SK66798A3 - Quinoline derivative, preparation method thereof, pharmaceutical composition containing the same and its use - Google Patents
Quinoline derivative, preparation method thereof, pharmaceutical composition containing the same and its use Download PDFInfo
- Publication number
- SK66798A3 SK66798A3 SK667-98A SK66798A SK66798A3 SK 66798 A3 SK66798 A3 SK 66798A3 SK 66798 A SK66798 A SK 66798A SK 66798 A3 SK66798 A3 SK 66798A3
- Authority
- SK
- Slovakia
- Prior art keywords
- ethylbenzyl
- carboxamide
- phenylquinoline
- alkyl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI002461 IT1276170B1 (it) | 1995-11-24 | 1995-11-24 | Derivati chinolinici |
IT96MI001689 IT1307331B1 (it) | 1996-08-02 | 1996-08-02 | Derivati chinolinici |
PCT/EP1996/005203 WO1997021680A1 (fr) | 1995-11-24 | 1996-11-22 | Derives de quinoline |
Publications (1)
Publication Number | Publication Date |
---|---|
SK66798A3 true SK66798A3 (en) | 1999-01-11 |
Family
ID=26331326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK667-98A SK66798A3 (en) | 1995-11-24 | 1996-11-22 | Quinoline derivative, preparation method thereof, pharmaceutical composition containing the same and its use |
Country Status (26)
Country | Link |
---|---|
US (1) | US6277862B1 (fr) |
EP (1) | EP0876347B1 (fr) |
JP (1) | JP2000501104A (fr) |
KR (1) | KR19990071597A (fr) |
CN (1) | CN1207730A (fr) |
AP (1) | AP9801237A0 (fr) |
AR (1) | AR004972A1 (fr) |
AT (1) | ATE289994T1 (fr) |
BG (1) | BG102558A (fr) |
BR (1) | BR9611820A (fr) |
CA (1) | CA2238298A1 (fr) |
CZ (1) | CZ157998A3 (fr) |
DE (1) | DE69634416T2 (fr) |
EA (1) | EA002124B1 (fr) |
ES (1) | ES2236757T3 (fr) |
IL (1) | IL124522A0 (fr) |
MX (1) | MX9804107A (fr) |
NO (1) | NO311212B1 (fr) |
NZ (1) | NZ323387A (fr) |
OA (1) | OA11010A (fr) |
PL (1) | PL326967A1 (fr) |
SK (1) | SK66798A3 (fr) |
TR (1) | TR199800924T2 (fr) |
TW (1) | TW353066B (fr) |
UY (1) | UY24733A1 (fr) |
WO (1) | WO1997021680A1 (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU219131B (hu) * | 1991-10-18 | 2001-02-28 | Monsanto Co. | Módszer és fungicid készítmény növények torsgombabetegségének gátlására és a hatóanyagok |
SE9703407D0 (sv) * | 1997-09-19 | 1997-09-19 | Astra Ab | New use |
SE9802073D0 (sv) | 1998-06-11 | 1998-06-11 | Astra Ab | New use |
GB9825554D0 (en) * | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
US7037922B1 (en) * | 2000-03-10 | 2006-05-02 | Neurogen Corporation | Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands |
CA2368455A1 (fr) | 1999-03-29 | 2000-10-05 | Neurogen Corporation | Derives de quinoline 4-substitues comme ligands de recepteurs de nk-3 et/ou de gabaa |
AU4802500A (en) | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
ES2254688T3 (es) * | 2001-04-11 | 2006-06-16 | Glaxosmithkline S.P.A. | Derivados de quinolina-4-carboxamida como antagonistas de los receptores nk-3 y nk-2. |
WO2002089802A2 (fr) * | 2001-05-08 | 2002-11-14 | Schering Corporation | Utilisation d'antagonistes de recepteur de neurokinine pour le traitement de maladies liees aux androgenes |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EP1594517B1 (fr) | 2003-01-28 | 2007-06-20 | Microbia, Inc. | Compositions pour le traitement de troubles gastro-intestinaux |
GB0303086D0 (en) * | 2003-02-11 | 2003-03-19 | Merck Sharp & Dohme | New compounds |
GB0419192D0 (en) | 2004-08-27 | 2004-09-29 | Merck Sharp & Dohme | Therapeutic agents |
CA2586446A1 (fr) * | 2004-11-09 | 2006-05-18 | Smithkline Beecham Corporation | Composes inhibiteurs de la phosphorylase du glycogene et compositions pharmaceutiques les comprenant |
GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
EP1915361A1 (fr) * | 2005-08-11 | 2008-04-30 | AstraZeneca AB | Alkylpyridyl quinolines en tant que modulateurs du récepteur des nk3 |
AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
TW201018662A (en) * | 2005-12-12 | 2010-05-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
WO2008151257A2 (fr) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CN101861303A (zh) * | 2007-09-28 | 2010-10-13 | 葛兰素史密丝克莱恩有限责任公司 | 糖原磷酸化酶抑制剂化合物和其药物组合物 |
CA2701120A1 (fr) * | 2007-09-28 | 2009-04-09 | Glaxosmithkline Llc | Compose inhibiteur de la glycogene phosphorylase et composition pharmaceutique contenant ledit compose |
EP2328910B1 (fr) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
WO2018129556A1 (fr) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Composés et procédés pour l'inhibition d'un antiport à médiation par échangeur sodium/proton (nhe) dans le traitement de troubles associés à une rétention d'eau ou à une surcharge en sel et de troubles du tractus gastro-intestinal |
