SMT201900501T1 - N-((4,6-dimetil-2-osso-l,2-diidropiridin-3-il)metil)-5- (etil(tetraidro-2h-piran-4-il)ammino)-4-metil-4'- (morfolinometil)-[l,1'-bifenil]-3-carbossammide bromidrato per l'uso nel trattamento di un disturbo proliferativo cellulare del sistema ematologico - Google Patents
N-((4,6-dimetil-2-osso-l,2-diidropiridin-3-il)metil)-5- (etil(tetraidro-2h-piran-4-il)ammino)-4-metil-4'- (morfolinometil)-[l,1'-bifenil]-3-carbossammide bromidrato per l'uso nel trattamento di un disturbo proliferativo cellulare del sistema ematologicoInfo
- Publication number
- SMT201900501T1 SMT201900501T1 SM20190501T SMT201900501T SMT201900501T1 SM T201900501 T1 SMT201900501 T1 SM T201900501T1 SM 20190501 T SM20190501 T SM 20190501T SM T201900501 T SMT201900501 T SM T201900501T SM T201900501 T1 SMT201900501 T1 SM T201900501T1
- Authority
- SM
- San Marino
- Prior art keywords
- methyl
- dihydropyridin
- morpholinomethyl
- pyran
- tetrahydro
- Prior art date
Links
- 239000004305 biphenyl Substances 0.000 title 1
- 210000005096 hematological system Anatomy 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261624215P | 2012-04-13 | 2012-04-13 | |
| EP16191716.6A EP3184523B1 (en) | 2012-04-13 | 2013-04-11 | N-((4,6-dimethyl-2-oxo-l,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2h-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[l,1'-biphenyl]-3-carboxamide hydrobromide for use in the treatment of a cell proliferative disorder of the hematologic system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201900501T1 true SMT201900501T1 (it) | 2019-11-13 |
Family
ID=49328166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20190501T SMT201900501T1 (it) | 2012-04-13 | 2013-04-11 | N-((4,6-dimetil-2-osso-l,2-diidropiridin-3-il)metil)-5- (etil(tetraidro-2h-piran-4-il)ammino)-4-metil-4'- (morfolinometil)-[l,1'-bifenil]-3-carbossammide bromidrato per l'uso nel trattamento di un disturbo proliferativo cellulare del sistema ematologico |
| SM20170132T SMT201700132T1 (it) | 2012-04-13 | 2013-04-11 | Forma di sale di un inibitore di istone metiltransferasi ezh2 umana |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM20170132T SMT201700132T1 (it) | 2012-04-13 | 2013-04-11 | Forma di sale di un inibitore di istone metiltransferasi ezh2 umana |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US9394283B2 (enExample) |
| EP (4) | EP3628670B1 (enExample) |
| JP (3) | JP6255382B2 (enExample) |
| KR (4) | KR20250005505A (enExample) |
| CN (2) | CN104603130B (enExample) |
| AU (2) | AU2013245878B2 (enExample) |
| BR (1) | BR112014025508B1 (enExample) |
| CA (1) | CA2870005C (enExample) |
| CY (2) | CY1119383T1 (enExample) |
| DK (3) | DK3184523T3 (enExample) |
| ES (3) | ES2617379T3 (enExample) |
| HR (2) | HRP20170295T1 (enExample) |
| HU (3) | HUE031976T2 (enExample) |
| IL (4) | IL282732B2 (enExample) |
| IN (1) | IN2014DN09068A (enExample) |
| LT (2) | LT2836491T (enExample) |
| MX (2) | MX384641B (enExample) |
| NZ (1) | NZ700761A (enExample) |
| PL (3) | PL2836491T3 (enExample) |
| PT (3) | PT3628670T (enExample) |
| RS (2) | RS55690B1 (enExample) |
| RU (1) | RU2658911C2 (enExample) |
| SG (3) | SG10201912109QA (enExample) |
| SI (2) | SI2836491T1 (enExample) |
| SM (2) | SMT201900501T1 (enExample) |
| WO (1) | WO2013155317A1 (enExample) |
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