SK4672003A3 - Non-imidazole compounds, pharmaceutical composition comprising same and use thereof - Google Patents
Non-imidazole compounds, pharmaceutical composition comprising same and use thereof Download PDFInfo
- Publication number
- SK4672003A3 SK4672003A3 SK467-2003A SK4672003A SK4672003A3 SK 4672003 A3 SK4672003 A3 SK 4672003A3 SK 4672003 A SK4672003 A SK 4672003A SK 4672003 A3 SK4672003 A3 SK 4672003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- alkyl
- mmol
- substituted
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24090100P | 2000-10-17 | 2000-10-17 | |
PCT/US2001/032151 WO2002032893A2 (fr) | 2000-10-17 | 2001-10-15 | Nouveaux composes non imidazole |
Publications (1)
Publication Number | Publication Date |
---|---|
SK4672003A3 true SK4672003A3 (en) | 2003-11-04 |
Family
ID=22908389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK467-2003A SK4672003A3 (en) | 2000-10-17 | 2001-10-15 | Non-imidazole compounds, pharmaceutical composition comprising same and use thereof |
Country Status (30)
Country | Link |
---|---|
US (3) | US6720328B2 (fr) |
EP (2) | EP1326858B1 (fr) |
JP (2) | JP4093859B2 (fr) |
KR (1) | KR100567266B1 (fr) |
CN (2) | CN1243751C (fr) |
AR (1) | AR035497A1 (fr) |
AT (2) | ATE420863T1 (fr) |
AU (2) | AU1535502A (fr) |
BR (1) | BR0114754A (fr) |
CA (1) | CA2424664C (fr) |
CY (2) | CY1105227T1 (fr) |
DE (2) | DE60115937T2 (fr) |
DK (2) | DK1326858T3 (fr) |
EC (1) | ECSP034559A (fr) |
ES (2) | ES2320008T3 (fr) |
HK (2) | HK1052935B (fr) |
HU (1) | HUP0303835A3 (fr) |
IL (1) | IL155031A0 (fr) |
MX (1) | MXPA03003529A (fr) |
NO (1) | NO325997B1 (fr) |
NZ (1) | NZ524857A (fr) |
PE (1) | PE20020507A1 (fr) |
PL (1) | PL361978A1 (fr) |
PT (1) | PT1571145E (fr) |
RU (2) | RU2301231C2 (fr) |
SI (1) | SI1326858T1 (fr) |
SK (1) | SK4672003A3 (fr) |
TW (2) | TWI258474B (fr) |
WO (1) | WO2002032893A2 (fr) |
ZA (1) | ZA200302521B (fr) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
GB2373186A (en) * | 2001-02-23 | 2002-09-18 | Astrazeneca Ab | Pharmaceutical combinations of a CCR3 antagonist and a compound which is usefulreatment of asthma, allergic disease or inflammation |
AU2002244271A1 (en) * | 2001-03-13 | 2002-09-24 | Pharmacopeia, Inc. | Non-imidazole compounds as histamine h3 antagonists |
AR036881A1 (es) * | 2001-10-15 | 2004-10-13 | Schering Corp | Un proceso para la preparacion de 4-(piperidil)(2-piridil)metanona-(e)-o-metiloxima y sales |
US7105505B2 (en) | 2002-04-18 | 2006-09-12 | Schering Corporation | Benzimidazole derivatives useful as histamine H3 antagonists |
AR040406A1 (es) | 2002-04-18 | 2005-04-06 | Schering Corp | Antagonistas de histamina h3 de benzimidazolona |
EP1539742B1 (fr) * | 2002-06-24 | 2006-11-08 | Schering Corporation | Derives d'indole utilises en tant qu'antagonistes h3 d'histamine |
EP2194058B1 (fr) | 2002-09-04 | 2013-11-27 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidines utiisables pour le traitement de maladies cancéreuses |
US8580782B2 (en) | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
US8673924B2 (en) | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
