SK6892002A3 - Novel il-8 receptor antagonists - Google Patents
Novel il-8 receptor antagonists Download PDFInfo
- Publication number
- SK6892002A3 SK6892002A3 SK689-2002A SK6892002A SK6892002A3 SK 6892002 A3 SK6892002 A3 SK 6892002A3 SK 6892002 A SK6892002 A SK 6892002A SK 6892002 A3 SK6892002 A3 SK 6892002A3
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- SOBWADTYOGHEPN-UHFFFAOYSA-N ethyl 3-[5-chloro-2-(4-methylphenyl)-1h-indol-3-yl]propanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCC(=O)OCC)=C1C1=CC=C(C)C=C1 SOBWADTYOGHEPN-UHFFFAOYSA-N 0.000 description 1
- OIPVSXWYNSFAIM-UHFFFAOYSA-N ethyl 4-(5-chloro-1h-indol-3-yl)butanoate Chemical compound C1=C(Cl)C=C2C(CCCC(=O)OCC)=CNC2=C1 OIPVSXWYNSFAIM-UHFFFAOYSA-N 0.000 description 1
- GPASYSYCKMVJLP-UHFFFAOYSA-N ethyl 4-(5-methyl-2-phenyl-1h-indol-3-yl)butanoate Chemical compound N1C2=CC=C(C)C=C2C(CCCC(=O)OCC)=C1C1=CC=CC=C1 GPASYSYCKMVJLP-UHFFFAOYSA-N 0.000 description 1
- GVFOLWOFBJMBPQ-UHFFFAOYSA-N ethyl 4-[5-chloro-2-(3-chlorophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OCC)=C1C1=CC=CC(Cl)=C1 GVFOLWOFBJMBPQ-UHFFFAOYSA-N 0.000 description 1
- JUMHKXADBOSWLU-UHFFFAOYSA-N ethyl 4-[5-chloro-2-(4-fluoro-3-methylphenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OCC)=C1C1=CC=C(F)C(C)=C1 JUMHKXADBOSWLU-UHFFFAOYSA-N 0.000 description 1
- OZVLINXYFHCFIP-UHFFFAOYSA-N ethyl 4-[5-chloro-2-(4-nitrophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OCC)=C1C1=CC=C([N+]([O-])=O)C=C1 OZVLINXYFHCFIP-UHFFFAOYSA-N 0.000 description 1
- VWYDIJUCDVTBEO-UHFFFAOYSA-N ethyl 5-(3,4-dichlorophenyl)-5-oxopentanoate Chemical compound CCOC(=O)CCCC(=O)C1=CC=C(Cl)C(Cl)=C1 VWYDIJUCDVTBEO-UHFFFAOYSA-N 0.000 description 1
- XBYIXIAOQPIYHO-UHFFFAOYSA-N ethyl 5-oxo-5-phenylpentanoate Chemical compound CCOC(=O)CCCC(=O)C1=CC=CC=C1 XBYIXIAOQPIYHO-UHFFFAOYSA-N 0.000 description 1
- ODRIXXZKVYCRTE-UHFFFAOYSA-N ethyl 6-oxo-6-phenylhexanoate Chemical compound CCOC(=O)CCCCC(=O)C1=CC=CC=C1 ODRIXXZKVYCRTE-UHFFFAOYSA-N 0.000 description 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003269 fluorescent indicator Substances 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- YFHXZQPUBCBNIP-UHFFFAOYSA-N fura-2 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=3OC(=CC=3C=2)C=2OC(=CN=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 YFHXZQPUBCBNIP-UHFFFAOYSA-N 0.000 description 1
- VPSRLGDRGCKUTK-UHFFFAOYSA-N fura-2-acetoxymethyl ester Chemical compound CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=C(C)C=C1OCCOC(C(=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)=CC2=C1OC(C=1OC(=CN=1)C(=O)OCOC(C)=O)=C2 VPSRLGDRGCKUTK-UHFFFAOYSA-N 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 210000000224 granular leucocyte Anatomy 0.000 description 1
- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
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- 230000004054 inflammatory process Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
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- 230000009545 invasion Effects 0.000 description 1
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
