OA11010A - Quinoline derivatives - Google Patents

Quinoline derivatives Download PDF

Info

Publication number
OA11010A
OA11010A OA9800061A OA9800061A OA11010A OA 11010 A OA11010 A OA 11010A OA 9800061 A OA9800061 A OA 9800061A OA 9800061 A OA9800061 A OA 9800061A OA 11010 A OA11010 A OA 11010A
Authority
OA
OAPI
Prior art keywords
compound
formula
alkyl
group
mmol
Prior art date
Application number
OA9800061A
Other languages
English (en)
Inventor
Giuseppe Amaldo Maria
Mario Grugni
Luca Francesco Raeglia
Carlo Farina
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI952461 external-priority patent/IT1276170B1/it
Priority claimed from IT96MI001689 external-priority patent/IT1307331B1/it
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of OA11010A publication Critical patent/OA11010A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
OA9800061A 1995-11-24 1998-05-22 Quinoline derivatives OA11010A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI952461 IT1276170B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
IT96MI001689 IT1307331B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici

Publications (1)

Publication Number Publication Date
OA11010A true OA11010A (en) 2003-03-06

Family

ID=26331326

Family Applications (1)

Application Number Title Priority Date Filing Date
OA9800061A OA11010A (en) 1995-11-24 1998-05-22 Quinoline derivatives

Country Status (26)

Country Link
US (1) US6277862B1 (fr)
EP (1) EP0876347B1 (fr)
JP (1) JP2000501104A (fr)
KR (1) KR19990071597A (fr)
CN (1) CN1207730A (fr)
AP (1) AP9801237A0 (fr)
AR (1) AR004972A1 (fr)
AT (1) ATE289994T1 (fr)
BG (1) BG102558A (fr)
BR (1) BR9611820A (fr)
CA (1) CA2238298A1 (fr)
CZ (1) CZ157998A3 (fr)
DE (1) DE69634416T2 (fr)
EA (1) EA002124B1 (fr)
ES (1) ES2236757T3 (fr)
IL (1) IL124522A0 (fr)
MX (1) MX9804107A (fr)
NO (1) NO311212B1 (fr)
NZ (1) NZ323387A (fr)
OA (1) OA11010A (fr)
PL (1) PL326967A1 (fr)
SK (1) SK66798A3 (fr)
TR (1) TR199800924T2 (fr)
TW (1) TW353066B (fr)
UY (1) UY24733A1 (fr)
WO (1) WO1997021680A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2119155C (fr) * 1991-10-18 1999-06-15 Dennis Paul Phillion Fongicides pour lutter contre le pietin-echaudage des vegetaux
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US7037922B1 (en) 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
EP1165542B1 (fr) 1999-03-29 2003-08-20 Neurogen Corporation Derives de quinoline substitues en position 4 en tant que ligands des recepteurs nk-3 et/ou gaba(a)
WO2000064877A1 (fr) 1999-04-26 2000-11-02 Neurogen Corporation 2-aminoquinolinecarboxamides: ligands de recepteurs de la neurokinine
WO2002083663A1 (fr) * 2001-04-11 2002-10-24 Glaxosmithkline S.P.A. Derives de quinoline-4-carboxamide comme antagonistes de recepteurs de nk-3 et nk-4
AU2002259147A1 (en) * 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
CN101787073B (zh) 2003-01-28 2013-12-25 艾恩伍德医药品股份有限公司 治疗胃肠病的方法和组合物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0303086D0 (en) * 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
JP2008519761A (ja) * 2004-11-09 2008-06-12 スミスクライン ビーチャム コーポレーション グリコーゲンホスホリラーゼ阻害化合物およびその医薬組成物
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
CN101282961A (zh) * 2005-08-11 2008-10-08 阿斯利康(瑞典)有限公司 作为nk3受体调节剂的烷基吡啶基喹啉
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) * 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
CA3089569C (fr) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
MX2010003440A (es) * 2007-09-28 2010-04-21 Glaxosmithkline Llc Compuesto inhibidor de glicogeno fosforilasa y composicion farmaceutica del mismo.
KR20100075568A (ko) * 2007-09-28 2010-07-02 글락소스미스클라인 엘엘씨 글리코겐 포스포릴라아제 억제제 화합물 및 이의 약제 조성물
EP2321341B1 (fr) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
WO2018129556A1 (fr) 2017-01-09 2018-07-12 Ardelyx, Inc. Composés et procédés pour l'inhibition d'un antiport à médiation par échangeur sodium/proton (nhe) dans le traitement de troubles associés à une rétention d'eau ou à une surcharge en sel et de troubles du tractus gastro-intestinal
ES2657938T3 (es) 2008-12-31 2018-03-07 Ardelyx, Inc. Compuestos y métodos para inhibir el antipuerto mediado por NHE en el tratamiento de trastornos asociados a la retención de líquidos o a la sobrecarga de sales y trastornos del tracto gastrointestinal
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN104902930A (zh) 2012-08-21 2015-09-09 阿德利克斯公司 在治疗与液体潴留或盐分过载相关的疾病和胃肠道疾病中用于抑制nhe-介导的反向转运的化合物和方法
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
ES2735992T3 (es) 2013-04-12 2019-12-23 Ardelyx Inc Compuestos de unión a NHE3 y procedimientos para inhibir el transporte de fosfatos
WO2014170648A1 (fr) 2013-04-19 2014-10-23 Astrazeneca Ab Composé antagoniste du récepteur nk3 (nk3ra) utilisé dans une méthode pour traiter le syndrome des ovaires polykystiques (sopk)
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
WO2017072629A1 (fr) 2015-10-29 2017-05-04 Cadila Healthcare Limited Combinaison pharmaceutique d'antagoniste du récepteur nk3 et de biguanides
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
EP3565808A1 (fr) 2017-01-09 2019-11-13 Ardelyx, Inc. Composés utiles pour le traitement de troubles du tractus digestif

