BR0015695A - Novos antagonistas dos receptores de il-8 - Google Patents
Novos antagonistas dos receptores de il-8Info
- Publication number
- BR0015695A BR0015695A BR0015695-7A BR0015695A BR0015695A BR 0015695 A BR0015695 A BR 0015695A BR 0015695 A BR0015695 A BR 0015695A BR 0015695 A BR0015695 A BR 0015695A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- new
- halogen
- formula
- aromatic ring
- Prior art date
Links
- 102000010681 interleukin-8 receptors Human genes 0.000 title abstract 2
- 108010038415 interleukin-8 receptors Proteins 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 102100036150 C-X-C motif chemokine 5 Human genes 0.000 abstract 1
- 108050006947 CXC Chemokine Proteins 0.000 abstract 1
- 102000019388 CXC chemokine Human genes 0.000 abstract 1
- -1 Gro Proteins 0.000 abstract 1
- 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 abstract 1
- 101000973997 Homo sapiens Nucleosome assembly protein 1-like 4 Proteins 0.000 abstract 1
- 101000947178 Homo sapiens Platelet basic protein Proteins 0.000 abstract 1
- 108090001007 Interleukin-8 Proteins 0.000 abstract 1
- 102100036154 Platelet basic protein Human genes 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"NOVOS ANTAGONISTAS DOS RECEPTORES DE IL-8". A presente invenção se refere a novos compostos que inibem a ação de quimioquinas CXC tais como a IL-8, o Gro, o NAP-2, o ENA-78 etc. sobre os seus receptores, ao processo de sua preparação, assim como à sua utilização para a obtenção de medicamentos. De acordo com a invenção, trata-se de derivados inéditos do indol, escolhidos do conjunto constituído: i) pelos produtos da fórmula: na qual X representa uma ligação dupla -C=C- ou um átomo de enxofre, R~ 1~, representa um halogênio, um grupamento nitro, um grupamento triflúor-metila ou um grupamento alquila de C~ 1-C~ 3~, R~ 2~, R~ 3~, R~ 4~ representam cada um independentemente um átomo de hidrogênio, um halogênio, um grupamento alquila de C~ 1~-C~ 3~, um grupamento nitro, um grupamento triflúor-metila ou um grupamento ciano, ou então R~ 2~ e R~ 3~ formam em conjunto, juntamente com o núcleo aromático ao qual eles estão ligados, um anel aromático condensado, e n é igual a 2 ou 3, e ii) pelos ésteres e sais de adição com uma base inorgânica ou orgânica dos compostos da fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9914837A FR2801585B1 (fr) | 1999-11-25 | 1999-11-25 | Nouveaux antagonistes des recepteurs de l'ii-8 |
PCT/FR2000/003278 WO2001038305A2 (fr) | 1999-11-25 | 2000-11-24 | Nouveaux antagonistes des recepteurs de l'il-8 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0015695A true BR0015695A (pt) | 2002-07-23 |
Family
ID=9552533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0015695-7A BR0015695A (pt) | 1999-11-25 | 2000-11-24 | Novos antagonistas dos receptores de il-8 |
Country Status (22)
Country | Link |
---|---|
US (1) | US6605633B1 (pt) |
EP (1) | EP1232144B1 (pt) |
JP (1) | JP2003514894A (pt) |
KR (1) | KR20020050280A (pt) |
CN (1) | CN1391556A (pt) |
AT (1) | ATE263150T1 (pt) |
AU (1) | AU2177601A (pt) |
BR (1) | BR0015695A (pt) |
CA (1) | CA2392225A1 (pt) |
CZ (1) | CZ20021810A3 (pt) |
DE (1) | DE60009544T2 (pt) |
ES (1) | ES2218266T3 (pt) |
FR (1) | FR2801585B1 (pt) |
HU (1) | HUP0203603A3 (pt) |
IL (1) | IL149838A0 (pt) |
MX (1) | MXPA02005232A (pt) |
NO (1) | NO20022460L (pt) |
NZ (1) | NZ519126A (pt) |
PL (1) | PL355724A1 (pt) |
RU (1) | RU2002113771A (pt) |
