SU1195901A3 - Способ получени смесей производных глицерина - Google Patents
Способ получени смесей производных глицерина Download PDFInfo
- Publication number
- SU1195901A3 SU1195901A3 SU802891303A SU2891303A SU1195901A3 SU 1195901 A3 SU1195901 A3 SU 1195901A3 SU 802891303 A SU802891303 A SU 802891303A SU 2891303 A SU2891303 A SU 2891303A SU 1195901 A3 SU1195901 A3 SU 1195901A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- sodium
- hours
- ratio
- compounds
- mixture
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims abstract description 9
- 150000002314 glycerols Chemical class 0.000 title description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 10
- 239000011734 sodium Substances 0.000 claims abstract description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical class OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 8
- -1 di-n-propyl acetyl Chemical group 0.000 claims abstract description 8
- 229940090181 propyl acetate Drugs 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 3
- 150000002148 esters Chemical class 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 description 15
- 206010010904 Convulsion Diseases 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000001773 anti-convulsant effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229940051269 1,3-dichloro-2-propanol Drugs 0.000 description 2
- DEWLEGDTCGBNGU-UHFFFAOYSA-N 1,3-dichloropropan-2-ol Chemical compound ClCC(O)CCl DEWLEGDTCGBNGU-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N 2-propanol Substances CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 241000237519 Bivalvia Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- YKYONYBAUNKHLG-UHFFFAOYSA-N n-Propyl acetate Natural products CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- ONQDRCKUHDTWRA-UHFFFAOYSA-N propane-1,2,3-triol;2-propylpentanoic acid Chemical compound OCC(O)CO.CCCC(C(O)=O)CCC ONQDRCKUHDTWRA-UHFFFAOYSA-N 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7907932 | 1979-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1195901A3 true SU1195901A3 (ru) | 1985-11-30 |
Family
ID=10503667
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU802891303A SU1195901A3 (ru) | 1979-03-06 | 1980-03-05 | Способ получени смесей производных глицерина |
| SU813276796A SU1052507A1 (ru) | 1979-03-06 | 1981-05-04 | Смесь 1,3- и 1,2-бис-/ди-н-пропилацетат/глицерина,обладающа противосудорожной активностью |
| SU833568904A SU1225481A3 (ru) | 1979-03-06 | 1983-03-29 | Способ получени смеси глицерил-1,2-и 1,3-бис/ди-н-пропилацетатов/,про вл ющей свойства депрессанта центральной нервной системы |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU813276796A SU1052507A1 (ru) | 1979-03-06 | 1981-05-04 | Смесь 1,3- и 1,2-бис-/ди-н-пропилацетат/глицерина,обладающа противосудорожной активностью |
| SU833568904A SU1225481A3 (ru) | 1979-03-06 | 1983-03-29 | Способ получени смеси глицерил-1,2-и 1,3-бис/ди-н-пропилацетатов/,про вл ющей свойства депрессанта центральной нервной системы |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4423071A (enExample) |
| EP (1) | EP0018342B1 (enExample) |
| JP (1) | JPS55141436A (enExample) |
| AR (1) | AR224394A1 (enExample) |
| AU (1) | AU534007B2 (enExample) |
| CA (1) | CA1162928A (enExample) |
| CS (1) | CS216526B2 (enExample) |
| CY (1) | CY1209A (enExample) |
| DD (2) | DD158773A5 (enExample) |
| DE (1) | DE3061960D1 (enExample) |
| DK (1) | DK93880A (enExample) |
| ES (1) | ES8103015A1 (enExample) |
| FI (1) | FI69449C (enExample) |
| GR (1) | GR70703B (enExample) |
| HK (1) | HK22384A (enExample) |
| HU (2) | HU188840B (enExample) |
| IE (1) | IE49539B1 (enExample) |
| IL (1) | IL59407A (enExample) |
| IN (1) | IN152492B (enExample) |
| MY (1) | MY8500075A (enExample) |
| NO (1) | NO152899C (enExample) |
| NZ (1) | NZ192944A (enExample) |
| OA (1) | OA06568A (enExample) |
| PL (1) | PL124023B1 (enExample) |
| PT (1) | PT70904A (enExample) |
| SG (1) | SG61583G (enExample) |
| SU (3) | SU1195901A3 (enExample) |
| YU (2) | YU41699B (enExample) |