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- 239000002609 medium Substances 0.000 description 1
- DFUDRRNGHQNNIZ-UHFFFAOYSA-N methyl 3-(2-bromo-5-chloro-1h-indol-3-yl)propanoate Chemical compound C1=C(Cl)C=C2C(CCC(=O)OC)=C(Br)NC2=C1 DFUDRRNGHQNNIZ-UHFFFAOYSA-N 0.000 description 1
- FJAZNPLDRGFDJW-UHFFFAOYSA-N methyl 3-(5-chloro-1h-indol-3-yl)propanoate Chemical compound C1=C(Cl)C=C2C(CCC(=O)OC)=CNC2=C1 FJAZNPLDRGFDJW-UHFFFAOYSA-N 0.000 description 1
- OVQQVQHQBJDLOB-UHFFFAOYSA-N methyl 3-[5-chloro-2-[4-(trifluoromethyl)phenyl]-1h-indol-3-yl]propanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCC(=O)OC)=C1C1=CC=C(C(F)(F)F)C=C1 OVQQVQHQBJDLOB-UHFFFAOYSA-N 0.000 description 1
- CJNJBGWUYIWIAA-UHFFFAOYSA-N methyl 4-(5-chloro-1h-indol-3-yl)butanoate Chemical compound C1=C(Cl)C=C2C(CCCC(=O)OC)=CNC2=C1 CJNJBGWUYIWIAA-UHFFFAOYSA-N 0.000 description 1
- NTKOUTAPLFWYFK-UHFFFAOYSA-N methyl 4-(5-chloro-2-naphthalen-2-yl-1h-indol-3-yl)butanoate Chemical compound C1=CC=CC2=CC(C3=C(C4=CC(Cl)=CC=C4N3)CCCC(=O)OC)=CC=C21 NTKOUTAPLFWYFK-UHFFFAOYSA-N 0.000 description 1
- ODVMHOCYBVZGGO-UHFFFAOYSA-N methyl 4-(5-chloro-2-thiophen-3-yl-1h-indol-3-yl)butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C=1C=CSC=1 ODVMHOCYBVZGGO-UHFFFAOYSA-N 0.000 description 1
- VFIVVBAGLVSEPY-UHFFFAOYSA-N methyl 4-[2-(4-bromophenyl)-5-chloro-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(Br)C=C1 VFIVVBAGLVSEPY-UHFFFAOYSA-N 0.000 description 1
- LZGVLKOMUMRLDW-UHFFFAOYSA-N methyl 4-[5-chloro-2-(3,4-dichlorophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(Cl)C(Cl)=C1 LZGVLKOMUMRLDW-UHFFFAOYSA-N 0.000 description 1
- GHJKHWGOSMMYHF-UHFFFAOYSA-N methyl 4-[5-chloro-2-(3,4-difluorophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(F)C(F)=C1 GHJKHWGOSMMYHF-UHFFFAOYSA-N 0.000 description 1
- FBJWFYVHGIBCBG-UHFFFAOYSA-N methyl 4-[5-chloro-2-(3,4-dimethylphenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(C)C(C)=C1 FBJWFYVHGIBCBG-UHFFFAOYSA-N 0.000 description 1
- LUJSBRSBKGWZPT-UHFFFAOYSA-N methyl 4-[5-chloro-2-(3-chloro-4-fluorophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(F)C(Cl)=C1 LUJSBRSBKGWZPT-UHFFFAOYSA-N 0.000 description 1
- LPRXKWZQYOUGQN-UHFFFAOYSA-N methyl 4-[5-chloro-2-(4-chloro-3-fluorophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(Cl)C(F)=C1 LPRXKWZQYOUGQN-UHFFFAOYSA-N 0.000 description 1
- QHBBHPAPEFIMKP-UHFFFAOYSA-N methyl 4-[5-chloro-2-(4-chlorophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(Cl)C=C1 QHBBHPAPEFIMKP-UHFFFAOYSA-N 0.000 description 1
- FVMMLLABWMHQAO-UHFFFAOYSA-N methyl 4-[5-chloro-2-(4-cyanophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(C#N)C=C1 FVMMLLABWMHQAO-UHFFFAOYSA-N 0.000 description 1
- SKBFVFDEFORDMN-UHFFFAOYSA-N methyl 4-[5-chloro-2-(4-fluoro-3-methylphenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(F)C(C)=C1 SKBFVFDEFORDMN-UHFFFAOYSA-N 0.000 description 1
- BVFSCFTYTIATON-UHFFFAOYSA-N methyl 4-[5-chloro-2-(4-fluorophenyl)-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(F)C=C1 BVFSCFTYTIATON-UHFFFAOYSA-N 0.000 description 1
- HWIXJWNZHDEOFV-UHFFFAOYSA-N methyl 4-[5-chloro-2-[4-(trifluoromethyl)phenyl]-1h-indol-3-yl]butanoate Chemical compound N1C2=CC=C(Cl)C=C2C(CCCC(=O)OC)=C1C1=CC=C(C(F)(F)F)C=C1 HWIXJWNZHDEOFV-UHFFFAOYSA-N 0.000 description 1
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
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- UUIQMZJEGPQKFD-UHFFFAOYSA-N n-butyric acid methyl ester Natural products CCCC(=O)OC UUIQMZJEGPQKFD-UHFFFAOYSA-N 0.000 description 1
- 238000006396 nitration reaction Methods 0.000 description 1
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- 150000002894 organic compounds Chemical class 0.000 description 1
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- 210000004303 peritoneum Anatomy 0.000 description 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
- QNMBSXGYAQZCTN-UHFFFAOYSA-N thiophen-3-ylboronic acid Chemical compound OB(O)C=1C=CSC=1 QNMBSXGYAQZCTN-UHFFFAOYSA-N 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9914837A FR2801585B1 (fr) | 1999-11-25 | 1999-11-25 | Nouveaux antagonistes des recepteurs de l'ii-8 |
| PCT/FR2000/003278 WO2001038305A2 (fr) | 1999-11-25 | 2000-11-24 | Nouveaux antagonistes des recepteurs de l'il-8 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK6892002A3 true SK6892002A3 (en) | 2002-10-08 |
Family
ID=9552533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK689-2002A SK6892002A3 (en) | 1999-11-25 | 2000-11-24 | Novel il-8 receptor antagonists |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6605633B1 (de) |
| EP (1) | EP1232144B1 (de) |
| JP (1) | JP2003514894A (de) |
| KR (1) | KR20020050280A (de) |
| CN (1) | CN1391556A (de) |
| AT (1) | ATE263150T1 (de) |
| AU (1) | AU2177601A (de) |
| BR (1) | BR0015695A (de) |
| CA (1) | CA2392225A1 (de) |
| CZ (1) | CZ20021810A3 (de) |
| DE (1) | DE60009544T2 (de) |
| ES (1) | ES2218266T3 (de) |
| FR (1) | FR2801585B1 (de) |
| HU (1) | HUP0203603A3 (de) |
| IL (1) | IL149838A0 (de) |
| MX (1) | MXPA02005232A (de) |
| NO (1) | NO20022460L (de) |
| NZ (1) | NZ519126A (de) |
| PL (1) | PL355724A1 (de) |
| RU (1) | RU2002113771A (de) |
| SK (1) | SK6892002A3 (de) |
| WO (1) | WO2001038305A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2824826B1 (fr) * | 2001-05-17 | 2003-11-07 | Fournier Lab Sa | Nouveaux derives de 5-cyano-1h-indole antagonistes des recepteurs de l'interleukine-8 |
| WO2003104180A1 (en) * | 2002-06-05 | 2003-12-18 | Natco Pharma Limited | Process for the preparation of 4-(4-fluorobenzoyl) butyric acid |
| US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| UA88767C2 (uk) | 2003-07-17 | 2009-11-25 | Плексікон, Інк. | Ppar активні сполуки |
| JP2008521829A (ja) | 2004-11-30 | 2008-06-26 | プレキシコン，インコーポレーテッド | Ｐｐａｒ活性化合物 |
| PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| CA3121910A1 (en) | 2018-12-17 | 2020-06-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
| JP2023515668A (ja) | 2020-03-06 | 2023-04-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｐｏｌ－１依存性巣状分節性糸球体硬化症を治療する方法 |
| JP2023529216A (ja) * | 2020-06-12 | 2023-07-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｐｏｌ１の阻害剤及びその使用 |