SK (1) | SK6892002A3 (pt) |
WO (1) | WO2001038305A2 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2824826B1 (fr) * | 2001-05-17 | 2003-11-07 | Fournier Lab Sa | Nouveaux derives de 5-cyano-1h-indole antagonistes des recepteurs de l'interleukine-8 |
AU2003237593A1 (en) * | 2002-06-05 | 2003-12-22 | Natco Pharma Limited | Process for the preparation of 4-(4-fluorobenzoyl) butyric acid |
KR20130023381A (ko) | 2003-07-17 | 2013-03-07 | 플렉시콘, 인코퍼레이티드 | Ppar 활성 화합물 |
US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
US7531568B2 (en) | 2004-11-30 | 2009-05-12 | Plexxikon, Inc. | PPAR active compounds |
PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
MX2021007152A (es) | 2018-12-17 | 2021-11-03 | Vertex Pharma | Inhibidores de apol1 y sus metodos de uso. |
EP4114385A1 (en) | 2020-03-06 | 2023-01-11 | Vertex Pharmaceuticals Incorporated | Methods of treating apol-1 dependent focal segmental glomerulosclerosis |
US20230014907A1 (en) * | 2020-06-12 | 2023-01-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
EP4204423A1 (en) | 2020-08-26 | 2023-07-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0800389A4 (en) * | 1994-12-13 | 1998-04-29 | Smithkline Beecham Corp | NEW COMPOUNDS |
CA2294064A1 (en) | 1997-07-29 | 1999-02-11 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
GB9905010D0 (en) | 1999-03-04 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
-
1999
- 1999-11-25 FR FR9914837A patent/FR2801585B1/fr not_active Expired - Fee Related
-
2000
- 2000-11-24 SK SK689-2002A patent/SK6892002A3/sk unknown
- 2000-11-24 IL IL14983800A patent/IL149838A0/xx unknown
- 2000-11-24 US US10/130,454 patent/US6605633B1/en not_active Expired - Fee Related
- 2000-11-24 KR KR1020027006183A patent/KR20020050280A/ko not_active Application Discontinuation
- 2000-11-24 NZ NZ519126A patent/NZ519126A/xx unknown
- 2000-11-24 CA CA002392225A patent/CA2392225A1/en not_active Abandoned
- 2000-11-24 JP JP2001539861A patent/JP2003514894A/ja active Pending
- 2000-11-24 PL PL00355724A patent/PL355724A1/xx not_active Application Discontinuation
- 2000-11-24 RU RU2002113771/04A patent/RU2002113771A/ru unknown
- 2000-11-24 WO PCT/FR2000/003278 patent/WO2001038305A2/fr not_active Application Discontinuation
- 2000-11-24 EP EP00985320A patent/EP1232144B1/fr not_active Expired - Lifetime
- 2000-11-24 HU HU0203603A patent/HUP0203603A3/hu unknown
- 2000-11-24 ES ES00985320T patent/ES2218266T3/es not_active Expired - Lifetime
- 2000-11-24 DE DE60009544T patent/DE60009544T2/de not_active Expired - Fee Related
- 2000-11-24 BR BR0015695-7A patent/BR0015695A/pt not_active Application Discontinuation
- 2000-11-24 MX MXPA02005232A patent/MXPA02005232A/es not_active Application Discontinuation
- 2000-11-24 AT AT00985320T patent/ATE263150T1/de not_active IP Right Cessation
- 2000-11-24 CZ CZ20021810A patent/CZ20021810A3/cs unknown
- 2000-11-24 AU AU21776/01A patent/AU2177601A/en not_active Abandoned
- 2000-11-24 CN CN00816057A patent/CN1391556A/zh active Pending
-
2002
- 2002-05-24 NO NO20022460A patent/NO20022460L/no unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001038305A2 (fr) | 2001-05-31 |
JP2003514894A (ja) | 2003-04-22 |
DE60009544D1 (de) | 2004-05-06 |
IL149838A0 (en) | 2002-11-10 |
AU2177601A (en) | 2001-06-04 |
NO20022460D0 (no) | 2002-05-24 |
EP1232144B1 (fr) | 2004-03-31 |
RU2002113771A (ru) | 2004-01-10 |
SK6892002A3 (en) | 2002-10-08 |
US6605633B1 (en) | 2003-08-12 |
MXPA02005232A (es) | 2002-11-07 |