| ZA (1) | ZA801081B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3437110A (en) * | 1965-08-16 | 1969-04-08 | Citation Mfg Co Inc | Fluid pressure relief valve |
| IL59407A (en) * | 1979-03-06 | 1983-12-30 | Sanofi Sa | Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them |
| US4654370A (en) * | 1979-03-12 | 1987-03-31 | Abbott Laboratories | Glyceryl valproates |
| US5185159A (en) * | 1983-07-20 | 1993-02-09 | Sanofi | Pharmaceutical composition based on valproic acid and a process for preparing it |
| IL72381A (en) * | 1983-07-20 | 1988-03-31 | Sanofi Sa | Pharmaceutical composition based on valproic acid |
| US4590282A (en) * | 1984-09-24 | 1986-05-20 | Sandoz Ltd. | Pest control agents |
| IE58569B1 (en) * | 1984-12-12 | 1993-10-06 | Syntex Inc | Alkoxy methyl ether and alkoxy methyl ester derivatives |
| DK157308C (da) * | 1985-02-27 | 1990-05-07 | Novo Nordisk As | Fremgangsmaade til fremstilling af acetal- eller ketalestere af polyoler eller monoestere af mono- eller disaccharider eller monoglycerider |
| US4591601A (en) * | 1985-04-12 | 1986-05-27 | Mcneilab, Inc. | Anticonvulsant dioxolane methane sulfamates |
| IT1190133B (it) * | 1986-06-19 | 1988-02-10 | Chiesi Farma Spa | Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| FR2627487B1 (fr) * | 1988-02-19 | 1991-03-29 | Martin Laboratoires | Nouveau derive de l'acide valproique, procede de preparation de ce compose ainsi que medicament antiepileptique le contenant |
| US5011977A (en) * | 1988-04-08 | 1991-04-30 | Eastman Kodak Company | Transesterification of alkoxyesters |
| JPH01299222A (ja) * | 1988-05-26 | 1989-12-04 | Otsuka Pharmaceut Factory Inc | 抗腫瘍剤 |
| FR2641986B1 (fr) * | 1989-01-26 | 1991-05-03 | Oreal | Procede de preparation de tensio-actifs non ioniques a partir de l'isopropylidene-1,2 epoxypropyl-3 glycerol et d'un acide carboxylique, nouveaux tensio-actifs non ioniques et leur utilisation |
| JPH02139136U (enExample) * | 1989-04-24 | 1990-11-20 | ||
| CA2060685A1 (en) * | 1991-03-04 | 1992-09-05 | Mahmood Sabahi | Ether-ester lubricant |
| CN1126987A (zh) * | 1994-04-19 | 1996-07-17 | 钟渊化学工业株式会社 | 三唑衍生物的制造方法 |
| DK0823897T3 (da) * | 1995-05-01 | 2004-12-06 | Scarista Ltd | Nicotinsyreestere og farmaceutiske præparater indeholdende disse |
| USRE40546E1 (en) * | 1996-05-01 | 2008-10-21 | Scarista, Ltd. | 1,3-Propane diol esters and ethers and methods for their use in drug delivery |
| MY118354A (en) * | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| DE19534519A1 (de) * | 1995-09-05 | 1997-07-10 | Desitin Arzneimittel Gmbh | Zucker oder Zuckeralkohole zur Verwendung als Antiepileptikum |
| US5763488A (en) * | 1995-10-30 | 1998-06-09 | Vertex Pharmaceuticals Incorporated | Methods and compositions using butyrate esters of threitol |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
| CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| JP4526741B2 (ja) * | 2001-07-18 | 2010-08-18 | 花王株式会社 | エーテルカルボキシレートモノグリセリド |
| FR2828487B1 (fr) * | 2001-08-09 | 2005-05-27 | Genfit S A | Nouveaux composes derives d'acides gras, preparation et utilisations |
| US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| FR2850650B1 (fr) * | 2003-01-31 | 2005-03-25 | Genfit S A | Utilisation therapeutique d'acylglycerols et de leurs analogues azotes et sulfures |
| EP1625336B9 (en) | 2003-05-21 | 2012-03-21 | Alexza Pharmaceuticals, Inc. | Use of a layer of solid fuel, method for producing such a layer and associated heating unit |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| AU2004322756B2 (en) | 2004-08-12 | 2011-04-14 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| SE532942C2 (sv) * | 2008-10-27 | 2010-05-18 | Perstorp Specialty Chem Ab | Smörjmedelsbasmassa med låg droppunkt |
| EP2354130A1 (en) * | 2010-02-02 | 2011-08-10 | Momentive Specialty Chemicals Research Belgium | Manufacture of an epoxyethyl carboxylate or glycidyl carboxylate |
| US9493661B2 (en) | 2011-11-17 | 2016-11-15 | Basf Coatings Gmbh | Glycerol diesters, method for producing same, and use of same in coatings materials |
