SU784767A3 - Способ получени карбонилзамещенных 1-сульфонилбензимидазолов - Google Patents

Способ получени карбонилзамещенных 1-сульфонилбензимидазолов Download PDF

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Publication number
SU784767A3
SU784767A3 SU782676705A SU2676705A SU784767A3 SU 784767 A3 SU784767 A3 SU 784767A3 SU 782676705 A SU782676705 A SU 782676705A SU 2676705 A SU2676705 A SU 2676705A SU 784767 A3 SU784767 A3 SU 784767A3
Authority
SU
USSR - Soviet Union
Prior art keywords
substituted
sulfonylbenzimidazoles
preparing carbonyl
carbonyl
preparing
Prior art date
Application number
SU782676705A
Other languages
English (en)
Inventor
Джонсон Пэйджет Чарльз
Весли Чамберлин Джеймс
Говард Вайкл Джеймс
Original Assignee
Эли Лилли Энд Компани (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани (Фирма) filed Critical Эли Лилли Энд Компани (Фирма)
Application granted granted Critical
Publication of SU784767A3 publication Critical patent/SU784767A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Description

порци ми насыщенного раствора хлористого натри , сушат и фильтруют дл  получени  227 мг в форме белого пористого вещества 1-диметиламиносуль фонил-2-амино-5(б)-tl-этоксииминдобензил )-бенэимидазола.
. CieHj.
Мол вес. 387.
Вычи6лено,%: С 55,80; Н 5,46j N 18,08.
Найдено,%: С 56,03 Н 5 33} N 18,27.
П р и м е р 2. При повторении опыта, описанного в примере 1, но с применением 718 г(2 ммоль) 1-диметиламйносульФинил-2-амино-5 (6)- с6-оксиининобенэил )-бензимидазола, 15 мл метанола, 120 мг (2,2 ммоль)метилата натри  и 600 мг (3,54 ммоль) 1-йодпропана получают 248 мг 1-диметиламиносульфонил-2-аминр-5 (6)- (альфа-пропоксииминобензил)-бензимидазола в форме твердого белого вещества ,
S
Мол.вес. 401.,
ВнчиЪлено,%: С 56,34 Н 5,77} , N 17,44.
Найдено,%: С 56,63; Н 5,54} 17,60.
N

Claims (1)

1. Патент Англии № 1205665,, кл. С(2)С, 1970.
SU782676705A 1975-08-28 1978-10-24 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов SU784767A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60841575A 1975-08-28 1975-08-28

Publications (1)

Publication Number Publication Date
SU784767A3 true SU784767A3 (ru) 1980-11-30

Family

ID=24436401

Family Applications (9)

Application Number Title Priority Date Filing Date
SU762390305A SU691089A3 (ru) 1975-08-28 1976-08-26 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU772524545A SU730300A3 (ru) 1975-08-28 1977-09-27 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU772525453A SU685151A3 (ru) 1975-08-28 1977-09-28 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU772526201A SU884570A3 (ru) 1975-08-28 1977-09-29 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU772527447A SU679140A3 (ru) 1975-08-28 1977-09-29 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU782647712A SU730301A3 (ru) 1975-08-28 1978-08-16 Способ получени замещенных 1-сульфонилбензимидазолов
SU782654600A SU727142A3 (ru) 1975-08-28 1978-08-31 Способ получени замещенных 1-сульфонилбензимидазолов
SU782676704A SU919593A3 (ru) 1975-08-28 1978-10-23 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU782676705A SU784767A3 (ru) 1975-08-28 1978-10-24 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов

Family Applications Before (8)

Application Number Title Priority Date Filing Date
SU762390305A SU691089A3 (ru) 1975-08-28 1976-08-26 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU772524545A SU730300A3 (ru) 1975-08-28 1977-09-27 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU772525453A SU685151A3 (ru) 1975-08-28 1977-09-28 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU772526201A SU884570A3 (ru) 1975-08-28 1977-09-29 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU772527447A SU679140A3 (ru) 1975-08-28 1977-09-29 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов
SU782647712A SU730301A3 (ru) 1975-08-28 1978-08-16 Способ получени замещенных 1-сульфонилбензимидазолов
SU782654600A SU727142A3 (ru) 1975-08-28 1978-08-31 Способ получени замещенных 1-сульфонилбензимидазолов
SU782676704A SU919593A3 (ru) 1975-08-28 1978-10-23 Способ получени карбонилзамещенных 1-сульфонилбензимидазолов