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS6399057A (ja) * 1986-06-27 1988-04-30 Nippon Shinyaku Co Ltd グリシン誘導体
BR9507788A (pt) * 1994-05-27 1997-09-23 Smithkline Beecham Spa Composto ou solvato ou sal do mesmo processo para a preparação do composto composição farmacêutica antagonista do receptor de NK3 uso do composto uso do antagonista do receptor de NG3 e processo para o tratamento e/ou profilaxia de distúrbios pulmonares e distúrbios convulsivos
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
NO982331D0 (no) 1998-05-22
NO311212B1 (no) 2001-10-29
AP9801237A0 (en) 1998-06-30
EA199800477A1 (ru) 1998-12-24
IL124522A0 (en) 1998-12-06
TR199800924T2 (xx) 1998-08-21
NZ323387A (en) 2000-02-28
ES2236757T3 (es) 2005-07-16
AR004972A1 (es) 1999-04-07
MX9804107A (es) 1998-09-30
KR19990071597A (ko) 1999-09-27
DE69634416D1 (de) 2005-04-07
UY24733A1 (es) 2001-08-27
PL326967A1 (en) 1998-11-09
BG102558A (bg) 1999-03-31
BR9611820A (pt) 1999-07-13
EP0876347B1 (fr) 2005-03-02
WO1997021680A1 (fr) 1997-06-19
SK66798A3 (en) 1999-01-11
CN1207730A (zh) 1999-02-10
EP0876347A1 (fr) 1998-11-11
JP2000501104A (ja) 2000-02-02
NO982331L (no) 1998-07-22
EA002124B1 (ru) 2001-12-24
ATE289994T1 (de) 2005-03-15
US6277862B1 (en) 2001-08-21
DE69634416T2 (de) 2005-12-29
CZ157998A3 (cs) 1998-12-16
CA2238298A1 (fr) 1997-06-19
TW353066B (en) 1999-02-21

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