SK8198A3 - Hormone patch - Google Patents
Hormone patch Download PDFInfo
- Publication number
- SK8198A3 SK8198A3 SK81-98A SK8198A SK8198A3 SK 8198 A3 SK8198 A3 SK 8198A3 SK 8198 A SK8198 A SK 8198A SK 8198 A3 SK8198 A3 SK 8198A3
- Authority
- SK
- Slovakia
- Prior art keywords
- therapeutic system
- transdermal therapeutic
- ethoxyethoxy
- ethanol
- oleic acid
- Prior art date
Links
- 229940088597 hormone Drugs 0.000 title claims description 9
- 239000005556 hormone Substances 0.000 title claims description 9
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims abstract description 26
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims abstract description 26
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000005642 Oleic acid Substances 0.000 claims abstract description 26
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims abstract description 26
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims abstract description 26
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract description 26
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims abstract description 23
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 19
- 239000000126 substance Substances 0.000 claims abstract description 15
- 239000000853 adhesive Substances 0.000 claims abstract description 11
- 230000001070 adhesive effect Effects 0.000 claims abstract description 11
- 239000003098 androgen Substances 0.000 claims abstract description 6
- 239000000262 estrogen Substances 0.000 claims abstract description 6
- 239000000583 progesterone congener Substances 0.000 claims abstract description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 19
- 239000010408 film Substances 0.000 claims description 15
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 14
- 229930182833 estradiol Natural products 0.000 claims description 14
- 229960005309 estradiol Drugs 0.000 claims description 12
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims description 11
- 229960001652 norethindrone acetate Drugs 0.000 claims description 11
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 10
- 229960004400 levonorgestrel Drugs 0.000 claims description 10
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 7
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- 229940011871 estrogen Drugs 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 4
- 229960002568 ethinylestradiol Drugs 0.000 claims description 4
- 229960003604 testosterone Drugs 0.000 claims description 4
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 claims description 3
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 3
- 238000010526 radical polymerization reaction Methods 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 2
- 239000013039 cover film Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 229960003575 estradiol acetate Drugs 0.000 claims description 2
- 239000000178 monomer Substances 0.000 claims description 2
- 239000000186 progesterone Substances 0.000 claims description 2
- 229960003387 progesterone Drugs 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 14
- 239000003623 enhancer Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 210000000434 stratum corneum Anatomy 0.000 description 5
- OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- -1 ethoxyethoxy Chemical group 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229940030486 androgens Drugs 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229920006267 polyester film Polymers 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000002110 toxicologic effect Effects 0.000 description 2
- 231100000027 toxicology Toxicity 0.000 description 2
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229960001616 chlormadinone acetate Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Power Steering Mechanism (AREA)
