SU793381A3 - Способ получени производных аминопропана или их солей в виде рацемата или оптически-активных антиподов - Google Patents
Способ получени производных аминопропана или их солей в виде рацемата или оптически-активных антиподов Download PDFInfo
- Publication number
- SU793381A3 SU793381A3 SU752100046A SU2100046A SU793381A3 SU 793381 A3 SU793381 A3 SU 793381A3 SU 752100046 A SU752100046 A SU 752100046A SU 2100046 A SU2100046 A SU 2100046A SU 793381 A3 SU793381 A3 SU 793381A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- alkyl
- alkoxy
- halogen
- acyl
- group
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract description 6
- 238000000034 method Methods 0.000 title description 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical class CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 18
- 125000002252 acyl group Chemical group 0.000 claims abstract description 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 150000005840 aryl radicals Chemical class 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 abstract description 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 6
- -1 acrylamino Chemical group 0.000 abstract description 5
- 239000002253 acid Substances 0.000 abstract description 4
- 125000003342 alkenyl group Chemical group 0.000 abstract description 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract description 4
- 125000001931 aliphatic group Chemical group 0.000 abstract description 3
- 125000000304 alkynyl group Chemical group 0.000 abstract description 3
- 125000003118 aryl group Chemical group 0.000 abstract description 3
- 125000003302 alkenyloxy group Chemical group 0.000 abstract description 2
- 125000004104 aryloxy group Chemical group 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract description 2
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940097217 cardiac glycoside Drugs 0.000 abstract 1
- 239000002368 cardiac glycoside Substances 0.000 abstract 1
- 229930002534 steroid glycoside Natural products 0.000 abstract 1
- 150000008143 steroidal glycosides Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N 2-propanol Substances CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 101150116749 chuk gene Proteins 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 150000002917 oxazolidines Chemical class 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2309887A DE2309887C2 (de) | 1973-02-28 | 1973-02-28 | 1-Aryloxy-2-hydroxy-3-alkinylaminopropan-Derivate und deren physiologisch verträgliche Säureadditionssalze, pharmazeutische Präparate und Herstellungsverfahren für die Verbindungen |
| DE19742403809 DE2403809C2 (de) | 1974-01-26 | 1974-01-26 | 1-Aryloxy-2-hydroxy-3-alkinylaminopropane und Verfahren zu ihrer Herstellung und pharmazeutische Präparate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU793381A3 true SU793381A3 (ru) | 1980-12-30 |
Family
ID=25764753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU752100046A SU793381A3 (ru) | 1973-02-28 | 1975-01-29 | Способ получени производных аминопропана или их солей в виде рацемата или оптически-активных антиподов |
Country Status (24)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA009902B1 (ru) * | 2004-02-13 | 2008-04-28 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си | Модуляторы рецепторов андрогенов |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038313A (en) * | 1970-01-08 | 1977-07-26 | Ciba-Geigy Corporation | Cycloalkylureido phenoxy propanolamines |
| US4035420A (en) * | 1972-07-06 | 1977-07-12 | Aktiebolaget Hassle | Substituted ureido alkylene phenoxy propanolamines |
| US4078146A (en) * | 1972-07-06 | 1978-03-07 | Aktiebolaget Hassle | Phenoxy propanolamines |
| GB1374366A (en) * | 1972-07-21 | 1974-11-20 | Science Union & Cie | Propanol derivatives and a process for their preparation |
| AT334385B (de) * | 1973-12-20 | 1976-01-10 | Chemie Linz Ag | Verfahren zur herstellung von neuen phenoxypropylaminderivaten und deren salzen |
| US4243681A (en) * | 1977-10-11 | 1981-01-06 | Mead Johnson & Company | Alkylthiophenoxypropanolamines and pharmaceutical compositions and uses thereof |
| DE2805404A1 (de) * | 1978-02-09 | 1979-08-16 | Merck Patent Gmbh | 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung |
| DE3009036A1 (de) * | 1980-03-08 | 1981-09-24 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung |
| DE3009047A1 (de) * | 1980-03-08 | 1981-09-24 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung |
