FI62104C - Foerfarande foer framstaellning av rent heparin - Google Patents
Foerfarande foer framstaellning av rent heparin Download PDFInfo
- Publication number
- FI62104C FI62104C FI773285A FI773285A FI62104C FI 62104 C FI62104 C FI 62104C FI 773285 A FI773285 A FI 773285A FI 773285 A FI773285 A FI 773285A FI 62104 C FI62104 C FI 62104C
- Authority
- FI
- Finland
- Prior art keywords
- heparin
- saline
- rent
- solution
- liters
- Prior art date
Links
- 229920000669 heparin Polymers 0.000 title description 31
- 229960002897 heparin Drugs 0.000 title description 29
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title description 27
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 23
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 239000000243 solution Substances 0.000 description 12
- 239000011780 sodium chloride Substances 0.000 description 11
- 239000002244 precipitate Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 239000012267 brine Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 9
- 239000002994 raw material Substances 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000005909 Kieselgur Substances 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000003957 anion exchange resin Substances 0.000 description 2
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000009938 salting Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- IHCCLXNEEPMSIO-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 IHCCLXNEEPMSIO-UHFFFAOYSA-N 0.000 description 1
- DFGKGUXTPFWHIX-UHFFFAOYSA-N 6-[2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]acetyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)C1=CC2=C(NC(O2)=O)C=C1 DFGKGUXTPFWHIX-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 229960003872 benzethonium Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000002920 hazardous waste Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000014508 negative regulation of coagulation Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2652272 | 1976-11-12 | ||
| DE2652272A DE2652272C2 (de) | 1976-11-12 | 1976-11-12 | Verfahren zur Herstellung von Heparin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI773285A7 FI773285A7 (fi) | 1978-05-13 |
| FI62104B FI62104B (fi) | 1982-07-30 |
| FI62104C true FI62104C (fi) | 1982-11-10 |
Family
ID=5993323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI773285A FI62104C (fi) | 1976-11-12 | 1977-11-02 | Foerfarande foer framstaellning av rent heparin |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4283530A (OSRAM) |
| JP (1) | JPS5844082B2 (OSRAM) |
| AR (1) | AR214759A1 (OSRAM) |
| AT (1) | AT354633B (OSRAM) |
| AU (1) | AU515671B2 (OSRAM) |
| BE (1) | BE860729A (OSRAM) |
| BG (1) | BG28425A3 (OSRAM) |
| BR (1) | BR7707493A (OSRAM) |
| CA (1) | CA1088522A (OSRAM) |
| CS (1) | CS208735B2 (OSRAM) |
| DD (1) | DD134352A5 (OSRAM) |
| DE (1) | DE2652272C2 (OSRAM) |
| DK (1) | DK142059C (OSRAM) |
| FI (1) | FI62104C (OSRAM) |
| FR (1) | FR2370757A1 (OSRAM) |
| GB (1) | GB1592806A (OSRAM) |
| GR (1) | GR65226B (OSRAM) |
| HU (1) | HU174644B (OSRAM) |
| IE (1) | IE47041B1 (OSRAM) |
| IL (1) | IL53254A (OSRAM) |
| IS (1) | IS2410A7 (OSRAM) |
| IT (1) | IT1088965B (OSRAM) |
| LU (1) | LU78488A1 (OSRAM) |
| NL (1) | NL179481C (OSRAM) |
| PL (1) | PL108607B1 (OSRAM) |
| RO (1) | RO78597A (OSRAM) |
| SE (1) | SE432875B (OSRAM) |