- Surgical Instruments (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19526864A DE19526864A1 (de) | 1995-07-22 | 1995-07-22 | Hormonpflaster |
| PCT/EP1996/003229 WO1997003698A1 (de) | 1995-07-22 | 1996-07-22 | Hormonpflaster |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK8198A3 true SK8198A3 (en) | 1998-06-03 |
Family
ID=7767564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK81-98A SK8198A3 (en) | 1995-07-22 | 1996-07-22 | Hormone patch |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5985311A (xx) |
| EP (1) | EP0840621B1 (xx) |
| JP (1) | JPH11504038A (xx) |
| KR (1) | KR19990035795A (xx) |
| CN (1) | CN1195994A (xx) |
| AT (1) | ATE212234T1 (xx) |
| AU (1) | AU6786696A (xx) |
| BR (1) | BR9609794A (xx) |
| CA (1) | CA2227538A1 (xx) |
| CZ (1) | CZ20498A3 (xx) |
| DE (3) | DE19526864A1 (xx) |
| DK (1) | DK0840621T3 (xx) |
| ES (1) | ES2171710T3 (xx) |
| HU (1) | HUP9900301A3 (xx) |
| MX (1) | MX9800469A (xx) |
| NO (1) | NO980277L (xx) |
| NZ (1) | NZ316026A (xx) |
| PL (1) | PL324552A1 (xx) |
| PT (1) | PT840621E (xx) |
| SK (1) | SK8198A3 (xx) |
| WO (1) | WO1997003698A1 (xx) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050276836A1 (en) * | 1997-06-11 | 2005-12-15 | Michelle Wilson | Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents |
| DE19728516C2 (de) * | 1997-07-04 | 1999-11-11 | Sanol Arznei Schwarz Gmbh | TTS zur Verabreichung von Levonorgestrel und gegebenenfalls Estradiol |
| FR2779062A1 (fr) * | 1998-06-02 | 1999-12-03 | Investigations Therapeutiques | Preparation sous forme galenique simple visant a limiter les effets induits durant la menopause et posterieurement et traitement avec cette preparation |
| DE19901085C2 (de) * | 1999-01-14 | 2003-12-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit einer selbstklebenden Matrix, enthaltend organische Säure-Additionssalze von Alkaloiden des Morphin- bzw. Morphinantyps |
| USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
| EP1216699A1 (de) * | 2000-12-21 | 2002-06-26 | Schering Aktiengesellschaft | Transdermalsystem enthaltend ein hochpotentes Gestagen |
| CA2445086C (en) | 2001-05-01 | 2008-04-08 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions |
| ES2587187T3 (es) | 2001-05-01 | 2016-10-21 | A. V. Topchiev Institute Of Petrochemical Synthesis | Composición bioadhesiva absorbente de agua bifásica |
| US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
| US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
| US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
| US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
| KR20030028253A (ko) * | 2001-09-27 | 2003-04-08 | (주)지씨아이 | 잔탄검과 알긴을 이용한 항고지단백혈증 경피투과제제의제조 |
| US8124122B2 (en) | 2002-08-09 | 2012-02-28 | Teikoku Seiyaku Co., Ltd. | Female hormone-containing patch |
| JP4919573B2 (ja) * | 2002-08-09 | 2012-04-18 | 帝國製薬株式会社 | ノルエチステロン含有外用貼付剤 |
| JP5027373B2 (ja) * | 2002-08-09 | 2012-09-19 | 帝國製薬株式会社 | エストラジオール含有貼付剤 |
| KR20040037653A (ko) * | 2002-10-29 | 2004-05-07 | 대한민국(경북대학교 총장) | 갈변 방지제 |
| JO2492B1 (en) | 2003-04-28 | 2009-10-05 | شيرينج ايه جي | A pharmaceutical formula in the form of aqueous gel for the skin use of its active ingredients |
| WO2005074894A1 (en) | 2004-01-30 | 2005-08-18 | Corium International | Rapidly dissolving film for delivery of an active agent |
| CN103497713B (zh) | 2004-08-05 | 2018-07-17 | 考里安国际公司 | 粘合剂组合物 |
| US20060121102A1 (en) * | 2004-09-27 | 2006-06-08 | Chia-Ming Chiang | Transdermal systems for the delivery of estrogens and progestins |
| JP5025268B2 (ja) * | 2004-11-10 | 2012-09-12 | 久光製薬株式会社 | 外用製剤及び貼付剤 |
| JP4919807B2 (ja) * | 2004-11-10 | 2012-04-18 | 久光製薬株式会社 | 外用製剤及び貼付剤 |
| JP5261183B2 (ja) * | 2005-09-23 | 2013-08-14 | ヘンケル・アーゲー・アンド・カンパニー・カーゲーアーアー | アクリルポリマー系接着剤 |
| EP1948221B1 (en) * | 2005-11-02 | 2015-04-08 | Syneron Medical Ltd. | Human growth hormone patch formulations |
| EP2112923A1 (en) | 2007-01-22 | 2009-11-04 | Targacept Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| JP5358574B2 (ja) * | 2007-08-17 | 2013-12-04 | アルション セラピューティクス， インコーポレイテッド | 高濃度の局所麻酔薬調合物 |
| US8119694B2 (en) * | 2008-08-15 | 2012-02-21 | Arcion Therapeutics, Inc. | High concentration local anesthetic formulations |
| DE102008059054A1 (de) * | 2008-11-26 | 2010-05-27 | Otto Bock Pur Life Science Gmbh | Polyurethanpflaster für die transdermale Applikation von Wirkstoffen und Verfahren zu dessen Herstellung |
| AU2010204986B2 (en) | 2009-01-14 | 2016-06-02 | Corium International, Inc. | Transdermal administration of tamsulosin |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
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| US5296230A (en) * | 1985-02-25 | 1994-03-22 | Rutgers, The State University Of New Jersey | Transdermal fertility control system and process |
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-
1995
- 1995-07-22 DE DE19526864A patent/DE19526864A1/de not_active Withdrawn
-
1996
- 1996-07-22 CZ CZ98204A patent/CZ20498A3/cs unknown
- 1996-07-22 PL PL96324552A patent/PL324552A1/xx unknown
- 1996-07-22 DE DE19680582T patent/DE19680582D2/de not_active Expired - Fee Related
- 1996-07-22 SK SK81-98A patent/SK8198A3/sk unknown
- 1996-07-22 CA CA002227538A patent/CA2227538A1/en not_active Abandoned
- 1996-07-22 DK DK96928368T patent/DK0840621T3/da active
- 1996-07-22 EP EP96928368A patent/EP0840621B1/de not_active Expired - Lifetime
- 1996-07-22 BR BR9609794A patent/BR9609794A/pt active Search and Examination
- 1996-07-22 PT PT96928368T patent/PT840621E/pt unknown
- 1996-07-22 DE DE59608650T patent/DE59608650D1/de not_active Expired - Fee Related
- 1996-07-22 AU AU67866/96A patent/AU6786696A/en not_active Abandoned
- 1996-07-22 HU HU9900301A patent/HUP9900301A3/hu unknown
- 1996-07-22 JP JP9506320A patent/JPH11504038A/ja not_active Ceased
- 1996-07-22 ES ES96928368T patent/ES2171710T3/es not_active Expired - Lifetime
- 1996-07-22 CN CN96196894A patent/CN1195994A/zh active Pending
- 1996-07-22 NZ NZ316026A patent/NZ316026A/xx unknown
- 1996-07-22 AT AT96928368T patent/ATE212234T1/de not_active IP Right Cessation
- 1996-07-22 WO PCT/EP1996/003229 patent/WO1997003698A1/de not_active Application Discontinuation
- 1996-07-22 KR KR1019980700454A patent/KR19990035795A/ko not_active Application Discontinuation
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1998
- 1998-01-15 MX MX9800469A patent/MX9800469A/es not_active IP Right Cessation
- 1998-01-21 NO NO980277A patent/NO980277L/no unknown
- 1998-01-22 US US09/010,534 patent/US5985311A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5985311A (en) | 1999-11-16 |
| KR19990035795A (ko) | 1999-05-25 |
| JPH11504038A (ja) | 1999-04-06 |
| WO1997003698A1 (de) | 1997-02-06 |
| EP0840621B1 (de) | 2002-01-23 |
| HUP9900301A3 (en) | 1999-11-29 |
| NZ316026A (en) | 1999-08-30 |
| NO980277D0 (no) | 1998-01-21 |
| DE19526864A1 (de) | 1997-01-23 |
| AU6786696A (en) | 1997-02-18 |
| DE19680582D2 (de) | 1998-10-29 |
| CA2227538A1 (en) | 1997-02-06 |
| EP0840621A1 (de) | 1998-05-13 |
| BR9609794A (pt) | 1999-03-16 |
| DE59608650D1 (de) | 2002-03-14 |
| DK0840621T3 (xx) | 2002-04-15 |
| MX9800469A (es) | 1998-09-30 |
| PT840621E (pt) | 2002-06-28 |
| ATE212234T1 (de) | 2002-02-15 |
| CN1195994A (zh) | 1998-10-14 |
| ES2171710T3 (es) | 2002-09-16 |
| PL324552A1 (en) | 1998-06-08 |
| HUP9900301A2 (hu) | 1999-06-28 |
| CZ20498A3 (cs) | 1998-06-17 |
| NO980277L (no) | 1998-01-21 |
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