| US4387103A (en) * | 1980-11-28 | 1983-06-07 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
| US4455317A (en) * | 1981-06-23 | 1984-06-19 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
| US4454154A (en) * | 1981-06-23 | 1984-06-12 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
| US4578403A (en) * | 1981-06-23 | 1986-03-25 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
| US4559359A (en) * | 1981-06-23 | 1985-12-17 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
| DE3248835A1 (de) * | 1981-06-23 | 1983-06-30 | American Hospital Supply Corp | Zusammensetzungen fuer die behandlung von glaukom |
| DE3133719A1 (de) * | 1981-08-26 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue 1-aryloxy-3-alkinylamino-2-propanole und verfahren zu ihrer herstellung |
| JPH02130007U (enrdf_load_stackoverflow) * | 1989-03-31 | 1990-10-26 | ||
| JP5838114B2 (ja) | 2012-04-02 | 2015-12-24 | 株式会社リガク | Ｘ線トポグラフィ装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459782A (en) * | 1963-08-26 | 1969-08-05 | Boehringer Sohn Ingelheim | 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes |
| GB1199037A (en) * | 1967-09-27 | 1970-07-15 | Ici Ltd | Alkanolamine Derivatives |
| US3541130A (en) * | 1967-02-06 | 1970-11-17 | Boehringer Sohn Ingelheim | 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes |
-
1974
- 1974-02-11 AT AT104774A patent/AT330150B/de not_active IP Right Cessation
- 1974-02-21 ES ES423466A patent/ES423466A1/es not_active Expired
- 1974-02-22 US US444713A patent/US3925446A/en not_active Expired - Lifetime
- 1974-02-25 CS CS7400001369A patent/CS186263B2/cs unknown
- 1974-02-25 FI FI544/74A patent/FI62054C/fi active
- 1974-02-26 BG BG026941A patent/BG20335A3/xx unknown
- 1974-02-26 BG BG026943A patent/BG20566A3/xx unknown
- 1974-02-26 BG BG026942A patent/BG20565A3/xx unknown
- 1974-02-26 BG BG025901A patent/BG20564A3/xx unknown
- 1974-02-26 DD DD176809A patent/DD110652A5/xx unknown
- 1974-02-26 BG BG026938A patent/BG20334A3/xx unknown
- 1974-02-26 BG BG026939A patent/BG21208A3/xx unknown
- 1974-02-26 HU HUBO1487A patent/HU168598B/hu unknown
- 1974-02-26 BG BG026940A patent/BG21394A3/xx unknown
- 1974-02-27 CA CA193,683A patent/CA1062717A/en not_active Expired
- 1974-02-27 PH PH15555*UA patent/PH9722A/en unknown
- 1974-02-27 CH CH1485677A patent/CH605689A5/xx not_active IP Right Cessation
- 1974-02-27 SE SE7402622A patent/SE411897B/sv not_active IP Right Cessation
- 1974-02-27 NO NO740670A patent/NO138062C/no unknown
- 1974-02-27 PL PL1974183356A patent/PL93591B1/pl unknown
- 1974-02-27 YU YU00500/74A patent/YU50074A/xx unknown
- 1974-02-27 JP JP49023221A patent/JPS594417B2/ja not_active Expired
- 1974-02-27 PL PL1974169115A patent/PL91560B1/pl unknown
- 1974-02-27 CH CH278074A patent/CH605636A5/xx not_active IP Right Cessation
- 1974-02-27 CH CH1485577A patent/CH605638A5/xx not_active IP Right Cessation
- 1974-02-27 CH CH1486077A patent/CH605691A5/xx not_active IP Right Cessation
- 1974-02-27 MX MX745493U patent/MX4592E/es unknown
- 1974-02-27 GB GB894974A patent/GB1450287A/en not_active Expired
- 1974-02-27 CH CH1485477A patent/CH605637A5/xx not_active IP Right Cessation
- 1974-02-27 CH CH1485977A patent/CH605690A5/xx not_active IP Right Cessation
- 1974-02-27 MX MX745489U patent/MX4588E/es unknown
- 1974-02-27 DK DK105174A patent/DK143128C/da not_active IP Right Cessation
- 1974-02-27 IL IL44301A patent/IL44301A/en unknown
- 1974-02-28 FR FR7406835A patent/FR2218900B1/fr not_active Expired
- 1974-02-28 NL NLAANVRAGE7402704,A patent/NL169733C/xx not_active IP Right Cessation
- 1974-02-28 IE IE428/74A patent/IE39482B1/xx unknown
- 1974-08-27 CH CH1485877A patent/CH605639A5/xx not_active IP Right Cessation
-
1975
- 1975-01-29 SU SU752100046A patent/SU793381A3/ru active
- 1975-04-04 ES ES436311A patent/ES436311A1/es not_active Expired
- 1975-04-04 ES ES436315A patent/ES436315A1/es not_active Expired
- 1975-04-04 ES ES436316A patent/ES436316A1/es not_active Expired
- 1975-04-04 ES ES436314A patent/ES436314A1/es not_active Expired
- 1975-04-04 ES ES436312A patent/ES436312A1/es not_active Expired
- 1975-04-04 ES ES436313A patent/ES436313A1/es not_active Expired
-
1980
- 1980-04-22 YU YU01095/80A patent/YU109580A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA009902B1 (ru) * | 2004-02-13 | 2008-04-28 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си | Модуляторы рецепторов андрогенов |
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