Country Status (28)

Country Link
US (1) US4118742A (ru)
JP (4) JPS5633392B2 (ru)
AR (4) AR219284A1 (ru)
AT (1) AT360005B (ru)
AU (1) AU502756B2 (ru)
BE (1) BE845641A (ru)
BG (1) BG27548A3 (ru)
CA (1) CA1064501A (ru)
CH (8) CH626612A5 (ru)
DD (1) DD126518A5 (ru)
DE (1) DE2638551A1 (ru)
DK (1) DK154764C (ru)
ES (5) ES451018A1 (ru)
FR (1) FR2321883A1 (ru)
GB (1) GB1562812A (ru)
GR (1) GR61627B (ru)
HU (1) HU173988B (ru)
IE (1) IE43531B1 (ru)
IL (1) IL50292A (ru)
MX (1) MX3654E (ru)
NL (1) NL7609414A (ru)
NZ (1) NZ181789A (ru)
PL (4) PL112910B1 (ru)
PT (1) PT65486B (ru)
RO (5) RO78125A (ru)
SU (9) SU691089A3 (ru)
YU (2) YU203476A (ru)
ZA (1) ZA765142B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191832A (en) * 1979-03-12 1980-03-04 Eli Lilly And Company Separation of syn and anti oximes of 1-sulfonyl-2-aminobenzimidazoles
ZA815698B (en) * 1980-08-28 1983-04-27 Lilly Co Eli Intranasal formulation
FR2521141A1 (fr) * 1982-02-09 1983-08-12 Rhone Poulenc Agrochimie Nouveaux derives du cyano-2 benzimidazole, leur preparation et leur utilisation comme fongicides
US4463181A (en) * 1982-04-08 1984-07-31 Eli Lilly And Company Process for removing sulfonyl groups from benzimidazole isomers
US4434288A (en) * 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US4420479A (en) * 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
IL68297A (en) * 1982-04-08 1986-09-30 Lilly Co Eli Process for removing 1-sulfonyl groups from 2-amino-5(6)-substituted benzimidazoles
US4483986A (en) * 1982-05-03 1984-11-20 Eli Lilly And Company 4-Nitrobenzophenone compounds
US4629811A (en) * 1982-05-03 1986-12-16 Eli Lilly And Company 3-sulfonylamino-4-aminobenzophenone derivatives
US4645861A (en) * 1982-05-03 1987-02-24 Eli Lilly And Company 3-sulfonylamino-4-amino phenyl acyl derivatives
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
US4501921A (en) * 1982-11-18 1985-02-26 Eli Lilly And Company Synthesis of alkylidene intermediates
US4435418A (en) * 1982-12-13 1984-03-06 Smithkline Beckman Corporation 5-Phenylethenylbenzimidazoles
JPS62196293U (ru) * 1986-06-03 1987-12-14
CA1339133C (en) * 1987-03-13 1997-07-29 Rikuo Nasu Imidazole compounds and biocidal composition comprising the same for controlling harmful organisms
JPS6410894A (en) * 1987-06-30 1989-01-13 Nitto Koji Kk Burying propulsion correcting method and device for propulsive pipe for burying hume pipe
US5545653A (en) * 1995-06-07 1996-08-13 Eli Lilly And Company Anti-viral compounds
WO1998055120A1 (en) * 1997-06-04 1998-12-10 Eli Lilly And Company Anti-viral compounds
US6358971B1 (en) 1998-05-20 2002-03-19 Eli Lilly And Company Anti-viral compounds
US7470723B2 (en) * 2003-03-05 2008-12-30 Celgene Corporation Diphenylethylene compounds and uses thereof
US8287843B2 (en) * 2003-06-23 2012-10-16 Colgate-Palmolive Company Antiplaque oral care compositions
SG144809A1 (en) * 2007-01-11 2008-08-28 Millipore U K Ltd Benzimidazole compounds and their use as chromatographic ligands
CN112752761B (zh) 2018-08-21 2024-03-29 杏林制药株式会社 双环杂芳族环衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1170737A (en) * 1964-05-27 1969-11-12 Fisons Pest Control Ltd Substituted Benzimadazoles and their use as Acaricides
US3682952A (en) * 1964-08-04 1972-08-08 Smith Kline French Lab 5(6)-n-butyl-2-carbomethoxy-benzimidazole
DE2034643A1 (de) * 1970-03-06 1971-09-16 Deutsche Akademie der Wissenschaften zu Berlin, χ 1199 Berlin Verfahren zur Herstellung von virustatisch wirksamen p-N-Methylnitrosaminophenyl-Verbindungen
BE795099A (fr) * 1972-02-09 1973-08-07 Bayer Ag Nouvelles 1-acyl-3-aminosulfonyl-2-imino-benzimidazolines, leur procede de preparation et leur application comme fongicides
BE795098A (fr) * 1972-02-09 1973-08-07 Bayer Ag Nouveaux 1-aminosulfonyl-2-amino-benzimidazoles, leur procede de preparation et leur application comme fongicides

