GB8717068D0 - Nitric ester derivative - Google Patents

Nitric ester derivative

Info

Publication number
GB8717068D0
GB8717068D0 GB878717068A GB8717068A GB8717068D0 GB 8717068 D0 GB8717068 D0 GB 8717068D0 GB 878717068 A GB878717068 A GB 878717068A GB 8717068 A GB8717068 A GB 8717068A GB 8717068 D0 GB8717068 D0 GB 8717068D0
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkylene
suitable substituent
substituted
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB878717068A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to GB878717068A priority Critical patent/GB8717068D0/en
Publication of GB8717068D0 publication Critical patent/GB8717068D0/en
Priority to US07/213,623 priority patent/US4923886A/en
Priority to PH37159A priority patent/PH24481A/en
Priority to IL86959A priority patent/IL86959A/xx
Priority to DK375988A priority patent/DK375988A/da
Priority to ZA884987A priority patent/ZA884987B/xx
Priority to JP63177362A priority patent/JPH0228167A/ja
Priority to PT88019A priority patent/PT88019B/pt
Priority to AT88111490T priority patent/ATE102928T1/de
Priority to EP88111490A priority patent/EP0300400B1/en
Priority to DE3888415T priority patent/DE3888415T2/de
Priority to MX1231788A priority patent/MX12317A/es
Priority to FI883402A priority patent/FI883402A7/fi
Priority to NO883208A priority patent/NO172049C/no
Priority to SU884356158A priority patent/SU1706388A3/ru
Priority to HU883775A priority patent/HU203227B/hu
Priority to KR1019880008995A priority patent/KR890002067A/ko
Priority to CN88104473A priority patent/CN1021046C/zh
Priority to AU19199/88A priority patent/AU623858B2/en
Priority to SU894614353A priority patent/SU1760984A3/ru
Priority to US07/494,545 priority patent/US5010093A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GB878717068A 1987-07-20 1987-07-20 Nitric ester derivative Pending GB8717068D0 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
GB878717068A GB8717068D0 (en) 1987-07-20 1987-07-20 Nitric ester derivative
US07/213,623 US4923886A (en) 1987-07-20 1988-06-30 Nitric ester derivative
PH37159A PH24481A (en) 1987-07-20 1988-07-01 Nitric ester derivatives,pharmaceutical composition containing said compounds and method of use thereof
IL86959A IL86959A (en) 1987-07-20 1988-07-03 Thiazole and oxazole derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same
DK375988A DK375988A (da) 1987-07-20 1988-07-06 Salpetersyreesterderivat
ZA884987A ZA884987B (en) 1987-07-20 1988-07-11 Nitric ester derivative
PT88019A PT88019B (pt) 1987-07-20 1988-07-15 Processo para a preparacao de um derivado de ester do acido nitrico
JP63177362A JPH0228167A (ja) 1987-07-20 1988-07-15 硝酸エステル誘導体
AT88111490T ATE102928T1 (de) 1987-07-20 1988-07-16 Salpetersaeureester-derivate.
EP88111490A EP0300400B1 (en) 1987-07-20 1988-07-16 Nitric acid ester derivative
DE3888415T DE3888415T2 (de) 1987-07-20 1988-07-16 Salpetersäureester-Derivate.
MX1231788A MX12317A (es) 1987-07-20 1988-07-18 Derivados de ester nitrico y procedimiento para suobtencion.
FI883402A FI883402A7 (fi) 1987-07-20 1988-07-18 Esterinitraattijohdos
NO883208A NO172049C (no) 1987-07-20 1988-07-19 Analogifremgangsmaate for fremstilling av terapeutisk aktive salpetersyreesterderivater
SU884356158A SU1706388A3 (ru) 1987-07-20 1988-07-19 Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами
HU883775A HU203227B (en) 1987-07-20 1988-07-19 Process for producing nitrate derivatives of oxazole and thiazole compounds and pharmaceutical compositions comprising same
KR1019880008995A KR890002067A (ko) 1987-07-20 1988-07-19 질산 에스테르 유도체
CN88104473A CN1021046C (zh) 1987-07-20 1988-07-19 硝酸酯衍生物的制备方法
AU19199/88A AU623858B2 (en) 1987-07-20 1988-07-20 Nitric ester derivative
SU894614353A SU1760984A3 (ru) 1987-07-20 1989-06-19 Способ получени тиазолилкарбамоилзамещенных эфирных производных азотной кислоты или их аддитивных солей с галоидводородными кислотами
US07/494,545 US5010093A (en) 1987-07-20 1990-03-16 Nitric ester derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878717068A GB8717068D0 (en) 1987-07-20 1987-07-20 Nitric ester derivative

Publications (1)

Publication Number Publication Date
GB8717068D0 true GB8717068D0 (en) 1987-08-26

Family

ID=10620954

Family Applications (1)

