776D1 (de) 2009-12-31
DE69232845D1 (de) 2002-12-19
DK0526253T3 (da) 2003-03-17
CA2682254C (en) 2012-02-21
DK1155695T3 (da) 2010-04-06
CN101066970A (zh) 2007-11-07
MX9204474A (es) 1993-12-01
ATE448787T1 (de) 2009-12-15
AP321A (en) 1994-02-28
CN1034810C (zh) 1997-05-07
AU2340892A (en) 1993-03-02
NO940322D0 (no) 1994-01-31
YU49259B (sh) 2004-12-31
CN1074924C (zh) 2001-11-21
GB9116601D0 (en) 1991-09-18
MD1434B2 (en) 2000-03-31
HK1008672A1 (en) 1999-05-14
TNSN92070A1 (fr) 1993-06-08
EE03002B1 (et) 1997-06-16
PT526253E (pt) 2003-03-31
HU9400285D0 (en) 1994-05-30
EP0526253B1 (en) 2002-11-13
KR100242454B1 (ko) 2000-03-02
US5618820A (en) 1997-04-08
JPH07500317A (ja) 1995-01-12
JP2960778B2 (ja) 1999-10-12
ZA925668B (en) 1993-04-28
PT1155695E (pt) 2010-02-02
RU2126405C1 (ru) 1999-02-20
ES2186667T3 (es) 2003-05-16
CA2114221A1 (en) 1993-02-18
NZ243637A (en) 1995-03-28
CN100542535C (zh) 2009-09-23
EP0526253A1 (en) 1993-02-03

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