Also Published As

Publication number Publication date
CH631447A5 (de) 1982-08-13
ES461641A1 (es) 1978-07-16
ES461644A1 (es) 1978-06-16
FR2321883A1 (fr) 1977-03-25
AR221037A1 (es) 1980-12-30
IL50292A (en) 1980-12-31
JPS57112389A (en) 1982-07-13
SU730300A3 (ru) 1980-04-25
DK386076A (da) 1977-03-01
IL50292A0 (en) 1976-10-31
HU173988B (hu) 1979-10-28
FR2321883B1 (ru) 1978-11-17
PL110145B1 (en) 1980-07-31
CH628035A5 (de) 1982-02-15
ATA636376A (de) 1980-05-15
GR61627B (en) 1978-12-04
SU691089A3 (ru) 1979-10-05
JPS591712B2 (ja) 1984-01-13
DK154764C (da) 1989-05-29
AT360005B (de) 1980-12-10
PT65486A (en) 1976-09-01
JPS52148074A (ru) 1977-12-08
RO78122A (ro) 1982-02-01
DE2638551C2 (ru) 1989-06-15
DK154764B (da) 1988-12-19
SU884570A3 (ru) 1981-11-23
PL115117B1 (en) 1981-03-31
IE43531B1 (en) 1981-03-25
CH627753A5 (de) 1982-01-29
PT65486B (en) 1978-03-24
PL106947B1 (pl) 1980-01-31
ES461643A1 (es) 1978-06-16
SU679140A3 (ru) 1979-08-05
BG27548A3 (en) 1979-11-12
JPS5823876B2 (ja) 1983-05-18
SU919593A3 (ru) 1982-04-07
CA1064501A (en) 1979-10-16
CH627748A5 (de) 1982-01-29
ES461642A1 (es) 1978-06-16
AR219284A1 (es) 1980-08-15
SU730301A3 (ru) 1980-04-25
AR220344A1 (es) 1980-10-31
AR221701A1 (es) 1981-03-13
JPS57112392A (en) 1982-07-13
BE845641A (fr) 1977-02-28
ES451018A1 (es) 1977-11-16
YU203476A (en) 1982-08-31
CH627455A5 (de) 1982-01-15
RO72313A (ro) 1982-09-09
US4118742A (en) 1978-10-03
AU502756B2 (en) 1979-08-09
CH630376A5 (de) 1982-06-15
SU685151A3 (ru) 1979-09-05
JPS57112388A (en) 1982-07-13
MX3654E (es) 1981-04-14
ZA765142B (en) 1978-04-26
CH626612A5 (ru) 1981-11-30
NZ181789A (en) 1979-01-11
NL7609414A (nl) 1977-03-02
RO78123A (ro) 1982-02-01
RO78125A (ro) 1982-10-26
YU39077A (en) 1982-10-31
GB1562812A (en) 1980-03-19
SU727142A3 (ru) 1980-04-05
DE2638551A1 (de) 1977-03-10
AU1698276A (en) 1978-02-23
PL112910B1 (en) 1980-11-29
CH630917A5 (de) 1982-07-15
RO78124A (ro) 1982-02-01
DD126518A5 (ru) 1977-07-20
IE43531L (en) 1977-02-28
JPS5633392B2 (ru) 1981-08-03

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