MX384641B - Forma de sal de un inhibidor de histona metiltransferasa humana ezh2. - Google Patents

Forma de sal de un inhibidor de histona metiltransferasa humana ezh2.

Info

Publication number
MX384641B
MX384641B MX2019000449A MX2019000449A MX384641B MX 384641 B MX384641 B MX 384641B MX 2019000449 A MX2019000449 A MX 2019000449A MX 2019000449 A MX2019000449 A MX 2019000449A MX 384641 B MX384641 B MX 384641B
Authority
MX
Mexico
Prior art keywords
inhibitor
salt form
histone methyltransferase
human histone
methyltransferase ezh2
Prior art date
Application number
MX2019000449A
Other languages
English (en)
Inventor
Arani Chanda
Frank Fang
Hyeong Wook Choi
Kevin Wayne Kuntz
Kristen Sanders
Kuan-Chun Huang
Steven Mathieu
Original Assignee
Epizyme Inc
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme Inc, Eisai R&D Man Co Ltd filed Critical Epizyme Inc
Publication of MX384641B publication Critical patent/MX384641B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se proporciona en la presente un bromhidrato de N-((4,6-dimetil-2-oxo-1,2,-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H-piran-4-il)amino)-4-metil-4'-(morfolinometil)-[1,1'-bifenil]-3-carboxamida. También se proporciona en la presente una forma polimorfa particular de este compuesto.
MX2019000449A 2012-04-13 2013-04-11 Forma de sal de un inhibidor de histona metiltransferasa humana ezh2. MX384641B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261624215P 2012-04-13 2012-04-13
PCT/US2013/036193 WO2013155317A1 (en) 2012-04-13 2013-04-11 Salt form of a human hi stone methyltransf erase ezh2 inhibitor

Publications (1)

Publication Number Publication Date
MX384641B true MX384641B (es) 2025-03-14

Family

ID=49328166

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019000449A MX384641B (es) 2012-04-13 2013-04-11 Forma de sal de un inhibidor de histona metiltransferasa humana ezh2.
MX2014012380A MX362339B (es) 2012-04-13 2013-04-11 Forma de sal de un inhibidor de histona metiltransferasa humana ezh2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014012380A MX362339B (es) 2012-04-13 2013-04-11 Forma de sal de un inhibidor de histona metiltransferasa humana ezh2.

Country Status (26)

Country Link
US (7) US9394283B2 (es)
EP (4) EP3184523B1 (es)
JP (3) JP6255382B2 (es)
KR (4) KR102120883B1 (es)
CN (2) CN104603130B (es)
AU (2) AU2013245878B2 (es)
BR (1) BR112014025508B1 (es)
CA (1) CA2870005C (es)
CY (2) CY1119383T1 (es)
DK (3) DK3184523T3 (es)
ES (3) ES2745016T3 (es)
HR (2) HRP20170295T1 (es)
HU (3) HUE031976T2 (es)
IL (4) IL296199B2 (es)
IN (1) IN2014DN09068A (es)
LT (2) LT2836491T (es)
MX (2) MX384641B (es)
NZ (1) NZ700761A (es)
PL (3) PL3184523T3 (es)
PT (3) PT3184523T (es)
RS (2) RS55690B1 (es)
RU (1) RU2658911C2 (es)
SG (3) SG10201608577RA (es)
SI (2) SI2836491T1 (es)
SM (2) SMT201900501T1 (es)
WO (1) WO2013155317A1 (es)

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