IE40905B1 - Substituted triphenylethylenes - Google Patents

Substituted triphenylethylenes

Info

Publication number
IE40905B1
IE40905B1 IE743/75A IE74375A IE40905B1 IE 40905 B1 IE40905 B1 IE 40905B1 IE 743/75 A IE743/75 A IE 743/75A IE 74375 A IE74375 A IE 74375A IE 40905 B1 IE40905 B1 IE 40905B1
Authority
IE
Ireland
Prior art keywords
denotes
lower alkyl
hydrogen
formula
group
Prior art date
Application number
IE743/75A
Other versions
IE40905L (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/457,931 external-priority patent/US4001229A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE40905L publication Critical patent/IE40905L/en
Publication of IE40905B1 publication Critical patent/IE40905B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

Pharmacologically active compounds of the formula Ia <IMAGE> or an acid addition salt thereof, wherein X denotes an R<6>SO2- group, R<1> and R<2> denote lower alkyl or together with the nitrogen atom to which they are bonded form a heterocyclic ring, R<3> and R<4> denote hydrogen, hydroxyl or methoxy, R<5> denotes hydrogen, halogen, nitro or lower alkyl or perfluoroalkyl, R<6> denotes lower alkyl and n denotes 2 or 3, are prepared by dehydration in that a solution of the corresponding triphenylethanols is heated in the presence of an acid. One application of this process is the preparation of compounds of the formula Ia, in which X is hydrogen, by catalytic elimination of the R<6>SO2- group by means of lithium aluminium chloride. The products have various valuable pharmacological properties and are in particular oestrogenically active, possess a post-coital anti-fertile action and furthermore exhibit anti-tumour activity. [GB1481648A]
IE743/75A 1974-04-04 1975-04-03 Substituted triphenylethylenes IE40905B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45793274A 1974-04-04 1974-04-04
US05/457,931 US4001229A (en) 1974-04-04 1974-04-04 Alkanesulfonamido triphenylethylenes

Publications (2)

Publication Number Publication Date
IE40905L IE40905L (en) 1975-10-04
IE40905B1 true IE40905B1 (en) 1979-09-12

Family

ID=27038784

Family Applications (1)

Application Number Title Priority Date Filing Date
IE743/75A IE40905B1 (en) 1974-04-04 1975-04-03 Substituted triphenylethylenes

Country Status (11)

Country Link
JP (1) JPS50137965A (en)
CH (1) CH614192A5 (en)
DE (1) DE2514809A1 (en)
DK (1) DK135375A (en)
FR (2) FR2266494B1 (en)
GB (1) GB1481648A (en)
IE (1) IE40905B1 (en)
LU (1) LU72188A1 (en)
NL (1) NL7503855A (en)
SE (1) SE418179B (en)
YU (1) YU71175A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572884A (en) * 1982-11-25 1986-02-25 Ricoh Company, Ltd. Stilbene derivatives and electrophotographic photoconductor comprising one stilbene derivative

Also Published As

Publication number Publication date
CH614192A5 (en) 1979-11-15
SE418179B (en) 1981-05-11
DE2514809A1 (en) 1975-10-16
GB1481648A (en) 1977-08-03
DK135375A (en) 1975-10-05
IE40905L (en) 1975-10-04
LU72188A1 (en) 1976-03-02
FR2266494A1 (en) 1975-10-31
AU7892475A (en) 1976-09-16
FR2391724B1 (en) 1981-12-04
FR2391724A1 (en) 1978-12-22
NL7503855A (en) 1975-10-07
JPS50137965A (en) 1975-11-01
FR2266494B1 (en) 1980-02-08
SE7503725L (en) 1975-10-06
YU71175A (en) 1982-06-18

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