CA2512899A1 (fr) | 2003-01-14 | 2004-08-05 | Arena Pharmaceuticals Inc. | Derives aryles et heteroaryles tri-substitues en position 1,2,3 en tant que modulateurs de metabolisme et prophylaxie et traitement de troubles lies au metabolisme |
US20050090527A1 (en) * | 2003-01-28 | 2005-04-28 | Schering Corporation | Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis |
PL1615909T3 (pl) | 2003-04-23 | 2009-01-30 | Glaxo Group Ltd | Pochodne piperazyny i ich zastosowanie w leczeniu chorób neurologicznych i psychicznych |
EP1646620B1 (fr) * | 2003-07-18 | 2007-08-15 | Glaxo Group Limited | Piperidines substituees utilisees en tant que ligands du recepteur h3 de l'histamine |
MX2007001561A (es) * | 2004-08-04 | 2007-04-16 | Schering Corp | Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas. |
GB0420831D0 (en) | 2004-09-17 | 2004-10-20 | Glaxo Group Ltd | Novel compounds |
DE602006010864D1 (de) * | 2005-06-20 | 2010-01-14 | Schering Corp | Kohlenstoffgebundene substituierte piperidine und derivate daraus als histamin-h3-antagonisten |
KR20080021082A (ko) | 2005-06-20 | 2008-03-06 | 쉐링 코포레이션 | 히스타민 h3 길항제로서 유용한 피페리딘 유도체 |
EP1931665A1 (fr) * | 2005-09-20 | 2008-06-18 | Schering Corporation | La 1-[[1-[(2-amin0-6-methyl-4-pyridinyl) methyl]-4-flu0r0-4-piperidinyl,]carbonyl]-4-[2-(2-pyridinyl)-3h-imidaz0[4, 5-b]pyridin-3-yl]piperidine, utile en tant qu'antagoniste de l'histamine h3 |
AU2006331770A1 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and H3 receptor antagonist/inverse agonist |
WO2007075688A2 (fr) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Derives substitues de l'aniline utilisables en tant qu'antagonistes de l'histamine h3 |
JP2009521448A (ja) * | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | ヒスタミンh3アンタゴニストとして有用なフェノキシピペリジンおよびそのアナログ |
EP1965862A2 (fr) * | 2005-12-21 | 2008-09-10 | Schering Corporation | Combinaison d'un antagoniste/agoniste inverse de h3 et d'un moderateur de l'appetit |
PE20071320A1 (es) | 2006-01-18 | 2007-12-29 | Schering Corp | Moduladores de receptores cannabinoides |
JP2010520199A (ja) * | 2007-03-02 | 2010-06-10 | シェーリング コーポレイション | ピペリジン誘導体およびその使用方法 |
KR20100051625A (ko) * | 2007-06-28 | 2010-05-17 | 인터벳 인터내셔널 비.브이. | Cb1 길항제로서의 치환된 피페라진 |
WO2009052068A1 (fr) * | 2007-10-17 | 2009-04-23 | Sanofi-Aventis | Urées de n-phényl-bipyrrolidine substituées et leur utilisation thérapeutique |
RU2477719C2 (ru) * | 2007-10-17 | 2013-03-20 | Санофи-Авентис | Замещенные n-фенилбипирролидинкарбоксамиды и их терапевтическое применение |
KR20100072077A (ko) * | 2007-10-17 | 2010-06-29 | 사노피-아벤티스 | 치환된 n페닐비피롤리딘 카복스아미드 및 이의 치료적 용도 |
EP2205558B1 (fr) * | 2007-10-17 | 2012-07-25 | Sanofi | Amides de n-phényl-pyrrolidinylméthylpyrrolidine substitués et leur utilisation thérapeutique comme modulateurs du récepteur h3 de l'histamine |
US8383657B2 (en) * | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
US20090221648A1 (en) * | 2007-12-21 | 2009-09-03 | Abbott Laboratories | Compositions for treatment of cognitive disorders |
ES2590604T3 (es) | 2008-01-04 | 2016-11-22 | Schabar Research Associates Llc | Composición que comprende un analgésico y un antihistamínico |
