CZ283765B6 - 1,3-Oxathiolannukleosidové analogy - Google Patents

1,3-Oxathiolannukleosidové analogy

Info

Publication number
CZ283765B6
CZ283765B6 CZ94203A CZ20394A CZ283765B6 CZ 283765 B6 CZ283765 B6 CZ 283765B6 CZ 94203 A CZ94203 A CZ 94203A CZ 20394 A CZ20394 A CZ 20394A CZ 283765 B6 CZ283765 B6 CZ 283765B6
Authority
CZ
Czechia
Prior art keywords
compound
mixture
oxathiolan
hydroxymethyl
fluoro
Prior art date
Application number
CZ94203A
Other languages
English (en)
Other versions
CZ20394A3 (en
Inventor
Dionne Gervais
Original Assignee
Biochem Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10699340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CZ283765(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biochem Pharma Inc. filed Critical Biochem Pharma Inc.
Publication of CZ20394A3 publication Critical patent/CZ20394A3/cs
Publication of CZ283765B6 publication Critical patent/CZ283765B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Řešení se týká 1,3-oxathiolannukleosidových analogů, konkrétně (-)-4-amino-5-fluor-1-(2-hy- droxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin- -2-onu a jeho farmaceuticky přijatelných derivátů a farmaceutických kompozic obsahujících uvedenou sloučeninu, které jsou použitelné k léčení virových infekcí.ŕ
CZ94203A 1991-08-01 1992-07-24 1,3-Oxathiolannukleosidové analogy CZ283765B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919116601A GB9116601D0 (en) 1991-08-01 1991-08-01 1,3-oxathiolane nucleoside analogues
PCT/CA1992/000321 WO1993003027A1 (en) 1991-08-01 1992-07-24 1,3-oxathiolane nucleoside analogues

Publications (2)

Publication Number Publication Date
CZ20394A3 CZ20394A3 (en) 1994-07-13
CZ283765B6 true CZ283765B6 (cs) 1998-06-17

Family

ID=10699340

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ94203A CZ283765B6 (cs) 1991-08-01 1992-07-24 1,3-Oxathiolannukleosidové analogy

Country Status (41)

Country Link
US (2) US5538975A (cs)
EP (2) EP1155695B1 (cs)
JP (1) JP2960778B2 (cs)
KR (1) KR100242454B1 (cs)
CN (5) CN1034810C (cs)
AP (1) AP321A (cs)
AT (2) ATE227720T1 (cs)
AU (1) AU659668B2 (cs)
BG (1) BG61693B1 (cs)
CA (2) CA2682254C (cs)
CZ (1) CZ283765B6 (cs)
DE (2) DE69233776D1 (cs)
DK (2) DK1155695T3 (cs)
EE (1) EE03002B1 (cs)
EG (1) EG20193A (cs)
ES (2) ES2186667T3 (cs)
FI (1) FI940435A (cs)
GB (1) GB9116601D0 (cs)
GE (1) GEP20002094B (cs)
HK (2) HK1008672A1 (cs)
HN (1) HN1997000118A (cs)
HU (2) HUT70030A (cs)
IL (1) IL102616A (cs)
MA (1) MA22919A1 (cs)
MD (1) MD1434C2 (cs)
MX (1) MX9204474A (cs)
NO (3) NO300842B1 (cs)
NZ (1) NZ243637A (cs)
OA (1) OA09883A (cs)
PH (1) PH30983A (cs)
PT (2) PT526253E (cs)
RS (1) RS49993B (cs)
RU (1) RU2126405C1 (cs)
SG (1) SG68541A1 (cs)
SK (1) SK280131B6 (cs)
TJ (1) TJ244R3 (cs)
TN (1) TNSN92070A1 (cs)
TW (2) TW366347B (cs)
WO (1) WO1993003027A1 (cs)
YU (1) YU49259B (cs)
ZA (1) ZA925668B (cs)

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Also Published As

Publication number Publication date
OA09883A (en) 1994-09-15
DE69232845T2 (de) 2003-04-24
EP1155695B1 (en) 2009-11-18
CN1034810C (zh) 1997-05-07
SK10494A3 (en) 1994-12-07
NO300842B1 (no) 1997-08-04
CA2114221A1 (en) 1993-02-18
DE69233776D1 (de) 2009-12-31
PH30983A (en) 1997-12-23
JP2960778B2 (ja) 1999-10-12
BG98616A (bg) 1995-03-31
CA2682254C (en) 2012-02-21
CN1302612A (zh) 2001-07-11
CN1132073A (zh) 1996-10-02
RU2126405C1 (ru) 1999-02-20
FI940435A0 (fi) 1994-01-28
NZ243637A (en) 1995-03-28
MD1434B2 (en) 2000-03-31
MD1434C2 (ro) 2000-12-31
HUT70030A (en) 1995-09-28
AU659668B2 (en) 1995-05-25
CN101066970A (zh) 2007-11-07
PT526253E (pt) 2003-03-31
US5618820A (en) 1997-04-08
DK0526253T3 (da) 2003-03-17
AP9200414A0 (en) 1992-07-31
TW366347B (en) 1999-08-11
CN101074228A (zh) 2007-11-21
PT1155695E (pt) 2010-02-02
DK1155695T3 (da) 2010-04-06
RS49993B (sr) 2008-09-29
GEP20002094B (en) 2000-05-10
ES2335968T3 (es) 2010-04-07
HN1997000118A (es) 1999-11-12
HU9400285D0 (en) 1994-05-30
TNSN92070A1 (fr) 1993-06-08
CA2114221C (en) 2009-12-22
YU72303A (sh) 2006-05-25
YU49259B (sh) 2004-12-31
IL102616A (en) 1996-10-31
ES2186667T3 (es) 2003-05-16
CN1074924C (zh) 2001-11-21
ZA925668B (en) 1993-04-28
ATE448787T1 (de) 2009-12-15
WO1993003027A1 (en) 1993-02-18
HK1008672A1 (en) 1999-05-14
NO2005017I2 (no) 2007-10-01
HK1038189A1 (en) 2002-03-08
NO2008009I1 (no) 2008-06-30
EP1155695A1 (en) 2001-11-21
NO940322D0 (no) 1994-01-31
MA22919A1 (fr) 1993-04-01
AU2340892A (en) 1993-03-02
CN1070191A (zh) 1993-03-24
BG61693B1 (bg) 1998-03-31
SG68541A1 (en) 1999-11-16
ATE227720T1 (de) 2002-11-15
EP0526253B1 (en) 2002-11-13
MD950114A (en) 1996-06-28
GB9116601D0 (en) 1991-09-18
TWI232217B (en) 2005-05-11
DE69232845D1 (de) 2002-12-19
US5538975A (en) 1996-07-23
AP321A (en) 1994-02-28
CZ20394A3 (en) 1994-07-13
JPH07500317A (ja) 1995-01-12
NO2005017I1 (no) 2005-09-05
YU74992A (sh) 1995-12-04
CN100542535C (zh) 2009-09-23
CA2682254A1 (en) 1993-02-18
SK280131B6 (sk) 1999-08-06
NO940322L (no) 1994-03-21
EG20193A (en) 1997-10-30
HU211333A9 (en) 1995-11-28
KR100242454B1 (ko) 2000-03-02
EP0526253A1 (en) 1993-02-03
IL102616A0 (en) 1993-01-14
TJ244R3 (en) 1999-11-24
EE03002B1 (et) 1997-06-16
FI940435A (fi) 1994-01-28
MX9204474A (es) 1993-12-01

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