SU1028237A3 - Способ получени гепарина - Google Patents
Способ получени гепарина Download PDFInfo
- Publication number
- SU1028237A3 SU1028237A3 SU772531003A SU2531003A SU1028237A3 SU 1028237 A3 SU1028237 A3 SU 1028237A3 SU 772531003 A SU772531003 A SU 772531003A SU 2531003 A SU2531003 A SU 2531003A SU 1028237 A3 SU1028237 A3 SU 1028237A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- solution
- sodium chloride
- heparin
- activity
- water
- Prior art date
Links
- 229920000669 heparin Polymers 0.000 title claims abstract description 21
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 229960002897 heparin Drugs 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 45
- 239000011780 sodium chloride Substances 0.000 claims abstract description 25
- 241001465754 Metazoa Species 0.000 claims abstract description 11
- 235000002639 sodium chloride Nutrition 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 6
- 210000000936 intestine Anatomy 0.000 claims description 5
- 210000003097 mucus Anatomy 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 17
- 239000012267 brine Substances 0.000 abstract description 11
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 abstract description 11
- 230000000968 intestinal effect Effects 0.000 abstract description 2
- 238000007796 conventional method Methods 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 45
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 238000001035 drying Methods 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000003456 ion exchange resin Substances 0.000 description 3
- 229920003303 ion-exchange polymer Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000003957 anion exchange resin Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 239000010802 sludge Substances 0.000 description 2
- AWFYPPSBLUWMFQ-UHFFFAOYSA-N 2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]-1-(1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CC2=C(CC1)NN=C2 AWFYPPSBLUWMFQ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 229940127090 anticoagulant agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2652272A DE2652272C2 (de) | 1976-11-12 | 1976-11-12 | Verfahren zur Herstellung von Heparin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1028237A3 true SU1028237A3 (ru) | 1983-07-07 |
Family
ID=5993323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772531003A SU1028237A3 (ru) | 1976-11-12 | 1977-10-19 | Способ получени гепарина |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4283530A (OSRAM) |
| JP (1) | JPS5844082B2 (OSRAM) |
| AR (1) | AR214759A1 (OSRAM) |
| AT (1) | AT354633B (OSRAM) |
| AU (1) | AU515671B2 (OSRAM) |
| BE (1) | BE860729A (OSRAM) |
| BG (1) | BG28425A3 (OSRAM) |
| BR (1) | BR7707493A (OSRAM) |
| CA (1) | CA1088522A (OSRAM) |
| CS (1) | CS208735B2 (OSRAM) |
| DD (1) | DD134352A5 (OSRAM) |
| DE (1) | DE2652272C2 (OSRAM) |
| DK (1) | DK142059C (OSRAM) |
| FI (1) | FI62104C (OSRAM) |
| FR (1) | FR2370757A1 (OSRAM) |
| GB (1) | GB1592806A (OSRAM) |
| GR (1) | GR65226B (OSRAM) |
| HU (1) | HU174644B (OSRAM) |
| IE (1) | IE47041B1 (OSRAM) |
| IL (1) | IL53254A (OSRAM) |
| IS (1) | IS2410A7 (OSRAM) |
| IT (1) | IT1088965B (OSRAM) |
| LU (1) | LU78488A1 (OSRAM) |
| NL (1) | NL179481C (OSRAM) |
| PL (1) | PL108607B1 (OSRAM) |
| RO (1) | RO78597A (OSRAM) |
| SE (1) | SE432875B (OSRAM) |
| SU (1) | SU1028237A3 (OSRAM) |
| YU (1) | YU260677A (OSRAM) |