| SU (1) | SU1028237A3 (OSRAM) |
| YU (1) | YU260677A (OSRAM) |
| ZA (1) | ZA776753B (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2800943C2 (de) * | 1978-01-06 | 1984-09-27 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verwendung von Darm-Salzlake zur Gewinnung von reinem Heparin |
| HU177887B (en) * | 1979-03-21 | 1982-01-28 | Richter Gedeon Vegyeszet | Process for preparing a raw material containing heparin |
| ATE15142T1 (de) * | 1981-05-21 | 1985-09-15 | Akzo Nv | Antithrombotikum auf basis von polysacchariden, verfahren zur dessen herstellung und medizinale zusammensetzungen. |
| WO2016137471A1 (en) * | 2015-02-26 | 2016-09-01 | Nantpharma, Llc | Method for enhanced heparin quality |
| RU2612813C1 (ru) * | 2015-12-07 | 2017-03-13 | Павел Андреевич Канаев | Способ получения гепарина |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2623001A (en) * | 1949-04-07 | 1952-12-23 | Bengt E G V Sylven | Preparing heparin |
| GB872214A (en) * | 1957-09-23 | 1961-07-05 | Upjohn Co | Extraction process for the recovery of heparin |
| DE1156938B (de) * | 1957-09-23 | 1963-11-07 | Upjohn Company Eine Ges Nach D | Verfahren zur Gewinnung von Heparin |
| US3058884A (en) * | 1959-09-14 | 1962-10-16 | Abbott Lab | Process for purifying heparin |
| NL301375A (OSRAM) * | 1962-12-10 | |||
| US4119774A (en) * | 1976-03-05 | 1978-10-10 | Ab Kabi | Heparin purification method |
-
1976
- 1976-11-12 DE DE2652272A patent/DE2652272C2/de not_active Expired
-
1977
- 1977-10-06 IS IS2410A patent/IS2410A7/is unknown
- 1977-10-19 SU SU772531003A patent/SU1028237A3/ru active
- 1977-10-26 NL NLAANVRAGE7711746,A patent/NL179481C/xx not_active IP Right Cessation
- 1977-10-28 IL IL53254A patent/IL53254A/xx unknown
- 1977-10-31 YU YU02606/77A patent/YU260677A/xx unknown
- 1977-11-01 DK DK486177A patent/DK142059C/da not_active IP Right Cessation
- 1977-11-02 AU AU30265/77A patent/AU515671B2/en not_active Expired
- 1977-11-02 FI FI773285A patent/FI62104C/fi not_active IP Right Cessation
- 1977-11-04 IE IE2248/77A patent/IE47041B1/en unknown
- 1977-11-05 BG BG037730A patent/BG28425A3/xx unknown
- 1977-11-07 CS CS777263A patent/CS208735B2/cs unknown
- 1977-11-09 RO RO7792068A patent/RO78597A/ro unknown
- 1977-11-09 AR AR269906A patent/AR214759A1/es active
- 1977-11-09 BR BR7707493A patent/BR7707493A/pt unknown
- 1977-11-10 GR GR54768A patent/GR65226B/el unknown
- 1977-11-10 SE SE7712732A patent/SE432875B/sv unknown
- 1977-11-10 FR FR7733883A patent/FR2370757A1/fr active Granted
- 1977-11-10 BE BE182551A patent/BE860729A/xx not_active IP Right Cessation
- 1977-11-10 PL PL1977202036A patent/PL108607B1/pl unknown
- 1977-11-10 DD DD77202002A patent/DD134352A5/xx unknown
- 1977-11-10 GB GB46840/77A patent/GB1592806A/en not_active Expired
- 1977-11-10 LU LU78488A patent/LU78488A1/de unknown
- 1977-11-11 ZA ZA00776753A patent/ZA776753B/xx unknown
- 1977-11-11 HU HU77SCHE629A patent/HU174644B/hu not_active IP Right Cessation
- 1977-11-11 JP JP52135592A patent/JPS5844082B2/ja not_active Expired
- 1977-11-11 AT AT806677A patent/AT354633B/de not_active IP Right Cessation
- 1977-11-11 IT IT29581/77A patent/IT1088965B/it active
- 1977-11-14 CA CA290,824A patent/CA1088522A/en not_active Expired
-
1979
- 1979-07-02 US US06/054,071 patent/US4283530A/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: SCHERING AKTIENGESELLSCHAFT |