SMT201800604T1 - Composti per il trattamento di obesita' e metodi di uso degli stessi - Google Patents

Composti per il trattamento di obesita' e metodi di uso degli stessi

Info

Publication number
SMT201800604T1
SMT201800604T1 SM20180604T SMT201800604T SMT201800604T1 SM T201800604 T1 SMT201800604 T1 SM T201800604T1 SM 20180604 T SM20180604 T SM 20180604T SM T201800604 T SMT201800604 T SM T201800604T SM T201800604 T1 SMT201800604 T1 SM T201800604T1
Authority
SM
San Marino
Prior art keywords
obesity
compounds
treatment
methods
Prior art date
Application number
SM20180604T
Other languages
English (en)
Italian (it)
Inventor
Ralph Mazitschek
Umut Ozcan
Joseph Majzoub
Isin Cakir
Serkan Cabi
Original Assignee
Massachusetts Gen Hospital
Childrens Medical Ct Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49304418&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201800604(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Gen Hospital, Childrens Medical Ct Corp filed Critical Massachusetts Gen Hospital
Publication of SMT201800604T1 publication Critical patent/SMT201800604T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
SM20180604T 2012-09-27 2013-09-26 Composti per il trattamento di obesita' e metodi di uso degli stessi SMT201800604T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261706153P 2012-09-27 2012-09-27
PCT/US2013/061911 WO2014052583A1 (en) 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof
EP13773562.7A EP2900230B1 (en) 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof

Publications (1)

Publication Number Publication Date
SMT201800604T1 true SMT201800604T1 (it) 2019-01-11

Family

ID=49304418

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20180604T SMT201800604T1 (it) 2012-09-27 2013-09-26 Composti per il trattamento di obesita' e metodi di uso degli stessi

Country Status (21)

Country Link
US (6) US9968575B2 (enExample)
EP (3) EP3434268B1 (enExample)
JP (2) JP6480864B2 (enExample)
CN (3) CN104822374A (enExample)
AU (3) AU2013323528B2 (enExample)
BR (1) BR112015006848A2 (enExample)
CA (2) CA2886393C (enExample)
CY (1) CY1121166T1 (enExample)
DK (1) DK2900230T3 (enExample)
ES (1) ES2696626T3 (enExample)
HR (1) HRP20181879T1 (enExample)
HU (1) HUE040496T2 (enExample)
LT (1) LT2900230T (enExample)
PL (1) PL2900230T3 (enExample)
PT (1) PT2900230T (enExample)
RS (1) RS58010B1 (enExample)
RU (2) RU2650646C2 (enExample)
SI (1) SI2900230T1 (enExample)
SM (1) SMT201800604T1 (enExample)
TR (1) TR201815668T4 (enExample)
WO (1) WO2014052583A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104822374A (zh) 2012-09-27 2015-08-05 儿童医学中心公司 用于治疗肥胖症的化合物和其使用方法
AU2015235979B2 (en) * 2014-03-26 2019-05-02 The Children’s Medical Center Corporation Celastrol and derivatives for the treatment of obesity
WO2015153933A1 (en) * 2014-04-03 2015-10-08 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
CN105985401B (zh) * 2015-02-16 2020-10-09 上海华拓医药科技发展有限公司 一种雷公藤红素衍生物、其制备方法及用途
WO2017070615A1 (en) * 2015-10-23 2017-04-27 Erx Pharmaceuticals, Inc. Analogs of celastrol
CN106905404B (zh) * 2017-01-13 2019-08-27 广东工业大学 熊果酸衍生物及其制备方法和应用
CN116133656A (zh) * 2021-09-09 2023-05-16 君德(新加坡)实验室有限公司 含脂肪酶抑制剂的高吸收性水凝胶
KR102470686B1 (ko) * 2022-06-07 2022-11-23 서울대학교산학협력단 디메틸제일아스테럴을 포함하는 대사성 질환 예방 또는 치료용 약학 조성물
CN119431489A (zh) * 2024-11-13 2025-02-14 肇源县总医院 一种雷公藤红素衍生物及其制备方法

