SE7509271L - WAY TO PRODUCE CHINOXALINE AND CHINAZOLINE DERIVATIVES - Google Patents

WAY TO PRODUCE CHINOXALINE AND CHINAZOLINE DERIVATIVES

Info

Publication number
SE7509271L
SE7509271L SE7509271A SE7509271A SE7509271L SE 7509271 L SE7509271 L SE 7509271L SE 7509271 A SE7509271 A SE 7509271A SE 7509271 A SE7509271 A SE 7509271A SE 7509271 L SE7509271 L SE 7509271L
Authority
SE
Sweden
Prior art keywords
formula
positions
compound
produce
quinoxaline
Prior art date
Application number
SE7509271A
Other languages
Swedish (sv)
Inventor
M B Thomas
M T Williams
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE7509271L publication Critical patent/SE7509271L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

1463520 Imidazoline compounds PFIZER Ltd 5 Sept 1975 [6 Sept 1974] 39143/74 Heading C2C The invention comprises a process for preparing compounds of the formula where Q represents a group of the formula in which the free valence may be in any one of the 5-, 6-, 7- or 8-positions in the quinoxaline or quinazoline nucleus; (R<SP>1</SP>) x represents up to 3 optional substituents in any of the remaining 5-, 6-, 7- or 8-positions, each R<SP>1</SP> being a halogen atom or a C 1 -C 6 alkyl, C 1 -C 6 alkoxy or trifluoromethyl group and x being 0 to 3; and R<SP>2</SP> represents an optional substituent in either of the 2- or 3-, or 2- or 4-positions of the quinoxaline or quinazoline nucleus, respectively, R<SP>2</SP> being a hydrogen atom or a C 1 -C 6 alkyl or C 1 -C 6 alkoxy group; which comprises heating a thioureido compound of the formula wherein Q is as defined above, to produce the corresponding isothiocyanate of the formula reacting the isothiocyanate with ethylene diamine to form a #-aminoethyl thioureido compound of the formula cyclizing the #-aminoethyl-thioureido compound to form the compound of the Formula (I), recovering the latter as the product, and, optionally, converting the product into a pharmaceutically acceptable acid addition salt.
SE7509271A 1974-09-06 1975-08-25 WAY TO PRODUCE CHINOXALINE AND CHINAZOLINE DERIVATIVES SE7509271L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3914374A GB1463520A (en) 1974-09-06 1974-09-06 Process for the production of imidazolines

Publications (1)

Publication Number Publication Date
SE7509271L true SE7509271L (en) 1975-12-29

Family

ID=10407882

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7509271A SE7509271L (en) 1974-09-06 1975-08-25 WAY TO PRODUCE CHINOXALINE AND CHINAZOLINE DERIVATIVES

Country Status (12)

Country Link
JP (1) JPS51149291A (en)
BE (1) BE833135A (en)
CA (1) CA1043791A (en)
DE (1) DE2538620A1 (en)
DK (1) DK398775A (en)
ES (1) ES440760A1 (en)
FI (1) FI752487A (en)
FR (1) FR2283899A1 (en)
GB (1) GB1463520A (en)
LU (1) LU73327A1 (en)
NL (1) NL7510473A (en)
SE (1) SE7509271L (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198442A (en) * 1989-10-12 1993-03-30 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5204347A (en) * 1989-10-12 1993-04-20 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines
US5077292A (en) * 1989-10-12 1991-12-31 Allergan, Inc. (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
US5326763A (en) * 1989-10-12 1994-07-05 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5112822A (en) * 1989-10-12 1992-05-12 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5021416A (en) * 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
US5237072A (en) * 1990-02-06 1993-08-17 Allergan, Inc. Method for producing amino-2-imidazoline derivatives
US5130441A (en) * 1990-02-06 1992-07-14 Allergan, Inc. Method for producing amino-2-imidazoline derivatives
JP3683908B2 (en) * 1993-10-13 2005-08-17 アラーガン、インコーポレイテッド Method of using (2-imidazolin-2-ylamino) quinoxaline derivative
US6323204B1 (en) 1993-10-13 2001-11-27 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
CA2505836C (en) 2004-05-06 2013-08-27 Alcon Inc. Topical brimonidine tartrate formulations that lack chlorine dioxide
WO2015097600A2 (en) 2013-12-24 2015-07-02 Sentiss Pharma Private Limited Topical brimonidine tartrate ophthalmic solution
JP6339364B2 (en) * 2013-12-27 2018-06-06 カズマパートナーズ株式会社 Amorphous brimonidine tartrate and method for producing the same
JP6270603B2 (en) * 2014-04-14 2018-01-31 カズマパートナーズ株式会社 Novel polymorph of brimonidine tartrate and process for producing the same
EP4142689A1 (en) 2020-04-29 2023-03-08 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of brinzolamide and brimonidine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795970A (en) * 1972-02-29 1973-08-27 Pfizer NEW DERIVATIVES OF QUINOLEINE, QUINOXALINE AND QUINAZOLINE ER PHARMACEUTICAL COMPOSITION CONTAINING THEM

Also Published As

Publication number Publication date
LU73327A1 (en) 1977-05-11
BE833135A (en) 1976-03-05
AU8430575A (en) 1977-03-03
DK398775A (en) 1976-03-07
NL7510473A (en) 1976-03-09
DE2538620A1 (en) 1976-03-18
FR2283899A1 (en) 1976-04-02
FI752487A (en) 1976-03-07
JPS51149291A (en) 1976-12-22
GB1463520A (en) 1977-02-02
CA1043791A (en) 1978-12-05
ES440760A1 (en) 1977-04-01

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