AU2013323528B2 - Compounds for the treatment of obesity and methods of use thereof - Google Patents

Compounds for the treatment of obesity and methods of use thereof Download PDF

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Publication number
AU2013323528B2
AU2013323528B2 AU2013323528A AU2013323528A AU2013323528B2 AU 2013323528 B2 AU2013323528 B2 AU 2013323528B2 AU 2013323528 A AU2013323528 A AU 2013323528A AU 2013323528 A AU2013323528 A AU 2013323528A AU 2013323528 B2 AU2013323528 B2 AU 2013323528B2
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AU
Australia
Prior art keywords
amide
ether
amine
carbamate
alkyl
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AU2013323528A
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AU2013323528A1 (en
Inventor
Serkan CABI
Isin CAKIR
Joseph MAJZOUB
Ralph Mazitschek
Umut Ozcan
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General Hospital Corp
Boston Children's Hospital
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General Hospital Corp
Boston Children's Hospital
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Application filed by General Hospital Corp, Boston Children's Hospital filed Critical General Hospital Corp
Publication of AU2013323528A1 publication Critical patent/AU2013323528A1/en
Assigned to THE GENERAL HOSPITAL CORPORATION, THE CHILDREN'S MEDICAL CENTER CORPORATION reassignment THE GENERAL HOSPITAL CORPORATION Request for Assignment Assignors: THE CHILDREN'S MEDICAL CENTER CORPORATION, THE MASSACHUSETTS GENERAL HOSPITAL
Priority to AU2016247206A priority Critical patent/AU2016247206B2/en
Application granted granted Critical
Publication of AU2013323528B2 publication Critical patent/AU2013323528B2/en
Priority to AU2018256619A priority patent/AU2018256619B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2013323528A 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof Active AU2013323528B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2016247206A AU2016247206B2 (en) 2012-09-27 2016-10-21 Compounds for the treatment of obesity and methods of use thereof
AU2018256619A AU2018256619B2 (en) 2012-09-27 2018-11-01 Compounds for the treatment of obesity and methods of use thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261706153P 2012-09-27 2012-09-27
US61/706,153 2012-09-27
PCT/US2013/061911 WO2014052583A1 (en) 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016247206A Division AU2016247206B2 (en) 2012-09-27 2016-10-21 Compounds for the treatment of obesity and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2013323528A1 AU2013323528A1 (en) 2015-04-09
AU2013323528B2 true AU2013323528B2 (en) 2016-11-10

Family

ID=49304418

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2013323528A Active AU2013323528B2 (en) 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof
AU2016247206A Active AU2016247206B2 (en) 2012-09-27 2016-10-21 Compounds for the treatment of obesity and methods of use thereof
AU2018256619A Ceased AU2018256619B2 (en) 2012-09-27 2018-11-01 Compounds for the treatment of obesity and methods of use thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2016247206A Active AU2016247206B2 (en) 2012-09-27 2016-10-21 Compounds for the treatment of obesity and methods of use thereof
AU2018256619A Ceased AU2018256619B2 (en) 2012-09-27 2018-11-01 Compounds for the treatment of obesity and methods of use thereof

Country Status (21)

Country Link
US (6) US9968575B2 (enExample)
EP (3) EP4082541A1 (enExample)
JP (2) JP6480864B2 (enExample)
CN (3) CN111529535A (enExample)
AU (3) AU2013323528B2 (enExample)
BR (1) BR112015006848A2 (enExample)
CA (2) CA3030272C (enExample)
CY (1) CY1121166T1 (enExample)
DK (1) DK2900230T3 (enExample)
ES (1) ES2696626T3 (enExample)
HR (1) HRP20181879T1 (enExample)
HU (1) HUE040496T2 (enExample)
LT (1) LT2900230T (enExample)
PL (1) PL2900230T3 (enExample)
PT (1) PT2900230T (enExample)
RS (1) RS58010B1 (enExample)
RU (2) RU2650646C2 (enExample)
SI (1) SI2900230T1 (enExample)
SM (1) SMT201800604T1 (enExample)
TR (1) TR201815668T4 (enExample)
WO (1) WO2014052583A1 (enExample)

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CN111529535A (zh) 2012-09-27 2020-08-14 儿童医学中心公司 用于治疗肥胖症的化合物和其使用方法
BR112016021985B1 (pt) * 2014-03-26 2022-08-30 The General Hospital Corporation Formulação farmacêutica
US20170209408A1 (en) * 2014-04-03 2017-07-27 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
CN105985401B (zh) * 2015-02-16 2020-10-09 上海华拓医药科技发展有限公司 一种雷公藤红素衍生物、其制备方法及用途
CN119241632A (zh) * 2015-10-23 2025-01-03 Erx制药股份有限公司 雷公藤红素的类似物
CN106905404B (zh) * 2017-01-13 2019-08-27 广东工业大学 熊果酸衍生物及其制备方法和应用
EP4392044A4 (en) * 2021-09-09 2025-01-22 Junion Labs Pte. Ltd. SUPERABSORBENT HYDROGELS WITH LIPASE INHIBITOR
KR102470686B1 (ko) * 2022-06-07 2022-11-23 서울대학교산학협력단 디메틸제일아스테럴을 포함하는 대사성 질환 예방 또는 치료용 약학 조성물
CN119431489A (zh) * 2024-11-13 2025-02-14 肇源县总医院 一种雷公藤红素衍生物及其制备方法

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Also Published As

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SMT201800604T1 (it) 2019-01-11
RU2650646C2 (ru) 2018-04-16
CY1121166T1 (el) 2020-05-29
RU2768868C2 (ru) 2022-03-25
HUE040496T2 (hu) 2019-03-28
US20180185314A1 (en) 2018-07-05
RS58010B1 (sr) 2019-02-28
JP6743211B2 (ja) 2020-08-19
PL2900230T3 (pl) 2019-02-28
JP2015531376A (ja) 2015-11-02
PT2900230T (pt) 2018-11-26
CN111529535A (zh) 2020-08-14
HK1213190A1 (en) 2016-06-30
CA2886393A1 (en) 2014-04-03
AU2016247206A1 (en) 2016-11-10
RU2018112067A (ru) 2019-03-07
AU2016247206B2 (en) 2018-08-02
TR201815668T4 (tr) 2018-11-21
WO2014052583A1 (en) 2014-04-03
RU2015115696A (ru) 2016-11-20
EP3434268B1 (en) 2022-04-20
JP2019070052A (ja) 2019-05-09
AU2013323528A1 (en) 2015-04-09
LT2900230T (lt) 2019-01-10
US12064408B2 (en) 2024-08-20
CA3030272A1 (en) 2014-04-03
EP4082541A1 (en) 2022-11-02
EP3434268A1 (en) 2019-01-30
CA3030272C (en) 2021-09-28
US20170304245A1 (en) 2017-10-26
CN111529534A (zh) 2020-08-14
US9968575B2 (en) 2018-05-15
US9925161B2 (en) 2018-03-27
US20150250753A1 (en) 2015-09-10
US20250161252A1 (en) 2025-05-22
AU2018256619A1 (en) 2018-11-22
US11045439B2 (en) 2021-06-29
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