JPH0228167A - 硝酸エステル誘導体 - Google Patents

硝酸エステル誘導体

Info

Publication number
JPH0228167A
JPH0228167A JP63177362A JP17736288A JPH0228167A JP H0228167 A JPH0228167 A JP H0228167A JP 63177362 A JP63177362 A JP 63177362A JP 17736288 A JP17736288 A JP 17736288A JP H0228167 A JPH0228167 A JP H0228167A
Authority
JP
Japan
Prior art keywords
group
formula
alkyl
hydrogen
nitrooxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63177362A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0331709B2 (enExample
Inventor
Yoichi Shiokawa
塩川　洋一
Koichi Takimoto
浩一 瀧本
Kohei Takenaka
竹中　康平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPH0228167A publication Critical patent/JPH0228167A/ja
Publication of JPH0331709B2 publication Critical patent/JPH0331709B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP63177362A 1987-07-20 1988-07-15 硝酸エステル誘導体 Granted JPH0228167A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8717068 1987-07-20
GB878717068A GB8717068D0 (en) 1987-07-20 1987-07-20 Nitric ester derivative

Publications (2)

Publication Number Publication Date
JPH0228167A true JPH0228167A (ja) 1990-01-30
JPH0331709B2 JPH0331709B2 (enExample) 1991-05-08

Family

ID=10620954

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63177362A Granted JPH0228167A (ja) 1987-07-20 1988-07-15 硝酸エステル誘導体

Country Status (19)

Country Link
US (2) US4923886A (enExample)
EP (1) EP0300400B1 (enExample)
JP (1) JPH0228167A (enExample)
KR (1) KR890002067A (enExample)
CN (1) CN1021046C (enExample)
AT (1) ATE102928T1 (enExample)
AU (1) AU623858B2 (enExample)
DE (1) DE3888415T2 (enExample)
DK (1) DK375988A (enExample)
FI (1) FI883402A7 (enExample)
GB (1) GB8717068D0 (enExample)
HU (1) HU203227B (enExample)
IL (1) IL86959A (enExample)
MX (1) MX12317A (enExample)
NO (1) NO172049C (enExample)
PH (1) PH24481A (enExample)
PT (1) PT88019B (enExample)
SU (2) SU1706388A3 (enExample)
ZA (1) ZA884987B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026931A1 (en) * 1995-03-02 1996-09-06 Sankyo Company, Limited Optically active thiazolidinone derivatives
US5891898A (en) * 1995-03-02 1999-04-06 Sankyo Company, Limited Method for treating or preventing ulcerative diseases by administering thia- or oxazolidinone compounds
JP2001520670A (ja) * 1997-03-26 2001-10-30 イッサム・リサーチ・アンド・ディベロープメント・カンパニー・リミテッド・オブ・ザ・ヘブルー・ユニヴァーシティ・オブ・エルサレム 芳香族及び複素環の硝酸誘導体

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3941438A1 (de) * 1989-12-15 1991-06-20 Hoechst Ag Neue 2-substituierte 4-(3-alkyl-5-tert.-butyl-4-hydroxy-phenyl)-thiazole, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
AU647599B2 (en) * 1991-03-27 1994-03-24 Sankyo Company Limited New thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
WO1996018620A1 (en) * 1994-12-15 1996-06-20 Sankyo Company, Limited Thiazolidinone compounds or angina pectoris remedy or preventive containing the same as active ingredient
CN101481359A (zh) * 1999-04-15 2009-07-15 布里斯托尔-迈尔斯斯奎布公司 环状蛋白酪氨酸激酶抑制剂
EP1450796B1 (en) * 2001-11-27 2008-04-09 F. Hoffmann-La Roche Ag Benzothiazole derivatives
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US6933308B2 (en) * 2002-12-20 2005-08-23 Bristol-Myers Squibb Company Aminoalkyl thiazole derivatives as KCNQ modulators
US7273866B2 (en) * 2002-12-20 2007-09-25 Bristol-Myers Squibb Company 2-aryl thiazole derivatives as KCNQ modulators
EP1753734A1 (en) * 2004-05-05 2007-02-21 Renopharm Ltd. Nitric oxide donors and uses thereof
US8134010B2 (en) * 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
US7968575B2 (en) * 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
DE102009037555A1 (de) * 2009-08-13 2011-03-03 Synovo Gmbh Ein neuartiges, schonendes Verfahren zur direkten Nitrierung von Hydroxyl-, Thiol- und Aminogruppen in organischen Molekülen mittels in situ generiertem Kohlensäuredinitrat
KR101045041B1 (ko) * 2009-10-27 2011-06-28 (주)에스엠이엔지 봉합침 제조방법
CA2839390C (en) * 2011-10-24 2015-09-15 Nicox S.A. Quinone based nitric oxide donating compounds
WO2014029841A1 (en) * 2012-08-23 2014-02-27 Cardiolynx Ag Extended release compositions of an aminoalkyl nitrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3433383A1 (de) * 1984-09-12 1986-03-20 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phenyl-acetonitril-derivate

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026931A1 (en) * 1995-03-02 1996-09-06 Sankyo Company, Limited Optically active thiazolidinone derivatives
US5891898A (en) * 1995-03-02 1999-04-06 Sankyo Company, Limited Method for treating or preventing ulcerative diseases by administering thia- or oxazolidinone compounds
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
CN1066725C (zh) * 1995-03-02 2001-06-06 三共株式会社 旋光性噻唑烷酮衍生物
JP2001520670A (ja) * 1997-03-26 2001-10-30 イッサム・リサーチ・アンド・ディベロープメント・カンパニー・リミテッド・オブ・ザ・ヘブルー・ユニヴァーシティ・オブ・エルサレム 芳香族及び複素環の硝酸誘導体

Also Published As

Publication number Publication date
DK375988A (da) 1989-01-21
ZA884987B (en) 1989-05-30
AU1919988A (en) 1989-01-27
GB8717068D0 (en) 1987-08-26
HU203227B (en) 1991-06-28
NO883208D0 (no) 1988-07-19
HUT47551A (en) 1989-03-28
PT88019B (pt) 1995-03-01
NO172049C (no) 1993-06-02
EP0300400B1 (en) 1994-03-16
US4923886A (en) 1990-05-08
DE3888415T2 (de) 1994-07-14
FI883402L (fi) 1989-01-21
MX12317A (es) 1993-09-01
SU1760984A3 (ru) 1992-09-07
JPH0331709B2 (enExample) 1991-05-08
PH24481A (en) 1990-07-18
DK375988D0 (da) 1988-07-06
CN1031226A (zh) 1989-02-22
PT88019A (pt) 1989-06-30
FI883402A0 (fi) 1988-07-18
IL86959A (en) 1992-12-01
AU623858B2 (en) 1992-05-28
IL86959A0 (en) 1988-12-30
SU1706388A3 (ru) 1992-01-15
FI883402A7 (fi) 1989-01-21
NO172049B (no) 1993-02-22
EP0300400A1 (en) 1989-01-25
NO883208L (no) 1989-01-23
KR890002067A (ko) 1989-04-07
CN1021046C (zh) 1993-06-02
US5010093A (en) 1991-04-23
DE3888415D1 (de) 1994-04-21
ATE102928T1 (de) 1994-04-15

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