SU1706388A3 - Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами - Google Patents

Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами Download PDF

Info

Publication number
SU1706388A3
SU1706388A3 SU884356158A SU4356158A SU1706388A3 SU 1706388 A3 SU1706388 A3 SU 1706388A3 SU 884356158 A SU884356158 A SU 884356158A SU 4356158 A SU4356158 A SU 4356158A SU 1706388 A3 SU1706388 A3 SU 1706388A3
Authority
SU
USSR - Soviet Union
Prior art keywords
alkyl
amino
spectrum
nitrooxyethyl
alkylene
Prior art date
Application number
SU884356158A
Other languages
English (en)
Russian (ru)
Inventor
Сиокава Йоуити
Такимото Коити
Такенака Кохеи
Original Assignee
Фудзисава Фармасьютикал Ко., Лтд (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фудзисава Фармасьютикал Ко., Лтд (Фирма) filed Critical Фудзисава Фармасьютикал Ко., Лтд (Фирма)
Application granted granted Critical
Publication of SU1706388A3 publication Critical patent/SU1706388A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SU884356158A 1987-07-20 1988-07-19 Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами SU1706388A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878717068A GB8717068D0 (en) 1987-07-20 1987-07-20 Nitric ester derivative

Publications (1)

Publication Number Publication Date
SU1706388A3 true SU1706388A3 (ru) 1992-01-15

Family

ID=10620954

Family Applications (2)

Application Number Title Priority Date Filing Date
SU884356158A SU1706388A3 (ru) 1987-07-20 1988-07-19 Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами
SU894614353A SU1760984A3 (ru) 1987-07-20 1989-06-19 Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU894614353A SU1760984A3 (ru) 1987-07-20 1989-06-19 Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами

Country Status (19)

Country Link
US (2) US4923886A (enExample)
EP (1) EP0300400B1 (enExample)
JP (1) JPH0228167A (enExample)
KR (1) KR890002067A (enExample)
CN (1) CN1021046C (enExample)
AT (1) ATE102928T1 (enExample)
AU (1) AU623858B2 (enExample)
DE (1) DE3888415T2 (enExample)
DK (1) DK375988A (enExample)
FI (1) FI883402A7 (enExample)
GB (1) GB8717068D0 (enExample)
HU (1) HU203227B (enExample)
IL (1) IL86959A (enExample)
MX (1) MX12317A (enExample)
NO (1) NO172049C (enExample)
PH (1) PH24481A (enExample)
PT (1) PT88019B (enExample)
SU (2) SU1706388A3 (enExample)
ZA (1) ZA884987B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3941438A1 (de) * 1989-12-15 1991-06-20 Hoechst Ag Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
US5298516A (en) * 1991-03-27 1994-03-29 Sankyo Company, Limited Thiazolidone compounds and method of using the same as a vasodilator
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
MX9704435A (es) * 1994-12-15 1997-10-31 Sankyio Company Ltd Compuestos de tiazolidinona y agente terapeutico o agente de prevencion para angina de pecho, que comprende los compuestos como un ingrediente activo.
NZ302391A (en) * 1995-03-02 1999-04-29 Sankyo Co Optically active thiazolidinone derivatives having vessel dilating and an anti-angina pectoris action and use thereof as pharmaceuticals
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
EP2308833A3 (en) 1999-04-15 2011-09-28 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
WO2003045385A1 (en) * 2001-11-27 2003-06-05 F. Hoffmann-La Roche Ag Benzothiazole derivatives
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US7273866B2 (en) * 2002-12-20 2007-09-25 Bristol-Myers Squibb Company 2-aryl thiazole derivatives as KCNQ modulators
US6933308B2 (en) * 2002-12-20 2005-08-23 Bristol-Myers Squibb Company Aminoalkyl thiazole derivatives as KCNQ modulators
US7968575B2 (en) * 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
WO2005105765A1 (en) * 2004-05-05 2005-11-10 Renopharm Ltd. Nitric oxide donors and uses thereof
US8134010B2 (en) * 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
DE102009037555A1 (de) * 2009-08-13 2011-03-03 Synovo Gmbh Ein neuartiges, schonendes Verfahren zur direkten Nitrierung von Hydroxyl-, Thiol- und Aminogruppen in organischen Molekülen mittels in situ generiertem Kohlensäuredinitrat
KR101045041B1 (ko) * 2009-10-27 2011-06-28 (주)에스엠이엔지 봉합침 제조방법
JP6158194B2 (ja) * 2011-10-24 2017-07-05 ニコックス サイエンス アイルランド キノン系一酸化窒素供与化合物
HK1214136A1 (zh) * 2012-08-23 2016-07-22 Cardiolynx Ag 硝酸氨基烷基酯的延长释放组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Европейский патент N° 0127150, кл. С 07 D 211/90, опублик. . Патент US V 000179, кл. 260- 4б7, опублик. 1976. Патент QUA W , кл. 260- 467, опублик. 1977. Патент US V , кл. 424- 266, опублик. 1980. *