EP2318388A2 (fr) | 2008-07-23 | 2011-05-11 | Schering Corporation | Dérivés spirocycliques tricycliques et leurs procédés d utilisation |
CA2739491A1 (fr) | 2008-10-16 | 2010-04-22 | Schering Corporation | Derives d'azine et leurs methodes d'utilisation |
EP2379564A1 (fr) | 2008-12-19 | 2011-10-26 | Schering Corporation | Dérivés hétérocycliques bicycliques et leurs procédés d'utilisation |
WO2010071822A1 (fr) | 2008-12-19 | 2010-06-24 | Schering Corporation | Dérivés de pipéridine et de pipérazine et leurs méthodes d'utilisation |
DK2421852T3 (da) * | 2009-04-22 | 2014-08-18 | Janssen Pharmaceutica Nv | Heteroaromatiske og aromatiske piperazinylazetidinylamider som monoacylglycerollipaseinhibitor |
US20120171126A1 (en) | 2009-06-16 | 2012-07-05 | Purakkattle Biju J | NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS COMPOSITIONS AND USES THEREOF |
US8785440B2 (en) | 2009-09-04 | 2014-07-22 | Biogen Idec Ma, Inc. | Bruton's tyrosine kinase inhibitors |
CN102712626B (zh) * | 2010-01-22 | 2014-09-17 | 大鹏药品工业株式会社 | 具有pgds抑制作用的哌嗪化合物 |
EP2619198A1 (fr) | 2010-09-22 | 2013-07-31 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement des troubles qui lui sont liés |
WO2013151982A1 (fr) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Méthodes et composés utiles pour traiter le prurit, et procédés d'identification desdits composés |
AR091273A1 (es) | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
CN105315267B (zh) * | 2014-07-30 | 2019-06-04 | 江苏恩华药业股份有限公司 | 一种酰胺类衍生物及其应用 |
MX2021011472A (es) | 2015-01-06 | 2022-08-17 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
SI3310760T1 (sl) | 2015-06-22 | 2023-02-28 | Arena Pharmaceuticals, Inc. | Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1 |
CN110049976A (zh) | 2016-07-21 | 2019-07-23 | 比奥根Ma公司 | 布鲁顿氏酪氨酸激酶抑制剂的琥珀酸盐形式和组合物 |
KR20190116416A (ko) | 2017-02-16 | 2019-10-14 | 아레나 파마슈티칼스, 인크. | 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법 |
CN110105263A (zh) * | 2019-05-13 | 2019-08-09 | 常州大学 | 一种阿米卡星中间体的合成方法 |
WO2022015784A1 (fr) | 2020-07-15 | 2022-01-20 | Schabar Research Associates Llc | Compositions de dose orale unitaire composées d'ibuprofène et de famotidine pour le traitement de la douleur aiguë et la réduction de la gravité et/ou du risque de brûlures d'estomac |
US11324727B2 (en) | 2020-07-15 | 2022-05-10 | Schabar Research Associates, Llc | Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR920701167A (ko) | 1989-07-07 | 1992-08-11 | 에릭 에스. 딕커 | 약제학적 활성 화합물 |
US5633250A (en) | 1991-12-18 | 1997-05-27 | Schering Corporation | Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms |
US5807872A (en) | 1992-12-16 | 1998-09-15 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
JPH07121939B2 (ja) | 1991-12-18 | 1995-12-25 | シェリング・コーポレーション | 窒素含有4または5員複素環で置換されたイミダゾリルまたはイミダゾイルアルキル化合物 |
HUT74386A (en) | 1993-11-15 | 1996-12-30 | Schering Corp | Phenyl-alkyl imidazoles as h3-receptor antagonists and pharmaceutical compositions containing them |
NZ323543A (en) * | 1995-11-17 | 1999-06-29 | Hoechst Marion Roussel Inc | Substituted 4-(1h-benzimidazol-2-yl-amino)piperidine derivatives useful for the treatment of allergic diseases |
CN1152682C (zh) | 1996-08-16 | 2004-06-09 | 先灵公司 | 用组胺受体拮抗剂组合物制备治疗上呼吸道变态反应的药物的用途 |
US5869479A (en) | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
US5990147A (en) | 1997-11-07 | 1999-11-23 | Schering Corporation | H3 receptor ligands of the phenyl-alkyl-imidazoles type |
US6034251A (en) | 1997-11-07 | 2000-03-07 | Schering Corporation | Phenyl-alkyl-imidazoles |
IL135729A0 (en) * | 1997-11-07 | 2001-05-20 | Schering Corp | H3 receptor ligands of the phenyl-alkyl-imidazoles type |
CN1329490A (zh) * | 1998-10-09 | 2002-01-02 | 先灵公司 | 用于治疗变应性疾病的组合物和方法 |
US6100279A (en) | 1998-11-05 | 2000-08-08 | Schering Corporation | Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom |
PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
AU2002244271A1 (en) | 2001-03-13 | 2002-09-24 | Pharmacopeia, Inc. | Non-imidazole compounds as histamine h3 antagonists |
AR040406A1 (es) * | 2002-04-18 | 2005-04-06 | Schering Corp | Antagonistas de histamina h3 de benzimidazolona |
US7105505B2 (en) * | 2002-04-18 | 2006-09-12 | Schering Corporation | Benzimidazole derivatives useful as histamine H3 antagonists |
EP1539742B1 (fr) * | 2002-06-24 | 2006-11-08 | Schering Corporation | Derives d'indole utilises en tant qu'antagonistes h3 d'histamine |
WO2004069338A1 (fr) * | 2003-01-31 | 2004-08-19 | Schering Corporation | Utilisation de combinaisons d'antagonistes du recepteur h1 et h3 de l'histamine pour la preparation d'un medicament destine au traitement d'etats cutanes et oculaires d'origine allergique |
-
2001
- 2001-10-12 PE PE2001001016A patent/PE20020507A1/es not_active Application Discontinuation
- 2001-10-15 DE DE60115937T patent/DE60115937T2/de not_active Expired - Lifetime
- 2001-10-15 EP EP01983968A patent/EP1326858B1/fr not_active Expired - Lifetime
- 2001-10-15 TW TW090125385A patent/TWI258474B/zh not_active IP Right Cessation
- 2001-10-15 CA CA002424664A patent/CA2424664C/fr not_active Expired - Fee Related
- 2001-10-15 EP EP05009405A patent/EP1571145B1/fr not_active Expired - Lifetime
- 2001-10-15 IL IL15503101A patent/IL155031A0/xx unknown
- 2001-10-15 PT PT05009405T patent/PT1571145E/pt unknown
- 2001-10-15 RU RU2003114748/04A patent/RU2301231C2/ru not_active IP Right Cessation
- 2001-10-15 CN CNB018175120A patent/CN1243751C/zh not_active Expired - Fee Related
- 2001-10-15 PL PL01361978A patent/PL361978A1/xx not_active Application Discontinuation
- 2001-10-15 SI SI200130466T patent/SI1326858T1/sl unknown
- 2001-10-15 KR KR1020037005283A patent/KR100567266B1/ko not_active IP Right Cessation
- 2001-10-15 AR ARP010104831A patent/AR035497A1/es not_active Application Discontinuation
- 2001-10-15 CN CN2005101310947A patent/CN1803795B/zh not_active Expired - Fee Related
- 2001-10-15 DK DK01983968T patent/DK1326858T3/da active
- 2001-10-15 AU AU1535502A patent/AU1535502A/xx active Pending
- 2001-10-15 US US09/978,267 patent/US6720328B2/en not_active Expired - Fee Related
- 2001-10-15 SK SK467-2003A patent/SK4672003A3/sk unknown
- 2001-10-15 NZ NZ524857A patent/NZ524857A/xx unknown
- 2001-10-15 AT AT05009405T patent/ATE420863T1/de active
- 2001-10-15 MX MXPA03003529A patent/MXPA03003529A/es active IP Right Grant
- 2001-10-15 HU HU0303835A patent/HUP0303835A3/hu unknown
