BR0308844A - Derivado de pirimidina bicìclica fundida e seus sais farmaceuticamente aceitáveis que atuam como antagonistas do receptor de taquicinina, bem como, as aplicações médicas desses compostos - Google Patents

Derivado de pirimidina bicìclica fundida e seus sais farmaceuticamente aceitáveis que atuam como antagonistas do receptor de taquicinina, bem como, as aplicações médicas desses compostos

Info

Publication number
BR0308844A
BR0308844A BR0308844-8A BR0308844A BR0308844A BR 0308844 A BR0308844 A BR 0308844A BR 0308844 A BR0308844 A BR 0308844A BR 0308844 A BR0308844 A BR 0308844A
Authority
BR
Brazil
Prior art keywords
pyrimidine derivative
bicyclically
compounds
pharmaceutically acceptable
well
Prior art date
Application number
BR0308844-8A
Other languages
English (en)
Inventor
Shigeki Seto
Asao Tanioka
Makoto Ikeda
Shigeru Izawa
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of BR0308844A publication Critical patent/BR0308844A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"DERIVADO DE PIRIMIDINA BICìCLICA FUNDIDA E SEUS SAIS FARMACEUTICAMENTE ACEITáVEIS QUE ATUAM COMO ANTAGONISTAS DO RECEPTOR DE TAQUICININA, BEM COMO, AS APLICAçõES MéDICAS DESSES COMPOSTOS". Novo composto derivado da pirimidina bicíclica fundida ou um sal da mesma que atua como um antagonista do receptor de taquicinina e, em particular, como um antagonista do receptor de NK1 é representado pela seguinte fórmula geral: onde cada um dos anéis A e B são um anel benzênico que pode incluir de 1 a 3 substituintes (qualquer par adjacente que possa ser ligado a um outro para formar um anel); o anel C é um anel que contém nitrogênio; R é um átomo de hidrogênio; um grupo alquila C~ 1~ a C~ 6~; um grupo alquilcarbonila C~ 1~ a C~ 6~; ou um grupo alquilsulfonila C~ 1~ a C~ 6~; m é 1 ou 2; e n é 2 ou 3.
BR0308844-8A 2002-03-26 2003-03-24 Derivado de pirimidina bicìclica fundida e seus sais farmaceuticamente aceitáveis que atuam como antagonistas do receptor de taquicinina, bem como, as aplicações médicas desses compostos BR0308844A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002084759 2002-03-26
PCT/JP2003/003488 WO2003080619A1 (fr) 2002-03-26 2003-03-24 Derives de pyrimidine bicycliques et fusionnes

Publications (1)

Publication Number Publication Date
BR0308844A true BR0308844A (pt) 2005-01-04

Family

ID=28449223

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308844-8A BR0308844A (pt) 2002-03-26 2003-03-24 Derivado de pirimidina bicìclica fundida e seus sais farmaceuticamente aceitáveis que atuam como antagonistas do receptor de taquicinina, bem como, as aplicações médicas desses compostos

Country Status (16)

Country Link
US (1) US7064119B2 (pt)
EP (1) EP1496059B1 (pt)
JP (1) JP4402959B2 (pt)
KR (1) KR20040093182A (pt)
CN (1) CN1330654C (pt)
AT (1) ATE370140T1 (pt)
AU (1) AU2003221205B2 (pt)
BR (1) BR0308844A (pt)
CA (1) CA2479277A1 (pt)
DE (1) DE60315626T2 (pt)
DK (1) DK1496059T3 (pt)
MX (1) MXPA04009300A (pt)
NO (1) NO20044331L (pt)
NZ (1) NZ535183A (pt)
PT (1) PT1496059E (pt)
WO (1) WO2003080619A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007509184A (ja) * 2003-10-27 2007-04-12 ノバルティス アクチエンゲゼルシャフト 尿失禁の処置におけるニューロキニンアンタゴニストの使用
US8102868B2 (en) * 2006-01-05 2012-01-24 Folusha Forte B.V., Llc Interleaved and directional wireless mesh network
US20070183439A1 (en) * 2006-01-05 2007-08-09 Osann Robert Jr Combined directional and mobile interleaved wireless mesh network
US20070297366A1 (en) * 2006-01-05 2007-12-27 Robert Osann Synchronized wireless mesh network
TW200914457A (en) * 2007-05-31 2009-04-01 Kyowa Hakko Kogyo Kk Pyrimidodiazepinone derivative
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770590A (en) 1995-03-24 1998-06-23 Takeda Chemical Industries, Ltd. Cyclic compounds, their prudiction and use
JP2976097B2 (ja) * 1995-03-24 1999-11-10 武田薬品工業株式会社 環状化合物、その製造法および剤
JP3993264B2 (ja) * 1995-03-24 2007-10-17 武田薬品工業株式会社 環状化合物、その製造法および剤
JP2002348289A (ja) * 2001-03-19 2002-12-04 Takeda Chem Ind Ltd ３環性複素環化合物、その製造法および用途

Also Published As

Publication number Publication date
JP4402959B2 (ja) 2010-01-20
CN1656098A (zh) 2005-08-17
PT1496059E (pt) 2007-10-29
DE60315626D1 (de) 2007-09-27
MXPA04009300A (es) 2005-01-25
JPWO2003080619A1 (ja) 2005-07-21
EP1496059A1 (en) 2005-01-12
DE60315626T2 (de) 2008-06-05
EP1496059A4 (en) 2006-02-08
US20050159409A1 (en) 2005-07-21
CN1330654C (zh) 2007-08-08
AU2003221205B2 (en) 2008-09-18
US7064119B2 (en) 2006-06-20
AU2003221205A1 (en) 2003-10-08
NZ535183A (en) 2006-03-31
KR20040093182A (ko) 2004-11-04
WO2003080619A1 (fr) 2003-10-02
EP1496059B1 (en) 2007-08-15
NO20044331L (no) 2004-10-25
CA2479277A1 (en) 2003-10-02
ATE370140T1 (de) 2007-09-15
DK1496059T3 (da) 2007-12-03

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 8A E 9A ANUIDADES.