GB1463520A - Process for the production of imidazolines - Google Patents

Process for the production of imidazolines

Info

Publication number
GB1463520A
GB1463520A GB3914374A GB3914374A GB1463520A GB 1463520 A GB1463520 A GB 1463520A GB 3914374 A GB3914374 A GB 3914374A GB 3914374 A GB3914374 A GB 3914374A GB 1463520 A GB1463520 A GB 1463520A
Authority
GB
United Kingdom
Prior art keywords
formula
positions
compound
quinoxaline
aminoethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3914374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB3914374A priority Critical patent/GB1463520A/en
Priority to SE7509271A priority patent/SE7509271L/en
Priority to AU84305/75A priority patent/AU489162B2/en
Priority to CA234,270A priority patent/CA1043791A/en
Priority to DE19752538620 priority patent/DE2538620A1/en
Priority to JP50105862A priority patent/JPS51149291A/en
Priority to FI752487A priority patent/FI752487A/fi
Priority to LU73327A priority patent/LU73327A1/xx
Priority to FR7527324A priority patent/FR2283899A1/en
Priority to DK398775A priority patent/DK398775A/en
Priority to NL7510473A priority patent/NL7510473A/en
Priority to BE159796A priority patent/BE833135A/en
Priority to ES440760A priority patent/ES440760A1/en
Publication of GB1463520A publication Critical patent/GB1463520A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1463520 Imidazoline compounds PFIZER Ltd 5 Sept 1975 [6 Sept 1974] 39143/74 Heading C2C The invention comprises a process for preparing compounds of the formula where Q represents a group of the formula in which the free valence may be in any one of the 5-, 6-, 7- or 8-positions in the quinoxaline or quinazoline nucleus; (R<SP>1</SP>) x represents up to 3 optional substituents in any of the remaining 5-, 6-, 7- or 8-positions, each R<SP>1</SP> being a halogen atom or a C 1 -C 6 alkyl, C 1 -C 6 alkoxy or trifluoromethyl group and x being 0 to 3; and R<SP>2</SP> represents an optional substituent in either of the 2- or 3-, or 2- or 4-positions of the quinoxaline or quinazoline nucleus, respectively, R<SP>2</SP> being a hydrogen atom or a C 1 -C 6 alkyl or C 1 -C 6 alkoxy group; which comprises heating a thioureido compound of the formula wherein Q is as defined above, to produce the corresponding isothiocyanate of the formula reacting the isothiocyanate with ethylene diamine to form a #-aminoethyl thioureido compound of the formula cyclizing the #-aminoethyl-thioureido compound to form the compound of the Formula (I), recovering the latter as the product, and, optionally, converting the product into a pharmaceutically acceptable acid addition salt.
GB3914374A 1974-09-06 1974-09-06 Process for the production of imidazolines Expired GB1463520A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB3914374A GB1463520A (en) 1974-09-06 1974-09-06 Process for the production of imidazolines
SE7509271A SE7509271L (en) 1974-09-06 1975-08-25 WAY TO PRODUCE CHINOXALINE AND CHINAZOLINE DERIVATIVES
AU84305/75A AU489162B2 (en) 1974-09-06 1975-08-27 Process for preparing imidazolinylamnquinoxalines
CA234,270A CA1043791A (en) 1974-09-06 1975-08-27 Process for preparing imidazolinylaminoquinoxalines
DE19752538620 DE2538620A1 (en) 1974-09-06 1975-08-29 PROCESS FOR THE PRODUCTION OF QUINOXALINE AND QUINAZOLINE DERIVATIVES
JP50105862A JPS51149291A (en) 1974-09-06 1975-09-01 Preparation method of imidazolinylaminoquinoxaline and quinazolines
FI752487A FI752487A (en) 1974-09-06 1975-09-04
LU73327A LU73327A1 (en) 1974-09-06 1975-09-04
FR7527324A FR2283899A1 (en) 1974-09-06 1975-09-05 PROCESS FOR PREPARING QUINAZOLINE DERIVATIVES
DK398775A DK398775A (en) 1974-09-06 1975-09-05 PROCEDURE FOR THE PREPARATION OF QUINOXALIN AND QUINAZOLIN DERIVATIVES
NL7510473A NL7510473A (en) 1974-09-06 1975-09-05 PROCESS FOR THE PREPARATION OF QUINOXALINE DERIVATIVES.
BE159796A BE833135A (en) 1974-09-06 1975-09-05 PROCESS FOR PREPARING QUINOXALINE DERIVATIVES, AND QUINAZOLINE
ES440760A ES440760A1 (en) 1974-09-06 1975-09-05 Process for the production of imidazolines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3914374A GB1463520A (en) 1974-09-06 1974-09-06 Process for the production of imidazolines

Publications (1)

Publication Number Publication Date
GB1463520A true GB1463520A (en) 1977-02-02

Family

ID=10407882

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3914374A Expired GB1463520A (en) 1974-09-06 1974-09-06 Process for the production of imidazolines

Country Status (12)

Country Link
JP (1) JPS51149291A (en)
BE (1) BE833135A (en)
CA (1) CA1043791A (en)
DE (1) DE2538620A1 (en)
DK (1) DK398775A (en)
ES (1) ES440760A1 (en)
FI (1) FI752487A (en)
FR (1) FR2283899A1 (en)
GB (1) GB1463520A (en)
LU (1) LU73327A1 (en)
NL (1) NL7510473A (en)
SE (1) SE7509271L (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552403A (en) * 1993-10-13 1996-09-03 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US6323204B1 (en) 1993-10-13 2001-11-27 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US7265117B2 (en) 2004-05-06 2007-09-04 Alcon, Inc. Topical brimonidine tartrate formulations that lack chlorine dioxide

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077292A (en) * 1989-10-12 1991-12-31 Allergan, Inc. (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
US5198442A (en) * 1989-10-12 1993-03-30 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5204347A (en) * 1989-10-12 1993-04-20 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines
US5112822A (en) * 1989-10-12 1992-05-12 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5326763A (en) * 1989-10-12 1994-07-05 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5021416A (en) * 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
US5237072A (en) * 1990-02-06 1993-08-17 Allergan, Inc. Method for producing amino-2-imidazoline derivatives
US5130441A (en) * 1990-02-06 1992-07-14 Allergan, Inc. Method for producing amino-2-imidazoline derivatives
US10517869B2 (en) 2013-12-24 2019-12-31 Sentiss Pharma Private Limited Topical brimonidine tartrate ophthalmic solution
JP6339364B2 (en) * 2013-12-27 2018-06-06 カズマパートナーズ株式会社 Amorphous brimonidine tartrate and method for producing the same
JP6270603B2 (en) * 2014-04-14 2018-01-31 カズマパートナーズ株式会社 Novel polymorph of brimonidine tartrate and process for producing the same
US20230218611A1 (en) 2020-04-29 2023-07-13 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of brinzolamide and brimonidine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795970A (en) * 1972-02-29 1973-08-27 Pfizer NEW DERIVATIVES OF QUINOLEINE, QUINOXALINE AND QUINAZOLINE ER PHARMACEUTICAL COMPOSITION CONTAINING THEM

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552403A (en) * 1993-10-13 1996-09-03 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5561132A (en) * 1993-10-13 1996-10-01 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5587376A (en) * 1993-10-13 1996-12-24 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5703077A (en) * 1993-10-13 1997-12-30 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5714486A (en) * 1993-10-13 1998-02-03 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5756503A (en) * 1993-10-13 1998-05-26 Allergan Methods for using (2-imidazolin-2-ylamino) Quinoxaline derivatives
US5773440A (en) * 1993-10-13 1998-06-30 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US6323204B1 (en) 1993-10-13 2001-11-27 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US7265117B2 (en) 2004-05-06 2007-09-04 Alcon, Inc. Topical brimonidine tartrate formulations that lack chlorine dioxide

Also Published As

Publication number Publication date
NL7510473A (en) 1976-03-09
JPS51149291A (en) 1976-12-22
DE2538620A1 (en) 1976-03-18
BE833135A (en) 1976-03-05
FR2283899A1 (en) 1976-04-02
SE7509271L (en) 1975-12-29
LU73327A1 (en) 1977-05-11
CA1043791A (en) 1978-12-05
DK398775A (en) 1976-03-07
AU8430575A (en) 1977-03-03
ES440760A1 (en) 1977-04-01
FI752487A (en) 1976-03-07

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee