JP6255382B2 - ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態 - Google Patents

ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態 Download PDF

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Publication number
JP6255382B2
JP6255382B2 JP2015505912A JP2015505912A JP6255382B2 JP 6255382 B2 JP6255382 B2 JP 6255382B2 JP 2015505912 A JP2015505912 A JP 2015505912A JP 2015505912 A JP2015505912 A JP 2015505912A JP 6255382 B2 JP6255382 B2 JP 6255382B2
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cancer
polymorph
compound
methyl
cell
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Japanese (ja)
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JP2015512942A (ja
JP2015512942A5 (enExample
Inventor
クーンツ，ケビン・ウェイン
ホワン，クワン−チュン
チョイ，ヒョン・ウク
サンダース，クリステン
マチュー，スティーブン
チャンダ，アラニ
ファン，フランク
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
JP2015505912A 2012-04-13 2013-04-11 ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態 Active JP6255382B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261624215P 2012-04-13 2012-04-13
US61/624,215 2012-04-13
PCT/US2013/036193 WO2013155317A1 (en) 2012-04-13 2013-04-11 Salt form of a human hi stone methyltransf erase ezh2 inhibitor

Related Child Applications (1)

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JP2017198642A Division JP6634058B2 (ja) 2012-04-13 2017-10-12 ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態

Publications (3)

Publication Number Publication Date
JP2015512942A JP2015512942A (ja) 2015-04-30
JP2015512942A5 JP2015512942A5 (enExample) 2016-06-09
JP6255382B2 true JP6255382B2 (ja) 2017-12-27

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JP2015505912A Active JP6255382B2 (ja) 2012-04-13 2013-04-11 ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態
JP2017198642A Active JP6634058B2 (ja) 2012-04-13 2017-10-12 ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態
JP2018187463A Pending JP2018199740A (ja) 2012-04-13 2018-10-02 ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態

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JP2018187463A Pending JP2018199740A (ja) 2012-04-13 2018-10-02 ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態

Country Status (26)

Country Link
US (7) US9394283B2 (enExample)
EP (4) EP2836491B1 (enExample)
JP (3) JP6255382B2 (enExample)
KR (4) KR102438340B1 (enExample)
CN (2) CN104603130B (enExample)
AU (2) AU2013245878B2 (enExample)
BR (1) BR112014025508B1 (enExample)
CA (1) CA2870005C (enExample)
CY (2) CY1119383T1 (enExample)
DK (3) DK2836491T3 (enExample)
ES (3) ES2745016T3 (enExample)
HR (2) HRP20170295T1 (enExample)
HU (3) HUE060881T2 (enExample)
IL (4) IL296199B2 (enExample)
IN (1) IN2014DN09068A (enExample)
LT (2) LT2836491T (enExample)
MX (2) MX362339B (enExample)
NZ (1) NZ700761A (enExample)
PL (3) PL3628670T3 (enExample)
PT (3) PT3628670T (enExample)
RS (2) RS55690B1 (enExample)
RU (1) RU2658911C2 (enExample)
SG (3) SG11201406468YA (enExample)
SI (2) SI3184523T1 (enExample)
SM (2) SMT201700132T1 (enExample)
WO (1) WO2013155317A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018002742A (ja) * 2012-04-13 2018-01-11 エピザイム，インコーポレイティド ヒトヒストンメチルトランスフェラーゼｅｚｈ２阻害剤の塩形態

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