- 2001-10-15 DE DE60137461T patent/DE60137461D1/de not_active Expired - Lifetime
- 2001-10-15 AT AT01983968T patent/ATE312833T1/de active
- 2001-10-15 ES ES05009405T patent/ES2320008T3/es not_active Expired - Lifetime
- 2001-10-15 AU AU2002215355A patent/AU2002215355B2/en not_active Ceased
- 2001-10-15 TW TW093131752A patent/TWI292399B/zh active
- 2001-10-15 BR BR0114754-4A patent/BR0114754A/pt not_active IP Right Cessation
- 2001-10-15 ES ES01983968T patent/ES2250500T3/es not_active Expired - Lifetime
- 2001-10-15 WO PCT/US2001/032151 patent/WO2002032893A2/fr active IP Right Grant
- 2001-10-15 DK DK05009405T patent/DK1571145T3/da active
- 2001-10-15 JP JP2002536275A patent/JP4093859B2/ja not_active Expired - Fee Related
-
2003
- 2003-03-31 ZA ZA200302521A patent/ZA200302521B/en unknown
- 2003-04-15 NO NO20031744A patent/NO325997B1/no not_active IP Right Cessation
- 2003-04-16 EC EC2003004559A patent/ECSP034559A/es unknown
- 2003-07-17 HK HK03105161.9A patent/HK1052935B/zh not_active IP Right Cessation
- 2003-10-31 US US10/699,189 patent/US7300941B2/en not_active Expired - Fee Related
-
2006
- 2006-01-23 HK HK06101045.7A patent/HK1081182A1/xx not_active IP Right Cessation
- 2006-03-09 CY CY20061100329T patent/CY1105227T1/el unknown
-
2007
- 2007-02-02 RU RU2007104096/04A patent/RU2007104096A/ru not_active Application Discontinuation
- 2007-03-09 JP JP2007061074A patent/JP2007145866A/ja active Pending
- 2007-11-20 US US11/943,315 patent/US20080119487A1/en not_active Abandoned
-
2009
- 2009-04-10 CY CY20091100417T patent/CY1110262T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK4672003A3 (en) | Non-imidazole compounds, pharmaceutical composition comprising same and use thereof | |
TWI804003B (zh) | Tlr7/8拮抗劑及其用途 | |
TWI457340B (zh) | 環狀苯胺基-吡啶并三類 | |
AU2002215355A1 (en) | Piperidine compounds as anti-allergic | |
CA2947338C (fr) | Composes polyfluores agissant en tant qu'inhibiteurs de la tyrosine kinase de bruton | |
US7456164B2 (en) | 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands | |
KR101964251B1 (ko) | 약학적 화합물 | |
EP1492789B1 (fr) | Derives de tropane utilises comme modulateur de ccr5 | |
KR20230042129A (ko) | 하이드라지드 함유 핵 수송 조절인자 및 이의 용도 | |
BRPI0510664B1 (pt) | derivados de fenol e tiofenol 3 ou 4-monosubstituído, composição farmacêutica, combinação e uso dos compostos para tratamento de doenças relacionadas ao h3, incluindo transtornos do sistema nervoso central e transtornos inflamatórios | |
ES2568508T3 (es) | Derivados de triazina como inhibidores de cinasas | |
MXPA05000193A (es) | Derivados de indol utiles como antagonistas de la histamina h2. | |
JP2008526895A (ja) | ヒスタミンh3アンタゴニストとして有用なイミダゾールおよびベンゾイミダゾール誘導体 | |
US7579471B2 (en) | Tropane derivatives useful in therapy | |
SG182435A1 (en) | Piperazine compound having a pgds inhibitory effect | |
NZ717552A (en) | Piperidine urea derivatives | |
ES2773511T3 (es) | Derivados de 1,4-dicarbonil-piperidilo | |
AU2006252027A1 (en) | Piperidine compounds as anti-allergic | |
BR112018004956B1 (pt) | Composto, composição farmacêutica, e, uso de um composto |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Suspended procedure due to non-payment of fee |