| TW202227456A (zh) | 2020-08-26 | 2022-07-16 | 美商維泰克斯製藥公司 | Ａｐｏｌ１抑制劑及其使用方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10510538A (ja) * | 1994-12-13 | 1998-10-13 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
| WO1999006354A1 (en) | 1997-07-29 | 1999-02-11 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| GB9905010D0 (en) * | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
-
1999
- 1999-11-25 FR FR9914837A patent/FR2801585B1/fr not_active Expired - Fee Related
-
2000
- 2000-11-24 CZ CZ20021810A patent/CZ20021810A3/cs unknown
- 2000-11-24 AU AU21776/01A patent/AU2177601A/en not_active Abandoned
- 2000-11-24 JP JP2001539861A patent/JP2003514894A/ja active Pending
- 2000-11-24 CN CN00816057A patent/CN1391556A/zh active Pending
- 2000-11-24 MX MXPA02005232A patent/MXPA02005232A/es not_active Application Discontinuation
- 2000-11-24 DE DE60009544T patent/DE60009544T2/de not_active Expired - Fee Related
- 2000-11-24 RU RU2002113771/04A patent/RU2002113771A/ru unknown
- 2000-11-24 HU HU0203603A patent/HUP0203603A3/hu unknown
- 2000-11-24 US US10/130,454 patent/US6605633B1/en not_active Expired - Fee Related
- 2000-11-24 CA CA002392225A patent/CA2392225A1/en not_active Abandoned
- 2000-11-24 BR BR0015695-7A patent/BR0015695A/pt not_active Application Discontinuation
- 2000-11-24 IL IL14983800A patent/IL149838A0/xx unknown
- 2000-11-24 EP EP00985320A patent/EP1232144B1/de not_active Expired - Lifetime
- 2000-11-24 AT AT00985320T patent/ATE263150T1/de not_active IP Right Cessation
- 2000-11-24 ES ES00985320T patent/ES2218266T3/es not_active Expired - Lifetime
- 2000-11-24 SK SK689-2002A patent/SK6892002A3/sk unknown
- 2000-11-24 NZ NZ519126A patent/NZ519126A/xx unknown
- 2000-11-24 KR KR1020027006183A patent/KR20020050280A/ko not_active Application Discontinuation
- 2000-11-24 PL PL00355724A patent/PL355724A1/xx not_active Application Discontinuation
- 2000-11-24 WO PCT/FR2000/003278 patent/WO2001038305A2/fr not_active Application Discontinuation
-
2002
- 2002-05-24 NO NO20022460A patent/NO20022460L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2177601A (en) | 2001-06-04 |
| ES2218266T3 (es) | 2004-11-16 |
| HUP0203603A3 (en) | 2004-03-01 |
| WO2001038305A2 (fr) | 2001-05-31 |
| CA2392225A1 (en) | 2001-05-31 |
| PL355724A1 (en) | 2004-05-17 |
| EP1232144A2 (de) | 2002-08-21 |
| JP2003514894A (ja) | 2003-04-22 |
| NZ519126A (en) | 2006-03-31 |
| HUP0203603A2 (hu) | 2003-02-28 |
| US6605633B1 (en) | 2003-08-12 |
| RU2002113771A (ru) | 2004-01-10 |
| NO20022460D0 (no) | 2002-05-24 |
| DE60009544D1 (de) | 2004-05-06 |
| ATE263150T1 (de) | 2004-04-15 |
| KR20020050280A (ko) | 2002-06-26 |
| CZ20021810A3 (cs) | 2002-08-14 |
| DE60009544T2 (de) | 2004-12-30 |
| FR2801585A1 (fr) | 2001-06-01 |
| WO2001038305A3 (fr) | 2002-01-24 |
| FR2801585B1 (fr) | 2002-02-15 |
| IL149838A0 (en) | 2002-11-10 |
| MXPA02005232A (es) | 2002-11-07 |
| NO20022460L (no) | 2002-05-24 |
| EP1232144B1 (de) | 2004-03-31 |
| BR0015695A (pt) | 2002-07-23 |
| CN1391556A (zh) | 2003-01-15 |
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