| ZA (1) | ZA776753B (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2612813C1 (ru) * | 2015-12-07 | 2017-03-13 | Павел Андреевич Канаев | Способ получения гепарина |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2800943C2 (de) * | 1978-01-06 | 1984-09-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verwendung von Darm-Salzlake zur Gewinnung von reinem Heparin |
| HU177887B (en) * | 1979-03-21 | 1982-01-28 | Richter Gedeon Vegyeszet | Process for preparing a raw material containing heparin |
| ATE15142T1 (de) * | 1981-05-21 | 1985-09-15 | Akzo Nv | Antithrombotikum auf basis von polysacchariden, verfahren zur dessen herstellung und medizinale zusammensetzungen. |
| WO2016137471A1 (en) * | 2015-02-26 | 2016-09-01 | Nantpharma, Llc | Method for enhanced heparin quality |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2623001A (en) * | 1949-04-07 | 1952-12-23 | Bengt E G V Sylven | Preparing heparin |
| GB872214A (en) * | 1957-09-23 | 1961-07-05 | Upjohn Co | Extraction process for the recovery of heparin |
| DE1156938B (de) * | 1957-09-23 | 1963-11-07 | Upjohn Company Eine Ges Nach D | Verfahren zur Gewinnung von Heparin |
| US3058884A (en) * | 1959-09-14 | 1962-10-16 | Abbott Lab | Process for purifying heparin |
| NL301375A (OSRAM) * | 1962-12-10 | |||
| US4119774A (en) * | 1976-03-05 | 1978-10-10 | Ab Kabi | Heparin purification method |
-
1976
- 1976-11-12 DE DE2652272A patent/DE2652272C2/de not_active Expired
-
1977
- 1977-10-06 IS IS2410A patent/IS2410A7/is unknown
- 1977-10-19 SU SU772531003A patent/SU1028237A3/ru active
- 1977-10-26 NL NLAANVRAGE7711746,A patent/NL179481C/xx not_active IP Right Cessation
- 1977-10-28 IL IL53254A patent/IL53254A/xx unknown
- 1977-10-31 YU YU02606/77A patent/YU260677A/xx unknown
- 1977-11-01 DK DK486177A patent/DK142059C/da not_active IP Right Cessation
- 1977-11-02 AU AU30265/77A patent/AU515671B2/en not_active Expired
- 1977-11-02 FI FI773285A patent/FI62104C/fi not_active IP Right Cessation
- 1977-11-04 IE IE2248/77A patent/IE47041B1/en unknown
- 1977-11-05 BG BG037730A patent/BG28425A3/xx unknown
- 1977-11-07 CS CS777263A patent/CS208735B2/cs unknown
- 1977-11-09 RO RO7792068A patent/RO78597A/ro unknown
- 1977-11-09 AR AR269906A patent/AR214759A1/es active
- 1977-11-09 BR BR7707493A patent/BR7707493A/pt unknown
- 1977-11-10 GR GR54768A patent/GR65226B/el unknown
- 1977-11-10 SE SE7712732A patent/SE432875B/sv unknown
- 1977-11-10 FR FR7733883A patent/FR2370757A1/fr active Granted
- 1977-11-10 BE BE182551A patent/BE860729A/xx not_active IP Right Cessation
- 1977-11-10 PL PL1977202036A patent/PL108607B1/pl unknown
- 1977-11-10 DD DD77202002A patent/DD134352A5/xx unknown
- 1977-11-10 GB GB46840/77A patent/GB1592806A/en not_active Expired
- 1977-11-10 LU LU78488A patent/LU78488A1/de unknown
- 1977-11-11 ZA ZA00776753A patent/ZA776753B/xx unknown
- 1977-11-11 HU HU77SCHE629A patent/HU174644B/hu not_active IP Right Cessation
- 1977-11-11 JP JP52135592A patent/JPS5844082B2/ja not_active Expired
- 1977-11-11 AT AT806677A patent/AT354633B/de not_active IP Right Cessation
- 1977-11-11 IT IT29581/77A patent/IT1088965B/it active
- 1977-11-14 CA CA290,824A patent/CA1088522A/en not_active Expired
-
1979
- 1979-07-02 US US06/054,071 patent/US4283530A/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 1. М сна индустри СССР, 1963, 4, с. 21-22. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2612813C1 (ru) * | 2015-12-07 | 2017-03-13 | Павел Андреевич Канаев | Способ получения гепарина |
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