PL355724A1 (en) | 2004-05-17 |
ES2218266T3 (es) | 2004-11-16 |
HUP0203603A3 (en) | 2004-03-01 |
EP1232144A2 (fr) | 2002-08-21 |
FR2801585A1 (fr) | 2001-06-01 |
DE60009544T2 (de) | 2004-12-30 |
HUP0203603A2 (hu) | 2003-02-28 |
CA2392225A1 (en) | 2001-05-31 |
NZ519126A (en) | 2006-03-31 |
FR2801585B1 (fr) | 2002-02-15 |
ATE263150T1 (de) | 2004-04-15 |
NO20022460L (no) | 2002-05-24 |
CZ20021810A3 (cs) | 2002-08-14 |
CN1391556A (zh) | 2003-01-15 |
WO2001038305A3 (fr) | 2002-01-24 |
KR20020050280A (ko) | 2002-06-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0309106A (pt) | Derivados de terfenila, seu preparo, as composições farmacêuticas que os contêm | |
BR0015695A (pt) | Novos antagonistas dos receptores de il-8 | |
BRPI0607532A2 (pt) | derivados de alcanamina de diidrobenzofuranila como agonistas de 5ht2c | |
BR9910124A (pt) | Tienilazolilalcóxietanaminas, suas preparações e suas aplicações como medicamentos | |
BR0307874A (pt) | Atividade de compostos azabicìclicos com receptor de acetilcolina nicotìnica alfa7 | |
BRPI0213393B8 (pt) | derivados de éter alquílico, ou um de seus sais, processo para produzir um derivado de éter alquílico, derivado de alquil-amida, ou um de seus sais, e, composição farmacêutica | |
BRPI0519262A2 (pt) | derivados de pirazol fundidos e mÉtodos de tratamento de distérbios metabàlicos-relacionados destes | |
BRPI9913542B8 (pt) | derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos | |
BR0111019A (pt) | 1-aminoalquil-lactamas substituìdas e seu uso como antagonistas de receptores muscarìnicos | |
BR0109235A (pt) | Derivados do ácido carboxìlico como antagonistas ip | |
BR0209499A (pt) | Composto, processo para produzir o composto, e, composição pesticida | |
BRPI0415769A (pt) | alcanaminas de diidrobenzofuranila e composições farmacêuticas contendo-as | |
BR0017063A (pt) | Piperidinas substituìdas, composições farmacêuticas contendo estes compostos e processos para prepará-las | |
BR0316950A (pt) | Derivados de indazol como antagonistas de crf | |
Ashok et al. | Design, Synthesis, and Biological Evaluation of 1‐(thiophen‐2‐yl)‐9H‐pyrido [3, 4‐b] indole Derivatives as Anti‐HIV‐1 Agents | |
BR0111061A (pt) | 1-aminoalquil-lactamas substituìdas e seu uso como antagonistas de receptor muscarìnico a61p 21/02 | |
BR0309748A (pt) | Derivados de n-acil piperidina e composição compreendendo os mesmos | |
BR0214695A (pt) | Derivados de pirazol com anel fundido | |
BRPI0607918A2 (pt) | tetraidro-piridoazepin-8-onas e compostos relacionados para o tratemento da esquizofrenia. | |
BRPI0415631A (pt) | derivados de tetrazol e métodos de tratamento de distúrbios metabólico-relacionados dos mesmos | |
BRPI0508404A (pt) | derivado de (indol-3-il)-heterociclo, composição farmacêutica, uso de um derivado de (indol-3-il)-heterociclo, e método de tratamento da dor | |
BRPI0406704A (pt) | Antagonistas de 5ht~7~ e agonistas inversos | |
NO973213L (no) | Nye 2-(1H)-quinolinforbindelser, fremgangsmåter ved fremstilling av slike samt farmasöytiske sammensetninger omfattende disse | |
BR0209877A (pt) | Derivados de piperidinacarboxamida, processo para a respectiva preparação e as composições farmacêuticas que os contêm | |
BR0308844A (pt) | Derivado de pirimidina bicìclica fundida e seus sais farmaceuticamente aceitáveis que atuam como antagonistas do receptor de taquicinina, bem como, as aplicações médicas desses compostos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |