ZA884987B - Nitric ester derivative - Google Patents

Nitric ester derivative

Info

Publication number
ZA884987B
ZA884987B ZA884987A ZA884987A ZA884987B ZA 884987 B ZA884987 B ZA 884987B ZA 884987 A ZA884987 A ZA 884987A ZA 884987 A ZA884987 A ZA 884987A ZA 884987 B ZA884987 B ZA 884987B
Authority
ZA
South Africa
Prior art keywords
alkyl
alkylene
suitable substituent
substituted
hydrogen
Prior art date
Application number
ZA884987A
Other languages
English (en)
Inventor
Youichi Shiokawa
Shiokawa Youichi
Koichi Takimoto
Takimoto Koichi
Kohei Takenaka
Takenaka Kohei
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of ZA884987B publication Critical patent/ZA884987B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26Radicals substituted by sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA884987A 1987-07-20 1988-07-11 Nitric ester derivative ZA884987B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878717068A GB8717068D0 (en) 1987-07-20 1987-07-20 Nitric ester derivative

Publications (1)

Publication Number Publication Date
ZA884987B true ZA884987B (en) 1989-05-30

Family

ID=10620954

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA884987A ZA884987B (en) 1987-07-20 1988-07-11 Nitric ester derivative

Country Status (19)

Country Link
US (2) US4923886A (xx)
EP (1) EP0300400B1 (xx)
JP (1) JPH0228167A (xx)
KR (1) KR890002067A (xx)
CN (1) CN1021046C (xx)
AT (1) ATE102928T1 (xx)
AU (1) AU623858B2 (xx)
DE (1) DE3888415T2 (xx)
DK (1) DK375988A (xx)
FI (1) FI883402A (xx)
GB (1) GB8717068D0 (xx)
HU (1) HU203227B (xx)
IL (1) IL86959A (xx)
MX (1) MX12317A (xx)
NO (1) NO172049C (xx)
PH (1) PH24481A (xx)
PT (1) PT88019B (xx)
SU (2) SU1706388A3 (xx)
ZA (1) ZA884987B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3941438A1 (de) * 1989-12-15 1991-06-20 Hoechst Ag Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
US5298516A (en) * 1991-03-27 1994-03-29 Sankyo Company, Limited Thiazolidone compounds and method of using the same as a vasodilator
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
CN1092649C (zh) * 1994-12-15 2002-10-16 三共株式会社 噻唑烷酮化合物或以其作为有效成分的心绞痛治疗剂或预防剂
CA2214386C (en) * 1995-03-02 2001-12-04 Sadao Ishihara Optically active thiazolidinone derivatives
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
WO2000062778A1 (en) 1999-04-15 2000-10-26 Bristol-Myers Squibb Co. Cyclic protein tyrosine kinase inhibitors
US6933308B2 (en) * 2002-12-20 2005-08-23 Bristol-Myers Squibb Company Aminoalkyl thiazole derivatives as KCNQ modulators
US7273866B2 (en) * 2002-12-20 2007-09-25 Bristol-Myers Squibb Company 2-aryl thiazole derivatives as KCNQ modulators
US8134010B2 (en) * 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
US7968575B2 (en) * 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
WO2005105765A1 (en) * 2004-05-05 2005-11-10 Renopharm Ltd. Nitric oxide donors and uses thereof
DE102009037555A1 (de) * 2009-08-13 2011-03-03 Synovo Gmbh Ein neuartiges, schonendes Verfahren zur direkten Nitrierung von Hydroxyl-, Thiol- und Aminogruppen in organischen Molekülen mittels in situ generiertem Kohlensäuredinitrat
KR101045041B1 (ko) * 2009-10-27 2011-06-28 (주)에스엠이엔지 봉합침 제조방법
WO2013060673A1 (en) * 2011-10-24 2013-05-02 Nicox S.A. Quinone based nitric oxide donating compounds
RU2015105097A (ru) * 2012-08-23 2016-10-10 Кардиолинкс Аг Композиции аминоалкилнитрата с пролонгированным высвобождением

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate

Also Published As

Publication number Publication date
JPH0228167A (ja) 1990-01-30
FI883402A0 (fi) 1988-07-18
CN1021046C (zh) 1993-06-02
HUT47551A (en) 1989-03-28
GB8717068D0 (en) 1987-08-26
PT88019A (pt) 1989-06-30
DE3888415D1 (de) 1994-04-21
AU1919988A (en) 1989-01-27
EP0300400A1 (en) 1989-01-25
MX12317A (es) 1993-09-01
NO172049B (no) 1993-02-22
PT88019B (pt) 1995-03-01
KR890002067A (ko) 1989-04-07
HU203227B (en) 1991-06-28
US4923886A (en) 1990-05-08
IL86959A0 (en) 1988-12-30
DK375988D0 (da) 1988-07-06
DE3888415T2 (de) 1994-07-14
JPH0331709B2 (xx) 1991-05-08
US5010093A (en) 1991-04-23
CN1031226A (zh) 1989-02-22
EP0300400B1 (en) 1994-03-16
PH24481A (en) 1990-07-18
ATE102928T1 (de) 1994-04-15
DK375988A (da) 1989-01-21
AU623858B2 (en) 1992-05-28
NO883208L (no) 1989-01-23
FI883402A (fi) 1989-01-21
SU1760984A3 (ru) 1992-09-07
IL86959A (en) 1992-12-01
SU1706388A3 (ru) 1992-01-15
NO883208D0 (no) 1988-07-19
NO172049C (no) 1993-06-02

Similar Documents

Publication Publication Date Title
GB8717068D0 (en) Nitric ester derivative
CA2126327A1 (en) Amidino derivatives and their use as nitric oxide synthase inhibitors
EP0193904A3 (en) Amino acid derivatives and processes for preparation thereof
ZA89389B (en) Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
HUT70052A (en) Process for producing pharmaceutical compositions containing pirimidone derivatives in the treatment of certain airway or skin diseases
EP0263506A3 (en) Anticonvulsant composition containing amino acid derivative and use of said amino acid derivative
DE3164314D1 (en) Azolylalkyl derivatives, process for their preparation and their use as fungicides
ES8701143A1 (es) Un procedimiento para la preparacion de nuevos aminas terciarias.
ZA885358B (en) Uricosuric composition
ES2061579T3 (es) Compuestos cefem y procedimientos para su preparacion.
EP0322248A3 (en) Compounds effective against cerebral insufficiency