RU2015105097A - Композиции аминоалкилнитрата с пролонгированным высвобождением - Google Patents

Композиции аминоалкилнитрата с пролонгированным высвобождением Download PDF

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RU2015105097A
RU2015105097A RU2015105097A RU2015105097A RU2015105097A RU 2015105097 A RU2015105097 A RU 2015105097A RU 2015105097 A RU2015105097 A RU 2015105097A RU 2015105097 A RU2015105097 A RU 2015105097A RU 2015105097 A RU2015105097 A RU 2015105097A
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sustained release
nitrate
release composition
composition
amino
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RU2015105097A
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Дирк САРТОР
Пьер ВАНКАН
Хуберт ШТЮКЛЕР
Армин ШЕРХАГ
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Кардиолинкс Аг
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Abstract

1. Композиция с пролонгированным высвобождением амино-С-С-алкил нитрата и его фармацевтически приемлемых солей, где высвобождение происходит в течение 4-24 часов.2. Композиция с пролонгированным высвобождением по п. 1, в которой амино-С-С-алкилнитрат выбран из 4-аминобутилнитрата, 3-аминопропилнитрата, 2-амино-1-метилэтилнитрата и 2-аминоэтилнитрата.3. Композиция с пролонгированным высвобождением по п. 1, в которой амино-С-С-алкилнитрат представляет собой 2-аминоэтилнитрат.4. Композиция с пролонгированным высвобождением по п. 3, где фармацевтически приемлемая соль 2-аминоэтилнитрата представляет собой тозилат.5. Композиция с пролонгированным высвобождением по любому из пп. 1-4, дополнительно содержащая другое фармацевтически активное соединение в виде комбинации с фиксированной дозой.6. Композиция с пролонгированным высвобождением по п. 5, в которой указанное другое фармацевтически активное соединение выбрано из группы блокаторов рецепторов ангиотензина, ингибиторов ангиотензинового фермента, антагонистов ренина, бета-блокаторов, блокаторов кальциевых каналов, антагонистов эндотелина, статинов, бигуанидов, глитазонов, сульфонилмочевин, антагонистов натрий-зависимого переносчика глюкозы (SGLT2), ингибиторов дипептидилпептидазы-4 (ДПП-4), антитромботических агентов, антитромбоцитарных агентов, антикоагулянтов, антиангинальных лекарственных средств, сосудорасширяющих средств и антагонистов альдостерона.7. Композиция с пролонгированным высвобождением по п. 5, в которой указанное другое фармацевтически активное соединение выбрано из валсартана, азилсартана, мазисентана, цилостазола, пиоглитазона, ситаглиптина и линаглиптина.8. Композиция с

Claims (16)

1. Композиция с пролонгированным высвобождением амино-С2-С6-алкил нитрата и его фармацевтически приемлемых солей, где высвобождение происходит в течение 4-24 часов.
2. Композиция с пролонгированным высвобождением по п. 1, в которой амино-С2-С6-алкилнитрат выбран из 4-аминобутилнитрата, 3-аминопропилнитрата, 2-амино-1-метилэтилнитрата и 2-аминоэтилнитрата.
3. Композиция с пролонгированным высвобождением по п. 1, в которой амино-С2-С6-алкилнитрат представляет собой 2-аминоэтилнитрат.
4. Композиция с пролонгированным высвобождением по п. 3, где фармацевтически приемлемая соль 2-аминоэтилнитрата представляет собой тозилат.
5. Композиция с пролонгированным высвобождением по любому из пп. 1-4, дополнительно содержащая другое фармацевтически активное соединение в виде комбинации с фиксированной дозой.
6. Композиция с пролонгированным высвобождением по п. 5, в которой указанное другое фармацевтически активное соединение выбрано из группы блокаторов рецепторов ангиотензина, ингибиторов ангиотензинового фермента, антагонистов ренина, бета-блокаторов, блокаторов кальциевых каналов, антагонистов эндотелина, статинов, бигуанидов, глитазонов, сульфонилмочевин, антагонистов натрий-зависимого переносчика глюкозы (SGLT2), ингибиторов дипептидилпептидазы-4 (ДПП-4), антитромботических агентов, антитромбоцитарных агентов, антикоагулянтов, антиангинальных лекарственных средств, сосудорасширяющих средств и антагонистов альдостерона.
7. Композиция с пролонгированным высвобождением по п. 5, в которой указанное другое фармацевтически активное соединение выбрано из валсартана, азилсартана, мазисентана, цилостазола, пиоглитазона, ситаглиптина и линаглиптина.
8. Композиция с пролонгированным высвобождением по любому из пп. 1-4 в виде пероральной лекарственной формы, в которой активный ингредиент или ингредиенты встроены в неионную полимерную матрицу и возможно содержат покрытие.
9. Композиция с пролонгированным высвобождением по п. 8 в форме множества частиц.
10. Композиция с пролонгированным высвобождением по п. 8 в форме множества частиц, помещенных в твердые капсулы.
11. Композиция с пролонгированным высвобождением по п. 8 в форме множества частиц, спрессованных в таблетку.
12. Композиция с пролонгированным высвобождением по п. 8 в форме осмотической системы доставки лекарственного средства.
13. Композиция с пролонгированным высвобождением по п. 5 в виде трансдермального пластыря.
14. Композиция с пролонгированным высвобождением по п. 13 в форме пластыря с лекарственным средством в адгезиве.
15. Композиция с пролонгированным высвобождением по п. 13 в форме резервуарного пластыря.
16. Способ лечения артериальной гипертензии, болезни Рейно, болезни Меньера или аргининянтарной ацидурии (АЯА), включающий введение терапевтически эффективного количества композиции 2-аминоэтилнитрата с пролонгированным высвобождением.
RU2015105097A 2012-08-23 2013-08-22 Композиции аминоалкилнитрата с пролонгированным высвобождением RU2015105097A (ru)

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WO2016135263A1 (en) 2015-02-27 2016-09-01 Armin Scherhag No donors for the treatment of stress-induced pulmonary haemorrhage in animals
KR20180092981A (ko) 2015-12-28 2018-08-20 욱크하르트 리미티드 빌다글립틴의 경구 삼투압성 약제학적 조성물
CN107303390A (zh) * 2017-01-22 2017-10-31 复旦大学附属华山医院 Dpp4抑制剂在制备治疗低氧性肺动脉高压药物中的用途

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CN104869985A (zh) 2015-08-26
PH12015500374A1 (en) 2015-04-20
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AU2013304942A1 (en) 2015-03-05
HK1214136A1 (zh) 2016-07-22
IL237317A0 (en) 2015-04-30
CA2881726A1 (en) 2014-02-27
KR20150043501A (ko) 2015-04-22
WO2014029841A1 (en) 2014-02-27
US20180008558A1 (en) 2018-01-11
JP2015526456A (ja) 2015-09-10
MX2015001990A (es) 2015-07-14
EP2887927A1 (en) 2015-07-01
US20150216992A1 (en) 2015-08-06
ZA201501072B (en) 2016-01-27
BR112015003733A2 (pt) 2017-07-04
EP2887927B1 (en) 2018-03-28

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