WO2010078449A2 (fr) | 2008-12-31 | 2010-07-08 | Ardelyx, Inc. | Composés et procédés d'inhibition d'un antiport à médiation par nhe dans le traitement de troubles associés à une rétention de fluide ou à une surcharge de sel et de troubles du tractus gastro-intestinal |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US20150336892A1 (en) | 2012-08-21 | 2015-11-26 | Ardelyx, Inc | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
EP2968439A2 (fr) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
CA2905438A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
EP3552630A1 (fr) | 2013-04-12 | 2019-10-16 | Ardelyx, Inc. | Composés de liaison à nhe3 pour inhiber le transport de phosphate |
WO2014170648A1 (fr) | 2013-04-19 | 2014-10-23 | Astrazeneca Ab | Composé antagoniste du récepteur nk3 (nk3ra) utilisé dans une méthode pour traiter le syndrome des ovaires polykystiques (sopk) |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
WO2017072629A1 (fr) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Combinaison pharmaceutique d'antagoniste du récepteur nk3 et de biguanides |
CN110267944B (zh) | 2017-01-09 | 2024-03-08 | 阿德利克斯股份有限公司 | 可用于治疗胃肠道病症的化合物 |
WO2018129557A1 (fr) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Inhibiteurs d'antiport à médiation par nhe |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
JPS63119455A (ja) * | 1986-06-27 | 1988-05-24 | Nippon Shinyaku Co Ltd | グリシン誘導体 |
EP0940391B1 (fr) * | 1994-05-27 | 2004-08-18 | GlaxoSmithKline S.p.A. | Dérivés de quinoléine en tant qu'antagonistes du récepteur de tachykinine NK3 |
IT1270615B (it) * | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
-
1996
- 1996-11-22 JP JP9521658A patent/JP2000501104A/ja active Pending
- 1996-11-22 EP EP96941023A patent/EP0876347B1/fr not_active Expired - Lifetime
- 1996-11-22 PL PL96326967A patent/PL326967A1/xx unknown
- 1996-11-22 AP APAP/P/1998/001237A patent/AP9801237A0/en unknown
- 1996-11-22 EA EA199800477A patent/EA002124B1/ru not_active IP Right Cessation
- 1996-11-22 US US09/077,151 patent/US6277862B1/en not_active Expired - Fee Related
- 1996-11-22 NZ NZ323387A patent/NZ323387A/en unknown
- 1996-11-22 WO PCT/EP1996/005203 patent/WO1997021680A1/fr not_active Application Discontinuation
- 1996-11-22 KR KR1019980703873A patent/KR19990071597A/ko not_active Application Discontinuation
- 1996-11-22 CA CA002238298A patent/CA2238298A1/fr not_active Abandoned
- 1996-11-22 TR TR1998/00924T patent/TR199800924T2/xx unknown
- 1996-11-22 CN CN96199753A patent/CN1207730A/zh active Pending
- 1996-11-22 BR BR9611820A patent/BR9611820A/pt not_active Application Discontinuation
- 1996-11-22 AT AT96941023T patent/ATE289994T1/de not_active IP Right Cessation
- 1996-11-22 CZ CZ981579A patent/CZ157998A3/cs unknown
- 1996-11-22 DE DE69634416T patent/DE69634416T2/de not_active Expired - Fee Related
- 1996-11-22 IL IL12452296A patent/IL124522A0/xx unknown
- 1996-11-22 ES ES96941023T patent/ES2236757T3/es not_active Expired - Lifetime
- 1996-11-22 SK SK667-98A patent/SK66798A3/sk unknown
- 1996-11-23 TW TW085114500A patent/TW353066B/zh active
- 1996-11-25 AR ARP960105317A patent/AR004972A1/es not_active Application Discontinuation
-
1997
- 1997-09-30 UY UY24733A patent/UY24733A1/es not_active Application Discontinuation
-
1998
- 1998-05-22 MX MX9804107A patent/MX9804107A/es unknown
- 1998-05-22 NO NO19982331A patent/NO311212B1/no unknown
- 1998-05-22 OA OA9800061A patent/OA11010A/en unknown
- 1998-06-18 BG BG102558A patent/BG102558A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
PL326967A1 (en) | 1998-11-09 |
AP9801237A0 (en) | 1998-06-30 |
NO311212B1 (no) | 2001-10-29 |
AR004972A1 (es) | 1999-04-07 |
CN1207730A (zh) | 1999-02-10 |
KR19990071597A (ko) | 1999-09-27 |
CA2238298A1 (fr) | 1997-06-19 |
ES2236757T3 (es) | 2005-07-16 |
NO982331D0 (no) | 1998-05-22 |
ATE289994T1 (de) | 2005-03-15 |
TR199800924T2 (xx) | 1998-08-21 |
DE69634416T2 (de) | 2005-12-29 |
BG102558A (bg) | 1999-03-31 |
MX9804107A (es) | 1998-09-30 |
EP0876347A1 (fr) | 1998-11-11 |
BR9611820A (pt) | 1999-07-13 |
US6277862B1 (en) | 2001-08-21 |
EP0876347B1 (fr) | 2005-03-02 |
UY24733A1 (es) | 2001-08-27 |
NO982331L (no) | 1998-07-22 |
IL124522A0 (en) | 1998-12-06 |
CZ157998A3 (cs) | 1998-12-16 |
WO1997021680A1 (fr) | 1997-06-19 |
DE69634416D1 (de) | 2005-04-07 |
JP2000501104A (ja) | 2000-02-02 |
TW353066B (en) | 1999-02-21 |
NZ323387A (en) | 2000-02-28 |
OA11010A (en) | 2003-03-06 |
EA002124B1 (ru) | 2001-12-24 |
EA199800477A1 (ru) | 1998-12-24 |
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