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA791659B (en) 1978-04-17 1980-04-30 Ici Ltd Process and apparatus for spraying liquid
GB8504253D0 (en) 1985-02-19 1985-03-20 Ici Plc Electrostatic spraying apparatus
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
MY107937A (en) 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
US5827734A (en) 1995-01-20 1998-10-27 University Of Washington Materials and methods for determining ob protein in a biological sample
US5552524A (en) 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
US5521283A (en) 1995-01-31 1996-05-28 Eli Lilly And Company Anti-obesity proteins
US5552522A (en) 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
US5532336A (en) 1995-01-31 1996-07-02 Eli Lilly And Company Anti-obesity proteins
US5552523A (en) 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
AU6028396A (en) 1995-06-07 1996-12-30 Amgen, Inc. Ob protein compositions and method
CZ416797A3 (cs) 1995-06-30 1998-06-17 Eli Lilly And Company Použití leptinu nebo leptonových mimetik pro výrobu léčiv pro léčení nebo prevenci diabetes mellitus a kompozice s jeho obsahem
MX9801159A (es) 1995-08-17 1998-05-31 Amgen Inc Metodos de reduccion o para mantener los niveles reducidos de lipidos en la sangre usando composiciones de proteina ob.
US5650167A (en) * 1995-11-16 1997-07-22 Dawa Incorporated Method and composition for treating hepatitis B
CA2236163A1 (en) 1995-11-22 1997-05-29 Amgen Inc. Methods of increasing lean tissue mass using ob protein compositions
US6936439B2 (en) 1995-11-22 2005-08-30 Amgen Inc. OB fusion protein compositions and methods
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
WO1997038014A1 (en) 1996-04-04 1997-10-16 Amgen Inc. Fibulin pharmaceutical compositions and related methods
EP1001768A1 (en) 1996-08-30 2000-05-24 Amgen Inc. Methods of increasing sensitivity of an individual to ob protein by upregulating ob protein receptor
HUP9904023A3 (en) 1996-09-20 2002-01-28 Hoechst Ag Use of leptin antagonists for treating insulin resistance in type ii diabetes
DK0839525T3 (da) 1996-10-31 2004-11-29 Takeda Pharmaceutical Præparat med forlænget frigivelse
US5880116A (en) * 1996-12-13 1999-03-09 Neurocal International Use of celastrol to treat alzheimer's disease
DK0954588T3 (da) 1996-12-20 2007-05-14 Amgen Inc OB fusionsprotein-sammensætninger og fremgangsmåder
HU226175B1 (en) 1997-04-17 2008-06-30 Amgen Inc Human ob protein suspension, process for producing thereof and use for production of pharmaceutical composition
KR20010013414A (ko) 1997-06-06 2001-02-26 피터 기딩스 당뇨병의 치료를 위한 렙틴 길항제의 용도
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6541033B1 (en) 1998-06-30 2003-04-01 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of leptin
EP1107793B1 (en) 1998-08-10 2004-10-27 Amgen Inc. Dextran-leptin conjugates, pharmaceutical compositions and related methods
WO2000020872A1 (en) 1998-10-02 2000-04-13 Amgen Inc. Method to determine a predisposition to leptin treatment
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
WO2000047741A1 (en) 1999-02-12 2000-08-17 Amgen Inc. Glycosylated leptin compositions and related methods
EP1444516B1 (en) 2001-10-22 2010-07-21 Amgen, Inc. Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
US8486457B2 (en) * 2002-10-21 2013-07-16 Metaproteomics, Llc. Compositions that treat or inhibit pathological conditions associated with inflammatory response
WO2004039832A2 (en) 2002-10-31 2004-05-13 Albany Medical College Leptin-related peptides
RU2346688C2 (ru) * 2002-12-06 2009-02-20 Фиброген, Инк. Регулирование содержания жира
EP1715539B1 (en) 2004-01-16 2012-11-07 Mitsubishi Materials Corporation Separator for fuel cell, method of producing separator, and solid oxide fuel cell
US20060253100A1 (en) * 2004-10-22 2006-11-09 Medtronic, Inc. Systems and Methods to Treat Pain Locally
AU2006300637C1 (en) 2005-09-30 2010-07-01 Morinaga Milk Industry Co., Ltd. Agent for improving insulin resistance
CA2628193C (en) 2005-11-01 2012-08-14 The Regents Of The University Of Michigan Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties
US20090131384A1 (en) 2006-03-22 2009-05-21 Syndexa Pharmaceuticals Corporation Compounds and methods for treatment of disorders associated with er stress
US20110263693A1 (en) * 2006-03-31 2011-10-27 Dana-Farber Cancer Institute, Inc. Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors
TW200824678A (en) 2006-08-11 2008-06-16 Combinatorx Inc Methods and compositions for the treatment of neurodegenerative disorders
JPWO2008020622A1 (ja) * 2006-08-17 2010-01-07 杏林製薬株式会社 新規なチエノ［２，３−ｄ］ピリミジン化合物
WO2008063513A2 (en) * 2006-11-13 2008-05-29 Trustees Of Columbia University In The City Of New York Selective proteasome inhibitors for treating diabetes
CN101279995A (zh) * 2007-04-03 2008-10-08 烟台靶点药物研究有限公司 一种雷公藤红素盐及其制备方法与用途
US7776894B2 (en) 2007-08-17 2010-08-17 Burnham Institute For Medical Research Compositions and methods for inhibiting growth and metastasis of melanoma
WO2009064298A1 (en) * 2007-11-14 2009-05-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity and obesity related diseases and disorders
CN101434635B (zh) * 2007-11-16 2012-05-16 上海华拓医药科技发展股份有限公司 一类具抗肿瘤活性的水溶性酚性三萜化合物及其制备方法
WO2009067245A2 (en) * 2007-11-20 2009-05-28 University Of Florida Research Foundation, Inc. Compositions and methods for tissue repair
US20090203605A1 (en) * 2008-02-01 2009-08-13 The Scripps Research Institute Methods For Treating A Condition Characterized By Dysfunction In Protein Homeostasis
CN101352444A (zh) * 2008-09-11 2009-01-28 中国科学院广州生物医药与健康研究院 雷公藤红素在制药中的新应用
US9132108B2 (en) 2009-04-17 2015-09-15 Hiroshima University Pharmaceutical composition for ameliorating and/or preventing leptin resistance, and use thereof
CN101704874A (zh) * 2009-11-26 2010-05-12 中国药科大学 五环三萜及其衍生物的二甲双胍盐、其制备方法及医药用途
JP5990160B2 (ja) 2010-04-12 2016-09-07 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーターを使用して肥満を処置する方法
CN101805390B (zh) 2010-04-13 2012-07-18 暨南大学 一种雷公藤红素衍生物及其用途
CN102309494A (zh) * 2010-07-01 2012-01-11 嘉兴学院 扁蒴藤素作为炎性细胞因子抑制剂的医药用途
EP2609108B1 (en) 2010-08-23 2015-12-16 Suzhou NeuPharma Co., Ltd. Certain chemical entities, compositions, and methods
US20130184272A1 (en) * 2010-09-17 2013-07-18 Takeda Pharmaceutical Company Limited Diabetes therapeutic agent
KR101180387B1 (ko) 2011-11-21 2012-09-10 동국대학교 산학협력단 엣지 추출을 위한 이미지 센서 및 이를 이용한 엣지 이미지 생성 방법.
BR112014029301A2 (pt) 2012-05-25 2017-07-25 Berg Llc métodos de tratamento de síndrome metabólica através de modulação da proteína choque térmico (hsp) 90-beta
CN104822374A (zh) * 2012-09-27 2015-08-05 儿童医学中心公司 用于治疗肥胖症的化合物和其使用方法
CN103524592B (zh) 2013-09-27 2015-08-05 安徽医科大学 一种雷公藤红素衍生物、该衍生物的生物盐及其制备方法与用途
US9601471B2 (en) 2015-04-23 2017-03-21 Apple Inc. Three layer stack structure

Also Published As

Publication number Publication date
EP4082541A1 (en) 2022-11-02
CA3030272A1 (en) 2014-04-03
TR201815668T4 (tr) 2018-11-21
LT2900230T (lt) 2019-01-10
AU2013323528B2 (en) 2016-11-10
HK1213190A1 (en) 2016-06-30
US20250161252A1 (en) 2025-05-22
PL2900230T3 (pl) 2019-02-28
US11045439B2 (en) 2021-06-29
JP6743211B2 (ja) 2020-08-19
BR112015006848A2 (pt) 2018-05-22
WO2014052583A1 (en) 2014-04-03
US10653654B2 (en) 2020-05-19
RU2018112067A3 (enExample) 2021-06-24
JP2019070052A (ja) 2019-05-09
ES2696626T3 (es) 2019-01-17
US20150250753A1 (en) 2015-09-10
DK2900230T3 (en) 2018-11-12
HUE040496T2 (hu) 2019-03-28
AU2016247206B2 (en) 2018-08-02
CA3030272C (en) 2021-09-28
PT2900230T (pt) 2018-11-26
US20170304245A1 (en) 2017-10-26
US20210008019A1 (en) 2021-01-14
HRP20181879T1 (hr) 2019-02-08
US12064408B2 (en) 2024-08-20
RS58010B1 (sr) 2019-02-28
EP3434268A1 (en) 2019-01-30
CY1121166T1 (el) 2020-05-29
CN111529535A (zh) 2020-08-14
RU2650646C2 (ru) 2018-04-16
SI2900230T1 (sl) 2019-01-31
RU2768868C2 (ru) 2022-03-25
US9925161B2 (en) 2018-03-27
AU2013323528A1 (en) 2015-04-09
EP3434268B1 (en) 2022-04-20
US9968575B2 (en) 2018-05-15
EP2900230B1 (en) 2018-08-15
US20180185314A1 (en) 2018-07-05
RU2018112067A (ru) 2019-03-07
AU2018256619A1 (en) 2018-11-22
CA2886393C (en) 2019-02-26
AU2018256619B2 (en) 2020-07-23
EP2900230A1 (en) 2015-08-05
JP6480864B2 (ja) 2019-03-13
CN104822374A (zh) 2015-08-05
US20210275482A1 (en) 2021-09-09
AU2016247206A1 (en) 2016-11-10
CN111529534A (zh) 2020-08-14
JP2015531376A (ja) 2015-11-02
RU2015115696A (ru) 2016-11-20
CA2886393A1 (en) 2014-04-03

Similar Documents

Publication Publication Date Title
IL261768B (en) Devices and methods for tissue treatment
IL263661A (en) Combination therapy for the treatment of glioblastoma
EP2867209A4 (en) COMPOUNDS AND THEIR THERAPEUTIC USES
IL238027A0 (en) 2-phenyl-5-heterocyclyl-tetrahydro-h2-pyran-3-amine compounds for use in the treatment of diabetes and related disorders
ZA201408055B (en) Compositions and methods for the treatment of local pain
SG2014014724A (en) METHODS FOR THE TREATMENT OF IL-1ß RELATED CONDITIONS
PT2900230T (pt) Compostos para o tratamento de obesidade e métodos de utilização dos mesmos
EP2867239A4 (en) OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF DIABETES
ZA201501503B (en) Bio-inoculant and use thereof for treatment of effluents
HRP20181761T1 (hr) Novi pripravak alfentanila za liječenje akutne boli
IL238126B (en) Compositions for the treatment and prevention of obesity
SMT201900064T1 (it) Composti e trattamento dell'obesita' e relativi metodi di uso
EP2934501A4 (en) USES AND METHOD FOR THE TREATMENT OF LIVER DISEASES OR DRESSES
ZA201408065B (en) Compositions and methods for the treatment of diabetes
LT2819655T (lt) Modafinilas, skirtas naudoti asmenų, kenčiančių nuo priklausomybės nuo kokaino, gydymui