Also Published As

Publication number Publication date
PT88019B (pt) 1995-03-01
NO172049C (no) 1993-06-02
AU623858B2 (en) 1992-05-28
SU1760984A3 (ru) 1992-09-07
NO883208L (no) 1989-01-23
DK375988A (da) 1989-01-21
US4923886A (en) 1990-05-08
IL86959A (en) 1992-12-01
AU1919988A (en) 1989-01-27
HUT47551A (en) 1989-03-28
CN1031226A (zh) 1989-02-22
DK375988D0 (da) 1988-07-06
ZA884987B (en) 1989-05-30
PH24481A (en) 1990-07-18
JPH0331709B2 (enExample) 1991-05-08
JPH0228167A (ja) 1990-01-30
NO883208D0 (no) 1988-07-19
IL86959A0 (en) 1988-12-30
US5010093A (en) 1991-04-23
FI883402L (fi) 1989-01-21
ATE102928T1 (de) 1994-04-15
NO172049B (no) 1993-02-22
CN1021046C (zh) 1993-06-02
EP0300400A1 (en) 1989-01-25
FI883402A0 (fi) 1988-07-18
FI883402A7 (fi) 1989-01-21
DE3888415T2 (de) 1994-07-14
PT88019A (pt) 1989-06-30
HU203227B (en) 1991-06-28
MX12317A (es) 1993-09-01
EP0300400B1 (en) 1994-03-16
GB8717068D0 (en) 1987-08-26
KR890002067A (ko) 1989-04-07
DE3888415D1 (de) 1994-04-21

Similar Documents

Publication Publication Date Title
SU1706388A3 (ru) Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами
SU1184443A3 (ru) Способ получени производных тиазола (его варианты)
US5773475A (en) Anticonvulsant enantiomeric amino acid derivatives
US20090143446A1 (en) Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof
PT2280696E (pt) Moduladores do recetor da prostaciclina (pgi2) úteis para o tratamento de distúrbios com ele relacionados
WO2000000463A1 (en) Anticonvulsant enantiomeric amino acid derivatives
FR2681067A1 (fr) Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
JPS6212754A (ja) Ｐａｆ合成阻害剤として有用なリン脂質類似体
EP0194464A1 (en) Amino acid derivatives and use thereof for the preparation of an anticonvulsant
KR20220006539A (ko) 티아졸린 항통각과민제의 제조 방법 및 다형체
US20060014740A1 (en) Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof
JP3642797B2 (ja) フェニルカルボキサミドイソオキサゾールの新誘導体及びそれらの塩類、それらの製造法及びこの製造法の新規な中間体、それらの薬剤としての用途並びにそれらを含有する製薬組成物
JPS63310872A (ja) ドーパミン−β−ヒドロキシラーゼ抑制剤
CA2034673A1 (en) 1-phenylalkyl-3-phenylurea derivative
SU1549480A3 (ru) Способ получени производных иминотиазолидина или их гидрохлоридов
EP0000452B1 (fr) Dérivés d'oxadiazole-1,2,4, leur préparation et leur application en thérapeutique.
SU784763A3 (ru) Способ получени производных 6- метокси-2-ацетилнафтилоксима или их хлоргидратов
EP0197386B1 (en) 2-(substituted sulfamyl) derivatives of 6-nitrobenzoic acid, process for their preparation and pharmaceutical compositions containing them
US4654369A (en) Esters of 2-(substituted sulfamyl)-6-nitro-benzoic acid and pharmaceutical compositions
US4647588A (en) 2-(substituted sulfamyl)-6-nitrobenzoic acid amides and pharmaceutical compositions
WO2005086638A2 (en) Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof
EP0280627B1 (fr) Nouveaux dérivés N-substitués de l'alpha-mercaptométhyl benzène propanamide, leur procédé de préparation, leur application à titre de médicaments et les compositions les renfermant
CA1193606A (en) Substituted phenylpyrazole derivatives, process for their preparation, medicaments based therein, and their use
FR2478629A1 (fr) Derives d'acides 2-cyano-ethyl-2-(n-benzoylamino) alcanoiques, leur procede de preparation et leur application en therapeutique
JPH07509703A (ja) ３‐および５‐置換１，２，３，４‐オキサトリアゾール‐５‐イミン化合物，その製造方法，前記化合物を含む医薬組成物，および薬物製造用の前記化合物の使用