Application Number Title Priority Date Filing Date
GB878717068A Pending GB8717068D0 (en) 1987-07-20 1987-07-20 Nitric ester derivative

Country Status (19)

Country Link
US (2) US4923886A (enExample)
EP (1) EP0300400B1 (enExample)
JP (1) JPH0228167A (enExample)
KR (1) KR890002067A (enExample)
CN (1) CN1021046C (enExample)
AT (1) ATE102928T1 (enExample)
AU (1) AU623858B2 (enExample)
DE (1) DE3888415T2 (enExample)
DK (1) DK375988A (enExample)
FI (1) FI883402A7 (enExample)
GB (1) GB8717068D0 (enExample)
HU (1) HU203227B (enExample)
IL (1) IL86959A (enExample)
MX (1) MX12317A (enExample)
NO (1) NO172049C (enExample)
PH (1) PH24481A (enExample)
PT (1) PT88019B (enExample)
SU (2) SU1706388A3 (enExample)
ZA (1) ZA884987B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3941438A1 (de) * 1989-12-15 1991-06-20 Hoechst Ag Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
US5298516A (en) * 1991-03-27 1994-03-29 Sankyo Company, Limited Thiazolidone compounds and method of using the same as a vasodilator
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
MX9704435A (es) * 1994-12-15 1997-10-31 Sankyio Company Ltd Compuestos de tiazolidinona y agente terapeutico o agente de prevencion para angina de pecho, que comprende los compuestos como un ingrediente activo.
NZ302391A (en) * 1995-03-02 1999-04-29 Sankyo Co Optically active thiazolidinone derivatives having vessel dilating and an anti-angina pectoris action and use thereof as pharmaceuticals
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
EP2308833A3 (en) 1999-04-15 2011-09-28 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
WO2003045385A1 (en) * 2001-11-27 2003-06-05 F. Hoffmann-La Roche Ag Benzothiazole derivatives
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US7273866B2 (en) * 2002-12-20 2007-09-25 Bristol-Myers Squibb Company 2-aryl thiazole derivatives as KCNQ modulators
US6933308B2 (en) * 2002-12-20 2005-08-23 Bristol-Myers Squibb Company Aminoalkyl thiazole derivatives as KCNQ modulators
US7968575B2 (en) * 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
WO2005105765A1 (en) * 2004-05-05 2005-11-10 Renopharm Ltd. Nitric oxide donors and uses thereof
US8134010B2 (en) * 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
DE102009037555A1 (de) * 2009-08-13 2011-03-03 Synovo Gmbh Ein neuartiges, schonendes Verfahren zur direkten Nitrierung von Hydroxyl-, Thiol- und Aminogruppen in organischen Molekülen mittels in situ generiertem Kohlensäuredinitrat
KR101045041B1 (ko) * 2009-10-27 2011-06-28 (주)에스엠이엔지 봉합침 제조방법
JP6158194B2 (ja) * 2011-10-24 2017-07-05 ニコックス サイエンス アイルランド キノン系一酸化窒素供与化合物
HK1214136A1 (zh) * 2012-08-23 2016-07-22 Cardiolynx Ag 硝酸氨基烷基酯的延长释放组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate

Also Published As

Publication number Publication date
PT88019B (pt) 1995-03-01
NO172049C (no) 1993-06-02
AU623858B2 (en) 1992-05-28
SU1760984A3 (ru) 1992-09-07
NO883208L (no) 1989-01-23
DK375988A (da) 1989-01-21
US4923886A (en) 1990-05-08
IL86959A (en) 1992-12-01
AU1919988A (en) 1989-01-27
HUT47551A (en) 1989-03-28
CN1031226A (zh) 1989-02-22
DK375988D0 (da) 1988-07-06
ZA884987B (en) 1989-05-30
PH24481A (en) 1990-07-18
JPH0331709B2 (enExample) 1991-05-08
JPH0228167A (ja) 1990-01-30
NO883208D0 (no) 1988-07-19
IL86959A0 (en) 1988-12-30
US5010093A (en) 1991-04-23
FI883402L (fi) 1989-01-21
ATE102928T1 (de) 1994-04-15
NO172049B (no) 1993-02-22
CN1021046C (zh) 1993-06-02
EP0300400A1 (en) 1989-01-25
FI883402A0 (fi) 1988-07-18
FI883402A7 (fi) 1989-01-21
DE3888415T2 (de) 1994-07-14
PT88019A (pt) 1989-06-30
SU1706388A3 (ru) 1992-01-15
HU203227B (en) 1991-06-28
MX12317A (es) 1993-09-01
EP0300400B1 (en) 1994-03-16
KR890002067A (ko) 1989-04-07
DE3888415D1 (de) 1994-04-21

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