JP2001520670A - 芳香族及び複素環の硝酸誘導体 - Google Patents
芳香族及び複素環の硝酸誘導体Info
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- JP2001520670A JP2001520670A JP54537598A JP54537598A JP2001520670A JP 2001520670 A JP2001520670 A JP 2001520670A JP 54537598 A JP54537598 A JP 54537598A JP 54537598 A JP54537598 A JP 54537598A JP 2001520670 A JP2001520670 A JP 2001520670A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
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- C—CHEMISTRY; METALLURGY
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- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.少なくとも1個の一酸化窒素供与基と、少なくとも1個の遊離スルフヒドリ ル基、または生体内で遊離スルフヒドリル基に転化し得る基とを含む有機化合物 である、一酸化窒素供与体。 2.少なくとも1個のスルフヒドリル基を、還元された−SH体または酸化され た−S−Sジスルフィド体のいずれかとして含む、請求項1の化合物。 3.1個以上の−ONO2基で置換され、または、末端−ONO2基を有する1個 以上の置換基を有し、そして、2個の連結した−S−原子を含有する5−または 6−員環を含む化合物;または、その−S−S基が非環状の構造であり、かつ、 環構造に1個の窒素を含有する芳香族核または複素環核の少なくとも1個と結合 し、その環には末端−ONO2基を有する置換基が付いている化合物;または、 1個の−S−原子と1個の窒素とを含有し、末端−ONO2基を有する少なくと も一個の置換基で置換されている5−員の複素環である化合物を含めた、請求項 1または2に記載の化合物。 4.以下の化合物: から選ばれる、請求項1に記載の化合物。 5.以下の化合物: から選ばれる、請求項1に記載の化合物。 6.少なくとも1個の一酸化窒素供与基と、少なくとも1個の遊離スルフヒドリ ル基、または生体内で遊離スルフヒドリル基に転化し得る基とを含む有機化合物 を活性成分として含み、一酸化窒素供与体が必要とされる疾患の治療に用いられ る医薬組成物。 7.その活性成分が、少なくとも1個のスルフヒドリル基を、還元された−SH 体または酸化された−S−Sジスルフィド体のいずれかとして含む化合物である 、請求項6の組成物。 8.その活性成分が、1個以上の−ONO2基で置換され、または、末端−ON O2基を有する置換基の1個以上を有し、そして、2個の連結した−S−原子を 含有する5−または6−員環を含む化合物;または、その−S−S−基が非環状 の構造であり、環構造に1個の窒素を含有する芳香族核または複素環核の少なく とも1個と結合し、その環には末端−ONO2基を有する置換基が付いている化 合物;または、1個の−S−原子と1個の窒素とを含有し、末端−ONO2基を 有する少なくとも一個の置換基で置換されている5−員の複素環である化合物を 含む、請求項6または7に記載の組成物。 9.その活性成分が、以下の化合物: から選ばれる、請求項6に記載の医薬組成物。 10.その活性成分が、以下の化合物: から選ばれる、請求項6に記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL120531A IL120531A (en) | 1997-03-26 | 1997-03-26 | Nitric oxide donors and pharmaceutical compositions containing them |
IL120531 | 1997-03-26 | ||
PCT/IL1998/000144 WO1998042661A1 (en) | 1997-03-26 | 1998-03-26 | Aromatic and heterocyclic nitrato derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001520670A true JP2001520670A (ja) | 2001-10-30 |
JP4637304B2 JP4637304B2 (ja) | 2011-02-23 |
Family
ID=11069962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54537598A Expired - Fee Related JP4637304B2 (ja) | 1997-03-26 | 1998-03-26 | 芳香族及び複素環の硝酸誘導体 |
Country Status (9)
Country | Link |
---|---|
US (3) | US6369071B1 (ja) |
EP (1) | EP0984928B1 (ja) |
JP (1) | JP4637304B2 (ja) |
AT (1) | ATE393140T1 (ja) |
AU (1) | AU742534B2 (ja) |
CA (1) | CA2284620A1 (ja) |
DE (1) | DE69839394T2 (ja) |
IL (1) | IL120531A (ja) |
WO (1) | WO1998042661A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2005533013A (ja) * | 2002-04-19 | 2005-11-04 | イスム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティ オブ エルサレム | 一酸化窒素供与基および反応性酸素種捕捉基を含有するβ作用薬化合物、ならびに呼吸障害の治療における該化合物の使用 |
JP2007507451A (ja) * | 2003-10-03 | 2007-03-29 | レイサー ソシエダッド アノニマ | 環状糖の二硫化物、硫化物、スルホキシド及びスルホン誘導体とその使用方法 |
JP2008510795A (ja) * | 2004-08-26 | 2008-04-10 | アッパラオ・サティアム | 新規バイオ開裂性リンカー |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005533013A (ja) * | 2002-04-19 | 2005-11-04 | イスム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティ オブ エルサレム | 一酸化窒素供与基および反応性酸素種捕捉基を含有するβ作用薬化合物、ならびに呼吸障害の治療における該化合物の使用 |
JP2007507451A (ja) * | 2003-10-03 | 2007-03-29 | レイサー ソシエダッド アノニマ | 環状糖の二硫化物、硫化物、スルホキシド及びスルホン誘導体とその使用方法 |
JP2011012081A (ja) * | 2003-10-03 | 2011-01-20 | Lacer Sa | 環状糖の二硫化物、硫化物、スルホキシド及びスルホン誘導体とその使用 |
JP4809769B2 (ja) * | 2003-10-03 | 2011-11-09 | レイサー ソシエダッド アノニマ | 環状糖の二硫化物、硫化物、スルホキシド及びスルホン誘導体とその使用方法 |
JP2008510795A (ja) * | 2004-08-26 | 2008-04-10 | アッパラオ・サティアム | 新規バイオ開裂性リンカー |
Also Published As
Publication number | Publication date |
---|---|
IL120531A0 (en) | 1997-07-13 |
US6642260B2 (en) | 2003-11-04 |
AU6516098A (en) | 1998-10-20 |
EP0984928B1 (en) | 2008-04-23 |
DE69839394D1 (de) | 2008-06-05 |
JP4637304B2 (ja) | 2011-02-23 |
IL120531A (en) | 2006-12-31 |
EP0984928A4 (en) | 2004-08-18 |
US6369071B1 (en) | 2002-04-09 |
EP0984928A1 (en) | 2000-03-15 |
US20020143187A1 (en) | 2002-10-03 |
DE69839394T2 (de) | 2009-05-07 |
WO1998042661A1 (en) | 1998-10-01 |
AU742534B2 (en) | 2002-01-03 |
CA2284620A1 (en) | 1998-10-01 |
US20040147598A1 (en) | 2004-07-29 |
ATE393140T1 (de) | 2008-05-15 |
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