| US9744542B2 (en) | 2013-07-29 | 2017-08-29 | Apeel Technology, Inc. | Agricultural skin grafting |
| WO2016187581A1 (en) | 2015-05-20 | 2016-11-24 | Apeel Technology, Inc. | Plant extract compositions and methods of preparation thereof |
| EP3349589B1 (en) | 2015-09-16 | 2022-12-14 | Apeel Technology, Inc. | Method for forming a protective coating by applying fatty acid glyceride compounds to a surface |
| ES2939007T3 (es) | 2015-12-10 | 2023-04-18 | Apeel Tech Inc | Composiciones de extractos de plantas para formar recubrimientos protectores |
| WO2017132281A1 (en) | 2016-01-26 | 2017-08-03 | Apeel Technology, Inc. | Method for preparing and preserving sanitized products |
| KR102638807B1 (ko) * | 2016-06-07 | 2024-02-21 | 더 제이. 데이비드 글래드스톤 인스티튜트, 어 테스터멘터리 트러스트 이스타빌리쉬드 언더 더 윌 오브 제이. 데이비드 글래드스톤 | 베타-히드록시부티레이트 및 부탄디올의 중쇄 지방산 에스테르 및 이것을 사용하는 조성물 및 이것을 사용하는 방법 |
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| EP3746138B1 (en) | 2018-02-02 | 2025-12-10 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
| US12245605B2 (en) | 2018-09-05 | 2025-03-11 | Apeel Technology, Inc. | Compounds and formulations for protective coatings |
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| US2362326A (en) * | 1940-11-06 | 1944-11-07 | American Cyanamid Co | Aromatic-glyceryl esters of alphahydroxyisobutyric acids |
| US2474796A (en) * | 1946-01-31 | 1949-06-28 | Wm S Merrell Co | Alkylaminoalkyl esters of alicyclyl-alicyclic carboxylic acids |
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| DE1289620B (de) * | 1961-02-14 | 1969-02-20 | Kolmar Laboratories | Kosmetische, pharmazeutische oder schuetzende Mittel zur Aufbringung auf die Haut, sowie Salbengrundlagen |
| US3282971A (en) * | 1963-06-19 | 1966-11-01 | Exxon Research Engineering Co | Fatty acid esters of polyhydric alcohols |
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1980
- 1980-02-18 IL IL59407A patent/IL59407A/xx unknown
- 1980-02-22 NZ NZ192944A patent/NZ192944A/en unknown
- 1980-02-25 GR GR61280A patent/GR70703B/el unknown
- 1980-02-26 AU AU55872/80A patent/AU534007B2/en not_active Ceased
- 1980-02-26 ZA ZA00801081A patent/ZA801081B/xx unknown
- 1980-03-03 US US06/126,191 patent/US4423071A/en not_active Expired - Lifetime
- 1980-03-04 DE DE8080870016T patent/DE3061960D1/de not_active Expired
- 1980-03-04 CY CY1209A patent/CY1209A/xx unknown
- 1980-03-04 EP EP80870016A patent/EP0018342B1/fr not_active Expired
- 1980-03-04 PL PL1980222446A patent/PL124023B1/pl unknown
- 1980-03-05 DK DK93880A patent/DK93880A/da not_active Application Discontinuation
- 1980-03-05 CS CS801530A patent/CS216526B2/cs unknown
- 1980-03-05 IE IE445/80A patent/IE49539B1/en unknown
- 1980-03-05 FI FI800683A patent/FI69449C/fi not_active IP Right Cessation
- 1980-03-05 OA OA57041A patent/OA06568A/xx unknown
- 1980-03-05 NO NO800626A patent/NO152899C/no unknown
- 1980-03-05 YU YU615/80A patent/YU41699B/xx unknown
- 1980-03-05 PT PT70904A patent/PT70904A/pt unknown
- 1980-03-05 CA CA000347041A patent/CA1162928A/en not_active Expired
- 1980-03-05 SU SU802891303A patent/SU1195901A3/ru active
- 1980-03-06 AR AR280197A patent/AR224394A1/es active
- 1980-03-06 HU HU83462A patent/HU188840B/hu not_active IP Right Cessation
- 1980-03-06 JP JP2901980A patent/JPS55141436A/ja active Granted
- 1980-03-06 HU HU80521A patent/HU183072B/hu not_active IP Right Cessation
- 1980-03-06 ES ES489250A patent/ES8103015A1/es not_active Expired
- 1980-03-06 IN IN261/CAL/80A patent/IN152492B/en unknown
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1981
- 1981-05-04 SU SU813276796A patent/SU1052507A1/ru active
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1982
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1983
- 1983-03-29 SU SU833568904A patent/SU1225481A3/ru active
- 1983-09-28 SG SG615/83A patent/SG61583G/en unknown
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1984
- 1984-03-15 HK HK223/84A patent/HK22384A/xx unknown
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1985
- 1985-12-30 MY MY75/85A patent/MY8500075A/xx unknown
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